"Reverse Genetics" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The use of techniques that produce a functional MUTATION or an effect on GENE EXPRESSION of a specific gene of interest in order to identify the role or activity of the gene product of that gene.
| Descriptor ID |
D059386
|
| MeSH Number(s) |
E05.393.731
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Reverse Genetics".
Below are MeSH descriptors whose meaning is more specific than "Reverse Genetics".
This graph shows the total number of publications written about "Reverse Genetics" by people in this website by year, and whether "Reverse Genetics" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Reverse Genetics" by people in Profiles.
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A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode. Am J Hum Genet. 2022 09 01; 109(9):1713-1723.
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Plasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses. Virus Res. 2021 01 02; 291:198193.
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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell. 2020 07 23; 182(2):429-446.e14.
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Generation of Recombinant Rotavirus Expressing NSP3-UnaG Fusion Protein by a Simplified Reverse Genetics System. J Virol. 2019 12 15; 93(24).
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Genetic strategies to tackle neurological diseases in fruit flies. Curr Opin Neurobiol. 2018 06; 50:24-32.
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A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats. J Virol. 2016 08 15; 90(16):7508-7518.
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Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies. J Virol. 2016 Apr; 90(8):3890-3901.
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Modeling congenital disease and inborn errors of development in Drosophila melanogaster. Dis Model Mech. 2016 Mar; 9(3):253-69.
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Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice. J Virol. 2015 Apr; 89(7):3737-45.
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A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis. Virology. 2012 Dec 05; 434(1):129-36.