"Wnt4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Wnt protein that is involved in regulating multiple developmental processes such as the formation of the KIDNEY; ADRENAL GLANDS; MAMMARY GLANDS; the PITUITARY GLAND; and the female reproductive system. Defects in WNT4 are a cause of ROKITANSKY KUSTER HAUSER SYNDROME.
| Descriptor ID |
D060528
|
| MeSH Number(s) |
D12.776.467.984.400 D23.529.984.400
|
| Concept/Terms |
Wnt4 Protein- Wnt4 Protein
- Wnt-4 Proteins
- Wnt 4 Proteins
- Wnt-4 Protein
- Wnt 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Wnt4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Wnt4 Protein".
This graph shows the total number of publications written about "Wnt4 Protein" by people in this website by year, and whether "Wnt4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Wnt4 Protein" by people in Profiles.
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WNT4 deficiency impacts heart, diaphragm, and palate development: Insights from human genetics, machine learning, and mouse models. Dev Biol. 2026 Jan; 529:66-80.
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Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects. Development. 2022 12 01; 149(23).
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E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling. Development. 2021 01 13; 148(1).
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Microtubule depolymerization attenuates WNT4/CaMKIIa signaling in mouse uterus and leads to implantation failure. Reproduction. 2019 07; 158(1):47-59.
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Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017 09 01; 23(9):646-653.
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The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451.
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WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 2011 Apr; 25(4):1176-87.
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Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development. Mol Endocrinol. 2010 Nov; 24(11):2099-113.
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WNT4 is required for normal ovarian follicle development and female fertility. FASEB J. 2010 Aug; 24(8):3010-25.
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Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human. J Biol Chem. 2007 Oct 26; 282(43):31725-32.