"Wnt Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
| Descriptor ID |
D051153
|
| MeSH Number(s) |
D12.776.467.984 D23.529.984
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Wnt Proteins".
Below are MeSH descriptors whose meaning is more specific than "Wnt Proteins".
This graph shows the total number of publications written about "Wnt Proteins" by people in this website by year, and whether "Wnt Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 3 | 3 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 3 | 3 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 6 | 6 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 7 | 7 |
| 2003 | 0 | 12 | 12 |
| 2004 | 0 | 7 | 7 |
| 2005 | 2 | 8 | 10 |
| 2006 | 8 | 6 | 14 |
| 2007 | 10 | 6 | 16 |
| 2008 | 7 | 9 | 16 |
| 2009 | 9 | 11 | 20 |
| 2010 | 11 | 10 | 21 |
| 2011 | 12 | 13 | 25 |
| 2012 | 9 | 4 | 13 |
| 2013 | 5 | 7 | 12 |
| 2014 | 4 | 7 | 11 |
| 2015 | 5 | 5 | 10 |
| 2016 | 1 | 4 | 5 |
| 2017 | 3 | 4 | 7 |
| 2018 | 2 | 3 | 5 |
| 2019 | 3 | 3 | 6 |
| 2020 | 5 | 3 | 8 |
| 2021 | 2 | 2 | 4 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Wnt Proteins" by people in Profiles.
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Mice Lacking Wnt9a or Wnt4 Are Prone to Develop Spontaneous Osteoarthritis With Age and Display Alteration in Either the Trabecular or Cortical Bone Compartment. J Bone Miner Res. 2022 07; 37(7):1335-1351.
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WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis. J Clin Invest. 2021 08 16; 131(16).
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A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res. 2021 09 01; 81(17):4441-4454.
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The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ?-Like 1-?-Catenin Protein Complex. J Pharmacol Exp Ther. 2021 Aug; 378(2):77-86.
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Perturbations of genes essential for M?llerian duct and W?lffian duct development in Mayer-Rokitansky-K?ster-Hauser syndrome. Am J Hum Genet. 2021 02 04; 108(2):337-345.
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Blockers of Wnt3a, Wnt10a, or ?-Catenin Prevent Chemotherapy-Induced Neuropathic Pain In Vivo. Neurotherapeutics. 2021 01; 18(1):601-614.
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Wnt activation as a therapeutic strategy in medulloblastoma. Nat Commun. 2020 08 28; 11(1):4323.
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Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression. Cancer Res. 2020 09 15; 80(18):3810-3819.
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Pediatric Posterior Fossa Medulloblastoma: The Role of Diffusion Imaging in Identifying Molecular Groups. J Neuroimaging. 2020 07; 30(4):503-511.
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Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12182-12191.