"Agouti Signaling Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
| Descriptor ID |
D054366
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| MeSH Number(s) |
D12.644.276.049 D12.776.467.049 D23.529.049
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Agouti Signaling Protein".
Below are MeSH descriptors whose meaning is more specific than "Agouti Signaling Protein".
This graph shows the total number of publications written about "Agouti Signaling Protein" by people in this website by year, and whether "Agouti Signaling Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Agouti Signaling Protein" by people in Profiles.
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Is epigenetics an important link between early life events and adult disease? Horm Res. 2009 Jan; 71 Suppl 1:13-6.
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Methyl donor supplementation prevents transgenerational amplification of obesity. Int J Obes (Lond). 2008 Sep; 32(9):1373-9.
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Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1517-28.
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Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female. FASEB J. 2007 Oct; 21(12):3380-5.
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Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect. 2006 Apr; 114(4):567-72.
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Blockade of melanocortin transmission inhibits cocaine reward. Eur J Neurosci. 2005 Apr; 21(8):2233-42.
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Coupled site-directed mutagenesis/transgenesis identifies important functional domains of the mouse agouti protein. Genetics. 1996 Sep; 144(1):255-64.
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Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics. 1995 May; 140(1):255-65.
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A transgenic mouse assay for agouti protein activity. Genetics. 1995 May; 140(1):267-74.
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The molecular basis for dominant yellow agouti coat color mutations. Bioessays. 1994 Oct; 16(10):705-7.