"EGF Family of Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are related to epidermal growth factor. They share in common a consensus sequence consisting of six spatially conserved CYSTEINE residues which form three intramolecular bonds. This consensus sequence is commonly referred to EGF motif and is considered essential for binding of the proteins to ERB RECEPTORS.
| Descriptor ID |
D066255
|
| MeSH Number(s) |
D12.644.276.382 D12.776.467.382 D23.529.382
|
| Concept/Terms |
EGF Family of Proteins- EGF Family of Proteins
- Proteins EGF Family
- Epidermal Growth Factors
- EGF Receptor Ligands
- Ligands, EGF Receptor
- Receptor Ligands, EGF
- Epidermal Growth Factor-Like Proteins
- Epidermal Growth Factor Like Proteins
|
Below are MeSH descriptors whose meaning is more general than "EGF Family of Proteins".
Below are MeSH descriptors whose meaning is more specific than "EGF Family of Proteins".
This graph shows the total number of publications written about "EGF Family of Proteins" by people in this website by year, and whether "EGF Family of Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 4 | 4 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "EGF Family of Proteins" by people in Profiles.
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CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017 Mar; 13(3):e1006654.
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An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors. Oncogene. 2016 Jan 28; 35(4):438-47.
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Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage. Mol Ther. 2014 Mar; 22(3):645-654.
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Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. Oncogene. 2014 May 29; 33(22):2846-56.
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HER family receptor and ligand status in thymic carcinoma. Lung Cancer. 2012 Sep; 77(3):515-21.
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LH-induced neuregulin 1 (NRG1) type III transcripts control granulosa cell differentiation and oocyte maturation. Mol Endocrinol. 2011 Jan; 25(1):104-16.
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Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility. Mol Endocrinol. 2010 Sep; 24(9):1794-804.
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The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary. Endocrinology. 2010 Jun; 151(6):2923-32.
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Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Gastroenterology. 2009 Apr; 136(4):1288-96.
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Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas. Oncol Rep. 2008 Jun; 19(6):1557-64.