Parathyroid Hormone-Related Protein
"Parathyroid Hormone-Related Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
| Descriptor ID |
D044162
|
| MeSH Number(s) |
D06.472.699.591 D12.644.276.908 D12.644.548.588 D12.776.467.890 D23.529.890
|
| Concept/Terms |
Parathyroid Hormone-Related Protein- Parathyroid Hormone-Related Protein
- Hormone-Related Protein, Parathyroid
- Parathyroid Hormone Related Protein
- Parathyroid Hormone-Like Protein
- Parathyroid Hormone Like Protein
- Parathyroid Hormone-Related Peptide
- Parathyroid Hormone Related Peptide
- PTHrP
- Tumor Hypercalcemic Factor
- Hypercalcemic Factor, Tumor
- Hypercalcemic Hormone of Malignancy
- PTH Like Tumor Factor
- PTH-Like Protein
- PTH Like Protein
- Parathyroid Hormone Like Tumor Factor
- PTH-Related Peptide
- PTH Related Peptide
|
Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone-Related Protein".
Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone-Related Protein".
This graph shows the total number of publications written about "Parathyroid Hormone-Related Protein" by people in this website by year, and whether "Parathyroid Hormone-Related Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 3 | 0 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Parathyroid Hormone-Related Protein" by people in Profiles.
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PTHrP Drives Pancreatic Cancer Growth and Metastasis and Reveals a New Therapeutic Vulnerability. Cancer Discov. 2021 07; 11(7):1774-1791.
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Hypercalcemia and cancer: Differential diagnosis and treatment. CA Cancer J Clin. 2018 09; 68(5):377-386.
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Parathyroid hormone stimulates adipose tissue browning: a pathway to muscle wasting. Curr Opin Clin Nutr Metab Care. 2017 May; 20(3):153-157.
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PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth. J Bone Miner Res. 2013 Mar; 28(3):598-607.
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Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46.
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Parathyroid hormone-related protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol 3-kinase/Akt signaling. Mol Cancer Res. 2009 Jul; 7(7):1119-31.
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EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol Cancer Ther. 2009 Jul; 8(7):1787-98.
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Hedgehog coordination of postnatal osteoclast and osteoblast activities. Dev Cell. 2008 May; 14(5):637-8.
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PTHrP contributes to the anti-proliferative and integrin alpha6beta4-regulating effects of 1,25-dihydroxyvitamin D(3). Steroids. 2007 Dec; 72(14):930-8.
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Islet cell tumors. Curr Probl Surg. 2006 Oct; 43(10):685-765.