CCN Intercellular Signaling Proteins
"CCN Intercellular Signaling Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.
| Descriptor ID |
D055511
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| MeSH Number(s) |
D12.644.276.200 D12.776.467.200 D12.776.860.300.200 D23.529.237
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "CCN Intercellular Signaling Proteins".
Below are MeSH descriptors whose meaning is more specific than "CCN Intercellular Signaling Proteins".
This graph shows the total number of publications written about "CCN Intercellular Signaling Proteins" by people in this website by year, and whether "CCN Intercellular Signaling Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "CCN Intercellular Signaling Proteins" by people in Profiles.
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Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors. Cancer. 2015 Nov 15; 121(22):4088-96.
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Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition. Int J Oncol. 2012 Jul; 41(1):189-200.
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Matricellular proteins in cardiac adaptation and disease. Physiol Rev. 2012 Apr; 92(2):635-88.
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IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells. 2008 Oct; 26(10):2735-45.
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WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev. 2000 Mar 01; 14(5):585-95.
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WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14717-22.