"Serrate-Jagged Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface proteins that consist of multiple extracellular EPIDERMAL GROWTH FACTOR - like repeat sequences (EGF repeats), including calcium-binding EGF repeats. They function as transmembrane ligands for NOTCH RECEPTORS to control CELL DIFFERENTIATION during development.
| Descriptor ID |
D000072099
|
| MeSH Number(s) |
D12.644.276.930 D12.776.157.125.797 D12.776.543.800 D23.529.930
|
| Concept/Terms |
Serrate-Jagged Proteins- Serrate-Jagged Proteins
- Serrate Jagged Proteins
- Jagged Proteins
- Serrate Protein
- Serrate Proteins
|
Below are MeSH descriptors whose meaning is more general than "Serrate-Jagged Proteins".
Below are MeSH descriptors whose meaning is more specific than "Serrate-Jagged Proteins".
This graph shows the total number of publications written about "Serrate-Jagged Proteins" by people in this website by year, and whether "Serrate-Jagged Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 |
| 2015 | 0 | 3 | 3 |
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Below are the most recent publications written about "Serrate-Jagged Proteins" by people in Profiles.
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Jagged1 (JAG1): Structure, expression, and disease associations. Gene. 2016 Jan 15; 576(1 Pt 3):381-4.
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Discordant clinical phenotype in monozygotic twins with Alagille syndrome: Possible influence of non-genetic factors. Am J Med Genet A. 2016 Feb; 170A(2):471-475.
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Exome sequencing reveals compound heterozygous mutations in ATP8B1 in a JAG1/NOTCH2 mutation-negative patient with clinically diagnosed Alagille syndrome. Am J Med Genet A. 2015 Apr; 167A(4):891-3.
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Notch3 pathway alterations in ovarian cancer. Cancer Res. 2014 Jun 15; 74(12):3282-93.
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Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. PLoS One. 2013; 8(4):e61807.
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Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013 Feb 11; 23(2):171-85.
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Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. Clin Cancer Res. 2011 Sep 01; 17(17):5674-85.
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Dysfunctional transforming growth factor-? signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer. 2011 Aug 15; 117(16):3691-702.
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Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin Cancer Res. 2008 Dec 15; 14(24):8052-60.
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20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75.