"Jagged-2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serrate-jagged protein that functions to modulate signal transduction from NOTCH RECEPTORS in CELL DIFFERENTIATION. It may also regulate the expression of CYTOKINES.
| Descriptor ID |
D000072101
|
| MeSH Number(s) |
D12.644.276.930.750 D12.776.157.125.797.750 D12.776.543.800.750 D23.529.930.750
|
| Concept/Terms |
Jagged-2 Protein- Jagged-2 Protein
- Jagged 2 Protein
- Serrate2 Protein
- Serrate-2 Protein
- Serrate 2 Protein
- Jagged2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Jagged-2 Protein".
Below are MeSH descriptors whose meaning is more specific than "Jagged-2 Protein".
This graph shows the total number of publications written about "Jagged-2 Protein" by people in this website by year, and whether "Jagged-2 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Jagged-2 Protein" by people in Profiles.
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BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells. Mol Cancer. 2015 Sep 22; 14:173.
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The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. J Clin Invest. 2011 Apr; 121(4):1373-85.
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Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3534-9.
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Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. J Biol Chem. 2009 Jun 26; 284(26):17766-74.
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Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. Clin Cancer Res. 2009 Apr 01; 15(7):2291-301.
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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet. 2003 Feb; 33(2):208-13.
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Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes. J Androl. 2001 Nov-Dec; 22(6):999-1011.
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JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. Mech Dev. 1997 Dec; 69(1-2):203-7.