"Jagged-1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serrate-jagged protein that functions as a ligand for NOTCH RECEPTORS. It may regulate CELL DIFFERENTIATION in HEMATOPOIESIS and PHYSIOLOGIC ANGIOGENESIS. Mutations in the Jagged-1 gene are associated with ALAGILLE SYNDROME 1.
| Descriptor ID |
D000072100
|
| MeSH Number(s) |
D12.644.276.930.500 D12.776.157.125.797.500 D12.776.543.800.500 D23.529.930.500
|
| Concept/Terms |
Jagged-1 Protein- Jagged-1 Protein
- Jagged 1 Protein
- Alagille Syndrome Protein
- Jagged1 Protein
- Serrate1 Protein
- Jagged-1
- Jagged 1
- Serrate-1 Protein
- Serrate 1 Protein
- CD339 Antigen
- Antigen, CD339
|
Below are MeSH descriptors whose meaning is more general than "Jagged-1 Protein".
Below are MeSH descriptors whose meaning is more specific than "Jagged-1 Protein".
This graph shows the total number of publications written about "Jagged-1 Protein" by people in this website by year, and whether "Jagged-1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 5 | 5 |
| 2016 | 1 | 1 | 2 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 2 | 1 | 3 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Jagged-1 Protein" by people in Profiles.
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Adeno-associated Virus-mediated Silencing of Sox4 Leads to Long-Term Amelioration of Liver Phenotypes in Mouse Models of Alagille Syndrome. Gastroenterology. 2025 Oct; 169(5):1000-1016.
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ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome. Hepatology. 2023 11 01; 78(5):1337-1351.
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Single-Cell Analysis Unveils the Role of the Tumor Immune Microenvironment and Notch Signaling in Dormant Minimal Residual Disease. Cancer Res. 2022 Mar 01; 82(5):885-899.
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Characterization of the Spectrum of Ophthalmic Changes in Patients With Alagille Syndrome. Invest Ophthalmol Vis Sci. 2021 06 01; 62(7):27.
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The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma. Asian Pac J Allergy Immunol. 2021 Mar; 39(1):44-52.
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Antiandrogen abiraterone and docetaxel treatments affect Notch1, Jagged1 and Hes1 expressions in metastatic prostate cancer cells. Exp Mol Pathol. 2021 04; 119:104607.
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Decreased Jagged1 expression in vascular smooth muscle cells delays endothelial regeneration in arteriovenous graft. Cardiovasc Res. 2020 11 01; 116(13):2142-2155.
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Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development. Dev Biol. 2020 06 01; 462(1):74-84.
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Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020 04; 71(4):1331-1349.
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Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification. Hum Mutat. 2019 12; 40(12):2197-2220.