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JIZHONG CHENG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R01DK124259     (CHENG, JIZHONG)Apr 1, 2020 - Mar 31, 2024
    NIH
    Interplay between skeletal muscle catabolism and remodeling of arteriovenous fistulae via YAP1/TAZ signaling
    Role: Principal Investigator
    R01DK095867     (CHENG, JIZHONG)Mar 15, 2013 - Jan 31, 2019
    NIH
    CHRONIC KIDNEY DISEASE ADVERSELY INFLUENCES VASCULAR FUNCTIONS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heralde FM, Barcena AJR, Perez JVD, Bernardino MR, Damasco JA, Cortes A, Del Mundo HC, San Valentin EMD, Klusman C, Canlas GM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Bioresorbable Mesenchymal Stem Cell-Loaded Electrospun Polymeric Scaffold Inhibits Neointimal Hyperplasia Following Arteriovenous Fistula Formation in a Rat Model of Chronic Kidney Disease. Adv Healthc Mater. 2023 10; 12(26):e2300960. PMID: 37395729; PMCID: PMC10592251.
      Citations:    Fields:    Translation:AnimalsCells
    2. Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas GM, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem-Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistula Maturation. Int J Mol Sci. 2023 Jul 21; 24(14). PMID: 37511512; PMCID: PMC10380871.
      Citations:    Fields:    Translation:AnimalsCells
    3. Barcena AJR, Perez JVD, Damasco JA, Bernardino MR, San Valentin EMD, Klusman C, Martin B, Cortes A, Canlas G, Del Mundo HC, Heralde FM, Avritscher R, Fowlkes N, Bouchard RR, Cheng J, Huang SY, Melancon MP. Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas. bioRxiv. 2023 Feb 03. PMID: 36778466; PMCID: PMC9915579.
      Citations:    
    4. Klusman C, Martin B, Perez JVD, Barcena AJR, Bernardino MR, San Valentin EMD, Damasco JA, Mundo HCD, Court K, Godin B, Fowlkes N, Bouchard R, Cheng J, Huang SY, Melancon MP. Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model. bioRxiv. 2023 Feb 03. PMID: 36778365; PMCID: PMC9915671.
      Citations:    
    5. Wu Y, Liang M, Huang F, Cheng OH, Xiao X, Lee TH, Truong L, Cheng J. Notch Blockade Specifically in Bone Marrow-Derived FSP-1-Positive Cells Ameliorates Renal Fibrosis. Cells. 2023 01 04; 12(2). PMID: 36672147; PMCID: PMC9856686.
      Citations: 1     Fields:    Translation:Animals
    6. Guo Q, Chen G, Cheng H, Qing Y, Truong L, Ma Q, Wang Y, Cheng J. Temporal regulation of notch activation improves arteriovenous fistula maturation. J Transl Med. 2022 11 23; 20(1):543. PMID: 36419038; PMCID: PMC9682688.
      Citations:    Fields:    Translation:AnimalsCells
    7. Sun J, Pan J, Liu Q, Cheng J, Tang Q, Ji Y, Cheng K, Wang R, Liu L, Wang D, Wu N, Zheng X, Li J, Zhang X, Zhu Z, Ding Y, Zheng F, Li J, Zhang Y, Yuan Y. Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury. Biomol Ther (Seoul). 2022 Sep 13. PMID: 36097885.
      Citations:    
    8. Feng S, Peden EK, Guo Q, Lee TH, Li Q, Yuan Y, Chen C, Huang F, Cheng J. Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure. J Biol Chem. 2022 05; 298(5):101816. PMID: 35278430; PMCID: PMC9052161.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X. Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun. 2021 09 06; 12(1):5296. PMID: 34489478; PMCID: PMC8421392.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Song K, Qing Y, Guo Q, Peden EK, Chen C, Mitch WE, Truong L, Cheng J. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease. JCI Insight. 2020 11 05; 5(21). PMID: 33001865; PMCID: PMC7710276.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Guo Q, Huang F, Qing Y, Feng S, Xiao X, Wang Y, Liang M, Wang T, Mitch WE, Cheng J. Decreased Jagged1 expression in vascular smooth muscle cells delays endothelial regeneration in arteriovenous graft. Cardiovasc Res. 2020 11 01; 116(13):2142-2155. PMID: 31913453; PMCID: PMC8453291.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Wang X, Balaji S, Steen EH, Blum AJ, Li H, Chan CK, Manson SR, Lu TC, Rae MM, Austin PF, Wight TN, Bollyky PL, Cheng J, Keswani SG. High-molecular weight hyaluronan attenuates tubulointerstitial scarring in kidney injury. JCI Insight. 2020 06 18; 5(12). PMID: 32396531; PMCID: PMC7406305.
      Citations: 7     Fields:    Translation:AnimalsCells
    13. Airy M, Lenihan CR, Ding VY, Montez-Rath ME, Cheng J, Navaneethan SD, Wasse H, Winkelmayer WC. Association Between Type of Vascular Access Used in Hemodialysis Patients and Subsequent Kidney Transplant Outcomes. Kidney Med. 2019 Nov-Dec; 1(6):383-390. PMID: 32734218; PMCID: PMC7384366.
      Citations: 1     
    14. Liang M, Guo Q, Huang F, Han G, Song K, Luo J, Cheng H, Hu H, Peden EK, Chen C, Mitch WE, Du J, Fu X, Truong L, Cheng J. Notch signaling in bone marrow-derived FSP-1?cells initiates neointima formation in arteriovenous?fistulas. Kidney Int. 2019 06; 95(6):1347-1358. PMID: 30799025; PMCID: PMC6763204.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    15. Liu M, Liu Q, Pei Y, Gong M, Cui X, Pan J, Zhang Y, Liu Y, Liu Y, Yuan X, Zhou H, Chen Y, Sun J, Wang L, Zhang X, Wang R, Li S, Cheng J, Ding Y, Ma T, Yuan Y. Aqp-1 Gene Knockout Attenuates Hypoxic Pulmonary Hypertension of Mice. Arterioscler Thromb Vasc Biol. 2019 01; 39(1):48-62. PMID: 30580569.
      Citations:    
    16. Wang W, Wang Z, Tian D, Zeng X, Liu Y, Fu Q, Liang A, Zhang Y, Gao Q, Cheng J, Wang Y. Integrin ?3 Mediates the Endothelial-to-Mesenchymal Transition via the Notch Pathway. Cell Physiol Biochem. 2018; 49(3):985. PMID: 30196283.
      Citations: 7     Fields:    Translation:HumansCells
    17. Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Yin S, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS, Hu H. TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. Immunity. 2018 07 17; 49(1):107-119.e4. PMID: 29958798; PMCID: PMC6051912.
      Citations:    
    18. Woodard LE, Welch RC, Williams FM, Luo W, Cheng J, Wilson MH. Hydrodynamic Renal Pelvis Injection for Non-viral Expression of Proteins in the Kidney. J Vis Exp. 2018 01 08; (131). PMID: 29364221; PMCID: PMC5907682.
      Citations:    
    19. Luo J, Chen G, Liang M, Xie A, Li Q, Guo Q, Sharma R, Cheng J. Reduced Expression of Glutathione S-Transferase a 4 Promotes Vascular Neointimal Hyperplasia in CKD. J Am Soc Nephrol. 2018 02; 29(2):505-517. PMID: 29127112; PMCID: PMC5791085.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Luo J, Feng J, Yu G, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O'Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Renner K, Liu Q, Hu H. Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch. J Allergy Clin Immunol. 2018 02; 141(2):608-619.e7. PMID: 28807414; PMCID: PMC5799031.
      Citations:    
    21. Liang M, Yu M, Xia R, Song K, Wang J, Luo J, Chen G, Cheng J. Yap/Taz Deletion in Gli+ Cell-Derived Myofibroblasts Attenuates Fibrosis. J Am Soc Nephrol. 2017 Nov; 28(11):3278-3290. PMID: 28768710; PMCID: PMC5661271.
      Citations:    
    22. Woodard LE, Cheng J, Welch RC, Williams FM, Luo W, Gewin LS, Wilson MH. Kidney-specific transposon-mediated gene transfer in vivo. Sci Rep. 2017 03 20; 7:44904. PMID: 28317878; PMCID: PMC5357952.
      Citations:    
    23. Luo J, Liang A, Liang M, Xia R, Rizvi Y, Wang Y, Cheng J. Serum Glucocorticoid-Regulated Kinase 1 Blocks CKD-Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3. J Am Soc Nephrol. 2016 09; 27(9):2797-808. PMID: 26880799; PMCID: PMC5004658.
      Citations: 15     Fields:    Translation:Animals
    24. Dong Y, Yang M, Zhang J, Peng X, Cheng J, Cui T, Du J. Depletion of CD8+ T Cells Exacerbates CD4+ T Cell-Induced Monocyte-to-Fibroblast Transition in Renal Fibrosis. J Immunol. 2016 Feb 15; 196(4):1874-81. PMID: 26773152.
      Citations: 16     Fields:    Translation:AnimalsCells
    25. Liu Y, Wang Y, Shi H, Jia L, Cheng J, Cui W, Li H, Li P, Du J. CARD9 mediates necrotic smooth muscle cell-induced inflammation in macrophages contributing to neointima formation of vein grafts. Cardiovasc Res. 2015 Oct 01; 108(1):148-58. PMID: 26243429; PMCID: PMC6279154.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Liang M, Wang Y, Liang A, Mitch WE, Roy-Chaudhury P, Han G, Cheng J. Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima. Kidney Int. 2015 Sep; 88(3):490-502. PMID: 25786100; PMCID: PMC4677993.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    27. Luo J, Liang M, Mitch WE, Danesh FR, Yu M, Cheng J. FSP-1 Impairs the Function of Endothelium Leading to Failure of Arteriovenous Grafts in Diabetic Mice. Endocrinology. 2015 Jun; 156(6):2200-10. PMID: 25774552; PMCID: PMC4430603.
      Citations:    Fields:    Translation:AnimalsCells
    28. Liang M, Woodard LE, Liang A, Luo J, Wilson MH, Mitch WE, Cheng J. Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis. Am J Pathol. 2015 May; 185(5):1234-50. PMID: 25783760; PMCID: PMC4419212.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    29. Liang M, Wang Y, Liang A, Dong JF, Du J, Cheng J. Impaired integrin ?3 delays endothelial cell regeneration and contributes to arteriovenous graft failure in mice. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):607-15. PMID: 25614287; PMCID: PMC4671198.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Liang M, Liang A, Wang Y, Jiang J, Cheng J. Smooth muscle cells from the anastomosed artery are the major precursors for neointima formation in both artery and vein grafts. Basic Res Cardiol. 2014; 109(5):431. PMID: 25107324; PMCID: PMC4259152.
      Citations: 13     Fields:    Translation:AnimalsCells
    31. Wang Y, Liang A, Luo J, Liang M, Han G, Mitch WE, Cheng J. Blocking Notch in endothelial cells prevents arteriovenous fistula failure despite CKD. J Am Soc Nephrol. 2014 Apr; 25(4):773-83. PMID: 24480830; PMCID: PMC3968498.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    32. Liang A, Wang Y, Han G, Truong L, Cheng J. Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula. Am J Physiol Renal Physiol. 2013 Jun 15; 304(12):F1413-20. PMID: 23576636; PMCID: PMC3680675.
      Citations: 33     Fields:    Translation:Animals
    33. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J. Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol. 2012 Dec; 228(4):448-58. PMID: 22711583; PMCID: PMC3760987.
      Citations: 13     Fields:    Translation:AnimalsCells
    34. Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J. Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF ?/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One. 2012; 7(5):e35144. PMID: 22574112; PMCID: PMC3344835.
      Citations: 107     Fields:    Translation:AnimalsCells
    35. Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J. Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1675-86. PMID: 22556335.
      Citations: 51     Fields:    Translation:AnimalsCells
    36. Li Y, Zhang C, Wu Y, Han Y, Cui W, Jia L, Cai L, Cheng J, Li H, Du J. Interleukin-12p35 deletion promotes CD4 T-cell-dependent macrophage differentiation and enhances angiotensin II-Induced cardiac fibrosis. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1662-74. PMID: 22556333.
      Citations: 33     Fields:    Translation:AnimalsCells
    37. Pan L, Li Y, Jia L, Qin Y, Qi G, Cheng J, Qi Y, Li H, Du J. Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation. PLoS One. 2012; 7(4):e35315. PMID: 22558139; PMCID: PMC3340377.
      Citations: 47     Fields:    Translation:AnimalsCells
    38. Zhang L, Dong Y, Dong Y, Cheng J, Du J. Role of integrin-?3 protein in macrophage polarization and regeneration of injured muscle. J Biol Chem. 2012 Feb 24; 287(9):6177-86. PMID: 22210777; PMCID: PMC3307266.
      Citations: 20     Fields:    Translation:AnimalsCells
    39. Cheng J, Wang Y, Liang A, Jia L, Du J. FSP-1 silencing in bone marrow cells suppresses neointima formation in vein graft. Circ Res. 2012 Jan 20; 110(2):230-40. PMID: 22116816.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    40. Qi G, Jia L, Li Y, Bian Y, Cheng J, Li H, Xiao C, Du J. Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent. Cardiovasc Toxicol. 2011 Jun; 11(2):157-67. PMID: 21373977.
      Citations: 29     Fields:    Translation:AnimalsCells
    41. Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J. Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. Am J Hypertens. 2011 Jun; 24(6):701-7. PMID: 21436792; PMCID: PMC3139445.
      Citations: 31     Fields:    Translation:AnimalsCells
    42. Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J. The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. Circ Res. 2010 Nov 12; 107(10):1265-74. PMID: 20884880.
      Citations: 19     Fields:    Translation:AnimalsCells
    43. Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010 Oct; 78(7):668-78. PMID: 20631674; PMCID: PMC3935313.
      Citations: 31     Fields:    Translation:AnimalsCells
    44. Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML. Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol. 2010 Sep; 49(3):499-507. PMID: 20488188; PMCID: PMC2917526.
      Citations: 91     Fields:    Translation:AnimalsCells
    45. Wu X, Cheng J, Li P, Yang M, Qiu S, Liu P, Du J. Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):471-6. PMID: 19965784.
      Citations: 26     Fields:    Translation:AnimalsCells
    46. Liu S, Cheng J, Tang C. Construction and expression of DNA vaccine pIRES-Sj97-Sj14-Sj26 and its immunogenicity in mice. J Huazhong Univ Sci Technolog Med Sci. 2007 Dec; 27(6):625-9. PMID: 18231727.
      Citations:    
    47. Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J. Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. J Biol Chem. 2007 Nov 23; 282(47):34268-75. PMID: 17878168.
      Citations: 11     Fields:    Translation:AnimalsCells
    48. Cheng J, Du J. Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1744-51. PMID: 17541019.
      Citations: 47     Fields:    Translation:AnimalsCells
    49. Cheng J, Cui R, Chen CH, Du J. Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology. 2007 May; 148(5):2085-94. PMID: 17289842.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    50. Guo P, Dai W, Liu S, Yang P, Cheng J, Liang L, Chen Z, Gao H. Construction and expression of bivalent membrane-anchored DNA vaccine encoding Sjl4FABP and Sj26GST genes. J Huazhong Univ Sci Technolog Med Sci. 2006; 26(5):493-6. PMID: 17219949.
      Citations:    
    51. Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J. Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB. Endocrinology. 2006 Mar; 147(3):1256-63. PMID: 16322063; PMCID: PMC3228638.
      Citations: 14     Fields:    Translation:AnimalsCells
    52. Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J. Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase. Circ Res. 2005 Nov 11; 97(10):975-82. PMID: 16224066.
      Citations: 30     Fields:    Translation:AnimalsCells
    53. Zhang L, Ma Y, Zhang J, Cheng J, Du J. A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: An IkappaB-independent, RSK-mediated phosphorylation of p65. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1148-53. PMID: 15802625.
      Citations: 27     Fields:    Translation:AnimalsCells
    54. Dai W, Liang L, Gao H, Huang H, Chen Z, Cheng J, Huangfu Y. Construction, expression and identification of a recombinant BCG vaccine encoding human Mycobacterium tuberculosis heat shock protein 65. J Huazhong Univ Sci Technolog Med Sci. 2004; 24(2):107-11, 123. PMID: 15315155.
      Citations:    Fields:    Translation:HumansCells
    55. Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC. Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76. Int J Oncol. 2003 Apr; 22(4):713-20. PMID: 12632060.
      Citations: 26     Fields:    Translation:HumansCells
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