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LI XIN

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressBox 358056, 850 Republican Street | N326
Seattle, WA 98109
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    Collapse Research 
    Collapse research activities and funding
    R13CA284512     (XIN, LI)Sep 1, 2023 - Aug 31, 2024
    NIH
    Support for the 2023 Society of Basic Urological Diseases annual meeting
    Role: Principal Investigator
    R01CA271457     (XIN, LI)Jul 1, 2022 - May 31, 2027
    NIH
    Stromal Foxf2 suppresses prostate cancer progression
    Role: Principal Investigator
    R01DK107436     (XIN, LI)Jul 1, 2016 - Apr 30, 2025
    NIH
    Molecular mechanisms of initiation of benign prostatic hyperplasia
    Role: Principal Investigator
    R21CA196570     (XIN, LI)Apr 1, 2016 - Mar 31, 2019
    NIH
    Reprogramming of Prostate Stromal Cells by Prostate Inflammation
    Role: Principal Investigator
    R01CA190378     (XIN, LI)Jul 7, 2015 - Jun 30, 2021
    NIH
    The Notch signaling in prostate homeostasis and carcinogenesis
    Role: Principal Investigator
    R01DK092202     (XIN, LI)Jul 1, 2011 - Aug 31, 2021
    NIH
    Prostate Epithelial Lineage Hierarchy
    Role: Principal Investigator
    R00CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2014
    NIH
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator
    K99CA125937     (XIN, LI)Sep 1, 2007 - Aug 31, 2009
    NIH
    Characterization of prostatic stem cells and prostate cancer-initiating cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xin LY, Winnie LHL, Lim TP, Jocelyn TQM, Chlebicki MP, Chung SJ, Hoon AKL, Liew YX, Lee HW, Lim TP, Teo JQ, Chlebicki MP, Chung SJ, Kwa ALH. High-concentration polymyxin B infusion: is it safe to give? Int J Antimicrob Agents. 2023 Jan; 61(1):106688. PMID: 36402447.
      Citations:    Fields:    
    2. Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L, Birchmeier W. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. 2019 05 02; 24(5):753-768.e6. PMID: 30982770; PMCID: PMC6548441.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    3. Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. iScience. 2019 Mar 29; 13:328-338. PMID: 30878879; PMCID: PMC6423355.
      Citations: 18     
    4. Janghorban M, Xin L, Rosen JM, Zhang XH. Notch Signaling as a Regulator of the Tumor Immune Response: To Target or Not To Target? Front Immunol. 2018; 9:1649. PMID: 30061899; PMCID: PMC6055003.
      Citations: 40     Fields:    
    5. Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N. SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein. Oncogene. 2017 08 17; 36(33):4767-4777. PMID: 28414305; PMCID: PMC5887163.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    6. Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, Xin L. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Mol Cell. 2016 09 15; 63(6):976-89. PMID: 27594448; PMCID: PMC5026614.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    7. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105; PMCID: PMC5216986.
      Citations: 9     Fields:    Translation:HumansAnimals
    8. Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, Xin L. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017 02 02; 36(5):618-627. PMID: 27345403; PMCID: PMC5192002.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    9. Toneff MJ, Sreekumar A, Tinnirello A, Hollander PD, Habib S, Li S, Ellis MJ, Xin L, Mani SA, Rosen JM. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016 06 17; 14:47. PMID: 27317311; PMCID: PMC4912796.
      Citations:    
    10. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469; PMCID: PMC4884142.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    11. Kwon OJ, Zhang B, Zhang L, Xin L. High fat diet promotes prostatic basal-to-luminal differentiation and accelerates initiation of prostate epithelial hyperplasia originated from basal cells. Stem Cell Res. 2016 05; 16(3):682-91. PMID: 27107344.
      Citations: 27     Fields:    Translation:AnimalsCells
    12. Wei X, Orjalo AV, Xin L. CD133 does not enrich for the stem cell activity in vivo in adult mouse prostates. Stem Cell Res. 2016 05; 16(3):597-606. PMID: 27010655.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    13. Su Q, Xin L. Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol. 2016 Feb; 31(2):149-57. PMID: 26521657; PMCID: PMC4822406.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Kwon OJ, Zhang L, Xin L. Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential. Stem Cells. 2016 Jan; 34(1):191-202. PMID: 26418304; PMCID: PMC4816225.
      Citations: 31     Fields:    Translation:AnimalsCells
    15. Shore AN, Chang CH, Kwon OJ, Weston MC, Zhang M, Xin L, Rosen JM. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Dev Biol. 2016 Jan 01; 409(1):202-217. PMID: 26526198; PMCID: PMC4688181.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Kwon OJ, Xin L. Prostate epithelial stem and progenitor cells. Am J Clin Exp Urol. 2014; 2(3):209-18. PMID: 25374923; PMCID: PMC4219311.
      Citations: 12     
    17. Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nat Commun. 2014 Jul 22; 5:4416. PMID: 25048699; PMCID: PMC4167399.
      Citations: 43     Fields:    Translation:AnimalsCells
    18. Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis. 2014 May 26; 3:e103. PMID: 24861463; PMCID: PMC4035695.
      Citations: 59     
    19. Kwon OJ, Zhang L, Ittmann MM, Xin L. Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):E592-600. PMID: 24367088; PMCID: PMC3918789.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    20. Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick FG, Schally AV, Frigo DE. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1a-mediated metabolic switch. Oncogene. 2014 Nov 06; 33(45):5251-61. PMID: 24186207; PMCID: PMC4009392.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    21. Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin L. A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 2014 Jun 12; 33(24):3099-108. PMID: 23851498; PMCID: PMC3916938.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Xin L. A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance. Asian J Androl. 2013 Jan; 15(1):85-6. PMID: 23223032; PMCID: PMC3684388.
      Citations: 2     Fields:    
    23. Xin L. Cells of origin for cancer: an updated view from prostate cancer. Oncogene. 2013 Aug 08; 32(32):3655-63. PMID: 23178496; PMCID: PMC3740004.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    24. Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L. Notch and TGF? form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 2012 Nov 02; 11(5):676-88. PMID: 23122291; PMCID: PMC3490134.
      Citations: 47     Fields:    Translation:AnimalsCells
    25. Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L. Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 2012 Oct; 21(5):1117-23. PMID: 22350718; PMCID: PMC3433578.
      Citations: 13     Fields:    Translation:AnimalsCells
    26. Choi N, Zhang B, Zhang L, Ittmann M, Xin L. Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. Cancer Cell. 2012 Feb 14; 21(2):253-65. PMID: 22340597; PMCID: PMC3285423.
      Citations: 192     Fields:    Translation:Animals
    27. Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM. Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells. 2011 Apr; 29(4):678-88. PMID: 21308863; PMCID: PMC3148789.
      Citations: 24     Fields:    Translation:AnimalsCells
    28. Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L. ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency. PLoS One. 2011 Mar 28; 6(3):e18271. PMID: 21464902; PMCID: PMC3065488.
      Citations: 49     Fields:    Translation:AnimalsCells
    29. Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 2011 Aug 11; 30(32):3522-36. PMID: 21423204; PMCID: PMC3139785.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    30. Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L. Dicer ablation impairs prostate stem cell activity and causes prostate atrophy. Stem Cells. 2010 Jul; 28(7):1260-9. PMID: 20517984; PMCID: PMC3030968.
      Citations: 16     Fields:    Translation:AnimalsCells
    31. Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells. Prostate. 2010 Feb 15; 70(3):297-304. PMID: 19827049; PMCID: PMC3031866.
      Citations: 9     Fields:    Translation:AnimalsCells
    32. Bu W, Xin L, Toneff M, Li L, Li Y. Lentivirus vectors for stably introducing genes into mammary epithelial cells in vivo. J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4):401-4. PMID: 19936990.
      Citations: 20     Fields:    Translation:AnimalsCells
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