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JOHN LYDON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01HD042311     (LYDON, JOHN P)Apr 1, 2002 - Jul 31, 2024
    NIH
    Molecular Analysis of Uterine Receptivity
    Role: Principal Investigator
    R01CA077530     (LYDON, JOHN P)Apr 1, 1998 - Apr 30, 2010
    NIH
    PROGESTERONE RECEPTOR IN BREAST DEVELOPMENT AND CANCER
    Role: Principal Investigator
    R29CA077530     (LYDON, JOHN P)Apr 1, 1998 - Mar 31, 2005
    NIH
    PROGESTERONE RECEPTOR AND BREAST CANCER
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Popli P, Oestreich AK, Maurya VK, Rowen MN, Masand R, Holtzman MJ, Zhang Y, Lydon J, Akira S, Moley KH, Kommagani R, Popli P, Oestreich AK, Maurya VK, Rowen MN, Masand R, Holtzman MJ, Zhang Y, Lydon J, Akira S, Moley KH, Kommagani R. The autophagy protein, ATG14 safeguards against unscheduled pyroptosis activation to enable embryo transport during early pregnancy. bioRxiv. 2024 Mar 20. PMID: 38562843; PMCID: PMC10983954.
      Citations:    
    2. Hai L, Maurya VK, DeMayo FJ, Lydon JP. Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor. Int J Mol Sci. 2024 Mar 19; 25(6). PMID: 38542422; PMCID: PMC10970820.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Chadchan SB, Popli P, Liao Z, Andreas E, Dias M, Wang T, Gunderson SJ, Jimenez PT, Lanza DG, Lanz RB, Foulds CE, Monsivais D, DeMayo FJ, Yalamanchili HK, Jungheim ES, Heaney JD, Lydon JP, Moley KH, O'Malley BW, Kommagani R. A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis. Nat Commun. 2024 Mar 02; 15(1):1947. PMID: 38431630; PMCID: PMC10908778.
      Citations:    Fields:    Translation:HumansAnimals
    4. Maurya VK, Szwarc MM, Lonard DM, Kommagani R, Wu SP, O'Malley BW, DeMayo FJ, Lydon JP. Steroid receptor coactivator-2 drives epithelial reprogramming that enables murine embryo implantation. FASEB J. 2023 12; 37(12):e23313. PMID: 37962238; PMCID: PMC10655894.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Oh Y, Quiroz E, Wang T, Medina-Laver Y, Redecke SM, Dominguez F, Lydon JP, DeMayo FJ, Wu SP. The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy. Front Endocrinol (Lausanne). 2023; 14:1229033. PMID: 37664846; PMCID: PMC10473531.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Brown M, Leon A, Kedzierska K, Moore C, Belnoue-Davis HL, Flach S, Lydon JP, DeMayo FJ, Lewis A, Bosse T, Tomlinson I, Church DN. Functional analysis reveals driver cooperativity and?novel mechanisms in endometrial carcinogenesis. EMBO Mol Med. 2023 Oct 11; 15(10):e17094. PMID: 37589076; PMCID: PMC10565641.
      Citations: 2     Fields:    Translation:HumansAnimals
    7. Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N, DeMayo FJ. Chromatin architectural factor CTCF is essential for progesterone-dependent uterine maturation. FASEB J. 2023 08; 37(8):e23103. PMID: 37489832; PMCID: PMC10372848.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Li R, Wang T, Marquardt RM, Lydon JP, Wu SP, DeMayo FJ. TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 08 01; 14(1):4605. PMID: 37528140; PMCID: PMC10393996.
      Citations: 1     Fields:    Translation:Humans
    9. Yang SC, Park M, Hong KH, La H, Park C, Wang P, Li G, Chen Q, Choi Y, DeMayo FJ, Lydon JP, Skalnik DG, Lim HJ, Hong SH, Park SH, Kim YS, Kim HR, Song H. CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis. Nat Commun. 2023 06 03; 14(1):3220. PMID: 37270588; PMCID: PMC10239508.
      Citations:    Fields:    Translation:HumansAnimals
    10. Popli P, Tang S, Chadchan SB, Talwar C, Rucker EB, Guan X, Monsivais D, Lydon JP, Stallings CL, Moley KH, Kommagani R. Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy. Dev Cell. 2023 05 22; 58(10):885-897.e4. PMID: 37040770; PMCID: PMC10289806.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Maurya VK, Ying Y, Lanza DG, Heaney JD, Lydon JP. A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor. Genesis. 2023 07; 61(3-4):e23515. PMID: 36949241; PMCID: PMC10514223.
      Citations:    Fields:    Translation:Animals
    12. Li Y, Martin TE, Hancock JM, Li R, Viswanathan S, Lydon JP, Zheng Y, Ye X. Visualization of preimplantation uterine fluid absorption in mice using Alexa Fluor? 488 Hydrazide?. Biol Reprod. 2023 02 13; 108(2):204-217. PMID: 36308434; PMCID: PMC9930399.
      Citations:    Fields:    Translation:Animals
    13. Maurya VK, Szwarc MM, Lonard DM, Gibbons WE, Wu SP, O'Malley BW, DeMayo FJ, Lydon JP. Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3. Front Reprod Health. 2022; 4:1033581. PMID: 36505394; PMCID: PMC9730893.
      Citations:    
    14. Sagae Y, Horie A, Yanai A, Ohara T, Nakakita B, Kitawaki Y, Okunomiya A, Tani H, Yamaguchi K, Hamanishi J, Lydon JP, Daikoku T, Watanabe H, Mandai M. Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth. Matrix Biol. 2023 01; 115:16-31. PMID: 36423736.
      Citations:    
    15. Yu X, Yi P, Panigrahi AK, Lumahan LEV, Lydon JP, Lonard DM, Lutdke SJ, Wang Z, O'Malley BW. Spatial definition of the human progesterone receptor-B transcriptional complex. iScience. 2022 Nov 18; 25(11):105321. PMID: 36325049; PMCID: PMC9618773.
      Citations: 2     
    16. Szwarc MM, Hai L, Maurya VK, Rajapakshe K, Perera D, Ittmann MM, Mo Q, Lin Y, Bettini ML, Coarfa C, Lydon JP. Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus. Cytokine. 2022 12; 160:156022. PMID: 36099756; PMCID: PMC10255830.
      Citations:    
    17. Pennington KA, Oestreich AK, Cataldo KH, Fogliatti CM, Lightner C, Lydon JP, Schulz LC. Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice. Biol Reprod. 2022 08 09; 107(2):546-556. PMID: 35349646.
      Citations:    Fields:    
    18. Soyama H, Nishio M, Otani J, Sakuma T, Takao S, Hara S, Masuda T, Mimori K, Toyokuni S, Lydon JP, Nakao K, Nishina H, Fukumoto T, Maehama T, Suzuki A. Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2123134119. PMID: 35858357; PMCID: PMC9303858.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Maurya VK, Szwarc MM, Fernandez-Valdivia R, Lonard DM, Yong S, Joshi N, Fazleabas AT, Lydon JP. Early growth response 1 transcription factor is essential for the pathogenic properties of human endometriotic epithelial cells. Reproduction. 2022 08 01; 164(2):41-54. PMID: 35679138; PMCID: PMC9339520.
      Citations:    Fields:    Translation:HumansCells
    20. Ahn SH, Nguyen SL, Kim TH, Jeong JW, Arora R, Lydon JP, Petroff MG. Corrigendum: Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy. Front Endocrinol (Lausanne). 2022; 13:958735. PMID: 35800431; PMCID: PMC9253860.
      Citations:    Fields:    
    21. Madhavan MK, DeMayo FJ, Lydon JP, Joshi NR, Fazleabas AT, Arora R. Aberrant uterine folding in mice disrupts implantation chamber formation and alignment of embryo-uterine axes. Development. 2022 06 01; 149(11). PMID: 35575097; PMCID: PMC9245188.
      Citations:    Fields:    Translation:HumansAnimals
    22. Smith KM, Dinh DT, Akison LK, Nicholls M, Dunning KR, Morimoto A, Lydon JP, Russell DL, Robker RL. Intraovarian, Isoform-Specific Transcriptional Roles of Progesterone Receptor in Ovulation. Cells. 2022 05 05; 11(9). PMID: 35563869; PMCID: PMC9105733.
      Citations:    Fields:    Translation:AnimalsCells
    23. Ahn SH, Nguyen SL, Kim TH, Jeong JW, Arora R, Lydon JP, Petroff MG. Nuclear Progesterone Receptor Expressed by the Cortical Thymic Epithelial Cells Dictates Thymus Involution in Murine Pregnancy. Front Endocrinol (Lausanne). 2022; 13:846226. PMID: 35498436; PMCID: PMC9046655.
      Citations:    Fields:    Translation:AnimalsCells
    24. Fang X, Ni N, Wang X, Tian Y, Ivanov I, Rijnkels M, Bayless KJ, Lydon JP, Li Q. EZH2 and Endometrial Cancer Development: Insights from a Mouse Model. Cells. 2022 03 07; 11(5). PMID: 35269532; PMCID: PMC8909840.
      Citations:    Fields:    Translation:HumansAnimals
    25. Jussila AR, Zhang B, Caves E, Kirti S, Steele M, Hamburg-Shields E, Lydon J, Ying Y, Lafyatis R, Rajagopalan S, Horsley V, Atit RP. Skin Fibrosis and Recovery Is Dependent on Wnt Activation via DPP4. J Invest Dermatol. 2022 06; 142(6):1597-1606.e9. PMID: 34808238; PMCID: PMC9120259.
      Citations:    Fields:    Translation:AnimalsCells
    26. Kelleher AM, Setlem R, DeMayo FJ, Lydon JP, Kraus WL, Dantzer F. Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci U S A. 2021 10 05; 118(40). PMID: 34580230; PMCID: PMC8501838.
      Citations:    Fields:    Translation:AnimalsCells
    27. McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, Hewitt SC, Korach KS, DeMayo FJ, Lydon JP, Monsivais D, Winuthayanon W. Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 2021 05; 35(5):e21563. PMID: 33818810; PMCID: PMC8189321.
      Citations: 1     Fields:    Translation:Animals
    28. Wang X, Wendel JRH, Emerson RE, DeMayo FJ, Lydon JP, Hawkins SM, Pra?a MSL. Vaginal Squamous Cell Carcinoma Develops in Mice with Conditional Arid1a Loss and Gain of Oncogenic Kras Driven by Progesterone Receptor Cre. Am J Pathol. 2021 07; 191(7):1281-1291. PMID: 33882289; PMCID: PMC8261476.
      Citations: 2     Fields:    Translation:Animals
    29. Maurya VK, DeMayo FJ, Lydon JP. Illuminating the "Black Box" of Progesterone-Dependent Embryo Implantation Using Engineered Mice. Front Cell Dev Biol. 2021; 9:640907. PMID: 33898429; PMCID: PMC8058370.
      Citations: 2     
    30. Peavey MC, Wu SP, Li R, Liu J, Emery OM, Wang T, Zhou L, Wetendorf M, Yallampalli C, Gibbons WE, Lydon JP, DeMayo FJ. Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility. Proc Natl Acad Sci U S A. 2021 03 16; 118(11). PMID: 33707208; PMCID: PMC7980420.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Kim YS, Yang SC, Park M, Choi Y, DeMayo FJ, Lydon JP, Kim HR, Lim HJ, Song H. Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice. Cell Prolif. 2021 Mar; 54(3):e12996. PMID: 33496365; PMCID: PMC7941225.
      Citations: 2     Fields:    Translation:Animals
    32. Fang X, Ni N, Gao Y, Lydon JP, Ivanov I, Rijnkels M, Bayless KJ, Li Q. Transforming growth factor beta signaling and decidual integrity in mice?. Biol Reprod. 2020 12 01; 103(6):1186-1198. PMID: 32902612; PMCID: PMC7711917.
      Citations: 4     Fields:    Translation:AnimalsCells
    33. Kim O, Park EY, Kwon SY, Shin S, Emerson RE, Shin YH, DeMayo FJ, Lydon JP, Coffey DM, Hawkins SM, Quilliam LA, Cheon DJ, Nephew KP, Karpf AR, Widschwendter M, Sood AK, Bast RC, Godwin AK, Miller KD, Cho CH, Kim J, Fern?ndez FM. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):31993-32004. PMID: 33262282; PMCID: PMC7749341.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Chi RA, Wang T, Huang CL, Wu SP, Young SL, Lydon JP, DeMayo FJ. WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight. 2020 11 19; 5(22). PMID: 33048843; PMCID: PMC7710275.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Li R, Wu SP, Zhou L, Nicol B, Lydon JP, Yao HH, DeMayo FJ. Increased FOXL2 expression alters uterine structures and functions?. Biol Reprod. 2020 10 29; 103(5):951-965. PMID: 32948877; PMCID: PMC7609875.
      Citations: 1     Fields:    Translation:AnimalsCells
    36. Wetendorf M, Li R, Wu SP, Liu J, Creighton CJ, Wang T, Janardhan KS, Willson CJ, Lanz RB, Lydon JP, DeMayo FJ, Murphy BD. Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms. Sci Signal. 2020 10 06; 13(652). PMID: 33023986; PMCID: PMC10251233.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    37. Wang X, Wendel JRH, Emerson RE, Broaddus RR, Creighton CJ, Rusch DB, Buechlein A, DeMayo FJ, Lydon JP, Hawkins SM. Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Oncogene. 2020 10; 39(40):6286-6299. PMID: 32843721; PMCID: PMC7541676.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    38. Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A. Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer Sci. 2020 Oct; 111(10):3576-3587. PMID: 32716083; PMCID: PMC7541006.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    39. DeMayo FJ, Lydon JP. 90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation. J Mol Endocrinol. 2020 07; 65(1):T1-T14. PMID: 31809260; PMCID: PMC7261627.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    40. Goolam M, Xypolita ME, Costello I, Lydon JP, DeMayo FJ, Bikoff EK, Robertson EJ, Mould AW. The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice. Nat Commun. 2020 06 03; 11(1):2782. PMID: 32493987; PMCID: PMC7270082.
      Citations: 5     Fields:    Translation:AnimalsCells
    41. Oestreich AK, Chadchan SB, Medvedeva A, Lydon JP, Jungheim ES, Moley KH, Kommagani R. The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization?. Biol Reprod. 2020 04 15; 102(4):843-851. PMID: 31901086; PMCID: PMC7124967.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    42. Park CJ, Lin PC, Zhou S, Barakat R, Bashir ST, Choi JM, Cacioppo JA, Oakley OR, Duffy DM, Lydon JP, Ko CJ. Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation. Cell Rep. 2020 04 14; 31(2):107496. PMID: 32294429; PMCID: PMC7211423.
      Citations: 12     Fields:    Translation:AnimalsCells
    43. Herrera GGB, Lierz SL, Harris EA, Donoghue LJ, Hewitt SC, Rodriguez KF, Jefferson WN, Lydon JP, DeMayo FJ, Williams CJ, Korach KS, Winuthayanon W. Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor a in the Isthmus and the Uterus. Endocrinology. 2020 02 01; 161(2). PMID: 31883000; PMCID: PMC7295936.
      Citations: 2     Fields:    Translation:Animals
    44. Wartenberg P, Boehm U, Lydon JP, Roelfsema F, Toufaily C, Schang G, Zhou X, Bernard DJ. Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice. J Endocrinol. 2020 01; 244(1):111-122. PMID: 31585440.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Oestreich AK, Chadchan SB, Popli P, Medvedeva A, Rowen MN, Stephens CS, Xu R, Lydon JP, Demayo FJ, Jungheim ES, Moley KH, Kommagani R. The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization. Endocrinology. 2020 Jan 01; 161(1). PMID: 31875883; PMCID: PMC6986551.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    46. Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, Lydon JP, Levin ER, Cooke PS. The histone methyltransferase EZH2 is required for normal uterine development and function in mice?. Biol Reprod. 2019 08 01; 101(2):306-317. PMID: 31201420; PMCID: PMC7302517.
      Citations: 14     Fields:    Translation:AnimalsCells
    47. Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, Lydon JP. Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland. Cytokine. 2019 11; 123:154745. PMID: 31226438; PMCID: PMC7443928.
      Citations:    Fields:    Translation:AnimalsCells
    48. de Oliveira V, Schaefer J, Calder M, Lydon JP, DeMayo FJ, Bhattacharya M, Radovick S, Babwah AV. Uterine Gaq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. FASEB J. 2019 08; 33(8):9374-9387. PMID: 31091422; PMCID: PMC6662978.
      Citations: 7     Fields:    Translation:AnimalsCells
    49. Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS. A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1). J Biol Chem. 2019 06 21; 294(25):9746-9759. PMID: 31073032; PMCID: PMC6597841.
      Citations: 12     Fields:    Translation:AnimalsCells
    50. Fang X, Ni N, Lydon JP, Ivanov I, Bayless KJ, Rijnkels M, Li Q. Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity. Am J Pathol. 2019 06; 189(6):1212-1225. PMID: 30954472; PMCID: PMC6547058.
      Citations: 10     Fields:    Translation:Animals
    51. Szwarc MM, Hai L, Gibbons WE, Mo Q, Lanz RB, DeMayo FJ, Lydon JP. Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization. J Steroid Biochem Mol Biol. 2019 05; 189:283-290. PMID: 30711473; PMCID: PMC6566904.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    52. Hierweger AM, Engler JB, Friese MA, Lydon J, DeMayo F, Arck PC, Reichardt HM, Mittr?cker HW. Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways. Am J Reprod Immunol. 2019 02; 81(2):e13084. PMID: 30604567; PMCID: PMC7457140.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    53. Hai L, Szwarc MM, Lanza DG, Heaney JD, Lydon JP. Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor. Genesis. 2019 03; 57(3):e23281. PMID: 30628160; PMCID: PMC6422732.
      Citations: 2     Fields:    Translation:Animals
    54. Ni N, Gao Y, Fang X, Melgar M, Vincent DF, Lydon JP, Li Q, Bartholin L. Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment. PLoS One. 2018; 13(12):e0209417. PMID: 30550590; PMCID: PMC6294433.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    55. Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ. FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet. 2018 11; 14(11):e1007787. PMID: 30452456; PMCID: PMC6277115.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    56. Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessey BA, Lanz RB, Lydon JP, DeMayo FJ. SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh. Nat Commun. 2018 10 24; 9(1):4421. PMID: 30356064; PMCID: PMC6200785.
      Citations: 27     Fields:    Translation:AnimalsCells
    57. Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS. Negative elongation factor is essential for endometrial function. FASEB J. 2019 02; 33(2):3010-3023. PMID: 30332301; PMCID: PMC6338652.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    58. Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O'Malley BW, Lydon JP. Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics Reproduction. 2018 10 16; 156(5):387-395. PMID: 30325183; PMCID: PMC6208442.
      Citations: 7     Fields:    Translation:HumansCells
    59. Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW. Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 09 03; 8(1):13134. PMID: 30177747; PMCID: PMC6120906.
      Citations: 1     Fields:    Translation:HumansCells
    60. Hai L, Szwarc MM, Wetendorf M, Wu SP, Peavey MC, Grimm SL, Edwards DP, DeMayo FJ, Lydon JP. A mouse model engineered to conditionally express the progesterone receptor-B isoform. Genesis. 2018 08; 56(8):e23223. PMID: 30004627; PMCID: PMC6141023.
      Citations: 2     Fields:    Translation:AnimalsCells
    61. Hai L, Szwarc MM, He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP. Uterine function in the mouse requires speckle-type poz protein. Biol Reprod. 2018 06 01; 98(6):856-869. PMID: 29546395; PMCID: PMC6105734.
      Citations: 6     Fields:    Translation:Animals
    62. Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP. Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biol Reprod. 2018 01 01; 98(1):15-27. PMID: 29186366; PMCID: PMC5819842.
      Citations: 11     Fields:    Translation:HumansCells
    63. Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse. J Vis Exp. 2017 10 24; (128). PMID: 29155779; PMCID: PMC5695270.
      Citations: 1     Fields:    Translation:Animals
    64. Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017 09 01; 23(9):646-653. PMID: 28911214; PMCID: PMC5909854.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    65. Gao Y, Lin P, Lydon JP, Li Q. Conditional abrogation of transforming growth factor-? receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice. J Pathol. 2017 09; 243(1):89-99. PMID: 28657664; PMCID: PMC5568928.
      Citations: 15     Fields:    Translation:AnimalsCells
    66. Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J, Wang H. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 12; 24(12):2013-2021. PMID: 28731465; PMCID: PMC5686342.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    67. El Zowalaty AE, Li R, Zheng Y, Lydon JP, DeMayo FJ, Ye X. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology. 2017 07 01; 158(7):2168-2178. PMID: 28498971; PMCID: PMC5505209.
      Citations: 12     Fields:    Translation:AnimalsCells
    68. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4816-4821. PMID: 28424251; PMCID: PMC5422785.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    69. Mapes J, Li Q, Kannan A, Anandan L, Laws M, Lydon JP, Bagchi IC, Bagchi MK. CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017 Mar; 13(3):e1006654. PMID: 28278176; PMCID: PMC5363987.
      Citations: 12     Fields:    Translation:AnimalsCells
    70. Szwarc MM, Kommagani R, Peavey MC, Hai L, Lonard DM, Lydon JP. A bioluminescence reporter mouse that monitors expression of constitutively active ?-catenin. PLoS One. 2017; 12(3):e0173014. PMID: 28253313; PMCID: PMC5333872.
      Citations: 2     Fields:    Translation:AnimalsCells
    71. Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. 2017 03 01; 158(3):640-651. PMID: 28005395; PMCID: PMC5460782.
      Citations: 20     Fields:    Translation:Animals
    72. Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biol Reprod. 2017 02 01; 96(2):313-326. PMID: 28203817; PMCID: PMC6225975.
      Citations: 27     Fields:    Translation:AnimalsCells
    73. Lydon J, Gargiulo L, May M, Rivero EM, Copsel S, Lamb C, Davio C, Lanari C, L?thy IA, Bruzzone A. A Novel Effect of ?-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer. J Mammary Gland Biol Neoplasia. 2017 03; 22(1):43-57. PMID: 28074314.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    74. Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse. PLoS One. 2017; 12(1):e0169312. PMID: 28046063; PMCID: PMC5207679.
      Citations: 3     Fields:    Translation:Animals
    75. Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ. A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell Rep. 2016 10 25; 17(5):1414-1425. PMID: 27783953; PMCID: PMC5084852.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    76. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105; PMCID: PMC5216986.
      Citations: 9     Fields:    Translation:HumansAnimals
    77. Gal A, Lin PC, Cacioppo JA, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, Ko C. Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice. PLoS One. 2016; 11(7):e0159534. PMID: 27441639; PMCID: PMC4956300.
      Citations: 15     Fields:    Translation:AnimalsCells
    78. McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology. 2016 09; 157(9):3309-19. PMID: 27309940; PMCID: PMC5007897.
      Citations: 22     Fields:    Translation:Animals
    79. Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B. The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker. Prostate. 2016 10; 76(14):1271-84. PMID: 27272765.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    80. Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH. Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus. Oncotarget. 2016 Apr 05; 7(14):17455-67. PMID: 27007157; PMCID: PMC4951225.
      Citations: 13     Fields:    Translation:Animals
    81. Kommagani R, Szwarc MM, Vasquez YM, Peavey MC, Mazur EC, Gibbons WE, Lanz RB, DeMayo FJ, Lydon JP. The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization. PLoS Genet. 2016 Apr; 12(4):e1005937. PMID: 27035670; PMCID: PMC4817989.
      Citations: 29     Fields:    Translation:HumansCells
    82. Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May; 30(5):518-32. PMID: 27018534; PMCID: PMC4853565.
      Citations: 10     Fields:    Translation:AnimalsCells
    83. Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS. Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Mar 22; 7(12):14885-97. PMID: 26910913; PMCID: PMC4924759.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    84. Stelzer IA, Mori M, DeMayo F, Lydon J, Arck PC, Solano ME. Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures. Cell Adh Migr. 2016 03 03; 10(1-2):2-17. PMID: 26914234; PMCID: PMC4853043.
      Citations: 1     Fields:    Translation:HumansAnimals
    85. Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H. Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep. 2016 Feb 02; 6:20242. PMID: 26833131; PMCID: PMC4735737.
      Citations: 10     Fields:    Translation:AnimalsCells
    86. Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. Uterine ALK3 is essential during the window of implantation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E387-95. PMID: 26721398; PMCID: PMC4725477.
      Citations: 27     Fields:    Translation:AnimalsCells
    87. Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA. Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15166-71. PMID: 26598666; PMCID: PMC4679013.
      Citations: 29     Fields:    Translation:Animals
    88. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function. PLoS One. 2015; 10(11):e0143652. PMID: 26580555; PMCID: PMC4651323.
      Citations:    Fields:    
    89. Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 05; 163(4):960-74. PMID: 26544941; PMCID: PMC4640214.
      Citations: 100     Fields:    Translation:HumansAnimals
    90. Convissar SM, Bennett J, Baumgarten SC, Lydon JP, DeMayo FJ, Stocco C. GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biol Reprod. 2015 Dec; 93(6):133. PMID: 26510866; PMCID: PMC4712692.
      Citations: 10     Fields:    Translation:AnimalsCells
    91. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2015 Oct; 50(10):1180. PMID: 26456788.
      Citations:    Fields:    
    92. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS Genet. 2015 Sep; 11(9):e1005515. PMID: 26418340; PMCID: PMC4587844.
      Citations: 1     Fields:    
    93. Kim TH, Yoo JY, Wang Z, Lydon JP, Khatri S, Hawkins SM, Leach RE, Fazleabas AT, Young SL, Lessey BA, Ku BJ, Jeong JW. ARID1A Is Essential for Endometrial Function during Early Pregnancy. PLoS Genet. 2015 Sep; 11(9):e1005537. PMID: 26378916; PMCID: PMC4574948.
      Citations: 36     Fields:    Translation:HumansAnimals
    94. Szwarc MM, Lydon JP, O'Malley BW. Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system". J Steroid Biochem Mol Biol. 2015 Sep; 153:144-50. PMID: 26291832.
      Citations:    Fields:    
    95. Szwarc MM, Lydon JP, O'Malley BW. Steroid receptor coactivators as therapeutic targets in the female reproductive system. J Steroid Biochem Mol Biol. 2015 Nov; 154:32-8. PMID: 26151740; PMCID: PMC5201167.
      Citations: 5     Fields:    Translation:HumansAnimals
    96. Szwarc MM, Kommagani R, Jacob AP, Dougall WC, Ittmann MM, Lydon JP. Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors. PLoS One. 2015; 10(6):e0128467. PMID: 26061636; PMCID: PMC4464738.
      Citations: 4     Fields:    Translation:AnimalsCells
    97. Nanjappa MK, Medrano TI, Lydon JP, Bigsby RM, Cooke PS. Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Biol Reprod. 2015 May; 92(5):122. PMID: 25882702.
      Citations: 4     Fields:    Translation:AnimalsCells
    98. Kowal MK, O'Rourke GE, Horst AK, Modest K, Barikbin R, Remus CC, Berger RG, Jago C, Ho H, Sass G, Parker VJ, Lydon JP, DeMayo FJ, Hecher K, Karimi K, Arck PC, Solano ME, Pl?sch T. Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 2015 Apr; 125(4):1726-38. PMID: 25774501; PMCID: PMC4396482.
      Citations: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    99. Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 2015 Mar 10; 4(3):313-322. PMID: 28447939; PMCID: PMC4376056.
      Citations: 19     Fields:    
    100. Bangari DS, Ashe KM, Desnick RJ, Maloney C, Lydon J, Piepenhagen P, Budman E, Leonard JP, Cheng SH, Marshall J, Thurberg BL. a-Galactosidase A knockout mice: progressive organ pathology resembles the type 2 later-onset phenotype of Fabry disease. Am J Pathol. 2015 Mar; 185(3):651-65. PMID: 25553976.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    101. Gao Y, Duran S, Lydon JP, DeMayo FJ, Burghardt RC, Bayless KJ, Li Q, Bartholin L. Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function. Biol Reprod. 2015 Feb; 92(2):34. PMID: 25505200; PMCID: PMC4435420.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    102. Grimm SL, Ward RD, Obr AE, Franco HL, Fernandez-Valdivia R, Kim JS, Roberts JM, Jeong JW, DeMayo FJ, Lydon JP, Edwards DP, Weigel NL. A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol. 2014 Dec; 28(12):2025-37. PMID: 25333515; PMCID: PMC4250360.
      Citations: 2     Fields:    Translation:AnimalsCells
    103. Akgul Y, Word RA, Ensign LM, Yamaguchi Y, Lydon J, Hanes J, Mahendroo M. Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. J Clin Invest. 2014 Dec; 124(12):5481-9. PMID: 25384213; PMCID: PMC4348952.
      Citations: 34     Fields:    Translation:Animals
    104. Kim TH, Yoo JY, Kim HI, Gilbert J, Ku BJ, Li J, Mills GB, Broaddus RR, Lydon JP, Lim JM, Yoon HG, Jeong JW. Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation. Cancer Res. 2014 Dec 15; 74(24):7371-82. PMID: 25377472; PMCID: PMC4268053.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    105. Szwarc MM, Kommagani R, Lessey BA, Lydon JP. The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. Biol Reprod. 2014 Nov; 91(5):122. PMID: 25297546; PMCID: PMC4434928.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    106. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res. 2014 Aug; 24(8):925-42. PMID: 24971735; PMCID: PMC4123295.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    107. Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451. PMID: 24945252; PMCID: PMC4063709.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    108. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PLoS One. 2014; 9(6):e98664. PMID: 24905738; PMCID: PMC4048228.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    109. Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May; 16(5):390-402. PMID: 25016594; PMCID: PMC4198742.
      Citations: 37     Fields:    Translation:HumansCells
    110. Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JP. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biol Reprod. 2014 Apr; 90(4):75. PMID: 24571987; PMCID: PMC4076383.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    111. van der Horst PH, van der Zee M, Heijmans-Antonissen C, Jia Y, DeMayo FJ, Lydon JP, van Deurzen CH, Ewing PC, Burger CW, Blok LJ. A mouse model for endometrioid ovarian cancer arising from the distal oviduct. Int J Cancer. 2014 Sep 01; 135(5):1028-37. PMID: 24474556.
      Citations: 13     Fields:    Translation:AnimalsCells
    112. Kim TH, Yu Y, Luo L, Lydon JP, Jeong JW, Kim JJ. Activated AKT pathway promotes establishment of endometriosis. Endocrinology. 2014 May; 155(5):1921-30. PMID: 24605828; PMCID: PMC3990849.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    113. Filant J, DeMayo FJ, Pru JK, Lydon JP, Spencer TE. Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice. Biol Reprod. 2014 Jan; 90(1):7. PMID: 24227756; PMCID: PMC7289345.
      Citations: 13     Fields:    Translation:AnimalsCells
    114. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2013 Dec; 48(12):1270-5. PMID: 24338880.
      Citations:    Fields:    Translation:HumansCells
    115. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013 Nov; 9(11):e1003863. PMID: 24244176; PMCID: PMC3828128.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    116. Bruno RD, Boulanger CA, Rosenfield SM, Anderson LH, Lydon JP, Smith GH. Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J Cell Sci. 2014 Jan 01; 127(Pt 1):27-32. PMID: 24190884; PMCID: PMC3874781.
      Citations: 7     Fields:    Translation:AnimalsCells
    117. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900. PMID: 24204309; PMCID: PMC3812085.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    118. Oh SJ, Shin JH, Kim TH, Lee HS, Yoo JY, Ahn JY, Broaddus RR, Taketo MM, Lydon JP, Leach RE, Lessey BA, Fazleabas AT, Lim JM, Jeong JW. ?-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pathol. 2013 Oct; 231(2):210-22. PMID: 23784889; PMCID: PMC4105844.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    119. Filant J, Lydon JP, Spencer TE. Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus. FASEB J. 2014 Jan; 28(1):230-43. PMID: 24025729; PMCID: PMC7092800.
      Citations: 25     Fields:    Translation:Animals
    120. Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol. 2013 Nov; 27(11):1808-24. PMID: 24014651; PMCID: PMC3805851.
      Citations: 28     Fields:    Translation:AnimalsCells
    121. Yoo YA, Son J, Mehta FF, DeMayo FJ, Lydon JP, Chung SH. Progesterone signaling inhibits cervical carcinogenesis in mice. Am J Pathol. 2013 Nov; 183(5):1679-1687. PMID: 24012679; PMCID: PMC3816255.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    122. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. PMID: 23853117; PMCID: PMC3799495.
      Citations: 56     Fields:    Translation:Animals
    123. Lindberg ME, Stodden GR, King ML, MacLean JA, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus. Biol Reprod. 2013 Jul; 89(1):8. PMID: 23740945; PMCID: PMC4076352.
      Citations: 10     Fields:    Translation:AnimalsCells
    124. Prizant H, Sen A, Light A, Cho SN, DeMayo FJ, Lydon JP, Hammes SR. Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs. Mol Endocrinol. 2013 Sep; 27(9):1403-14. PMID: 23820898; PMCID: PMC3753421.
      Citations: 25     Fields:    Translation:Animals
    125. Large MJ, Duggavathi R, DeMayo FJ, Lydon JP, Schoonjans K, Kovanci E, Murphy BD, Zhang C. Liver receptor homolog-1 is essential for pregnancy. Nat Med. 2013 Aug; 19(8):1061-6. PMID: 23817023; PMCID: PMC3983050.
      Citations: 34     Fields:    Translation:HumansAnimals
    126. Kim TH, Lee DK, Cho SN, Orvis GD, Behringer RR, Lydon JP, Ku BJ, McCampbell AS, Broaddus RR, Jeong JW. Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer. Cancer Res. 2013 Aug 15; 73(16):5090-9. PMID: 23811943; PMCID: PMC3745525.
      Citations: 15     Fields:    Translation:AnimalsCells
    127. Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM. BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun; 123(6):2539-50. PMID: 23676498; PMCID: PMC3668851.
      Citations: 58     Fields:    Translation:AnimalsCells
    128. Lee JH, Kim TH, Oh SJ, Yoo JY, Akira S, Ku BJ, Lydon JP, Jeong JW. Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus. FASEB J. 2013 Jul; 27(7):2553-63. PMID: 23531596; PMCID: PMC3688751.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    129. van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, DeMayo FJ, Lydon JP, Burger CW, Fodde R, Blok LJ. Alterations in Wnt-?-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 2013 May; 230(1):48-58. PMID: 23288720.
      Citations: 21     Fields:    Translation:AnimalsCells
    130. Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development. 2013 Apr; 140(7):1397-401. PMID: 23462470.
      Citations: 51     Fields:    Translation:AnimalsCells
    131. Lue Y, Wang C, Lydon JP, Leung A, Li J, Swerdloff RS. Functional role of progestin and the progesterone receptor in the suppression of spermatogenesis in rodents. Andrology. 2013 Mar; 1(2):308-17. PMID: 23408752.
      Citations: 12     Fields:    Translation:AnimalsCells
    132. Kawagoe J, Li Q, Mussi P, Liao L, Lydon JP, DeMayo FJ, Xu J. Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. Dev Cell. 2012 Oct 16; 23(4):858-65. PMID: 23079602; PMCID: PMC3479668.
      Citations: 19     Fields:    Translation:Animals
    133. Lee JH, Lydon JP, Kim CH. Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. Eur J Immunol. 2012 Oct; 42(10):2683-96. PMID: 22740122; PMCID: PMC3668644.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    134. Hawkins SM, Andreu-Vieyra CV, Kim TH, Jeong JW, Hodgson MC, Chen R, Creighton CJ, Lydon JP, Gunaratne PH, DeMayo FJ, Matzuk MM. Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Mol Endocrinol. 2012 Sep; 26(9):1552-66. PMID: 22798293; PMCID: PMC3434527.
      Citations: 17     Fields:    Translation:AnimalsCells
    135. Han SJ, Hawkins SM, Begum K, Jung SY, Kovanci E, Qin J, Lydon JP, DeMayo FJ, O'Malley BW. A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med. 2012 Jul; 18(7):1102-11. PMID: 22660634; PMCID: PMC3541027.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    136. Park CB, DeMayo FJ, Lydon JP, Dufort D. NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod. 2012 Jun; 86(6):194. PMID: 22378764; PMCID: PMC4480152.
      Citations: 18     Fields:    Translation:Animals
    137. Margaill I, Zhang S, Labombarda F, Delespierre B, Liere P, Marchand-Leroux C, O'Malley BW, Lydon JP, De Nicola AF, Sitruk-Ware R, Mattern C, Plotkine M, Schumacher M, Guennoun R, Liu A, Coqueran B. Progesterone receptors: a key for neuroprotection in experimental stroke. Endocrinology. 2012 Aug; 153(8):3747-57. PMID: 22635678; PMCID: PMC3979171.
      Citations: 41     Fields:    Translation:AnimalsCells
    138. Rubel CA, Lanz RB, Kommagani R, Franco HL, Lydon JP, DeMayo FJ. Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus. Mol Endocrinol. 2012 Aug; 26(8):1428-42. PMID: 22638070; PMCID: PMC3404303.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    139. Park S, Yoon S, Zhao Y, Park SE, Liao L, Xu J, Lydon JP, DeMayo FJ, O'Malley BW, Bagchi MK, Katzenellenbogen BS. Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA. Endocrinology. 2012 Aug; 153(8):3982-94. PMID: 22585830; PMCID: PMC3404350.
      Citations: 13     Fields:    Translation:AnimalsCells
    140. Reardon SN, King ML, MacLean JA, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus. Biol Reprod. 2012 May; 86(5):141, 1-10. PMID: 22378759; PMCID: PMC3364924.
      Citations: 41     Fields:    Translation:AnimalsCells
    141. Rubel CA, Franco HL, Jeong JW, Lydon JP, DeMayo FJ. GATA2 is expressed at critical times in the mouse uterus during pregnancy. Gene Expr Patterns. 2012 May-Jun; 12(5-6):196-203. PMID: 22476030.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    142. Franco HL, Rubel CA, Large MJ, Wetendorf M, Fernandez-Valdivia R, Jeong JW, Spencer TE, Behringer RR, Lydon JP, Demayo FJ. Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function. FASEB J. 2012 Mar; 26(3):1218-27. PMID: 22155565; PMCID: PMC3289500.
      Citations: 77     Fields:    Translation:AnimalsCells
    143. Daikoku T, Cha J, Sun X, Tranguch S, Xie H, Fujita T, Hirota Y, Lydon J, DeMayo F, Maxson R, Dey SK. Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity. Dev Cell. 2011 Dec 13; 21(6):1014-25. PMID: 22100262; PMCID: PMC3241866.
      Citations: 98     Fields:    Translation:AnimalsCells
    144. Afshar Y, Jeong JW, Roqueiro D, DeMayo F, Lydon J, Radtke F, Radnor R, Miele L, Fazleabas A. Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse. FASEB J. 2012 Jan; 26(1):282-94. PMID: 21990372; PMCID: PMC3250240.
      Citations: 40     Fields:    Translation:AnimalsCells
    145. Fernandez-Valdivia R, Lydon JP. From the ranks of mammary progesterone mediators, RANKL takes the spotlight. Mol Cell Endocrinol. 2012 Jun 24; 357(1-2):91-100. PMID: 21964466; PMCID: PMC3253322.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    146. Nagashima T, Kim J, Li Q, Lydon JP, DeMayo FJ, Lyons KM, Matzuk MM. Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol. 2011 Oct; 25(10):1740-59. PMID: 21868453; PMCID: PMC3182424.
      Citations: 39     Fields:    Translation:AnimalsCells
    147. Park S, Zhao Y, Yoon S, Xu J, Liao L, Lydon J, DeMayo F, O'Malley BW, Katzenellenbogen BS. Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. Endocrinology. 2011 Nov; 152(11):4336-49. PMID: 21862609; PMCID: PMC3199013.
      Citations: 14     Fields:    Translation:AnimalsCells
    148. Wang Y, Jia Y, Franken P, Smits R, Ewing PC, Lydon JP, DeMayo FJ, Burger CW, Anton Grootegoed J, Fodde R, Blok LJ. Loss of APC function in mesenchymal cells surrounding the M?llerian duct leads to myometrial defects in adult mice. Mol Cell Endocrinol. 2011 Jul 20; 341(1-2):48-54. PMID: 21664244.
      Citations: 7     Fields:    Translation:AnimalsCells
    149. Dunlap KA, Filant J, Hayashi K, Rucker EB, Song G, Deng JM, Behringer RR, DeMayo FJ, Lydon J, Jeong JW, Spencer TE. Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice. Biol Reprod. 2011 Aug; 85(2):386-96. PMID: 21508348; PMCID: PMC3142262.
      Citations: 62     Fields:    Translation:Animals
    150. Li Q, Kannan A, DeMayo FJ, Lydon JP, Cooke PS, Yamagishi H, Srivastava D, Bagchi MK, Bagchi IC. The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science. 2011 Feb 18; 331(6019):912-6. PMID: 21330545; PMCID: PMC3320855.
      Citations: 165     Fields:    Translation:AnimalsCells
    151. He B, Kim TH, Kommagani R, Feng Q, Lanz RB, Jeong JW, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. Estrogen-regulated prohibitin is required for mouse uterine development and adult function. Endocrinology. 2011 Mar; 152(3):1047-56. PMID: 21209023; PMCID: PMC3040048.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    152. Franco HL, Dai D, Lee KY, Rubel CA, Roop D, Boerboom D, Jeong JW, Lydon JP, Bagchi IC, Bagchi MK, DeMayo FJ. WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J. 2011 Apr; 25(4):1176-87. PMID: 21163860; PMCID: PMC3058697.
      Citations: 141     Fields:    Translation:AnimalsCells
    153. Mukherjee A, Soyal SM, Li J, Ying Y, Szwarc MM, He B, Kommagani R, Hodgson MC, Hiremath M, Cowin P, Lydon JP. A mouse transgenic approach to induce ?-catenin signaling in a temporally controlled manner. Transgenic Res. 2011 Aug; 20(4):827-40. PMID: 21120693.
      Citations: 6     Fields:    Translation:AnimalsCells
    154. Lydon JP, O'Malley BW. Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis. Endocrinology. 2011 Jan; 152(1):19-25. PMID: 21047941; PMCID: PMC3219052.
      Citations: 24     Fields:    Translation:HumansCells
    155. Hayashi K, Yoshioka S, Reardon SN, Rucker EB, Spencer TE, DeMayo FJ, Lydon JP, MacLean JA. WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. Biol Reprod. 2011 Feb; 84(2):308-19. PMID: 20962251; PMCID: PMC3071266.
      Citations: 46     Fields:    Translation:Animals
    156. Mukherjee A, Soyal SM, Li J, Ying Y, He B, DeMayo FJ, Lydon JP. Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB J. 2010 Nov; 24(11):4408-19. PMID: 20605949; PMCID: PMC2974417.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    157. Lydon JP. Stem cells: Cues from steroid hormones. Nature. 2010 Jun 10; 465(7299):695-6. PMID: 20535190.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    158. Jeong JW, Kwak I, Lee KY, Kim TH, Large MJ, Stewart CL, Kaestner KH, Lydon JP, DeMayo FJ. Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod. 2010 Sep; 83(3):396-403. PMID: 20484741; PMCID: PMC2924802.
      Citations: 95     Fields:    Translation:Animals
    159. Lee DK, Kurihara I, Jeong JW, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY. Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization. Mol Endocrinol. 2010 May; 24(5):930-40. PMID: 20219888; PMCID: PMC2870934.
      Citations: 40     Fields:    Translation:Animals
    160. Franco HL, Lee KY, Rubel CA, Creighton CJ, White LD, Broaddus RR, Lewis MT, Lydon JP, Jeong JW, DeMayo FJ. Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. Biol Reprod. 2010 May; 82(5):991-9. PMID: 20130264; PMCID: PMC2857637.
      Citations: 28     Fields:    Translation:AnimalsCells
    161. Fernandez-Valdivia R, Jeong J, Mukherjee A, Soyal SM, Li J, Ying Y, Demayo FJ, Lydon JP. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis. 2010 Feb; 48(2):106-13. PMID: 20029965; PMCID: PMC2819579.
      Citations: 35     Fields:    Translation:AnimalsCells
    162. Rubel CA, Jeong JW, Tsai SY, Lydon JP, Demayo FJ. Epithelial-stromal interaction and progesterone receptors in the mouse uterus. Semin Reprod Med. 2010 Jan; 28(1):27-35. PMID: 20104426.
      Citations: 28     Fields:    Translation:AnimalsCells
    163. Franco HL, Lee KY, Broaddus RR, White LD, Lanske B, Lydon JP, Jeong JW, DeMayo FJ. Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol Reprod. 2010 Apr; 82(4):783-90. PMID: 20056671; PMCID: PMC2842491.
      Citations: 32     Fields:    Translation:AnimalsCells
    164. Kim TH, Lee DK, Franco HL, Lydon JP, Jeong JW. ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice. Biol Reprod. 2010 Apr; 82(4):706-13. PMID: 20018910; PMCID: PMC2842487.
      Citations: 20     Fields:    Translation:Animals
    165. Kim TH, Wang J, Lee KY, Franco HL, Broaddus RR, Lydon JP, Jeong JW, Demayo FJ. The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action. J Oncol. 2010; 2010:139087. PMID: 19884980; PMCID: PMC2768008.
      Citations: 27     
    166. Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS. Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer Res. 2009 Aug 15; 69(16):6463-72. PMID: 19679546; PMCID: PMC2741085.
      Citations: 50     Fields:    Translation:AnimalsCells
    167. Lydon JP, Edwards DP. Finally! A model for progesterone receptor action in normal human breast. Endocrinology. 2009 Jul; 150(7):2988-90. PMID: 19549883; PMCID: PMC2703515.
      Citations: 5     Fields:    Translation:HumansAnimals
    168. Jeong JW, Lee HS, Lee KY, White LD, Broaddus RR, Zhang YW, Vande Woude GF, Giudice LC, Young SL, Lessey BA, Tsai SY, Lydon JP, DeMayo FJ. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8677-82. PMID: 19439667; PMCID: PMC2681319.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    169. Simon L, Spiewak KA, Ekman GC, Kim J, Lydon JP, Bagchi MK, Bagchi IC, DeMayo FJ, Cooke PS. Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma. Endocrinology. 2009 Aug; 150(8):3871-6. PMID: 19372202; PMCID: PMC2717869.
      Citations: 33     Fields:    Translation:Animals
    170. Jodhka PK, Kaur P, Underwood W, Lydon JP, Singh M. The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. Endocrinology. 2009 Jul; 150(7):3162-8. PMID: 19325006; PMCID: PMC2703540.
      Citations: 30     Fields:    Translation:AnimalsCells
    171. Fernandez-Valdivia R, Mukherjee A, Ying Y, Li J, Paquet M, DeMayo FJ, Lydon JP. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol. 2009 Apr 01; 328(1):127-39. PMID: 19298785.
      Citations: 69     Fields:    Translation:AnimalsCells
    172. Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP. Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology. 2008 Dec; 149(12):6236-50. PMID: 18687774; PMCID: PMC2613059.
      Citations: 42     Fields:    Translation:AnimalsCells
    173. Daikoku T, Hirota Y, Tranguch S, Joshi AR, DeMayo FJ, Lydon JP, Ellenson LH, Dey SK. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008 Jul 15; 68(14):5619-27. PMID: 18632614; PMCID: PMC2824329.
      Citations: 117     Fields:    Translation:AnimalsCells
    174. Laws MJ, Taylor RN, Sidell N, DeMayo FJ, Lydon JP, Gutstein DE, Bagchi MK, Bagchi IC. Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival. Development. 2008 Aug; 135(15):2659-68. PMID: 18599509; PMCID: PMC2692722.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    175. Rickard DJ, Iwaniec UT, Evans G, Hefferan TE, Hunter JC, Waters KM, Lydon JP, O'Malley BW, Khosla S, Spelsberg TC, Turner RT. Bone growth and turnover in progesterone receptor knockout mice. Endocrinology. 2008 May; 149(5):2383-90. PMID: 18276762; PMCID: PMC2329269.
      Citations: 20     Fields:    Translation:AnimalsCells
    176. Franco HL, Jeong JW, Tsai SY, Lydon JP, DeMayo FJ. In vivo analysis of progesterone receptor action in the uterus during embryo implantation. Semin Cell Dev Biol. 2008 Apr; 19(2):178-86. PMID: 18280760.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    177. Kim J, Sato M, Li Q, Lydon JP, Demayo FJ, Bagchi IC, Bagchi MK. Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice. Mol Cell Biol. 2008 Mar; 28(5):1770-82. PMID: 18172011; PMCID: PMC2258771.
      Citations: 49     Fields:    Translation:AnimalsCells
    178. Mukherjee A, Amato P, Allred DC, DeMayo FJ, Lydon JP. Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human. Nucl Recept Signal. 2007 Nov 30; 5:e011. PMID: 18174919; PMCID: PMC2121321.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    179. Xie H, Wang H, Tranguch S, Iwamoto R, Mekada E, Demayo FJ, Lydon JP, Das SK, Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18315-20. PMID: 17986609; PMCID: PMC2084340.
      Citations: 50     Fields:    Translation:Animals
    180. He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60. PMID: 17932104; PMCID: PMC2234581.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    181. Mukherjee A, Soyal SM, Fernandez-Valdivia R, DeMayo FJ, Lydon JP. Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor. Genesis. 2007 Oct; 45(10):639-46. PMID: 17941046.
      Citations: 7     Fields:    Translation:AnimalsCells
    182. Hiremath M, Lydon JP, Cowin P. The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor. Development. 2007 Oct; 134(20):3703-12. PMID: 17881490.
      Citations: 11     Fields:    Translation:AnimalsCells
    183. Lee KY, Jeong JW, Tsai SY, Lydon JP, DeMayo FJ. Mouse models of implantation. Trends Endocrinol Metab. 2007 Aug; 18(6):234-9. PMID: 17588769.
      Citations: 32     Fields:    Translation:Animals
    184. Jeong JW, Lee KY, Han SJ, Aronow BJ, Lydon JP, O'Malley BW, DeMayo FJ. The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression. Endocrinology. 2007 Sep; 148(9):4238-50. PMID: 17556502.
      Citations: 32     Fields:    Translation:Animals
    185. Kurihara I, Lee DK, Petit FG, Jeong J, Lee K, Lydon JP, DeMayo FJ, Tsai MJ, Tsai SY. COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet. 2007 Jun; 3(6):e102. PMID: 17590085; PMCID: PMC1892047.
      Citations: 105     Fields:    Translation:AnimalsCells
    186. Lee KY, Jeong JW, Wang J, Ma L, Martin JF, Tsai SY, Lydon JP, DeMayo FJ. Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol. 2007 Aug; 27(15):5468-78. PMID: 17515606; PMCID: PMC1952078.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    187. Fernandez-Valdivia R, Mukherjee A, Amato P, Allred DC, Nguyen J, DeMayo FJ, Lydon JP. Progesterone-action in the murine uterus and mammary gland requires steroid receptor coactivator 2: relevance to the human. Front Biosci. 2007 May 01; 12:3640-7. PMID: 17485327.
      Citations: 6     Fields:    Translation:HumansAnimals
    188. Mukherjee A, Soyal SM, Wheeler DA, Fernandez-Valdivia R, Nguyen J, DeMayo FJ, Lydon JP. Targeting iCre expression to murine progesterone receptor cell-lineages using bacterial artificial chromosome transgenesis. Genesis. 2006 Dec; 44(12):601-10. PMID: 17149722.
      Citations: 5     Fields:    Translation:AnimalsCells
    189. Mukherjee A, Amato P, Allred DC, Fernandez-Valdivia R, Nguyen J, O'Malley BW, DeMayo FJ, Lydon JP. Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human. J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):22-31. PMID: 17045797.
      Citations: 11     Fields:    Translation:HumansAnimals
    190. Lee K, Jeong J, Kwak I, Yu CT, Lanske B, Soegiarto DW, Toftgard R, Tsai MJ, Tsai S, Lydon JP, DeMayo FJ. Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Nat Genet. 2006 Oct; 38(10):1204-9. PMID: 16951680.
      Citations: 128     Fields:    Translation:AnimalsCells
    191. Mukherjee A, Soyal SM, Fernandez-Valdivia R, Gehin M, Chambon P, Demayo FJ, Lydon JP, O'Malley BW. Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Mol Cell Biol. 2006 Sep; 26(17):6571-83. PMID: 16914740; PMCID: PMC1592830.
      Citations: 62     Fields:    Translation:AnimalsCells
    192. Hashimoto-Partyka MK, Lydon JP, Iruela-Arispe ML. Generation of a mouse for conditional excision of progesterone receptor. Genesis. 2006 Aug; 44(8):391-5. PMID: 16868919.
      Citations: 9     Fields:    Translation:AnimalsCells
    193. Woolley SC, O'Malley B, Lydon J, Crews D. Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice. Behav Brain Res. 2006 Feb 28; 167(2):197-204. PMID: 16413068.
      Citations: 6     Fields:    Translation:Animals
    194. Schneider JS, Burgess C, Sleiter NC, DonCarlos LL, Lydon JP, O'Malley B, Levine JE. Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse. Endocrinology. 2005 Oct; 146(10):4340-8. PMID: 16002522.
      Citations: 24     Fields:    Translation:Animals
    195. Jeong JW, Lee KY, Kwak I, White LD, Hilsenbeck SG, Lydon JP, DeMayo FJ. Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor. Endocrinology. 2005 Aug; 146(8):3490-505. PMID: 15845616.
      Citations: 75     Fields:    Translation:Animals
    196. Fernandez-Valdivia R, Mukherjee A, Mulac-Jericevic B, Conneely OM, DeMayo FJ, Amato P, Lydon JP. Revealing progesterone's role in uterine and mammary gland biology: insights from the mouse. Semin Reprod Med. 2005 Feb; 23(1):22-37. PMID: 15714387.
      Citations: 29     Fields:    Translation:Animals
    197. Soyal SM, Mukherjee A, Lee KY, Li J, Li H, DeMayo FJ, Lydon JP. Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis. 2005 Feb; 41(2):58-66. PMID: 15682389.
      Citations: 209     Fields:    Translation:Animals
    198. Fang Z, Yang S, Lydon JP, DeMayo F, Tamura M, Gurates B, Bulun SE. Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis. Fertil Steril. 2004 Sep; 82(3):673-8. PMID: 15374713.
      Citations: 23     Fields:    Translation:Animals
    199. Shi HY, Lydon JP, Zhang M. Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development. Mol Endocrinol. 2004 Sep; 18(9):2196-207. PMID: 15178746.
      Citations: 6     Fields:    Translation:AnimalsCells
    200. Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, Lydon JP. Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models. Steroids. 2003 Nov; 68(10-13):779-87. PMID: 14667968.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    201. Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2003 Nov; 68(10-13):771-8. PMID: 14667967.
      Citations: 83     Fields:    Translation:HumansAnimals
    202. Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9744-9. PMID: 12897242; PMCID: PMC187836.
      Citations: 233     Fields:    Translation:AnimalsCells
    203. Conneely OM, Jericevic BM, Lydon JP. Progesterone receptors in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):205-14. PMID: 14635795.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    204. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 01; 63(5):1067-72. PMID: 12615724.
      Citations: 37     Fields:    Translation:Animals
    205. Schneider JS, Stone MK, Wynne-Edwards KE, Horton TH, Lydon J, O'Malley B, Levine JE. Progesterone receptors mediate male aggression toward infants. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2951-6. PMID: 12601162; PMCID: PMC151447.
      Citations: 36     Fields:    Translation:Animals
    206. Chatterton RT, Lydon JP, Mehta RG, Mateo ET, Pletz A, Jordan VC. Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. Cancer Lett. 2002 Dec 15; 188(1-2):47-52. PMID: 12406547.
      Citations: 10     Fields:    Translation:Animals
    207. Soyal S, Ismail PM, Li J, Mulac-Jericevic B, Conneely OM, Lydon JP. Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast Cancer Res. 2002; 4(5):191-6. PMID: 12223123; PMCID: PMC138743.
      Citations: 16     Fields:    Translation:Animals
    208. Conneely OM, Mulac-Jericevic B, DeMayo F, Lydon JP, O'Malley BW. Reproductive functions of progesterone receptors. Recent Prog Horm Res. 2002; 57:339-55. PMID: 12017551.
      Citations: 100     Fields:    Translation:HumansAnimals
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