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CAROLYN SMITH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Urology
    DivisionUrology

    TitleSenior Associate Dean
    InstitutionBaylor College of Medicine
    DepartmentGraduate School of Biomedical Sciences
    DivisionGraduate Sch of Biomedical Sciences


    Collapse Research 
    Collapse research activities and funding
    T32GM136554     (VAN DEN VEYVER, IGNATIA B)Jul 1, 2020 - Jun 30, 2025
    NIH
    The Clinical Translational Research Certificate of Added Qualification Program
    Role: Co-Principal Investigator
    K12GM084897     (SMITH, CAROLYN LOUISE)Aug 1, 2008 - Jul 31, 2018
    NIH
    Research Education and Career Horizons Program
    Role: Principal Investigator
    R03CA119271     (SMITH, CAROLYN LOUISE)Jun 1, 2008 - May 31, 2011
    NIH
    Antiestrogen Regulation of Bladder Cancer
    Role: Principal Investigator
    R01DK064038     (SMITH, CAROLYN L)Feb 1, 2004 - Jan 31, 2009
    NIH
    Negative Regulation of Estrogen Receptors
    Role: Principal Investigator
    R01DK053002     (SMITH, CAROLYN LOUISE)Sep 22, 1997 - Apr 30, 2021
    NIH
    ESTROGEN RECEPTOR-COREGULATOR FUNCTIONAL INTERACTIONS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smith CL, Santen RJ, Komm B, Mirkin S. Breast-related effects of selective estrogen receptor modulators and tissue-selective estrogen complexes. Breast Cancer Res. 2014 Jun 18; 16(3):212. PMID: 25928299; PMCID: PMC4076629.
      Citations: 3     Fields:    Translation:Humans
    2. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014 Mar 20; 507(7492):315-22. PMID: 24476821; PMCID: PMC3962515.
      Citations: 1166     Fields:    Translation:HumansCells
    3. SMITH CL, Santen RJ, Komm B and Mirkin S . Breast-related effects of selective estrogen receptor modulators and tissue selective estrogen complexes. Breast Cancer Research. 2014; 16:212-226.
    4. Jiang XR, Wang P, Smith CL, Zhu BT. Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity. J Med Chem. 2013 Apr 11; 56(7):2779-90. PMID: 23448346; PMCID: PMC3666588.
      Citations: 4     Fields:    Translation:HumansCells
    5. Smith CL, Migliaccio I, Chaubal V, Wu MF, Pace MC, Hartmaier R, Jiang S, Edwards DP, Hilsenbeck SG, Oesterreich S, Guti?rrez MC. Elevated nuclear expression of the SMRT corepressor in breast cancer is associated with earlier tumor recurrence. Breast Cancer Res Treat. 2012 Nov; 136(1):253-65. PMID: 23015261; PMCID: PMC3511772.
      Citations: 10     Fields:    Translation:HumansCells
    6. Hoffman KL, Lerner SP, Smith CL. Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation. Horm Cancer. 2013 Feb; 4(1):24-35. PMID: 22965848; PMCID: PMC3541450.
      Citations: 20     Fields:    Translation:HumansCells
    7. SMITH CL, Brown KA and Simpson ER . Regulation of estrogen receptor activity and aromatase expression: roles of selective estrogen receptor modulators and metabolic factors. Translational Endocrinology & Metabolism. 2012; 3:45-73.
    8. Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol. 2010 Nov; 6(11):837-43. PMID: 20924370; PMCID: PMC2974172.
      Citations: 60     Fields:    Translation:HumansCells
    9. Williams CC, Basu A, El-Gharbawy A, Carrier LM, Smith CL, Rowan BG. Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2. BMC Biochem. 2009 Dec 31; 10:36. PMID: 20043841; PMCID: PMC2811108.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    10. Giamas G, Castellano L, Feng Q, Knippschild U, Jacob J, Thomas RS, Coombes RC, Smith CL, Jiao LR, Stebbing J. CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions. Nucleic Acids Res. 2009 May; 37(9):3110-23. PMID: 19339517; PMCID: PMC2685087.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    11. Sonpavde G, Okuno N, Weiss H, Yu J, Shen SS, Younes M, Jian W, Lerner SP, Smith CL. Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma. Urology. 2007 Jun; 69(6):1221-6. PMID: 17572228.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    12. Jaber BM, Gao T, Huang L, Karmakar S, Smith CL. The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators. Mol Endocrinol. 2006 Nov; 20(11):2695-710. PMID: 16840538.
      Citations: 9     Fields:    Translation:HumansCells
    13. Borja-Cacho E, Cooney AJ, Smith CL, Lemus AE, Larrea F, Garc?a-Becerra R, P?rez-Palacios G. Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens. J Steroid Biochem Mol Biol. 2006 May; 99(2-3):108-14. PMID: 16616843.
      Citations: 2     Fields:    Translation:HumansCells
    14. Zheng FF, Wu RC, Smith CL, O'Malley BW. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005 Sep; 25(18):8273-84. PMID: 16135815; PMCID: PMC1234335.
      Citations: 39     Fields:    Translation:HumansCells
    15. Labhart P, Karmakar S, Salicru EM, Egan BS, Alexiadis V, O'Malley BW, Smith CL. Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1339-44. PMID: 15677324; PMCID: PMC547886.
      Citations: 62     Fields:    Translation:HumansCells
    16. SMITH CL. Estrogen receptor targeted therapies: mechanisms of action and future developments. Menopause Management. 2005; 14(Suppl 1):40-43.
    17. Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP. The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament. Matrix Biol. 2004 Aug; 23(5):323-9. PMID: 15464364.
      Citations: 23     Fields:    Translation:AnimalsCells
    18. Jaber BM, Mukopadhyay R, Smith CL. Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment. J Mol Endocrinol. 2004 Feb; 32(1):307-23. PMID: 14766010.
      Citations: 7     Fields:    Translation:HumansCells
    19. Cavarretta IT, Martini L, Motta M, Smith CL, Melcangi RC. SRC-1 is involved in the control of the gene expression of myelin protein Po. J Mol Neurosci. 2004; 24(2):217-26. PMID: 15456935.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Narayanan R, Smith CL, Weigel NL. Vector-averaged gravity-induced changes in cell signaling and vitamin D receptor activity in MG-63 cells are reversed by a 1,25-(OH)2D3 analog, EB1089. Bone. 2002 Sep; 31(3):381-8. PMID: 12231410.
      Citations: 4     Fields:    Translation:HumansCells
    21. Walters MR, Dutertre M, Smith CL. SKF-82958 is a subtype-selective estrogen receptor-alpha (ERalpha ) agonist that induces functional interactions between ERalpha and AP-1. J Biol Chem. 2002 Jan 18; 277(3):1669-79. PMID: 11700319.
      Citations: 9     Fields:    Translation:HumansCells
    22. Coleman KM, Smith CL. Intracellular signaling pathways: nongenomic actions of estrogens and ligand-independent activation of estrogen receptors. Front Biosci. 2001 Oct 01; 6:D1379-91. PMID: 11578956.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    23. Lemus AE, Jackson KJ, Coleman KM, Dace R, Smith CL, Cooney AJ, Larrea F, Garc?a-Becerra R, Garc?a GA, P?rez-Palacios G. A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha. Endocrinology. 2001 Sep; 142(9):3791-9. PMID: 11517155.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Distefano E, Trentalance A, Smith CL, Marino M. Estradiol-induced IP(3) mediates the estrogen receptor activity expressed in human cells. Mol Cell Endocrinol. 2001 Aug 20; 182(1):19-26. PMID: 11500235.
      Citations: 11     Fields:    Translation:HumansCells
    25. Stenoien DL, Nye AC, Mancini MG, Patel K, Dutertre M, O'Malley BW, Smith CL, Belmont AS, Mancini MA. Ligand-mediated assembly and real-time cellular dynamics of estrogen receptor alpha-coactivator complexes in living cells. Mol Cell Biol. 2001 Jul; 21(13):4404-12. PMID: 11390668; PMCID: PMC87100.
      Citations: 49     Fields:    Translation:AnimalsCells
    26. Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith CL, O'Malley BW, Mancini MA. FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Nat Cell Biol. 2001 Jan; 3(1):15-23. PMID: 11146621.
      Citations: 122     Fields:    Translation:HumansCells
    27. Dutertre M, Smith CL. Molecular mechanisms of selective estrogen receptor modulator (SERM) action. J Pharmacol Exp Ther. 2000 Nov; 295(2):431-7. PMID: 11046073.
      Citations: 73     Fields:    Translation:Humans
    28. Lonard DM, Nawaz Z, Smith CL, O'Malley BW. The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell. 2000 Jun; 5(6):939-48. PMID: 10911988.
      Citations: 185     Fields:    Translation:HumansCells
    29. Stenoien DL, Mancini MG, Patel K, Allegretto EA, Smith CL, Mancini MA. Subnuclear trafficking of estrogen receptor-alpha and steroid receptor coactivator-1. Mol Endocrinol. 2000 Apr; 14(4):518-34. PMID: 10770489.
      Citations: 57     Fields:    Translation:HumansCells
    30. Smith CL, O'Malley BW. Evolving concepts of selective estrogen receptor action: from basic science to clinical applications. Trends Endocrinol Metab. 1999 Oct; 10(8):299-300. PMID: 10481159.
      Citations: 2     Fields:    
    31. Nawaz Z, Lonard DM, Dennis AP, Smith CL, O'Malley BW. Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):1858-62. PMID: 10051559; PMCID: PMC26701.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    32. Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW. The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol. 1999 Feb; 19(2):1182-9. PMID: 9891052; PMCID: PMC116047.
      Citations: 145     Fields:    Translation:HumansCells
    33. Smith CL. Multiple intracellular signaling pathways cross-talk with the estrogen receptor. J Med Food. 1999; 2(3-4):177. PMID: 19281373.
      Citations:    Fields:    
    34. Smith CL, Kreutner W. In vitro glucocorticoid receptor binding and transcriptional activation by topically active glucocorticoids. Arzneimittelforschung. 1998 Sep; 48(9):956-60. PMID: 9793625.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    35. Stenoien D, Sharp ZD, Smith CL, Mancini MA. Functional subnuclear partitioning of transcription factors. J Cell Biochem. 1998 Aug 01; 70(2):213-21. PMID: 9671227.
      Citations: 8     Fields:    Translation:HumansCells
    36. Smith CL. Cross-talk between peptide growth factor and estrogen receptor signaling pathways. Biol Reprod. 1998 Mar; 58(3):627-32. PMID: 9510949.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    37. Smith CL, Nawaz Z, O'Malley BW. Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol. 1997 Jun; 11(6):657-66. PMID: 9171229.
      Citations: 127     Fields:    Translation:HumansCells
    38. Smith CL, Tsai MJ, O'Malley BW, O?ate SA. CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8884-8. PMID: 8799122; PMCID: PMC38563.
      Citations: 77     Fields:    Translation:HumansCells
    39. Apostolakis EM, Garai J, Fox C, Smith CL, Watson SJ, Clark JH, O'Malley BW. Dopaminergic regulation of progesterone receptors: brain D5 dopamine receptors mediate induction of lordosis by D1-like agonists in rats. J Neurosci. 1996 Aug 15; 16(16):4823-34. PMID: 8756415; PMCID: PMC6579300.
      Citations: 15     Fields:    Translation:AnimalsCells
    40. Smith CL, Conneely OM, O'Malley BW. Oestrogen receptor activation in the absence of ligand. Biochem Soc Trans. 1995 Nov; 23(4):935-9. PMID: 8654870.
      Citations: 1     Fields:    Translation:HumansCells
    41. O'Malley BW, Schrader WT, Mani S, Smith C, Weigel NL, Conneely OM, Clark JH. An alternative ligand-independent pathway for activation of steroid receptors. Recent Prog Horm Res. 1995; 50:333-47. PMID: 7740165.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    42. Hammond GL, Bocchinfuso WP, Orava M, Smith CL, van den Ende A, van Enk A. Serum distribution of two contraceptive progestins: 3-ketodesogestrel and gestodene. Contraception. 1994 Oct; 50(4):301-18. PMID: 7813219.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    43. Hammond GL, Smith CL, Grolla A, Warmels-Rodenhiser S, Hodgert H, Murai JT, Siiteri PK, L?hteenm?ki P. Squirrel monkey corticosteroid-binding globulin: primary structure and comparison with the human protein. Endocrinology. 1994 Feb; 134(2):891-8. PMID: 8299584.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Smith CL, Conneely OM, O'Malley BW. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6120-4. PMID: 8327492; PMCID: PMC46879.
      Citations: 42     Fields:    Translation:HumansCells
    45. Scrocchi LA, Orava M, Smith CL, Han VK, Hammond GL. Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice. Endocrinology. 1993 Feb; 132(2):903-9. PMID: 7916682.
      Citations: 9     Fields:    Translation:AnimalsCells
    46. Yang K, Smith CL, Dales D, Hammond GL, Challis JR. Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development. Endocrinology. 1992 Nov; 131(5):2120-6. PMID: 1425412.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Smith CL, Power SG, Hammond GL. A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol. J Steroid Biochem Mol Biol. 1992 Aug; 42(7):671-6. PMID: 1504007.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    48. Smith CL, Hammond GL. Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat. Endocrinology. 1992 Apr; 130(4):2245-51. PMID: 1547738.
      Citations: 17     Fields:    Translation:AnimalsCells
    49. Smith CL, Hammond GL. An amino acid substitution in biobreeding rat corticosteroid binding globulin results in reduced steroid binding affinity. J Biol Chem. 1991 Oct 05; 266(28):18555-9. PMID: 1917978.
      Citations: 4     Fields:    Translation:AnimalsCells
    50. Smith CL, Hammond GL. Ontogeny of corticosteroid-binding globulin biosynthesis in the rat. Endocrinology. 1991 Feb; 128(2):983-8. PMID: 1989877.
      Citations: 5     Fields:    Translation:Animals
    51. Hammond GL, Smith CL, Underhill DA. Molecular studies of corticosteroid binding globulin structure, biosynthesis and function. J Steroid Biochem Mol Biol. 1991; 40(4-6):755-62. PMID: 1958574.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    52. Hammond GL, Smith CL, Underhill CM, Nguyen VT. Interaction between corticosteroid binding globulin and activated leukocytes in vitro. Biochem Biophys Res Commun. 1990 Oct 15; 172(1):172-7. PMID: 2222468.
      Citations: 3     Fields:    Translation:HumansCells
    53. Seralini GE, Smith CL, Hammond GL. Rabbit corticosteroid-binding globulin: primary structure and biosynthesis during pregnancy. Mol Endocrinol. 1990 Aug; 4(8):1166-72. PMID: 2293023.
      Citations: 3     Fields:    Translation:AnimalsCells
    54. Hammond GL, Smith CL, Paterson NA, Sibbald WJ. A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils. J Clin Endocrinol Metab. 1990 Jul; 71(1):34-9. PMID: 2370299.
      Citations: 50     Fields:    Translation:HumansCells
    55. Hammond GL, Underhill DA, Rykse HM, Smith CL. The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs. Mol Endocrinol. 1989 Nov; 3(11):1869-76. PMID: 2608061.
      Citations: 17     Fields:    Translation:HumansCells
    56. Seralini GE, Underhill CM, Smith CL, Nguyen VT, Hammond GL. Biological half-life and transfer of maternal corticosteroid-binding globulin to amniotic fluid in the rabbit. Endocrinology. 1989 Sep; 125(3):1321-5. PMID: 2759028.
      Citations: 1     Fields:    Translation:Animals
    57. Smith CL, Hammond GL. Rat corticosteroid binding globulin: primary structure and messenger ribonucleic acid levels in the liver under different physiological conditions. Mol Endocrinol. 1989 Feb; 3(2):420-6. PMID: 2710140.
      Citations: 4     Fields:    Translation:AnimalsCells
    58. . Morphogenetic and gonadotrophic effects of a juvenile hormone analogue ((7s)-hydroprene) in last instar female larvae of Diploptera punctata. Physiological Entomology. 1989; 14:165-172.
    59. Smith CL, Hammond GL. The amino acid sequence of rat CBG deduced from a cDNA, and identification of CBG mRNA in the liver under different physiological states. Steroids. 1988 Oct; 52(4):331-2. PMID: 3250013.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    60. Bardin CW, Gunsalus GL, Musto NA, Cheng CY, Reventos J, Smith C, Underhill DA, Hammond G. Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors. J Steroid Biochem. 1988; 30(1-6):131-9. PMID: 3386241.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    61. Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW. Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5153-7. PMID: 3299377; PMCID: PMC298812.
      Citations: 39     Fields:    Translation:HumansCells
    62. Hammond GL, Underhill DA, Smith CL, Goping IS, Harley MJ, Musto NA, Cheng CY, Bardin CW. The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain. FEBS Lett. 1987 May 04; 215(1):100-4. PMID: 3569533.
      Citations: 10     Fields:    Translation:HumansCells
    63. Younoszai MK, Smith C, Finch MH. Comparison of in vitro jejunal uptake of L-valine and L-lysine in the rat during maturation. J Pediatr Gastroenterol Nutr. 1985 Dec; 4(6):992-7. PMID: 3934359.
      Citations:    Fields:    Translation:Animals
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