Selective Estrogen Receptor Modulators
"Selective Estrogen Receptor Modulators" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
| Descriptor ID |
D020845
|
| MeSH Number(s) |
D06.347.360.827 D27.505.696.399.450.360.827
|
| Concept/Terms |
Selective Estrogen Receptor Modulators- Selective Estrogen Receptor Modulators
- SERMs
- Estrogen Receptor Modulators, Selective
- Selective Estrogen Receptor Modulator
- SERM
- Estrogen Receptor Modulator, Selective
|
Below are MeSH descriptors whose meaning is more general than "Selective Estrogen Receptor Modulators".
Below are MeSH descriptors whose meaning is more specific than "Selective Estrogen Receptor Modulators".
This graph shows the total number of publications written about "Selective Estrogen Receptor Modulators" by people in this website by year, and whether "Selective Estrogen Receptor Modulators" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 4 | 0 | 4 |
| 2000 | 5 | 1 | 6 |
| 2001 | 6 | 1 | 7 |
| 2002 | 4 | 2 | 6 |
| 2003 | 4 | 3 | 7 |
| 2004 | 5 | 1 | 6 |
| 2005 | 5 | 6 | 11 |
| 2006 | 3 | 3 | 6 |
| 2007 | 5 | 1 | 6 |
| 2008 | 1 | 3 | 4 |
| 2009 | 4 | 1 | 5 |
| 2010 | 5 | 0 | 5 |
| 2011 | 2 | 4 | 6 |
| 2012 | 3 | 0 | 3 |
| 2013 | 3 | 0 | 3 |
| 2014 | 6 | 4 | 10 |
| 2015 | 6 | 2 | 8 |
| 2016 | 0 | 1 | 1 |
| 2017 | 3 | 1 | 4 |
| 2018 | 2 | 0 | 2 |
| 2019 | 2 | 1 | 3 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Selective Estrogen Receptor Modulators" by people in Profiles.
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In memory of V. Craig Jordan (1947-2024): "Father of tamoxifen" and discoverer of SERMs. J Steroid Biochem Mol Biol. 2024 Nov; 244:106598.
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Estrogen Receptor Signaling in the Immune System. Endocr Rev. 2023 01 12; 44(1):117-141.
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Elacestrant and the Promise of Oral SERDs. J Clin Oncol. 2022 10 01; 40(28):3227-3229.
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Current and emerging estrogen receptor-targeted therapies for the treatment of breast cancer. Essays Biochem. 2021 12 17; 65(6):985-1001.
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Turning scientific serendipity into discoveries in breast cancer research and treatment: a tale of PhD students and a 50-year roaming tamoxifen team. Breast Cancer Res Treat. 2021 Nov; 190(1):19-38.
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Next-Generation Endocrine Therapies for Breast Cancer. J Clin Oncol. 2021 04 20; 39(12):1383-1388.
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Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline PART II. J Urol. 2021 Jan; 205(1):44-51.
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The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. Mol Cancer Ther. 2020 07; 19(7):1395-1405.
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Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies. Gynecol Oncol. 2019 07; 154(1):199-206.
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The SERM Saga, Something from Nothing: American Cancer Society/SSO Basic Science Lecture. Ann Surg Oncol. 2019 Jul; 26(7):1981-1990.