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ORLA CONNEELY

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    R01CA160747     (CONNEELY, ORLA M.)Sep 10, 2012 - Jun 30, 2017
    NIH
    DISCOVERY OF SMALL MOLECULAR ACTIVATORS OF NR4A ORPHAN NUCLEAR RECEPTORS
    Role: Principal Investigator
    R01CA111411     (CONNEELY, ORLA M.)Jan 18, 2006 - Dec 31, 2011
    NIH
    NR4A Nuclear Receptor Function in Leukemia
    Role: Principal Investigator
    R13DK060097     (CONNEELY, ORLA M.)Jun 15, 2001 - Jun 14, 2002
    NIH
    Conference on Lactoferrin: Functions and Applications
    Role: Principal Investigator
    R01DK052429     (CONNEELY, ORLA M.)Jul 1, 1997 - Jun 30, 2002
    NIH
    FUNCTIONS OF THE NURR 1 SUBFAMILY OF NUCLEAR RECEPTORS
    Role: Principal Investigator
    N01HD063256     (CONNEELY, ORLA M.)Jun 1, 1996
    NIH/NICHD
    BREEDING MOUSE COLONY--LACTOFERRIN GENE NULL MUTATION
    Role: Principal Investigator
    R01HD032007     (CONNEELY, ORLA M.)Aug 1, 1994 - Nov 30, 2009
    NIH
    Progesterone Receptor A and B Proteins in Reproduction
    Role: Principal Investigator
    R21HD032007     (CONNEELY, ORLA M.)Aug 1, 1994 - Mar 2, 1999
    NIH
    PROGESTERONE RECEPTOR A AND B PROTEINS IN REPRODUCTION
    Role: Principal Investigator
    R01HD027965     (CONNEELY, ORLA M.)Feb 1, 1992 - Jan 31, 1996
    NIH
    BIOLOGICAL FUNCTIONS OF LACTOFERRIN IN NUTRITION
    Role: Principal Investigator
    R55HD027965     (CONNEELY, ORLA M.)Sep 30, 1991 - Sep 29, 1992
    NIH
    BIOLOGICAL FUNCTIONS OF LACTOFERRIN IN NUTRITION
    Role: Principal Investigator
    R01RR006499     (CONNEELY, ORLA M.)Feb 12, 1991 - Feb 11, 1994
    NIH
    NOVEL HOST SYSTEM TO STUDY STEROID HORMONE ACTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Call SG, Duren RP, Panigrahi AK, Nguyen L, Freire PR, Grimm SL, Coarfa C, Conneely OM. Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors. Sci Rep. 2020 02 18; 10(1):2851. PMID: 32071334; PMCID: PMC7029036.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    2. Boudreaux SP, Duren RP, Call SG, Nguyen L, Freire PR, Narayanan P, Redell MS, Conneely OM. Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia. Leukemia. 2019 01; 33(1):52-63. PMID: 29884904; PMCID: PMC6286710.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    3. Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. PLoS One. 2018; 13(3):e0194913. PMID: 29590203; PMCID: PMC5874056.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    4. Freire PR, Conneely OM. NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPa and inflammatory signaling. Blood. 2018 03 08; 131(10):1081-1093. PMID: 29343483; PMCID: PMC5863701.
      Citations: 21     Fields:    Translation:AnimalsCells
    5. Wu H, Bi J, Peng Y, Huo L, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J. Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Oncotarget. 2017 Aug 15; 8(33):54364-54377. PMID: 28903348; PMCID: PMC5589587.
      Citations: 22     Fields:    
    6. Duren RP, Boudreaux SP, Conneely OM. Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells. PLoS One. 2016; 11(3):e0150450. PMID: 26938745; PMCID: PMC4777543.
      Citations: 17     Fields:    Translation:HumansCells
    7. Acharya KD, Finkelstein SD, Bless EP, Nettles SA, Mulac-Jericevic B, Conneely OM, Mani SK, Tetel MJ. Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus eNeuro. 2015 Jul-Aug; 2(4). PMID: 26465008; PMCID: PMC4596027.
      Citations: 5     Fields:    
    8. Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Chao LC, Metzger D. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015 Apr; 35(7):1125-38. PMID: 25605333; PMCID: PMC4355536.
      Citations: 19     Fields:    Translation:AnimalsCells
    9. Garcia-Faroldi G, Melo FR, Bruemmer D, Conneely OM, Pejler G, Lundequist A. Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content. PLoS One. 2014; 9(2):e89311. PMID: 24586680; PMCID: PMC3930735.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Lain AR, Creighton CJ, Conneely OM. Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis. Mol Endocrinol. 2013 Oct; 27(10):1743-61. PMID: 23979845; PMCID: PMC3787126.
      Citations: 21     Fields:    Translation:AnimalsCells
    11. Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013 Mar; 54(3):806-815. PMID: 23288947; PMCID: PMC3617954.
      Citations: 29     Fields:    Translation:AnimalsCells
    12. Zhou L, Ruvolo VR, McQueen T, Chen W, Samudio IJ, Conneely O, Konopleva M, Andreeff M. HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML. Leukemia. 2013 Jun; 27(6):1358-68. PMID: 23247046; PMCID: PMC3892989.
      Citations: 23     Fields:    Translation:HumansCells
    13. Boudreaux SP, Ramirez-Herrick AM, Duren RP, Conneely OM. Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia. Oncogenesis. 2012 Jul 02; 1:e19. PMID: 23552735; PMCID: PMC3412651.
      Citations: 17     
    14. Ramirez-Herrick AM, Mullican SE, Sheehan AM, Conneely OM. Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice. Blood. 2011 Mar 03; 117(9):2681-90. PMID: 21205929; PMCID: PMC3062356.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    15. Sirin O, Lukov GL, Mao R, Conneely OM, Goodell MA. The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells. Nat Cell Biol. 2010 Dec; 12(12):1213-9. PMID: 21076412; PMCID: PMC3059561.
      Citations: 53     Fields:    Translation:AnimalsCells
    16. Zhao Y, Howatt DA, Gizard F, Nomiyama T, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Daugherty A, Bruemmer D. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ Res. 2010 Aug 20; 107(4):501-11. PMID: 20558821; PMCID: PMC2924939.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    17. Conneely OM. Progesterone receptors and ovulation. Handb Exp Pharmacol. 2010; (198):37-44. PMID: 20839085.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Circulation. 2009 Feb 03; 119(4):577-86. PMID: 19153266; PMCID: PMC2748681.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    19. Ward PP, Mendoza-Meneses M, Park PW, Conneely OM. Stimulus-dependent impairment of the neutrophil oxidative burst response in lactoferrin-deficient mice. Am J Pathol. 2008 Apr; 172(4):1019-29. PMID: 18321995; PMCID: PMC2276410.
      Citations: 27     Fields:    Translation:AnimalsCells
    20. Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res. 2007 Dec 15; 67(24):12026-33. PMID: 18089834.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Mullican SE, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J, Conneely OM. Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med. 2007 Jun; 13(6):730-5. PMID: 17515897.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    22. Conneely OM, Otto C. Progestins and the mammary gland. From basic science to clinical applications. Preface. Ernst Schering Found Symp Proc. 2007; (1):V-VII. PMID: 18540567.
      Citations:    Fields:    Translation:HumansAnimals
    23. Conneely OM, Mulac-Jericevic B, Arnett-Mansfield R. Progesterone signaling in mammary gland development. Ernst Schering Found Symp Proc. 2007; (1):45-54. PMID: 18543434.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    24. Mote PA, Arnett-Mansfield RL, Gava N, deFazio A, Mulac-Jericevic B, Conneely OM, Clarke CL. Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology. 2006 Dec; 147(12):5503-12. PMID: 16980438.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D. The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation. J Biol Chem. 2006 Nov 03; 281(44):33467-76. PMID: 16945922; PMCID: PMC1829169.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    26. Brayman MJ, Julian J, Mulac-Jericevic B, Conneely OM, Edwards DP, Carson DD. Progesterone receptor isoforms A and B differentially regulate MUC1 expression in uterine epithelial cells. Mol Endocrinol. 2006 Oct; 20(10):2278-91. PMID: 16740655.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    27. Mani SK, Reyna AM, Chen JZ, Mulac-Jericevic B, Conneely OM. Differential response of progesterone receptor isoforms in hormone-dependent and -independent facilitation of female sexual receptivity. Mol Endocrinol. 2006 Jun; 20(6):1322-32. PMID: 16484336.
      Citations: 29     Fields:    Translation:Animals
    28. Ward PP, Paz E, Conneely OM. Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci. 2005 Nov; 62(22):2540-8. PMID: 16261256; PMCID: PMC11139086.
      Citations: 103     Fields:    Translation:HumansAnimals
    29. Imam SZ, Jankovic J, Ali SF, Skinner JT, Xie W, Conneely OM, Le WD. Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. FASEB J. 2005 Sep; 19(11):1441-50. PMID: 16126911.
      Citations: 18     Fields:    Translation:Animals
    30. Fernandez-Valdivia R, Mukherjee A, Mulac-Jericevic B, Conneely OM, DeMayo FJ, Amato P, Lydon JP. Revealing progesterone's role in uterine and mammary gland biology: insights from the mouse. Semin Reprod Med. 2005 Feb; 23(1):22-37. PMID: 15714387.
      Citations: 29     Fields:    Translation:Animals
    31. Mulac-Jericevic B, Conneely OM. Reproductive tissue-selective actions of progesterone receptors. Ernst Schering Res Found Workshop. 2005; (52):19-37. PMID: 15704466.
      Citations: 5     Fields:    Translation:HumansAnimals
    32. Conneely OM, P?nni? T. nor-1 regulates hippocampal axon guidance, pyramidal cell survival, and seizure susceptibility. Mol Cell Biol. 2004 Oct; 24(20):9070-8. PMID: 15456880; PMCID: PMC517886.
      Citations: 38     Fields:    Translation:AnimalsCells
    33. Mulac-Jericevic B, Conneely OM. Reproductive tissue selective actions of progesterone receptors. Reproduction. 2004 Aug; 128(2):139-46. PMID: 15280552.
      Citations: 85     Fields:    Translation:Animals
    34. Conneely OM, Mulac-Jericevic B, Lydon JP. Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms. Steroids. 2003 Nov; 68(10-13):771-8. PMID: 14667967.
      Citations: 83     Fields:    Translation:HumansAnimals
    35. Ismail PM, Amato P, Soyal SM, DeMayo FJ, Conneely OM, O'Malley BW, Lydon JP. Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models. Steroids. 2003 Nov; 68(10-13):779-87. PMID: 14667968.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    36. Smits SM, Ponnio T, Conneely OM, Burbach JP, Smidt MP. Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci. 2003 Oct; 18(7):1731-8. PMID: 14622207.
      Citations: 73     Fields:    Translation:AnimalsCells
    37. Mulac-Jericevic B, Lydon JP, DeMayo FJ, Conneely OM. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9744-9. PMID: 12897242; PMCID: PMC187836.
      Citations: 233     Fields:    Translation:AnimalsCells
    38. Conneely OM, Jericevic BM, Lydon JP. Progesterone receptors in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia. 2003 Apr; 8(2):205-14. PMID: 14635795.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    39. Ward PP, Mendoza-Meneses M, Cunningham GA, Conneely OM. Iron status in mice carrying a targeted disruption of lactoferrin. Mol Cell Biol. 2003 Jan; 23(1):178-85. PMID: 12482971; PMCID: PMC140657.
      Citations: 45     Fields:    Translation:Animals
    40. Conneely OM, Jericevic BM. Progesterone regulation of reproductive function through functionally distinct progesterone receptor isoforms. Rev Endocr Metab Disord. 2002 Sep; 3(3):201-9. PMID: 12215715.
      Citations: 9     Fields:    Translation:Humans
    41. Soyal S, Ismail PM, Li J, Mulac-Jericevic B, Conneely OM, Lydon JP. Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast Cancer Res. 2002; 4(5):191-6. PMID: 12223123; PMCID: PMC138743.
      Citations: 15     Fields:    Translation:Animals
    42. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. McEvoy AN, Murphy EA, Ponnio T, Conneely OM, Bresnihan B, FitzGerald O, Murphy EP. Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5'-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J Immunol. 2002 Mar 15; 168(6):2979-87. PMID: 11884470.
      Citations: 43     Fields:    Translation:HumansCells
    44. Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM. The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol Cell Biol. 2002 Feb; 22(3):935-45. PMID: 11784868; PMCID: PMC133552.
      Citations: 36     Fields:    Translation:Animals
    45. Ward PP, Uribe-Luna S, Conneely OM. Lactoferrin and host defense. Biochem Cell Biol. 2002; 80(1):95-102. PMID: 11908649.
      Citations: 58     Fields:    Translation:HumansAnimals
    46. Conneely OM, Mulac-Jericevic B, DeMayo F, Lydon JP, O'Malley BW. Reproductive functions of progesterone receptors. Recent Prog Horm Res. 2002; 57:339-55. PMID: 12017551.
      Citations: 101     Fields:    Translation:HumansAnimals
    47. Medina D, Sivaraman L, Hilsenbeck SG, Conneely O, Ginger M, Rosen J, Omalle BW. Mechanisms of hormonal prevention of breast cancer. Ann N Y Acad Sci. 2001 Dec; 952:23-35. PMID: 11795441.
      Citations: 21     Fields:    Translation:HumansAnimals
    48. Sivaraman L, Conneely OM, Medina D, O'Malley BW. p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12379-84. PMID: 11606748; PMCID: PMC60062.
      Citations: 47     Fields:    Translation:Animals
    49. Sivaraman L, Hilsenbeck SG, Zhong L, Gay J, Conneely OM, Medina D, O'Malley BW. Early exposure of the rat mammary gland to estrogen and progesterone blocks co-localization of estrogen receptor expression and proliferation. J Endocrinol. 2001 Oct; 171(1):75-83. PMID: 11572792.
      Citations: 13     Fields:    Translation:Animals
    50. Conneely OM. Antiinflammatory activities of lactoferrin. J Am Coll Nutr. 2001 Oct; 20(5 Suppl):389S-395S; discussion 396S-397S. PMID: 11603648.
      Citations: 41     Fields:    Translation:HumansAnimals
    51. Karas RH, van Eickels M, Lydon JP, Roddy S, Kwoun M, Aronovitz M, Baur WE, Conneely O, O'Malley BW, Mendelsohn ME. A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest. 2001 Aug; 108(4):611-8. PMID: 11518735; PMCID: PMC209395.
      Citations: 9     Fields:    Translation:AnimalsCells
    52. Conneely OM, Mulac-Jericevic B, Lydon JP, De Mayo FJ. Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice. Mol Cell Endocrinol. 2001 Jun 20; 179(1-2):97-103. PMID: 11420134.
      Citations: 71     Fields:    Translation:Animals
    53. Conneely OM. Perspective: female steroid hormone action. Endocrinology. 2001 Jun; 142(6):2194-9. PMID: 11356662.
      Citations: 8     Fields:    Translation:HumansAnimals
    54. Murphy EP, McEvoy A, Conneely OM, Bresnihan B, FitzGerald O. Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis. Arthritis Rheum. 2001 Apr; 44(4):782-93. PMID: 11315917.
      Citations: 25     Fields:    Translation:HumansCells
    55. Conneely OM, Lydon JP. Progesterone receptors in reproduction: functional impact of the A and B isoforms. Steroids. 2000 Oct-Nov; 65(10-11):571-7. PMID: 11108861.
      Citations: 48     Fields:    Translation:HumansAnimals
    56. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science. 2000 Sep 08; 289(5485):1751-4. PMID: 10976068.
      Citations: 210     Fields:    Translation:AnimalsCells
    57. Sivaraman L, Nawaz Z, Medina D, Conneely OM, O'Malley BW. The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis. Breast Cancer Res Treat. 2000 Aug; 62(3):185-95. PMID: 11072783.
      Citations: 4     Fields:    Translation:Animals
    58. Lydon JP, Sivaraman L, Conneely OM. A reappraisal of progesterone action in the mammary gland. J Mammary Gland Biol Neoplasia. 2000 Jul; 5(3):325-38. PMID: 14973394.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    59. Cumberbatch M, Dearman RJ, Uribe-Luna S, Headon DR, Ward PP, Conneely OM, Kimber I. Regulation of epidermal Langerhans cell migration by lactoferrin. Immunology. 2000 May; 100(1):21-8. PMID: 10809955; PMCID: PMC2326987.
      Citations: 16     Fields:    Translation:AnimalsCells
    60. Conneely OM, Lydon JP, De Mayo F, O'Malley BW. Reproductive functions of the progesterone receptor. J Soc Gynecol Investig. 2000 Jan-Feb; 7(1 Suppl):S25-32. PMID: 10732326.
      Citations: 18     Fields:    Translation:HumansAnimals
    61. Le W, Conneely OM, He Y, Jankovic J, Appel SH. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. J Neurochem. 1999 Nov; 73(5):2218-21. PMID: 10537083.
      Citations: 53     Fields:    Translation:AnimalsCells
    62. Tibbetts TA, DeMayo F, Rich S, Conneely OM, O'Malley BW. Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12021-6. PMID: 10518569; PMCID: PMC18405.
      Citations: 53     Fields:    Translation:AnimalsCells
    63. Le W, Conneely OM, Zou L, He Y, Saucedo-Cardenas O, Jankovic J, Mosier DR, Appel SH. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol. 1999 Oct; 159(2):451-8. PMID: 10506516.
      Citations: 42     Fields:    Translation:AnimalsCells
    64. Tibbetts TA, Conneely OM, O'Malley BW. Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus. Biol Reprod. 1999 May; 60(5):1158-65. PMID: 10208978.
      Citations: 61     Fields:    Translation:AnimalsCells
    65. Ward PP, Mendoza-Meneses M, Mulac-Jericevic B, Cunningham GA, Saucedo-Cardenas O, Teng CT, Conneely OM. Restricted spatiotemporal expression of lactoferrin during murine embryonic development. Endocrinology. 1999 Apr; 140(4):1852-60. PMID: 10098524.
      Citations: 15     Fields:    Translation:AnimalsCells
    66. Tibbetts TA, Mendoza-Meneses M, O'Malley BW, Conneely OM. Mutual and intercompartmental regulation of estrogen receptor and progesterone receptor expression in the mouse uterus. Biol Reprod. 1998 Nov; 59(5):1143-52. PMID: 9780321.
      Citations: 49     Fields:    Translation:AnimalsCells
    67. Sivaraman L, Stephens LC, Markaverich BM, Clark JA, Krnacik S, Conneely OM, O'Malley BW, Medina D. Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats. Carcinogenesis. 1998 Sep; 19(9):1573-81. PMID: 9771927.
      Citations: 40     Fields:    Translation:Animals
    68. Jeng MH, Kao C, Sivaraman L, Krnacik S, Chung LW, Medina D, Conneely OM, O'Malley BW. Reconstitution of estrogen-dependent transcriptional activation of an adenoviral target gene in select regions of the rat mammary gland. Endocrinology. 1998 Jun; 139(6):2916-25. PMID: 9607802.
      Citations: 3     Fields:    Translation:AnimalsCells
    69. Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, De Mayo F, Burbach JP, Conneely OM. Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):4013-8. PMID: 9520484; PMCID: PMC19954.
      Citations: 221     Fields:    Translation:AnimalsCells
    70. Ward PP, Mendoza MM, Saucedo-Cardenas O, Teng CT, Conneely OM. Restricted spatiotemporal expression of lactoferrin during murine embryogenesis. Adv Exp Med Biol. 1998; 443:91-100. PMID: 9781347.
      Citations: 1     Fields:    Translation:Animals
    71. Kimber I, Cumberbatch M, Dearman RJ, Ward P, Headon DR, Conneely OM. Regulation by lactoferrin of epidermal Langerhans cell migration. Adv Exp Med Biol. 1998; 443:251-5. PMID: 9781366.
      Citations:    Fields:    Translation:AnimalsCells
    72. Ward PP, Chu H, Zhou X, Conneely OM. Expression and characterization of recombinant murine lactoferrin. Gene. 1997 Dec 19; 204(1-2):171-6. PMID: 9434181.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    73. Chappell PE, Lydon JP, Conneely OM, O'Malley BW, Levine JE. Endocrine defects in mice carrying a null mutation for the progesterone receptor gene. Endocrinology. 1997 Oct; 138(10):4147-52. PMID: 9322923.
      Citations: 56     Fields:    Translation:Animals
    74. Said TK, Conneely OM, Medina D, O'Malley BW, Lydon JP. Progesterone, in addition to estrogen, induces cyclin D1 expression in the murine mammary epithelial cell, in vivo. Endocrinology. 1997 Sep; 138(9):3933-9. PMID: 9275084.
      Citations: 25     Fields:    Translation:AnimalsCells
    75. Gangolli EA, Conneely OM, O'Malley BW. Neurotransmitters activate the human estrogen receptor in a neuroblastoma cell line. J Steroid Biochem Mol Biol. 1997 Apr; 61(1-2):1-9. PMID: 9328204.
      Citations: 7     Fields:    Translation:HumansCells
    76. Saucedo-Cardenas O, Kardon R, Ediger TR, Lydon JP, Conneely OM. Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1. Gene. 1997 Mar 10; 187(1):135-9. PMID: 9073077.
      Citations: 24     Fields:    Translation:AnimalsCells
    77. Murphy EP, Conneely OM. Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. Mol Endocrinol. 1997 Jan; 11(1):39-47. PMID: 8994186.
      Citations: 41     Fields:    Translation:AnimalsCells
    78. Ward PP, Cunningham GA, Conneely OM. Commercial production of lactoferrin, a multifunctional iron-binding glycoprotein. Biotechnol Genet Eng Rev. 1997; 14:303-19. PMID: 9188157.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    79. Mani SK, Allen JM, Lydon JP, Mulac-Jericevic B, Blaustein JD, DeMayo FJ, Conneely O, O'Malley BW. Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice. Mol Endocrinol. 1996 Dec; 10(12):1728-37. PMID: 8961281.
      Citations: 48     Fields:    Translation:AnimalsCells
    80. Miehlke S, Reddy R, Osato MS, Ward PP, Conneely OM, Graham DY. Direct activity of recombinant human lactoferrin against Helicobacter pylori. J Clin Microbiol. 1996 Oct; 34(10):2593-4. PMID: 8880527; PMCID: PMC229326.
      Citations: 12     Fields:    Translation:HumansCells
    81. Ward PP, Zhou X, Conneely OM. Cooperative interactions between the amino- and carboxyl-terminal lobes contribute to the unique iron-binding stability of lactoferrin. J Biol Chem. 1996 May 31; 271(22):12790-4. PMID: 8662718.
      Citations: 7     Fields:    Translation:HumansCells
    82. Lydon JP, DeMayo FJ, Conneely OM, O'Malley BW. Reproductive phenotpes of the progesterone receptor null mutant mouse. J Steroid Biochem Mol Biol. 1996 Jan; 56(1-6 Spec No):67-77. PMID: 8603049.
      Citations: 73     Fields:    Translation:Animals
    83. Murphy EP, Dobson AD, Keller C, Conneely OM. Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors. Gene Expr. 1996; 5(3):169-79. PMID: 8882640; PMCID: PMC6138016.
      Citations: 21     Fields:    Translation:Cells
    84. Saucedo-Cardenas O, Conneely OM. Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system. J Mol Neurosci. 1996; 7(1):51-63. PMID: 8835782.
      Citations: 32     Fields:    Translation:Animals
    85. Smith CL, Conneely OM, O'Malley BW. Oestrogen receptor activation in the absence of ligand. Biochem Soc Trans. 1995 Nov; 23(4):935-9. PMID: 8654870.
      Citations: 1     Fields:    Translation:HumansCells
    86. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA, Shyamala G, Conneely OM, O'Malley BW. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995 Sep 15; 9(18):2266-78. PMID: 7557380.
      Citations: 577     Fields:    Translation:Animals
    87. Moore E, Helly VR, Conneely OM, Ward PP, Power RF, Headon DR. Molecular cloning, expression and evaluation of phosphohydrolases for phytate-degrading activity. J Ind Microbiol. 1995 May; 14(5):396-402. PMID: 7612216.
      Citations: 2     Fields:    Translation:AnimalsCells
    88. Ward PP, Piddington CS, Cunningham GA, Zhou X, Wyatt RD, Conneely OM. A system for production of commercial quantities of human lactoferrin: a broad spectrum natural antibiotic. Biotechnology (N Y). 1995 May; 13(5):498-503. PMID: 9634791.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    89. O'Malley BW, Schrader WT, Mani S, Smith C, Weigel NL, Conneely OM, Clark JH. An alternative ligand-independent pathway for activation of steroid receptors. Recent Prog Horm Res. 1995; 50:333-47. PMID: 7740165.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    90. Law SW, Conneely OM, O'Malley BW. Molecular cloning of a novel member of the nuclear receptor superfamily related to the orphan receptor, TR2. Gene Expr. 1994; 4(1-2):77-84. PMID: 7841789; PMCID: PMC6134373.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    91. Poletti A, Conneely OM, McDonnell DP, Schrader WT, O'Malley BW, Weigel NL. Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites. Biochemistry. 1993 Sep 21; 32(37):9563-9. PMID: 8373763.
      Citations: 2     Fields:    Translation:AnimalsCells
    92. Smith CL, Conneely OM, O'Malley BW. Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6120-4. PMID: 8327492; PMCID: PMC46879.
      Citations: 42     Fields:    Translation:HumansCells
    93. Cunningham GA, Headon DR, Conneely OM. Structural organization of the mouse lactoferrin gene. Biochem Biophys Res Commun. 1992 Dec 30; 189(3):1725-31. PMID: 1482377.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    94. Law SW, Conneely OM, DeMayo FJ, O'Malley BW. Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol. 1992 Dec; 6(12):2129-35. PMID: 1491694.
      Citations: 105     Fields:    Translation:AnimalsCells
    95. Ward PP, May GS, Headon DR, Conneely OM. An inducible expression system for the production of human lactoferrin in Aspergillus nidulans. Gene. 1992 Dec 01; 122(1):219-23. PMID: 1452033.
      Citations: 5     Fields:    Translation:HumansAnimals
    96. O'Malley BW, Conneely OM. Orphan receptors: in search of a unifying hypothesis for activation. Mol Endocrinol. 1992 Sep; 6(9):1359-61. PMID: 1331771.
      Citations: 35     Fields:    Translation:AnimalsCells
    97. Lydon JP, O'Malley BR, Saucedo O, Lee T, Headon DR, Conneely OM. Nucleotide and primary amino acid sequence of porcine lactoferrin. Biochim Biophys Acta. 1992 Aug 17; 1132(1):97-9. PMID: 1511016.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    98. Power RF, Conneely OM, O'Malley BW. New insights into activation of the steroid hormone receptor superfamily. Trends Pharmacol Sci. 1992 Aug; 13(8):318-23. PMID: 1413090.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    99. Ward PP, Lo JY, Duke M, May GS, Headon DR, Conneely OM. Production of biologically active recombinant human lactoferrin in Aspergillus oryzae. Biotechnology (N Y). 1992 Jul; 10(7):784-9. PMID: 1368268.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    100. Poletti A, Weigel NL, McDonnell DP, Schrader WT, O'Malley BW, Conneely OM. A novel, highly regulated, rapidly inducible system for the expression of chicken progesterone receptor, cPRA, in Saccharomyces cerevisiae. Gene. 1992 May 01; 114(1):51-8. PMID: 1316867.
      Citations: 1     Fields:    Translation:AnimalsCells
    101. Lydon JP, Power RF, Conneely OM. Differential modes of activation define orphan subclasses within the steroid/thyroid receptor superfamily. Gene Expr. 1992; 2(3):273-83. PMID: 1450665; PMCID: PMC6057375.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    102. Conneely OM, Power RF, O'Malley BW. Regulation of gene expression by dopamine: implications in drug addiction. NIDA Res Monogr. 1992; 126:84-97. PMID: 1491719.
      Citations:    Fields:    Translation:HumansAnimals
    103. Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW. Dopaminergic and ligand-independent activation of steroid hormone receptors. Science. 1991 Dec 13; 254(5038):1636-9. PMID: 1749936.
      Citations: 116     Fields:    Translation:AnimalsCells
    104. Schowalter DB, Sullivan WP, Maihle NJ, Dobson AD, Conneely OM, O'Malley BW, Toft DO. Characterization of progesterone receptor binding to the 90- and 70-kDa heat shock proteins. J Biol Chem. 1991 Nov 05; 266(31):21165-73. PMID: 1939158.
      Citations: 8     Fields:    Translation:AnimalsCells
    105. Bradshaw MS, Tsai SY, Leng XH, Dobson AD, Conneely OM, O'Malley BW, Tsai MJ. Studies on the mechanism of functional cooperativity between progesterone and estrogen receptors. J Biol Chem. 1991 Sep 05; 266(25):16684-90. PMID: 1885597.
      Citations: 8     Fields:    Translation:Cells
    106. Power RF, Lydon JP, Conneely OM, O'Malley BW. Dopamine activation of an orphan of the steroid receptor superfamily. Science. 1991 Jun 14; 252(5012):1546-8. PMID: 2047861.
      Citations: 46     Fields:    Translation:AnimalsCells
    107. Power RF, Conneely OM, McDonnell DP, Clark JH, Butt TR, Schrader WT, O'Malley BW. High level expression of a truncated chicken progesterone receptor in Escherichia coli. J Biol Chem. 1990 Jan 25; 265(3):1419-24. PMID: 2153132.
      Citations: 4     Fields:    Translation:AnimalsCells
    108. Munjaal RP, Conneely OM, O'Malley BW. In situ detection of progesterone receptor mRNA in the chicken oviduct using probe-on slides. Biotechniques. 1989 Nov-Dec; 7(10):1104-8. PMID: 2629842.
      Citations: 1     Fields:    Translation:AnimalsCells
    109. Conneely OM, Kettelberger DM, Tsai MJ, Schrader WT, O'Malley BW. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem. 1989 Aug 25; 264(24):14062-4. PMID: 2760059.
      Citations: 33     Fields:    Translation:AnimalsCells
    110. Dobson AD, Conneely OM, Beattie W, Maxwell BL, Mak P, Tsai MJ, Schrader WT, O'Malley BW. Mutational analysis of the chicken progesterone receptor. J Biol Chem. 1989 Mar 05; 264(7):4207-11. PMID: 2917996.
      Citations: 9     Fields:    Translation:AnimalsCells
    111. Carson-Jurica MA, Lee AT, Dobson AW, Conneely OM, Schrader WT, O'Malley BW. Interaction of the chicken progesterone receptor with heat shock protein (HSP) 90. J Steroid Biochem. 1989; 34(1-6):1-9. PMID: 2626012.
      Citations: 8     Fields:    Translation:AnimalsCells
    112. Conneely OM, Dobson AD, Carson MA, Maxwell BL, Tsai MJ, Schrader WT, O'Malley BW. Structure-function relationships of the chicken progesterone receptor. Biochem Soc Trans. 1988 Oct; 16(5):683-7. PMID: 2466711.
      Citations:    Fields:    Translation:HumansAnimals
    113. Conneely OM, Maxwell BL, Toft DO, Schrader WT, O'Malley BW. The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun. 1987 Dec 16; 149(2):493-501. PMID: 3426587.
      Citations: 32     Fields:    Translation:AnimalsCells
    114. Huckaby CS, Conneely OM, Beattie WG, Dobson AD, Tsai MJ, O'Malley BW. Structure of the chromosomal chicken progesterone receptor gene. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8380-4. PMID: 3479797; PMCID: PMC299546.
      Citations: 23     Fields:    Translation:AnimalsCells
    115. Carson MA, Tsai MJ, Conneely OM, Maxwell BL, Clark JH, Dobson AD, Elbrecht A, Toft DO, Schrader WT, O'Malley BW. Structure-function properties of the chicken progesterone receptor A synthesized from complementary deoxyribonucleic acid. Mol Endocrinol. 1987 Nov; 1(11):791-801. PMID: 3153463.
      Citations: 8     Fields:    Translation:AnimalsCells
    116. Conneely OM, Dobson AD, Tsai MJ, Beattie WG, Toft DO, Huckaby CS, Zarucki T, Schrader WT, O'Malley BW. Sequence and expression of a functional chicken progesterone receptor. Mol Endocrinol. 1987 Aug; 1(8):517-25. PMID: 3153474.
      Citations: 8     Fields:    Translation:AnimalsCells
    117. Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW, et al. The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2. Proc Natl Acad Sci U S A. 1987 May; 84(9):2877-81. PMID: 3472240; PMCID: PMC304763.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    118. Gope ML, Kristo PA, Conneely OM, Beattie WG, Zarucki-Schulz T, O'Malley BW, Kulomaa MS, Kein?nen RA. Molecular cloning of the chicken avidin cDNA. Nucleic Acids Res. 1987 Apr 24; 15(8):3595-606. PMID: 3575102; PMCID: PMC340752.
      Citations: 15     Fields:    Translation:AnimalsCells
    119. Maxwell BL, McDonnell DP, Conneely OM, Schulz TZ, Greene GL, O'Malley BW. Structural organization and regulation of the chicken estrogen receptor. Mol Endocrinol. 1987 Jan; 1(1):25-35. PMID: 2901032.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    120. Kulomaa MS, Weigel NL, Kleinsek DA, Beattie WG, Conneely OM, March C, Zarucki-Schulz T, Schrader WT, O'Malley BW. Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequence. Biochemistry. 1986 Oct 07; 25(20):6244-51. PMID: 3024703.
      Citations: 16     Fields:    Translation:AnimalsCells
    121. Conneely OM, Sullivan WP, Toft DO, Birnbaumer M, Cook RG, Maxwell BL, Zarucki-Schulz T, Greene GL, Schrader WT, O'Malley BW. Molecular cloning of the chicken progesterone receptor. Science. 1986 Aug 15; 233(4765):767-70. PMID: 2426779.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
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