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ERIC CHANG

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center


    Collapse Research 
    Collapse research activities and funding
    R21CA226567     (CHANG, ERIC C)Jun 4, 2018 - May 31, 2021
    NIH
    A novel N-Ras pathway driving DCIS to basal-like breast cancer
    Role: Principal Investigator
    R01CA107187     (CHANG, ERIC C)Apr 19, 2005 - Mar 31, 2009
    NIH
    Selective control of multiple Ras signaling activities
    Role: Principal Investigator
    R01CA090464     (CHANG, ERIC C)Apr 1, 2001 - Jan 31, 2013
    NIH
    REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC. Neurofibromin Is an Estrogen Receptor-a Transcriptional Co-repressor in Breast Cancer. Cancer Cell. 2020 03 16; 37(3):387-402.e7. PMID: 32142667; PMCID: PMC7286719.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    2. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574; PMCID: PMC4512851.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    3. Sellin JN, Reichardt W, Bishop AJ, Suki D, Rhines LD, Settle SH, Brown PD, Li J, Rao G, Chang EL, Tatsui CE. Factors affecting survival in 37 consecutive patients undergoing de novo stereotactic radiosurgery for contiguous sites of vertebral body metastasis from renal cell carcinoma. J Neurosurg Spine. 2015 Jan; 22(1):52-9. PMID: 25360530.
      Citations: 11     Fields:    Translation:Humans
    4. Grosshans DR, Zhu XR, Melancon A, Allen PK, Poenisch F, Palmer M, McAleer MF, McGovern SL, Gillin M, DeMonte F, Chang EL, Brown PD, Mahajan A. Spot scanning proton therapy for malignancies of the base of skull: treatment planning, acute toxicities, and preliminary clinical outcomes. Int J Radiat Oncol Biol Phys. 2014 Nov 01; 90(3):540-6. PMID: 25304948.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    5. Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, Wu RY, Li X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Gillin MT, Mahajan A, Grosshans DR. A single-field integrated boost treatment planning technique for spot scanning proton therapy. Radiat Oncol. 2014 Sep 11; 9:202. PMID: 25212571; PMCID: PMC4262206.
      Citations: 11     Fields:    Translation:Humans
    6. Wang Y, Allen PK, Mahajan A, McCutcheon IE, Rao G, Rhines LD, Tatsui CE, Armstrong TS, Maor MH, Chang EL, Brown PD, Li J, Tsai CJ. Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD Anderson Cancer Center experience. Neurosurgery. 2014 Sep; 75(3):205-14; discussion 213-4. PMID: 24818785.
      Citations: 10     Fields:    Translation:Humans
    7. Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers. Nat Commun. 2014 Aug 07; 5:4577. PMID: 25099679; PMCID: PMC4130357.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    8. . Accurate Segmentation of Touching Cells in Multi-channel Microscopy Images with Geodesic Distance Based Clustering. Neurocomputing. 2014; In press..
    9. . International Symposium on Neural Networks (ISNN13). A Novel Geodesic Distance Based Clustering Approach to Delineating Boundaries of Touching Cells. 2013; 7952:315-322.
    10. Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 2012 Oct 25; 31(43):4630-8. PMID: 22231449; PMCID: PMC3326214.
      Citations: 15     Fields:    Translation:HumansCells
    11. Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, Anderson P, Green HL, Mahajan A. Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):317-26. PMID: 22104361; PMCID: PMC4005898.
      Citations: 19     Fields:    Translation:Humans
    12. Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, Azeem S, Rhines LD, Chang EL. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience. Cancer. 2011 Aug 01; 117(15):3509-16. PMID: 21319143.
      Citations: 46     Fields:    Translation:Humans
    13. Walker GV, Ahmed S, Allen P, Gidley PW, Woo SY, DeMonte F, Chang EL, Mahajan A. Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):e819-23. PMID: 21277110.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    14. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303; PMCID: PMC3017639.
      Citations: 14     Fields:    Translation:HumansCells
    15. Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, Chang EL. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. PMID: 19632064.
      Citations: 52     Fields:    Translation:Humans
    16. Torres MA, Chang EL, Mahajan A, Lege DG, Riley BA, Zhang X, Lii M, Kornguth DG, Pelloski CE, Woo SY. Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9. PMID: 19356861.
      Citations: 11     Fields:    Translation:Humans
    17. Nguyen QN, Chang EL. Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 2008 Jul; 10(4):338-43. PMID: 18778560.
      Citations: 11     Fields:    Translation:Humans
    18. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007 Aug; 7(2):151-60. PMID: 17688054.
      Citations: 132     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    19. Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer. 2006 Nov 01; 107(9):2228-36. PMID: 17019739.
      Citations: 16     Fields:    Translation:Humans
    20. Selek U, Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1097-106. PMID: 15234044.
      Citations: 64     Fields:    Translation:Humans
    21. Yen HC, Chang EC. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14370-5. PMID: 11121040; PMCID: PMC18925.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    22. Chen CR, Chen J, Chang EC. A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. Mol Biol Cell. 2000 Dec; 11(12):4067-77. PMID: 11102508; PMCID: PMC15057.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):517-22. PMID: 9892665; PMCID: PMC15168.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    24. Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6180-4. PMID: 7597098; PMCID: PMC41666.
      Citations: 65     Fields:    Translation:AnimalsCells
    25. Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 1994 Oct 07; 79(1):131-41. PMID: 7923372.
      Citations: 142     Fields:    Translation:AnimalsCells
    26. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol. 1993 Jan; 13(1):487-95. PMID: 8417346; PMCID: PMC358928.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    27. Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9831-5. PMID: 1384061; PMCID: PMC50227.
      Citations: 47     Fields:    Translation:AnimalsCells
    28. Chang EC, Crawford BF, Hong Z, Bilinski T, Kosman DJ. Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. J Biol Chem. 1991 Mar 05; 266(7):4417-24. PMID: 1999425.
      Citations: 23     Fields:    Translation:AnimalsCells
    29. Chang EC, Kosman DJ. O2-dependent methionine auxotrophy in Cu,Zn superoxide dismutase-deficient mutants of Saccharomyces cerevisiae. J Bacteriol. 1990 Apr; 172(4):1840-5. PMID: 2180907; PMCID: PMC208677.
      Citations: 22     Fields:    Translation:AnimalsCells
    30. Chang EC, Kosman DJ, Willsky GR. Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae. J Bacteriol. 1989 Nov; 171(11):6349-52. PMID: 2681165; PMCID: PMC210510.
      Citations: 6     Fields:    Translation:Animals
    31. Chang EC, Kosman DJ. Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress. J Biol Chem. 1989 Jul 25; 264(21):12172-8. PMID: 2545701.
      Citations: 45     Fields:    Translation:Animals
    32. . Cloning and Biological Activity of the Cu, Zn SOD gene of S. cerevisiae. UCLA Symp. Mol. Cell. Biol. New Ser. 1988; 82:173-182.
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