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DANIEL MEDINA

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address
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    R01CA084320     (MEDINA, DANIEL NONE)Jan 1, 2000 - Dec 31, 2005
    NIH
    P53 AND MOUSE MAMMARY TUMORIGENESIS
    Role: Principal Investigator
    U01CA084243     (ROSEN, JEFFREY)Sep 30, 1999 - Mar 31, 2010
    NIH
    Mouse Models of Human Breast Cancer
    Role: Co-Principal Investigator
    P01CA064255     (MEDINA, DANIEL NONE)Aug 1, 1995 - Apr 30, 2008
    NIH
    Mechanisms of the Hormonal Prevention of Breast Cancer
    Role: Principal Investigator
    R01CA063137     (MEDINA, DANIEL NONE)May 1, 1994 - Apr 30, 1997
    NIH
    IMMORTALIZATION AND MAMMORY TUMORIGENESIS
    Role: Principal Investigator
    R13CA055154     (MEDINA, DANIEL NONE)Aug 1, 1991 - Jul 31, 1992
    NIH
    GORDON RESEARCH CONFERENCE--MAMMARY GLAND BIOLOGY
    Role: Principal Investigator
    R01CA047112     (MEDINA, DANIEL NONE)Apr 1, 1988 - Nov 30, 1999
    NIH
    EARLY EVENTS IN MULTIPLE-STAGE MAMMARY TUMORIGENESIS
    Role: Principal Investigator
    R01CA039017     (MEDINA, DANIEL NONE)Jan 1, 1985 - Dec 31, 1987
    NIH
    CELL LINEAGES IN NORMAL AND PRENEOPLASTIC MAMMARY GROWTH
    Role: Principal Investigator
    R01CA011944     (MEDINA, DANIEL NONE)Sep 30, 1977 - Apr 30, 2005
    NIH
    BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aguinaga M, Rezaei M, Monroy I, Mechtouf N, P?rez J, Moreno E, Valdespino Y, Galaz C, Razo G, Medina D, Pi?a R, Slim R. The genetics of recurrent hydatidiform moles in Mexico: further evidence of a strong founder effect for one mutation in NLRP7 and its widespread. J Assist Reprod Genet. 2021 Jul; 38(7):1879-1886. PMID: 33751332; PMCID: PMC8324737.
      Citations:    
    2. Newman JH, Chesson CB, Herzog NL, Bommareddy PK, Aspromonte SM, Pepe R, Estupinian R, Aboelatta MM, Buddhadev S, Tarabichi S, Lee M, Li S, Medina DJ, Giurini EF, Gupta KH, Guevara-Aleman G, Rossi M, Nowicki C, Abed A, Goldufsky JW, Broucek JR, Redondo RE, Rotter D, Jhawar SR, Wang SJ, Kohlhapp FJ, Kaufman HL, Thomas PG, Gupta V, Kuzel TM, Reiser J, Paras J, Kane MP, Singer EA, Malhotra J, Denzin LK, Sant'Angelo DB, Rabson AB, Lee LY, Lasfar A, Langenfeld J, Schenkel JM, Fidler MJ, Ruiz ES, Marzo AL, Rudra JS, Silk AW, Zloza A. Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer. Proc Natl Acad Sci U S A. 2020 01 14; 117(2):1119-1128. PMID: 31888983; PMCID: PMC6969546.
      Citations:    
    3. Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR, Libutti SK, Mehnert JM, Zloza A. Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration. J Immunother Cancer. 2019 05 22; 7(1):136. PMID: 31118108; PMCID: PMC6532211.
      Citations:    
    4. Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. PLoS One. 2018; 13(3):e0194913. PMID: 29590203; PMCID: PMC5874056.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon YC, Zhong H, Medina DJ, Kerrigan J, Stein MN, Kim IY, Davis TW, DiPaola RS, Bertino JR, Sabaawy HE. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clin Cancer Res. 2016 Dec 15; 22(24):6176-6191. PMID: 27307599; PMCID: PMC5159329.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    6. Boregowda RK, Medina DJ, Markert E, Bryan MA, Chen W, Chen S, Rabkin A, Vido MJ, Gunderson SI, Chekmareva M, Foran DJ, Lasfar A, Goydos JS, Cohen-Solal KA. The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma. Oncotarget. 2016 May 17; 7(20):29689-707. PMID: 27102439; PMCID: PMC5045426.
      Citations:    
    7. Kittrell F, Valdez K, Elsarraj H, Hong Y, Medina D, Behbod F. Mouse Mammary Intraductal (MIND) Method for Transplantation of Patient Derived Primary DCIS Cells and Cell Lines. Bio Protoc. 2016 Mar 05; 6(5). PMID: 27446983; PMCID: PMC4950990.
      Citations: 8     
    8. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574; PMCID: PMC4512851.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    9. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287; PMCID: PMC4359526.
      Citations: 5     
    10. Dolfi SC, Medina DJ, Haffty BG, Yang JM, Hirshfield KM, J?ger AV. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Aug 01; 350(1-2):52-60. PMID: 24747123; PMCID: PMC5500211.
      Citations: 13     Fields:    Translation:HumansCells
    11. Medina DJ, Abass-Shereef J, Walton K, Goodell L, Aviv H, Strair RK, Budak-Alpdogan T. Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One. 2014; 9(4):e91042. PMID: 24722054; PMCID: PMC3982953.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERa)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-5522. PMID: 24276237; PMCID: PMC4032816.
      Citations: 30     Fields:    Translation:AnimalsCells
    13. Rehman SK, Li SH, Wyszomierski SL, Wang Q, Li P, Sahin O, Xiao Y, Zhang S, Xiong Y, Yang J, Wang H, Guo H, Zhang JD, Medina D, Muller WJ, Yu D. 14-3-3? orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer Res. 2014 Jan 01; 74(1):363-373. PMID: 24197133; PMCID: PMC3947305.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Mehta MS, Dolfi SC, Bronfenbrener R, Bilal E, Chen C, Moore D, Lin Y, Rahim H, Aisner S, Kersellius RD, Teh J, Chen S, Toppmeyer DL, Medina DJ, Ganesan S, Vazquez A, Hirshfield KM. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One. 2013; 8(7):e69851. PMID: 23922822; PMCID: PMC3724883.
      Citations: 14     Fields:    Translation:HumansCells
    15. Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. Separation by cell size enriches for mammary stem cell repopulation activity. Stem Cells Transl Med. 2013 Mar; 2(3):199-203. PMID: 23408103; PMCID: PMC3659766.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Mazumdar A, Medina D, Kittrell FS, Zhang Y, Hill JL, Edwards DE, Bissonnette RP, Brown PH. The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice. Cancer Prev Res (Phila). 2012 Oct; 5(10):1195-202. PMID: 22926341; PMCID: PMC3837417.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Medina D, Edwards DG, Kittrell F, Lee S, Allred DC. Intra-mammary ductal transplantation: a tool to study premalignant progression. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):131-3. PMID: 22688217.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Budak-Alpdogan T, Jeganathan G, Lee KC, Mrowiec ZR, Medina DJ, Todd D, Moore D, Bertino JR, Strair R. Irradiated allogeneic cells enhance umbilical cord blood stem cell engraftment in immunodeficient mice. Bone Marrow Transplant. 2012 Dec; 47(12):1569-76. PMID: 22609880.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    19. Lewis MT, Landua JD, Adams HC, Medina D. A mystery wrapped in an enigma: Matrigel enhancement of mammary cell growth and morphogenesis. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):99-101. PMID: 22581302.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    20. Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2778-83. PMID: 21633010; PMCID: PMC3286979.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    21. Kittrell FS, Carletti MZ, Kerbawy S, Heestand J, Xian W, Zhang M, Lamarca HL, Sonnenberg A, Rosen JM, Medina D, Behbod F. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res. 2011 Apr 05; 13(2):R41. PMID: 21466693; PMCID: PMC3219204.
      Citations: 7     Fields:    Translation:AnimalsCells
    22. Medina D. Of mice and women: A short history of mouse mammary cancer research with an emphasis on the paradigms inspired by the transplantation method. Cold Spring Harb Perspect Biol. 2010 Oct; 2(10):a004523. PMID: 20630995; PMCID: PMC2944362.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV. Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer. Cancer Prev Res (Phila). 2010 Mar; 3(3):312-21. PMID: 20145191; PMCID: PMC2833223.
      Citations: 11     Fields:    Translation:AnimalsCells
    24. Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009 Mar 06; 8:15. PMID: 19267898; PMCID: PMC2669049.
      Citations:    Fields:    Translation:Animals
    25. Medina D, Kittrell F, Hill J, Zhang Y, Hilsenbeck SG, Bissonette R, Brown PH. Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib. Cancer Prev Res (Phila). 2009 Feb; 2(2):168-74. PMID: 19174577; PMCID: PMC2995265.
      Citations: 7     Fields:    Translation:Animals
    26. Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13033-8. PMID: 18728194; PMCID: PMC2529090.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    27. Medina D. Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens. J Mammary Gland Biol Neoplasia. 2008 Sep; 13(3):271-7. PMID: 18663563.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    28. Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 2008 Jun 15; 68(12):4674-82. PMID: 18559513; PMCID: PMC2459340.
      Citations: 158     Fields:    Translation:AnimalsCells
    29. Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res. 2007 Dec 15; 67(24):12026-33. PMID: 18089834.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    30. Li Z, Schem C, Shi YH, Medina D, Zhang M. Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis. 2008; 25(4):389-400. PMID: 17965942.
      Citations: 25     Fields:    Translation:AnimalsCells
    31. Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA. Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol. 2008 Jan 01; 313(1):130-41. PMID: 17996864; PMCID: PMC2234269.
      Citations: 20     Fields:    Translation:Animals
    32. Goepfert TM, Moreno-Smith M, Edwards DG, Pathak S, Medina D, Brinkley WR. Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer. 2007 Mar 01; 120(5):985-94. PMID: 17131329.
      Citations: 11     Fields:    Translation:AnimalsCells
    33. Medina D. Chemical carcinogenesis of rat and mouse mammary glands. Breast Dis. 2007; 28:63-8. PMID: 18057544.
      Citations: 19     Fields:    Translation:Animals
    34. Lee S, Mohsin SK, Mao S, Hilsenbeck SG, Medina D, Allred DC. Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer. Breast Cancer Res. 2006; 8(1):R6. PMID: 16417654; PMCID: PMC1413990.
      Citations: 41     Fields:    Translation:Humans
    35. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 01; 65(17):7993-8002. PMID: 16140972.
      Citations: 57     Fields:    Translation:AnimalsCells
    36. Medina D. Mammary developmental fate and breast cancer risk. Endocr Relat Cancer. 2005 Sep; 12(3):483-95. PMID: 16172188.
      Citations: 47     Fields:    Translation:Humans
    37. Medina D, Kittrell FS, Hill J, Shepard A, Thordarson G, Brown P. Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis. Cancer Res. 2005 Apr 15; 65(8):3493-6. PMID: 15833886.
      Citations: 20     Fields:    Translation:Animals
    38. Medina D, Kittrell F. Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia. J Cell Sci. 2005 Jan 01; 118(Pt 1):123-7. PMID: 15585572.
      Citations: 11     Fields:    Translation:AnimalsCells
    39. Allred DC, Brown P, Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res. 2004; 6(6):240-5. PMID: 15535853; PMCID: PMC1064085.
      Citations: 88     Fields:    Translation:Humans
    40. Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16. PMID: 15313898.
      Citations: 24     Fields:    Translation:AnimalsCells
    41. Yi Y, Shepard A, Kittrell F, Mulac-Jericevic B, Medina D, Said TK. p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell. 2004 May; 15(5):2302-11. PMID: 15105443; PMCID: PMC404024.
      Citations: 9     Fields:    Translation:AnimalsCells
    42. Medina D. Stromal fibroblasts influence human mammary epithelial cell morphogenesis. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4723-4. PMID: 15051868; PMCID: PMC387314.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    43. Medina D. Breast cancer: the protective effect of pregnancy. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 2):380S-4S. PMID: 14734495.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    44. Said TK, Medina D. Cell cycle genes in a mouse mammary hyperplasia model. J Mammary Gland Biol Neoplasia. 2004 Jan; 9(1):81-93. PMID: 15082920.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    45. Medina D, Kittrell FS. p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis. Cancer Res. 2003 Oct 01; 63(19):6140-3. PMID: 14559792.
      Citations: 30     Fields:    Translation:Animals
    46. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 01; 63(5):1067-72. PMID: 12615724.
      Citations: 38     Fields:    Translation:Animals
    47. Kong G, Chua SS, Yijun Y, Kittrell F, Moraes RC, Medina D, Said TK. Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development. Oncogene. 2002 Oct 17; 21(47):7214-25. PMID: 12370811.
      Citations: 14     Fields:    Translation:AnimalsCells
    48. Medina D. Biological and molecular characteristics of the premalignant mouse mammary gland. Biochim Biophys Acta. 2002 Oct 02; 1603(1):1-9. PMID: 12242106.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    49. Goepfert TM, Adigun YE, Zhong L, Gay J, Medina D, Brinkley WR. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res. 2002 Jul 15; 62(14):4115-22. PMID: 12124350.
      Citations: 64     Fields:    Translation:AnimalsCells
    50. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
      Citations: 9     Fields:    Translation:AnimalsCells
    51. Medina D, Kittrell FS, Shepard A, Stephens LC, Jiang C, Lu J, Allred DC, McCarthy M, Ullrich RL. Biological and genetic properties of the p53 null preneoplastic mammary epithelium. FASEB J. 2002 Jun; 16(8):881-3. PMID: 11967232.
      Citations: 55     Fields:    Translation:Animals
    52. Medina D, Ullrich R, Meyn R, Wiseman R, Donehower L. Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis. Environ Mol Mutagen. 2002; 39(2-3):178-83. PMID: 11921187.
      Citations: 9     Fields:    Translation:Animals
    53. Sivaraman L, Medina D. Hormone-induced protection against breast cancer. J Mammary Gland Biol Neoplasia. 2002 Jan; 7(1):77-92. PMID: 12160088.
      Citations: 34     Fields:    Translation:HumansAnimals
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