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JIANMING XU

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R21DE033147     (FAKHOURI, WALID D.)Aug 1, 2023 - Jul 31, 2025
    NIH
    The function of TWIST1 acetylation in cell fate and tissue development
    Role: Co-Principal Investigator
    R01CA193455     (XU, JIANMING)Dec 1, 2015 - Nov 30, 2021
    NIH
    NCOA6, A Novel Tumor Suppressor of Endometrial Cancer
    Role: Principal Investigator
    R01CA119689     (XU, JIANMING)Jul 8, 2005 - Apr 30, 2012
    NIH
    Role of AIB3 in Mammary Gland and Breast Cancer
    Role: Principal Investigator
    R01CA112403     (XU, JIANMING)Dec 1, 2004 - Mar 31, 2019
    NIH
    The Role of SRC-1 in Breast Cancer
    Role: Principal Investigator
    R01DK058242     (XU, JIANMING)Sep 15, 2000 - May 31, 2015
    NIH
    Roles of SRC-3 in Development and Disease
    Role: Principal Investigator
    F32CA068676     (XU, JIANMING)Jan 2, 1996
    NIH
    STAGE SPECIFIC EXPRESSION OF ONCOGENE AND BREAST CANCER
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien JC, Xu Y, Feng Z, Yang Z, Xu Y, Theissen SM, Li Y, Young L, Xu J. NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer Res. 2014 Jul 01; 74(13):3477-88. PMID: 24769444; PMCID: PMC4083628.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    2. Xu Y, Xu Y, Liao L, Zhou N, Theissen SM, Liao XH, Nguyen H, Ludwig T, Qin L, Martinez JD, Jiang J, Xu J. Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol. 2013 Oct; 183(4):1281-1292. PMID: 23906809; PMCID: PMC3791869.
      Citations: 17     Fields:    Translation:Animals
    3. Tien JC, Liu Z, Liao L, Wang F, Xu Y, Wu YL, Zhou N, Ittmann M, Xu J. The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. Cancer Res. 2013 Jul 01; 73(13):3997-4008. PMID: 23650284; PMCID: PMC3732785.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    4. York B, Tsimelzon A, Louet JF, Chopra AR, Reineke EL, Zhou S, Stevens RD, Wenner BR, Ilkayeva O, Bain JR, Xu J, Hilsenbeck SG, Newgard CB, O'Malley BW, Sagen JV. Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family. Mol Endocrinol. 2013 Feb; 27(2):366-80. PMID: 23315938; PMCID: PMC3683811.
      Citations: 16     Fields:    Translation:Animals
    5. Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW. SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. PLoS One. 2012; 7(12):e53395. PMID: 23300926; PMCID: PMC3534027.
      Citations: 17     Fields:    Translation:AnimalsCells
    6. Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y, Zhu L. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan; 154(1):150-8. PMID: 23211707; PMCID: PMC3529365.
      Citations: 28     Fields:    Translation:AnimalsCells
    7. Kawagoe J, Li Q, Mussi P, Liao L, Lydon JP, DeMayo FJ, Xu J. Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. Dev Cell. 2012 Oct 16; 23(4):858-65. PMID: 23079602; PMCID: PMC3479668.
      Citations: 19     Fields:    Translation:Animals
    8. Tien JC, Xu J. Steroid receptor coactivator-3 as a potential molecular target for cancer therapy. Expert Opin Ther Targets. 2012 Nov; 16(11):1085-96. PMID: 22924430; PMCID: PMC3640986.
      Citations: 19     Fields:    Translation:HumansAnimals
    9. Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z. Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol Cell. 2012 Sep 28; 47(6):839-50. PMID: 22885005; PMCID: PMC3462252.
      Citations: 53     Fields:    Translation:HumansCells
    10. York B, Reineke EL, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW, Sagen JV. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012 May 02; 15(5):752-63. PMID: 22560224; PMCID: PMC3349072.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    11. Zhou J, Qin L, Tien JC, Gao L, Chen X, Wang F, Hsieh JT, Xu J. Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. J Biol Chem. 2012 May 18; 287(21):17248-17256. PMID: 22465996; PMCID: PMC3366845.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    12. Al-Otaiby M, Tassi E, Schmidt MO, Chien CD, Baker T, Salas AG, Xu J, Furlong M, Schlegel R, Riegel AT, Wellstein A. Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing. Am J Pathol. 2012 Apr; 180(4):1474-84. PMID: 22342158; PMCID: PMC3349901.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Hartmaier RJ, Richter AS, Gillihan RM, Sallit JZ, McGuire SE, Wang J, Lee AV, Osborne CK, O'Malley BW, Brown PH, Xu J, Skaar TC, Philips S, Rae JM, Azzouz F, Li L, Hayden J, Henry NL, Nguyen AT, Stearns V, Hayes DF, Flockhart DA, Oesterreich S. A SNP in steroid receptor coactivator-1 disrupts a GSK3? phosphorylation site and is associated with altered tamoxifen response in bone. Mol Endocrinol. 2012 Feb; 26(2):220-7. PMID: 22174377; PMCID: PMC3275159.
      Citations: 10     Fields:    Translation:HumansCells
    14. McCartan D, Bolger JC, Byrne C, Hao Y, Qin L, McIlroy M, Xu J, Hill AD, Young LS, Fagan A, Gaora P?. Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer. Cancer Res. 2012 Jan 01; 72(1):220-9. PMID: 22072566; PMCID: PMC3681815.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    15. Qin Q, Xu Y, He T, Qin C, Xu J. Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms. Cell Res. 2012 Jan; 22(1):90-106. PMID: 21876555; PMCID: PMC3351934.
      Citations: 193     Fields:    Translation:HumansAnimalsCells
    16. Dearth RK, Kuiatse I, Wang YF, Liao L, Hilsenbeck SG, Brown PH, Xu J, Lee AV. A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis. BMC Cancer. 2011 Aug 25; 11:377. PMID: 21867536; PMCID: PMC3189189.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Park S, Zhao Y, Yoon S, Xu J, Liao L, Lydon J, DeMayo F, O'Malley BW, Katzenellenbogen BS. Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. Endocrinology. 2011 Nov; 152(11):4336-49. PMID: 21862609; PMCID: PMC3199013.
      Citations: 14     Fields:    Translation:AnimalsCells
    18. Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Xu J, Yu C. SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism. J Hepatol. 2012 Jan; 56(1):210-7. PMID: 21827731; PMCID: PMC3232307.
      Citations: 8     Fields:    Translation:AnimalsCells
    19. Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20; 30(42):4350-64. PMID: 21577200; PMCID: PMC3158261.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    20. Lambert-Blot M, Mitchell C, Bretes H, Collin de l'Hortet A, Chereau F, Sotiropoulos A, Kopchick JJ, Liao L, Xu J, Guidotti JE, Zerrad-Saadi A, Baud V, Gilgenkrantz H. GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation. Endocrinology. 2011 Jul; 152(7):2731-41. PMID: 21540290.
      Citations: 23     Fields:    Translation:AnimalsCells
    21. Li Q, Xu J. Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms. Int J Biol Sci. 2011 Apr 19; 7(5):505-16. PMID: 21552418; PMCID: PMC3088874.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Hong J, Zhou J, Fu J, He T, Qin J, Wang L, Liao L, Xu J. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness. Cancer Res. 2011 Jun 01; 71(11):3980-90. PMID: 21502402; PMCID: PMC3107354.
      Citations: 127     Fields:    Translation:HumansCells
    23. Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L, Xu J. Steroid receptor coactivator-1 upregulates integrin a5 expression to promote breast cancer cell adhesion and migration. Cancer Res. 2011 Mar 01; 71(5):1742-51. PMID: 21343398; PMCID: PMC3076137.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    24. Ma X, Xu L, Wang S, Cui B, Li X, Xu J, Ning G. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis. J Hepatol. 2011 Aug; 55(2):445-52. PMID: 21184786.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    25. Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab. 2010 Dec 01; 12(6):606-18. PMID: 21109193; PMCID: PMC3024581.
      Citations: 37     Fields:    Translation:AnimalsCells
    26. Chen Q, Chen T, Xu Y, Zhu J, Jiang Y, Zhao Y, Xu J, Yu C. Steroid receptor coactivator 3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis. J Immunol. 2010 Nov 01; 185(9):5444-52. PMID: 20881187; PMCID: PMC3640995.
      Citations: 13     Fields:    Translation:AnimalsCells
    27. Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L, Xu J. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 2011 Feb; 21(2):275-89. PMID: 20714342; PMCID: PMC3193433.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    28. Viswakarma N, Jia Y, Bai L, Vluggens A, Borensztajn J, Xu J, Reddy JK. Coactivators in PPAR-Regulated Gene Expression. PPAR Res. 2010; 2010. PMID: 20814439; PMCID: PMC2929611.
      Citations: 72     
    29. Chen X, Liu Z, Xu J. The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct; 24(10):1917-34. PMID: 20685850; PMCID: PMC2954639.
      Citations: 22     Fields:    Translation:Animals
    30. York B, Yu C, Liu Z, Nikolai BC, Wu RC, Finegold M, Xu J, O'Malley BW, Sagen JV. Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11122-7. PMID: 20534466; PMCID: PMC2890746.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    31. Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia. 2010 Jun; 58(8):932-42. PMID: 20155818; PMCID: PMC2903613.
      Citations: 16     Fields:    Translation:AnimalsCells
    32. Wang WL, Li Q, Xu J, Cvekl A. Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15; 21(14):2453-68. PMID: 20484573; PMCID: PMC2903674.
      Citations: 19     Fields:    Translation:AnimalsCells
    33. Xu L, Ma X, Li J, Li X, Xu J, Wang S, Ning G. SRC-3 deficient mice developed fat redistribution under high-fat diet. Endocrine. 2010 Aug; 38(1):60-6. PMID: 20960103.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J. Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem. 2010 Jan 22; 285(4):2758-70. PMID: 19910458; PMCID: PMC2807331.
      Citations: 64     Fields:    Translation:AnimalsCells
    35. Xu J, Wu RC, O'Malley BW. Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer. 2009 Sep; 9(9):615-30. PMID: 19701241; PMCID: PMC2908510.
      Citations: 256     Fields:    Translation:HumansAnimalsCells
    36. Ma X, Xu L, Wang S, Chen H, Xu J, Li X, Ning G. Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis. Lab Invest. 2009 Aug; 89(8):903-14. PMID: 19488034; PMCID: PMC3620314.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    37. Lachize S, Apostolakis EM, van der Laan S, Tijssen AM, Xu J, de Kloet ER, Meijer OC. Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):8038-42. PMID: 19416907; PMCID: PMC2683087.
      Citations: 40     Fields:    Translation:AnimalsCells
    38. Qin L, Liu Z, Chen H, Xu J. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 2009 May 01; 69(9):3819-27. PMID: 19383905; PMCID: PMC2911143.
      Citations: 88     Fields:    Translation:AnimalsCells
    39. Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z. Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK. J Biol Chem. 2009 May 22; 284(21):14377-85. PMID: 19293151; PMCID: PMC2682886.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    40. Tien JC, Zhou S, Xu J. The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression. Int J Biol Sci. 2009; 5(3):256-64. PMID: 19305643; PMCID: PMC2659009.
      Citations: 15     Fields:    Translation:AnimalsCells
    41. Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):151-6. PMID: 19109434; PMCID: PMC2629242.
      Citations: 66     Fields:    Translation:Animals
    42. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140; PMCID: PMC2668604.
      Citations: 96     Fields:    Translation:AnimalsCells
    43. Oh AS, Lahusen JT, Chien CD, Fereshteh MP, Zhang X, Dakshanamurthy S, Xu J, Kagan BL, Wellstein A, Riegel AT. Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Mol Cell Biol. 2008 Nov; 28(21):6580-93. PMID: 18765637; PMCID: PMC2573238.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    44. Liu Z, Liao L, Zhou S, Xu J. Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci. 2008 Jul 23; 4(4):202-7. PMID: 18690289; PMCID: PMC2491728.
      Citations: 8     Fields:    Translation:AnimalsCells
    45. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008 Oct; 28(19):5937-50. PMID: 18644862; PMCID: PMC2547002.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    46. Fereshteh MP, Tilli MT, Kim SE, Xu J, O'Malley BW, Wellstein A, Furth PA, Riegel AT. The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res. 2008 May 15; 68(10):3697-706. PMID: 18483252; PMCID: PMC3641830.
      Citations: 61     Fields:    Translation:AnimalsCells
    47. Liao L, Chen X, Wang S, Parlow AF, Xu J. Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol. 2008 Apr; 28(7):2460-9. PMID: 18212051; PMCID: PMC2268437.
      Citations: 30     Fields:    Translation:HumansAnimals
    48. Sanyal A, Xu J, O'Malley BW, Spelsberg TC, Khosla S, M?dder UI. The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice. Bone. 2008 Feb; 42(2):414-21. PMID: 18055287; PMCID: PMC2248556.
      Citations: 11     Fields:    Translation:Animals
    49. Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA. Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol. 2008 Jan 01; 313(1):130-41. PMID: 17996864; PMCID: PMC2234269.
      Citations: 20     Fields:    Translation:Animals
    50. Li Q, Chu MJ, Xu J. Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. Mol Cell Biol. 2007 Dec; 27(23):8073-86. PMID: 17908797; PMCID: PMC2169164.
      Citations: 19     Fields:    Translation:AnimalsCells
    51. Xia J, Liao L, Sarkar J, Matsumoto K, Reddy JK, Xu J, Kemper B. Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members. Arch Biochem Biophys. 2007 Dec 01; 468(1):49-57. PMID: 17950690; PMCID: PMC2151205.
      Citations: 5     Fields:    Translation:AnimalsCells
    52. Yuan Y, Qin L, Liu D, Wu RC, Mussi P, Zhou S, Songyang Z, Xu J. Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression. Cancer Res. 2007 Sep 01; 67(17):8032-42. PMID: 17804714; PMCID: PMC2412956.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    53. Chung AC, Zhou S, Liao L, Tien JC, Greenberg NM, Xu J. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007 Jun 15; 67(12):5965-75. PMID: 17575167; PMCID: PMC2898573.
      Citations: 32     Fields:    Translation:Animals
    54. Yuan Y, Xu J. Loss-of-function deletion of the steroid receptor coactivator-1 gene in mice reduces estrogen effect on the vascular injury response. Arterioscler Thromb Vasc Biol. 2007 Jul; 27(7):1521-7. PMID: 17446438; PMCID: PMC2435268.
      Citations: 12     Fields:    Translation:Animals
    55. Yu C, York B, Wang S, Feng Q, Xu J, O'Malley BW. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell. 2007 Mar 09; 25(5):765-78. PMID: 17349961; PMCID: PMC1864954.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    56. Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW. Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16716-21. PMID: 17065319; PMCID: PMC1636521.
      Citations: 25     Fields:    Translation:AnimalsCells
    57. Mussi P, Yu C, O'Malley BW, Xu J. Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3. Mol Endocrinol. 2006 Dec; 20(12):3105-19. PMID: 16916939.
      Citations: 37     Fields:    Translation:HumansCells
    58. Yang Z, Wolf IM, Chen H, Periyasamy S, Chen Z, Yong W, Shi S, Zhao W, Xu J, Srivastava A, Shou W, S?nchez ER. FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform. Mol Endocrinol. 2006 Nov; 20(11):2682-94. PMID: 16873445; PMCID: PMC2661205.
      Citations: 51     Fields:    Translation:AnimalsCells
    59. Yeom SY, Kim GH, Kim CH, Jung HD, Kim SY, Park JY, Pak YK, Rhee DK, Kuang SQ, Xu J, Han DJ, Song DK, Lee JW, Lee KU, Kim SW. Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Mol Cell Biol. 2006 Jun; 26(12):4553-63. PMID: 16738321; PMCID: PMC1489122.
      Citations: 12     Fields:    Translation:AnimalsCells
    60. Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J. Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology. 2006 Aug; 147(8):3877-88. PMID: 16709615.
      Citations: 33     Fields:    Translation:AnimalsCells
    61. Winnay JN, Xu J, O'Malley BW, Hammer GD. Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function. Endocrinology. 2006 Mar; 147(3):1322-32. PMID: 16339206.
      Citations: 24     Fields:    Translation:AnimalsCells
    62. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 01; 65(17):7993-8002. PMID: 16140972.
      Citations: 57     Fields:    Translation:AnimalsCells
    63. Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 2006 Jan; 20(1):45-55. PMID: 16141356.
      Citations: 43     Fields:    Translation:AnimalsCells
    64. Ying H, Furuya F, Willingham MC, Xu J, O'Malley BW, Cheng SY. Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone. Mol Cell Biol. 2005 Sep; 25(17):7687-95. PMID: 16107715; PMCID: PMC1190271.
      Citations: 11     Fields:    Translation:Cells
    65. Han SJ, Jeong J, Demayo FJ, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol. 2005 Sep; 25(18):8150-65. PMID: 16135805; PMCID: PMC1234322.
      Citations: 18     Fields:    Translation:AnimalsCells
    66. Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai MJ, O'Malley BW. Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9487-92. PMID: 15983373; PMCID: PMC1172261.
      Citations: 20     Fields:    Translation:Animals
    67. Xu J. Preparation, culture, and immortalization of mouse embryonic fibroblasts. Curr Protoc Mol Biol. 2005 May; Chapter 28:Unit 28.1. PMID: 18265366.
      Citations: 125     Fields:    Translation:AnimalsCells
    68. Park SE, Xu J, Frolova A, Liao L, O'Malley BW, Katzenellenbogen BS. Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol. 2005 Mar; 25(5):1989-99. PMID: 15713652; PMCID: PMC549370.
      Citations: 46     Fields:    Translation:AnimalsCells
    69. Nishihara E, O'Malley BW, Xu J. Nuclear receptor coregulators are new players in nervous system development and function. Mol Neurobiol. 2004 Dec; 30(3):307-25. PMID: 15655254.
      Citations: 10     Fields:    Translation:HumansAnimals
    70. Wu HY, Hamamori Y, Xu J, Chang SC, Saluna T, Chang MF, O'Malley BW, Kedes L. Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD. J Biol Chem. 2005 Feb 04; 280(5):3129-37. PMID: 15563453.
      Citations: 10     Fields:    Translation:AnimalsCells
    71. Zhang H, Kuang SQ, Liao L, Zhou S, Xu J. Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice. Cancer Res. 2004 Oct 01; 64(19):7169-77. PMID: 15466215.
      Citations: 19     Fields:    Translation:AnimalsCells
    72. IJpenberg A, Tan NS, Gelman L, Kersten S, Seydoux J, Xu J, Metzger D, Canaple L, Chambon P, Wahli W, Desvergne B. In vivo activation of PPAR target genes by RXR homodimers. EMBO J. 2004 May 19; 23(10):2083-91. PMID: 15103326; PMCID: PMC424365.
      Citations: 66     Fields:    Translation:AnimalsCells
    73. Mark M, Yoshida-Komiya H, Gehin M, Liao L, Tsai MJ, O'Malley BW, Chambon P, Xu J. Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4453-8. PMID: 15070739; PMCID: PMC384768.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    74. Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004 Mar 01; 64(5):1875-85. PMID: 14996752.
      Citations: 89     Fields:    Translation:AnimalsCells
    75. Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW. Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. J Biol Chem. 2004 Feb 20; 279(8):7131-5. PMID: 14645241.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    76. Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O'Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S, M?dder UI. Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice. Endocrinology. 2004 Feb; 145(2):913-21. PMID: 14563705.
      Citations: 36     Fields:    Translation:Animals
    77. Kamiya Y, Zhang XY, Ying H, Kato Y, Willingham MC, Xu J, O'Malley BW, Cheng SY. Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone. Endocrinology. 2003 Sep; 144(9):4144-53. PMID: 12933689.
      Citations: 18     Fields:    Translation:Animals
    78. Monks DA, Xu J, O'Malley BW, Jordan CL. Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons. Neuroendocrinology. 2003 Jul; 78(1):45-51. PMID: 12869799.
      Citations: 9     Fields:    Translation:AnimalsCells
    79. Xu J. The role of SRC-3 in estrogen-dependent vasoprotection during vascular wall remodeling postinjury. Nucl Recept Signal. 2003; 1:e002. PMID: 16604175; PMCID: PMC1402224.
      Citations:    Fields:    
    80. Xu J, Li Q. Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol. 2003 Sep; 17(9):1681-92. PMID: 12805412.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    81. Sadow PM, Chassande O, Koo EK, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE. Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone. Mol Cell Endocrinol. 2003 May 30; 203(1-2):65-75. PMID: 12782404.
      Citations: 13     Fields:    Translation:Animals
    82. Zhang H, Liao L, Kuang SQ, Xu J. Spatial distribution of the messenger ribonucleic acid and protein of the nuclear receptor coactivator, amplified in breast cancer-3, in mice. Endocrinology. 2003 Apr; 144(4):1435-43. PMID: 12639927.
      Citations: 11     Fields:    Translation:Animals
    83. Sadow PM, Koo E, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Seo H, Murata Y, Weiss RE. Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary. Mol Endocrinol. 2003 May; 17(5):882-94. PMID: 12576486.
      Citations: 9     Fields:    Translation:AnimalsCells
    84. Nishihara E, Yoshida-Komiya H, Chan CS, Liao L, Davis RL, O'Malley BW, Xu J. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci. 2003 Jan 01; 23(1):213-22. PMID: 12514218; PMCID: PMC6742154.
      Citations: 51     Fields:    Translation:AnimalsCells
    85. Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):3-14. PMID: 12650696.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    86. Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J. Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J Biol Chem. 2002 Nov 22; 277(47):45356-60. PMID: 12368298.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    87. Sadow PM, Chassande O, Gauthier K, Samarut J, Xu J, O'Malley BW, Weiss RE. Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E36-46. PMID: 12388168.
      Citations: 12     Fields:    Translation:AnimalsCells
    88. Xu J, O'Malley BW. Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function. Rev Endocr Metab Disord. 2002 Sep; 3(3):185-92. PMID: 12215713.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    89. Liao L, Kuang SQ, Yuan YH, Xu JM. A rapid and cost-effective screening method for identification of targeted embryonic stem cells. Shi Yan Sheng Wu Xue Bao. 2002 Sep; 35(3):163-8. PMID: 15344375.
      Citations:    Fields:    Translation:AnimalsCells
    90. Yuan Y, Liao L, Tulis DA, Xu J. Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen. Circulation. 2002 Jun 04; 105(22):2653-9. PMID: 12045172.
      Citations: 29     Fields:    Translation:Animals
    91. Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW. Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol. 2002 May; 22(10):3549-61. PMID: 11971985; PMCID: PMC133790.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    92. Takeuchi Y, Murata Y, Sadow P, Hayashi Y, Seo H, Xu J, O'Malley BW, Weiss RE, Refetoff S. Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo. Endocrinology. 2002 Apr; 143(4):1346-52. PMID: 11897691.
      Citations: 19     Fields:    Translation:Animals
    93. Weiss RE, Gehin M, Xu J, Sadow PM, O'Malley BW, Chambon P, Refetoff S. Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency. Endocrinology. 2002 Apr; 143(4):1554-7. PMID: 11897715.
      Citations: 9     Fields:    Translation:Animals
    94. Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW. The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6379-84. PMID: 10823921; PMCID: PMC18611.
      Citations: 195     Fields:    Translation:Animals
    95. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM. Activation of PPARgamma coactivator-1 through transcription factor docking. Science. 1999 Nov 12; 286(5443):1368-71. PMID: 10558993.
      Citations: 249     Fields:    Translation:AnimalsCells
    96. Ning G, Jurecic V, Baldini A, Xu J. Structure and chromosomal locations of mouse steroid receptor coactivator gene family. In Vitro Cell Dev Biol Anim. 1999 Sep; 35(8):481-6. PMID: 10501088.
      Citations: 3     Fields:    Translation:Animals
    97. McKenna NJ, Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW. Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions. J Steroid Biochem Mol Biol. 1999 Apr-Jun; 69(1-6):3-12. PMID: 10418975.
      Citations: 80     Fields:    Translation:HumansAnimals
    98. Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S. Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone. EMBO J. 1999 Apr 01; 18(7):1900-4. PMID: 10202153; PMCID: PMC1171275.
      Citations: 71     Fields:    Translation:Animals
    99. Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai MJ, O'Malley BW. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998 Mar 20; 279(5358):1922-5. PMID: 9506940.
      Citations: 192     Fields:    Translation:AnimalsCells
    100. Wang Y, Xu J, Pierson T, O'Malley BW, Tsai SY. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther. 1997 May; 4(5):432-41. PMID: 9274720.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    101. Xu J, Nawaz Z, Tsai SY, Tsai MJ, O'Malley BW. The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12195-9. PMID: 8901556; PMCID: PMC37966.
      Citations: 17     Fields:    Translation:HumansCells
    102. McKeehan K, McKeehan WI, Xu J, Liao L. Kinase-inactive splice variants of the activin type I receptor. In Vitro Cell Dev Biol Anim. 1996 Mar; 32(3):131-4. PMID: 8925134.
      Citations:    Fields:    Translation:Cells
    103. Feng S, Xu J, Wang F, Kan M, McKeehan WL. Nuclear localization of a complex of fibroblast growth factor(FGF)-1 and an NH2-terminal fragment of FGF receptor isoforms R4 and R1alpha in human liver cells. Biochim Biophys Acta. 1996 Jan 10; 1310(1):67-73. PMID: 9244177.
      Citations: 8     Fields:    Translation:HumansCells
    104. Wang F, Kan M, Xu J, Yan G, McKeehan WL. Ligand-specific structural domains in the fibroblast growth factor receptor. J Biol Chem. 1995 Apr 28; 270(17):10222-30. PMID: 7730326.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    105. Wang F, Kan M, Yan G, Xu J, McKeehan WL. Alternately spliced NH2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. J Biol Chem. 1995 Apr 28; 270(17):10231-5. PMID: 7730327.
      Citations: 41     Fields:    Translation:AnimalsCells
    106. Xu J, McKeehan K, Matsuzaki K, McKeehan WL. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 1995 Mar 17; 270(11):6308-13. PMID: 7890768.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    107. Prudovsky I, Savion N, Zhan X, Friesel R, Xu J, Hou J, McKeehan WL, Maciag T. Intact and functional fibroblast growth factor (FGF) receptor-1 trafficks near the nucleus in response to FGF-1. J Biol Chem. 1994 Dec 16; 269(50):31720-4. PMID: 7527394.
      Citations: 13     Fields:    Translation:AnimalsCells
    108. Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan WL. Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):7957-61. PMID: 8058741; PMCID: PMC44523.
      Citations: 7     Fields:    Translation:HumansCells
    109. Shi E, Kan M, Xu J, Wang F, Hou J, McKeehan WL. Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol Cell Biol. 1993 Jul; 13(7):3907-18. PMID: 8321198; PMCID: PMC359927.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    110. Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M. A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor. J Biol Chem. 1993 Jun 15; 268(17):12719-23. PMID: 8389764.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    111. Kan M, Wang F, Xu J, Crabb JW, Hou J, McKeehan WL. An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science. 1993 Mar 26; 259(5103):1918-21. PMID: 8456318.
      Citations: 87     Fields:    Translation:HumansCells
    112. Hou J, Kan M, Wang F, Xu JM, Nakahara M, McBride G, McKeehan K, McKeehan WL. Substitution of putative half-cystine residues in heparin-binding fibroblast growth factor receptors. Loss of binding activity in both two and three loop isoforms. J Biol Chem. 1992 Sep 05; 267(25):17804-8. PMID: 1325450.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    113. Xu J, Nakahara M, Crabb JW, Shi E, Matuo Y, Fraser M, Kan M, Hou J, McKeehan WL. Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms. J Biol Chem. 1992 Sep 05; 267(25):17792-803. PMID: 1325449.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    114. Kan M, Yan GC, Xu J, Nakahara M, Hou J. Receptor phenotype underlies differential response of hepatocytes and nonparenchymal cells to heparin-binding fibroblast growth factor type 1 (aFGF) and type 2 (bFGF). In Vitro Cell Dev Biol. 1992 Jul-Aug; 28A(7-8):515-20. PMID: 1381709.
      Citations: 5     Fields:    Translation:AnimalsCells
    115. Shi E, Kan M, Xu JM, McKeehan WL. 16-kilodalton heparin binding (fibroblast) growth factor type one appears in a stable 40-kilodalton complex after receptor-dependent internalization. J Biol Chem. 1991 Mar 25; 266(9):5774-9. PMID: 2005115.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
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