Nuclear Receptor Coactivator 3
"Nuclear Receptor Coactivator 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
| Descriptor ID |
D056921
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| MeSH Number(s) |
D08.811.913.050.134.415.500.150 D12.644.360.024.314.300 D12.776.157.057.080.300 D12.776.476.024.394.300 D12.776.660.675.300 D12.776.930.617.300
|
| Concept/Terms |
Nuclear Receptor Coactivator 3- Nuclear Receptor Coactivator 3
- Thyroid Hormone Receptor Activator Molecule 1
- Amplified in Breast Cancer-1 Protein
- Amplified in Breast Cancer 1 Protein
- Steroid Receptor Coactivator 3
- Nuclear Receptor Coactivator-3
- Receptor-Associated Coactivator 3
- Receptor Associated Coactivator 3
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivator 3".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivator 3".
This graph shows the total number of publications written about "Nuclear Receptor Coactivator 3" by people in this website by year, and whether "Nuclear Receptor Coactivator 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 6 | 6 |
| 2003 | 0 | 8 | 8 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 9 | 9 |
| 2006 | 0 | 10 | 10 |
| 2007 | 0 | 7 | 7 |
| 2008 | 0 | 12 | 12 |
| 2009 | 1 | 6 | 7 |
| 2010 | 10 | 1 | 11 |
| 2011 | 4 | 1 | 5 |
| 2012 | 5 | 0 | 5 |
| 2013 | 3 | 3 | 6 |
| 2014 | 5 | 1 | 6 |
| 2015 | 6 | 0 | 6 |
| 2016 | 2 | 0 | 2 |
| 2017 | 3 | 2 | 5 |
| 2018 | 4 | 0 | 4 |
| 2019 | 0 | 1 | 1 |
| 2020 | 2 | 1 | 3 |
| 2021 | 3 | 2 | 5 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Nuclear Receptor Coactivator 3" by people in Profiles.
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Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 04 11; 67(7):5333-5350.
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Steroid receptor coactivator 3 is a key modulator of regulatory T cell-mediated tumor evasion. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2221707120.
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Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 10 31; 24(1):73.
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Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670.
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A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399.
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Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).
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Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.
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Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441.
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Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 01 01; 81(1):50-63.
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Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. Mol Cell. 2020 09 03; 79(5):812-823.e4.