"beta-Lactamases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
| Descriptor ID |
D001618
|
| MeSH Number(s) |
D08.811.277.087.180
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "beta-Lactamases".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactamases".
This graph shows the total number of publications written about "beta-Lactamases" by people in this website by year, and whether "beta-Lactamases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 5 | 0 | 5 |
| 1995 | 2 | 0 | 2 |
| 1996 | 4 | 0 | 4 |
| 1997 | 2 | 0 | 2 |
| 1998 | 3 | 2 | 5 |
| 1999 | 2 | 2 | 4 |
| 2000 | 1 | 1 | 2 |
| 2001 | 3 | 2 | 5 |
| 2002 | 3 | 0 | 3 |
| 2003 | 3 | 2 | 5 |
| 2004 | 4 | 1 | 5 |
| 2005 | 3 | 0 | 3 |
| 2007 | 5 | 2 | 7 |
| 2008 | 2 | 0 | 2 |
| 2009 | 4 | 2 | 6 |
| 2010 | 2 | 1 | 3 |
| 2011 | 6 | 2 | 8 |
| 2012 | 5 | 2 | 7 |
| 2013 | 3 | 3 | 6 |
| 2014 | 3 | 1 | 4 |
| 2015 | 6 | 1 | 7 |
| 2016 | 5 | 2 | 7 |
| 2017 | 7 | 3 | 10 |
| 2018 | 4 | 0 | 4 |
| 2019 | 2 | 4 | 6 |
| 2020 | 5 | 5 | 10 |
| 2021 | 4 | 4 | 8 |
| 2022 | 2 | 4 | 6 |
| 2023 | 2 | 8 | 10 |
| 2024 | 1 | 3 | 4 |
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Below are the most recent publications written about "beta-Lactamases" by people in Profiles.
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Penicillin susceptibility among Staphylococcus aureus skin and soft tissue infections at a children's hospital. Microbiol Spectr. 2024 Oct 03; 12(10):e0086924.
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Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12):e2313513121.
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The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 Mar 06; 68(3):e0110823.
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Structural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185. mBio. 2024 Feb 14; 15(2):e0287423.
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Exploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 01 11; 67(1):620-642.
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Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 Jan; 300(1):105493.
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Genetic determinants underlying the progressive phenotype of ?-lactam/?-lactamase inhibitor resistance in Escherichia coli. Microbiol Spectr. 2023 Dec 12; 11(6):e0222123.
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High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated ?-lactamase CMY-185 variant. J Antimicrob Chemother. 2023 10 03; 78(10):2442-2450.
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Temporal dynamics of genetically heterogeneous extended-spectrum cephalosporin-resistant Escherichia coli bloodstream infections. mSphere. 2023 08 24; 8(4):e0018323.
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Older patient age and prior antimicrobial use strongly predict antimicrobial resistance in Escherichia coli isolates recovered from urinary tract infections among female outpatients. PLoS One. 2023; 18(5):e0285427.