"Histone Deacetylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
| Descriptor ID |
D006655
|
| MeSH Number(s) |
D08.811.277.087.520
|
| Concept/Terms |
Histone Deacetylases- Histone Deacetylases
- Deacetylases, Histone
- Histone Deacetylase
- Deacetylase, Histone
- HDAC Proteins
|
Below are MeSH descriptors whose meaning is more general than "Histone Deacetylases".
Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylases".
This graph shows the total number of publications written about "Histone Deacetylases" by people in this website by year, and whether "Histone Deacetylases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 2 | 2 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 4 | 1 | 5 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 8 | 9 |
| 2010 | 3 | 4 | 7 |
| 2011 | 6 | 3 | 9 |
| 2012 | 4 | 4 | 8 |
| 2013 | 3 | 5 | 8 |
| 2014 | 4 | 1 | 5 |
| 2015 | 1 | 4 | 5 |
| 2016 | 2 | 5 | 7 |
| 2017 | 2 | 1 | 3 |
| 2018 | 2 | 1 | 3 |
| 2019 | 4 | 1 | 5 |
| 2020 | 3 | 0 | 3 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 2 | 1 | 3 |
| 2025 | 1 | 2 | 3 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "Histone Deacetylases" by people in Profiles.
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HDAC3 promotes Sertoli cell maturation and maintains the blood-testis barrier dynamics. FASEB J. 2024 03 15; 38(5):e23526.
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HDAC3 controls male fertility through enzyme-independent transcriptional regulation at the meiotic exit of spermatogenesis. Nucleic Acids Res. 2021 05 21; 49(9):5106-5123.
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Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism. Nat Commun. 2021 03 31; 12(1):1981.
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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. 2019 11 11; 36(5):528-544.e10.
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The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism. J Mol Cell Biol. 2019 02 01; 11(2):133-143.
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Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis. EBioMedicine. 2019 Feb; 40:717-732.
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In Vitro Anticancer Properties of Table Grape Powder Extract (GPE) in Prostate Cancer. Nutrients. 2018 Nov 20; 10(11).
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Copper oxide nanoparticles induce anticancer activity in A549 lung cancer cells by inhibition of histone deacetylase. Biotechnol Lett. 2018 Feb; 40(2):249-256.
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Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018 08 15; 471:22-32.
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The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo. Oncotarget. 2017 Mar 07; 8(10):16367-16386.