"beta-Lactam Resistance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.
| Descriptor ID |
D018440
|
| MeSH Number(s) |
G06.099.225.500 G06.225.347.500 G07.690.773.984.269.347.500
|
| Concept/Terms |
beta-Lactam Resistance- beta-Lactam Resistance
- beta Lactam Resistance
- beta-Lactamase Resistant
- Resistant, beta-Lactamase
- beta Lactamase Resistant
- beta-Lactam Resistant
- beta Lactam Resistant
- beta-Lactamase Resistance
- Resistance, beta-Lactamase
- beta Lactamase Resistance
|
Below are MeSH descriptors whose meaning is more general than "beta-Lactam Resistance".
Below are MeSH descriptors whose meaning is more specific than "beta-Lactam Resistance".
This graph shows the total number of publications written about "beta-Lactam Resistance" by people in this website by year, and whether "beta-Lactam Resistance" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 1 | 3 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 3 | 0 | 3 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 1 | 3 |
| 2017 | 3 | 0 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 3 | 1 | 4 |
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Below are the most recent publications written about "beta-Lactam Resistance" by people in Profiles.
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KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155.
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A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255.
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Urine zinc concentrations allow proper expression of metallo-?-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2020 10 01; 75(10):3077-3079.
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Antagonism between substitutions in ?-lactamase explains a path not taken in the evolution of bacterial drug resistance. J Biol Chem. 2020 05 22; 295(21):7376-7390.
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Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-?-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient. Antimicrob Agents Chemother. 2020 03 24; 64(4).
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A Standard Numbering Scheme for Class C ?-Lactamases. Antimicrob Agents Chemother. 2020 02 21; 64(3).
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What the Clinical Microbiologist Should Know About Pharmacokinetics/Pharmacodynamics in the Era of Emerging Multidrug Resistance: Focusing on ?-Lactam/?-Lactamase Inhibitor Combinations. Clin Lab Med. 2019 09; 39(3):473-485.
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Carbapenemases among Acinetobacter species isolated from NICU of a tertairy care hospital in Karachi. J Pak Med Assoc. 2017 Oct; 67(10):1547-1551.
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Whole-Genome Sequencing Accurately Identifies Resistance to Extended-Spectrum ?-Lactams for Major Gram-Negative Bacterial Pathogens. Clin Infect Dis. 2017 09 01; 65(5):738-745.
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Determining ?-lactam exposure threshold to suppress resistance development in Gram-negative bacteria. J Antimicrob Chemother. 2017 05 01; 72(5):1421-1428.