"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
| Descriptor ID |
D056926
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
|
| Concept/Terms |
CLOCK Proteins- CLOCK Proteins
- Circadian Locomotor Output Cycles Kaput Proteins
- CLOCK Protein
|
Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".
Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".
This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 2 | 4 |
| 2013 | 3 | 2 | 5 |
| 2014 | 1 | 3 | 4 |
| 2015 | 2 | 2 | 4 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.
-
Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer Discov. 2020 03; 10(3):371-381.
-
Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep. 2018 12 18; 25(12):3299-3314.e6.
-
The genomic basis of circadian and circalunar timing adaptations in a midge. Nature. 2016 12 01; 540(7631):69-73.
-
Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice. Endocrinology. 2016 Feb; 157(2):913-27.
-
Circadian Dysfunction Induces Leptin Resistance in Mice. Cell Metab. 2015 Sep 01; 22(3):448-59.
-
GENE REGULATION. Discrete functions of nuclear receptor Rev-erba couple metabolism to the clock. Science. 2015 Jun 26; 348(6242):1488-92.
-
Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Mol Psychiatry. 2015 Nov; 20(11):1406-19.
-
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan; 101(1):135-43.
-
Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2. Biol Psychiatry. 2015 Mar 01; 77(5):425-433.
-
WIDE AWAKE mediates the circadian timing of sleep onset. Neuron. 2014 Apr 02; 82(1):151-66.