"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
| Descriptor ID |
D056926
|
| MeSH Number(s) |
D08.811.913.050.134.415.500.049 D12.644.128.100 D12.776.189.200 D12.776.260.103.562 D12.776.930.125.562
|
| Concept/Terms |
CLOCK Proteins- CLOCK Proteins
- Circadian Locomotor Output Cycles Kaput Proteins
- CLOCK Protein
|
Below are MeSH descriptors whose meaning is more general than "CLOCK Proteins".
Below are MeSH descriptors whose meaning is more specific than "CLOCK Proteins".
This graph shows the total number of publications written about "CLOCK Proteins" by people in this website by year, and whether "CLOCK Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 3 | 3 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 2 | 4 |
| 2016 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "CLOCK Proteins" by people in Profiles.
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The Polymethoxyflavone Sudachitin Modulates the Circadian Clock and Improves Liver Physiology. Mol Nutr Food Res. 2023 05; 67(9):e2200270.
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Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022 06 03; 10(6):770-784.
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Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer Discov. 2020 03; 10(3):371-381.
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Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock. Cancer Discov. 2019 11; 9(11):1556-1573.
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Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters. Elife. 2019 07 11; 8.
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The Nuclear Receptor and Clock Repressor Rev-erba Suppresses Myogenesis. Sci Rep. 2019 03 14; 9(1):4585.
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Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep. 2018 12 18; 25(12):3299-3314.e6.
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The genomic basis of circadian and circalunar timing adaptations in a midge. Nature. 2016 12 01; 540(7631):69-73.
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Conditional Deletion of Bmal1 in Ovarian Theca Cells Disrupts Ovulation in Female Mice. Endocrinology. 2016 Feb; 157(2):913-27.
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Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock ?19/+ mice contributes to improved glucose homeostasis. Sci Rep. 2015 Jul 31; 5:12801.