T-Cell Acute Lymphocytic Leukemia Protein 1
"T-Cell Acute Lymphocytic Leukemia Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix transcription factor that plays a critical role in HEMATOPOIESIS and as a positive regulator in the differentiation of ERYTHROID CELLS. Chromosome translocations involving the TAL-1 gene are associated with T-CELL ACUTE LYMPHOCYTIC LEUKEMIA.
| Descriptor ID |
D000073942
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| MeSH Number(s) |
D12.776.260.103.829 D12.776.624.664.700.960 D12.776.930.125.829
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "T-Cell Acute Lymphocytic Leukemia Protein 1".
Below are MeSH descriptors whose meaning is more specific than "T-Cell Acute Lymphocytic Leukemia Protein 1".
This graph shows the total number of publications written about "T-Cell Acute Lymphocytic Leukemia Protein 1" by people in this website by year, and whether "T-Cell Acute Lymphocytic Leukemia Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "T-Cell Acute Lymphocytic Leukemia Protein 1" by people in Profiles.
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Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children. J Natl Cancer Inst. 2019 12 01; 111(12):1350-1357.
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Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53.
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Stress hematopoiesis is regulated by the Kr?ppel-like transcription factor ZBP-89. Stem Cells. 2014 Mar; 32(3):791-801.
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Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. J Biol Chem. 2013 Nov 29; 288(48):34719-28.
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SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood. 2011 Jul 21; 118(3):723-35.
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Systematic identification of transcription factors associated with patient survival in cancers. BMC Genomics. 2009 May 15; 10:225.
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Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009 Feb 06; 4(2):180-6.
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Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP. J Biol Chem. 2008 Jan 11; 283(2):684-92.
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Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood. 2006 Aug 01; 108(3):986-92.
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The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res. 2005 Sep 01; 65(17):7596-602.