Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
| Descriptor ID |
D019860
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| MeSH Number(s) |
D08.811.913.696.620.682.725.800.315 D12.776.624.664.700.128
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| Concept/Terms |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- p56 lck
- Proto-Oncogene Protein c-lck
- Protein c-lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- c-lck, Proto-Oncogene Protein
- Proto-Oncogene Protein lck
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein lck
- lck, Proto-Oncogene Protein
- lck Kinase
- Kinase, lck
- Protein Tyrosine Kinase p56(lck)
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in this website by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.
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The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration. Blood. 2007 Jun 15; 109(12):5122-8.
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Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006 Apr; 7(4):411-7.
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T-cell receptor/CD28 engagement when combined with prostaglandin E2 treatment leads to potent activation of human T-cell leukemia virus type 1. J Virol. 2003 Oct; 77(20):11170-9.
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SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem. 1999 Sep 24; 274(39):27583-9.
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Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase. J Immunol. 1998 Nov 15; 161(10):5404-12.
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Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem J. 1998 Mar 15; 330 ( Pt 3):1123-8.
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CD28-dependent killing by human YT cells requires phosphatidylinositol 3-kinase activation. Eur J Immunol. 1996 Jun; 26(6):1278-84.
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Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J Biol Chem. 1996 Mar 22; 271(12):7079-83.
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CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide-3 kinase correlate with Ca(2+)-independent costimulatory activity. Eur J Immunol. 1994 Nov; 24(11):2732-9.
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Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells. Eur J Immunol. 1993 Oct; 23(10):2488-97.