"src-Family Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.
| Descriptor ID |
D019061
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.800
|
| Concept/Terms |
src-Family Kinases- src-Family Kinases
- src Family Kinases
- src-Family Tyrosine Kinases
- Tyrosine Kinases, src-Family
- src Family Tyrosine Kinases
- src Tyrosine Kinases
- Kinases, src Tyrosine
- Tyrosine Kinases, src
- Protein-Tyrosine Kinases, src
- Kinases, src Protein-Tyrosine
- src Protein-Tyrosine Kinases
- src Kinases
- Kinases, src
|
Below are MeSH descriptors whose meaning is more general than "src-Family Kinases".
Below are MeSH descriptors whose meaning is more specific than "src-Family Kinases".
This graph shows the total number of publications written about "src-Family Kinases" by people in this website by year, and whether "src-Family Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 1 | 3 |
| 1996 | 6 | 2 | 8 |
| 1997 | 3 | 1 | 4 |
| 1998 | 2 | 0 | 2 |
| 1999 | 4 | 2 | 6 |
| 2000 | 2 | 5 | 7 |
| 2001 | 3 | 6 | 9 |
| 2002 | 1 | 5 | 6 |
| 2003 | 5 | 5 | 10 |
| 2004 | 5 | 4 | 9 |
| 2005 | 8 | 8 | 16 |
| 2006 | 8 | 13 | 21 |
| 2007 | 11 | 8 | 19 |
| 2008 | 7 | 1 | 8 |
| 2009 | 12 | 6 | 18 |
| 2010 | 9 | 10 | 19 |
| 2011 | 9 | 8 | 17 |
| 2012 | 3 | 6 | 9 |
| 2013 | 10 | 4 | 14 |
| 2014 | 5 | 7 | 12 |
| 2015 | 3 | 2 | 5 |
| 2016 | 6 | 5 | 11 |
| 2017 | 5 | 5 | 10 |
| 2018 | 3 | 2 | 5 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 4 | 5 |
| 2021 | 2 | 0 | 2 |
| 2022 | 1 | 2 | 3 |
| 2024 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "src-Family Kinases" by people in Profiles.
-
Using machine learning to dissect host kinases required for Leishmania internalization and development. Mol Biochem Parasitol. 2024 12; 260:111651.
-
Inhibition of glycolysis and Src/Akt signaling reduces Caveolin-1-enhanced metastasis. Biomed Pharmacother. 2024 Jul; 176:116841.
-
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 12 15; 206(12):1463-1479.
-
Engineered kinases as a tool for phosphorylation of selected targets in vivo. J Cell Biol. 2022 10 03; 221(10).
-
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Sci Signal. 2022 05 10; 15(733):eabh3066.
-
Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. Bioorg Chem. 2021 11; 116:105344.
-
SRC Signaling in Cancer and Tumor Microenvironment. Adv Exp Med Biol. 2021; 1270:57-71.
-
The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis. Oncogene. 2021 01; 40(2):384-395.
-
Therapeutic role of recurrent ESR1-CCDC170 gene fusions in breast cancer endocrine resistance. Breast Cancer Res. 2020 08 08; 22(1):84.
-
PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation. Commun Biol. 2020 08 05; 3(1):428.