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TIEMO KLISCH

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
Address1250 MOURSUND STREET
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pugazenthi S, Patel B, English CW, Leidig WA, McGeehan KP, McCornack CR, Mok S, Anzaldua-Campos M, Nouri SH, Roberts K, Chatrath A, Khan A, Gadot R, Yano H, Klisch TJ, Harmanci AS, Patel AJ, Kim AH. Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution. Sci Adv. 2024 Oct 25; 10(43):eadn4419. PMID: 39441930; PMCID: PMC11498213.
      Citations:    Fields:    Translation:HumansCells
    2. Shetty A, Wang S, Khan AB, English CW, Nouri SH, Magill ST, Raleigh DR, Klisch TJ, Harmanci AO, Patel AJ, Harmanci AS. Correction to: Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data. J Neurooncol. 2024 Jul; 168(3):525. PMID: 38834749.
      Citations:    Fields:    
    3. Shetty A, Wang S, Khan AB, English CW, Nouri SH, Magill ST, Raleigh DR, Klisch TJ, Harmanci AO, Patel AJ, Harmanci AS. Leveraging single-cell sequencing to classify and characterize tumor subgroups in bulk RNA-sequencing data. J Neurooncol. 2024 Jul; 168(3):515-524. PMID: 38811523.
      Citations:    Fields:    Translation:HumansCells
    4. Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC. Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome. Cell Genom. 2024 Jun 12; 4(6):100566. PMID: 38788713; PMCID: PMC11228955.
      Citations: 3     Fields:    Translation:HumansCells
    5. Harmanci AS, Boudreau B, Lau S, Hosseingholi Nouri S, Mandel JJ, Lu HC, Harmanci AO, Klisch TJ, Levine JM, Patel AJ. Aggressive human MenG C meningiomas have a molecular counterpart in canines. Acta Neuropathol. 2024 02 20; 147(1):42. PMID: 38376654.
      Citations: 1     Fields:    Translation:HumansAnimals
    6. Mirian C, Jensen LR, Juratli TA, Maier AD, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, G?resir E, Yamamoto J, Kim YZ, Lee JH, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Ey?poglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Guo F, G?es P, de Paiva Neto MA, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Broechner A, Bach MJ, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T. The importance of considering competing risks in recurrence analysis of intracranial meningioma. J Neurooncol. 2024 Feb; 166(3):503-511. PMID: 38336917; PMCID: PMC10876814.
      Citations:    Fields:    Translation:Humans
    7. Chen WC, Choudhury A, Youngblood MW, Polley MC, Mirchia K, Suwala AK, Won M, Harmanci AS, Klisch TJ, Nguyen MP, Vasudevan HN, McCortney K, Yu TJ, Bhave V, Chan JW, Perlow HK, Palmer JD, Haberler C, Berghoff AS, Preusser M, Nicolaides TP, Mawrin C, Agnihotri S, Resnick A, Rood BR, Chew J, Young JS, Boreta L, Braunstein SE, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer JE, Chandler JP, Solomon DA, Rogers CL, Pugh SL, Mehta MP, Sneed PK, Berger MS, Horbinski CM, McDermott MW, Perry A, Bi WL, Sahm F, Magill ST, Raleigh DR, Lucas CG, Maas SLN, Bayley JC, Harmanci AO, Lam TC, Pu JK, Li LF, Leung GK, Patel AJ. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Nat Med. 2023 Dec; 29(12):3067-3076. PMID: 37944590; PMCID: PMC11073469.
      Citations: 4     Fields:    Translation:Humans
    8. Khan AB, Patel R, McDonald MF, Goethe E, English C, Gadot R, Shetty A, Nouri SH, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ. Integrated clinical genomic analysis reveals xenobiotic metabolic genes are downregulated in meningiomas of current smokers. J Neurooncol. 2023 Jun; 163(2):397-405. PMID: 37318677.
      Citations:    Fields:    Translation:Humans
    9. Raleigh D, Chen W, Choudhury A, Youngblood M, Polley MY, Lucas CH, Mirchia K, Maas S, Suwala A, Won M, Bayley J, Harmanci A, Harmanci A, Klisch T, Nguyen M, Vasudevan H, McCortney K, Yu T, Bhave V, Lam TC, Pu J, Leung G, Chang J, Perlow H, Palmer J, Haberler C, Berghoff A, Preusser M, Nicolaides T, Mawrin C, Agnihotri S, Resnick A, Rood B, Chew J, Young J, Boreta L, Braunstein S, Schulte J, Butowski N, Santagata S, Spetzler D, Bush NAO, Villanueva-Meyer J, Chandler J, Solomon D, Rogers C, Pugh S, Mehta M, Sneed P, Berger M, Horbinski C, McDermott M, Perry A, Bi W, Patel A, Sahm F, Magill S. Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses. Res Sq. 2023 Mar 20. PMID: 36993741; PMCID: PMC10055655.
      Citations:    
    10. Bayley JC, Harmanci AS, Santagata S, Klisch T, Perry A, Bi WL, Sahm F, Magill ST, Choudhury A, Chen WC, Lucas CG, Maas SLN, Patel AJ, Raleigh DR. Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol. 2023 03 14; 25(3):520-530. PMID: 36227281; PMCID: PMC10013643.
      Citations: 9     Fields:    Translation:HumansCells
    11. Khan AB, English CW, Chen WC, Athukuri P, Bayley JC, Brandt VL, Shetty A, Hadley CC, Choudhury A, Lu HC, Harmanci AO, Harmanci AS, Magill ST, Raleigh DR, Klisch TJ, Patel AJ. Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma. Acta Neuropathol. 2023 04; 145(4):501-503. PMID: 36729132; PMCID: PMC10323927.
      Citations: 4     Fields:    Translation:Humans
    12. Harmanci A, Harmanci AS, Klisch TJ, Patel AJ. XCVATR: detection and characterization of variant impact on the Embeddings of single -cell and bulk RNA-sequencing samples. BMC Genomics. 2022 Dec 20; 23(1):841. PMID: 36539717; PMCID: PMC9764736.
      Citations:    Fields:    
    13. Bayley JC, Hadley CC, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ. Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies. Sci Adv. 2022 02 04; 8(5):eabm6247. PMID: 35108039; PMCID: PMC11313601.
      Citations: 3     Fields:    Translation:HumansCells
    14. Jackson HN, Hadley CC, Khan AB, Gadot R, Bayley JC, Shetty A, Mandel J, Jalali A, Gallagher KK, Sweeney AD, Harmanci AO, Harmanci AS, Klisch T, Gopinath SP, Rao G, Yoshor D, Patel AJ. Racial and Socioeconomic Disparities in Patients With Meningioma: A Retrospective Cohort Study. Neurosurgery. 2022 01 01; 90(1):114-123. PMID: 34982878; PMCID: PMC9514723.
      Citations:    Fields:    Translation:Humans
    15. Gadot R, Khan AB, Patel R, Goethe E, Shetty A, Hadley CC, V JCB, Harmanci AS, Klisch TJ, Yoshor D, Sheth SA, Patel AJ. Predictors of postoperative seizure outcome in supratentorial meningioma. J Neurosurg. 2022 Aug 01; 137(2):515-524. PMID: 35099915.
      Citations: 2     Fields:    
    16. Khan AB, Gadot R, Shetty A, Bayley JC, Hadley CC, Cardenas MF, Jalali A, Harmanci AS, Harmanci AO, Wheeler DA, Klisch TJ, Patel AJ. Identification of novel fusion transcripts in meningioma. J Neurooncol. 2020 Sep; 149(2):219-230. PMID: 32949309; PMCID: PMC7553203.
      Citations:    Fields:    Translation:Humans
    17. Zhang H, Qi L, Du Y, Huang LF, Braun FK, Kogiso M, Zhao Y, Li C, Lindsay H, Zhao S, Injac SG, Baxter PA, Su JM, Stephan C, Keller C, Heck KA, Harmanci A, Harmanci AO, Yang J, Klisch TJ, Li XN, Patel AJ. Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma. Cancers (Basel). 2020 Jun 05; 12(6). PMID: 32517016; PMCID: PMC7352400.
      Citations: 5     
    18. Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, Settembre C, Finegold MJ, Forbes SJ, Ballabio A. TFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 05 18; 11(1):2461. PMID: 32424153; PMCID: PMC7235048.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Lee S, Karas PJ, Hadley CC, Bayley V JC, Khan AB, Jalali A, Sweeney AD, Klisch TJ, Patel AJ. The Role of Merlin/NF2 Loss in Meningioma Biology. Cancers (Basel). 2019 Oct 24; 11(11). PMID: 31652973; PMCID: PMC6893739.
      Citations: 11     
    20. Patel AJ, Wan YW, Al-Ouran R, Revelli JP, Cardenas MF, Oneissi M, Xi L, Jalali A, Magnotti JF, Muzny DM, Doddapaneni H, Sebastian S, Heck KA, Goodman JC, Gopinath SP, Liu Z, Rao G, Plon SE, Yoshor D, Wheeler DA, Zoghbi HY, Klisch TJ. Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21715-21726. PMID: 31591222; PMCID: PMC6815170.
      Citations: 35     Fields:    Translation:HumansCells
    21. Pastore N, Vainshtein A, Herz NJ, Huynh T, Brunetti L, Klisch TJ, Mutarelli M, Annunziata P, Kinouchi K, Brunetti-Pierri N, Sassone-Corsi P, Ballabio A. Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock. EMBO J. 2019 06 17; 38(12). PMID: 31126958; PMCID: PMC6576167.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    22. Bayley V JC, Goethe EA, Srinivasan VM, Klisch TJ, Mandel JJ, Patel AJ. Newly Diagnosed Optic Pathway Glioma During Pregnancy. World Neurosurg. 2019 Jul; 127:58-62. PMID: 30878749.
      Citations: 1     Fields:    Translation:Humans
    23. Pal R, Palmieri M, Chaudhury A, di Ronza A, Neilson JR, Rodney GG, Sardiello M, Klisch TJ. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 10 19; 9(1):4351. PMID: 30341294; PMCID: PMC6195609.
      Citations: 15     Fields:    Translation:Cells
    24. Klisch TJ, Vainshtein A, Patel AJ, Zoghbi HY. Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth. Elife. 2017 11 23; 6. PMID: 29168692; PMCID: PMC5736349.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    25. Lombardi LM, Zaghlula M, Sztainberg Y, Baker SA, Klisch TJ, Tang AA, Huang EJ, Zoghbi HY. An RNA interference screen identifies druggable regulators of MeCP2 stability. Sci Transl Med. 2017 Aug 23; 9(404). PMID: 28835516; PMCID: PMC5736385.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Xie WR, Jen HI, Seymour ML, Yeh SY, Pereira FA, Groves AK, Klisch TJ, Zoghbi HY. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017 09 06; 37(36):8583-8594. PMID: 28729444; PMCID: PMC6596675.
      Citations: 13     Fields:    Translation:AnimalsCells
    27. Beechar VB, Srinivasan VM, Reznik OE, Sen A, Klisch TJ, Ropper AE, Mandel JJ, Heck KA, Seipel TJ, Patel AJ. Intraventricular Cavernomas of the Third Ventricle: Report of 2 Cases and a Systematic Review of the Literature. World Neurosurg. 2017 Sep; 105:935-943.e3. PMID: 28648908.
      Citations: 3     Fields:    Translation:Humans
    28. Pastore N, Vainshtein A, Klisch TJ, Armani A, Huynh T, Herz NJ, Polishchuk EV, Sandri M, Ballabio A. TFE3 regulates whole-body energy metabolism in cooperation with TFEB. EMBO Mol Med. 2017 05; 9(5):605-621. PMID: 28283651; PMCID: PMC5412821.
      Citations: 40     Fields:    Translation:AnimalsCells
    29. Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 2016 10 25; 5. PMID: 27779468; PMCID: PMC5104516.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    30. Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF. Transcriptional Regulation by ATOH1 and its Target SPDEF in?the?Intestine. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):51-71. PMID: 28174757; PMCID: PMC5247424.
      Citations: 29     Fields:    
    31. Quan XJ, Yuan L, Claeys A, De Geest N, Yan J, van der Kant R, Xie WR, Klisch TJ, Shymkowitz J, Rousseau F, Bollen M, Beullens M, Zoghbi HY, Hassan BA, Tiberi L, Vanderhaeghen P. Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis. Cell. 2016 Jan 28; 164(3):460-75. PMID: 26824657.
      Citations: 26     Fields:    Translation:AnimalsCells
    32. Cai T, Jen HI, Kang H, Klisch TJ, Zoghbi HY, Groves AK. Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor. J Neurosci. 2015 Apr 08; 35(14):5870-83. PMID: 25855195; PMCID: PMC4388939.
      Citations: 76     Fields:    Translation:AnimalsCells
    33. Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A, Klisch TJ. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013 Jun; 15(6):647-58. PMID: 23604321; PMCID: PMC3699877.
      Citations: 449     Fields:    Translation:HumansAnimalsCells
    34. Huang WH, Tupal S, Huang TW, Ward CS, Neul JL, Klisch TJ, Gray PA, Zoghbi HY. Atoh1 governs the migration of postmitotic neurons that shape respiratory effectiveness at birth and chemoresponsiveness in adulthood. Neuron. 2012 Sep 06; 75(5):799-809. PMID: 22958821; PMCID: PMC3464459.
      Citations: 29     Fields:    Translation:HumansAnimals
    35. Bjerknes M, Khandanpour C, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Cheng H, M?r?y T, Mart?n MG. Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol. 2012 Feb 15; 362(2):194-218. PMID: 22185794; PMCID: PMC6050067.
      Citations: 56     Fields:    Translation:AnimalsCells
    36. Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. J Neurosci. 2011 Jul 27; 31(30):10859-71. PMID: 21795538; PMCID: PMC3153066.
      Citations: 29     Fields:    Translation:AnimalsCells
    37. Klisch TJ, Xi Y, Flora A, Wang L, Li W, Zoghbi HY. In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3288-93. PMID: 21300888; PMCID: PMC3044384.
      Citations: 77     Fields:    Translation:AnimalsCells
    38. Flora A, Klisch TJ, Schuster G, Zoghbi HY. Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science. 2009 Dec 04; 326(5958):1424-7. PMID: 19965762; PMCID: PMC3638077.
      Citations: 84     Fields:    Translation:AnimalsCells
    39. Rose MF, Ren J, Ahmad KA, Chao HT, Klisch TJ, Flora A, Greer JJ, Zoghbi HY. Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12; 64(3):341-54. PMID: 19914183; PMCID: PMC2818435.
      Citations: 87     Fields:    Translation:AnimalsCells
    40. Miesegaes GR, Klisch TJ, Thaller C, Ahmad KA, Atkinson RC, Zoghbi HY. Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development. Dev Biol. 2009 Mar 15; 327(2):339-51. PMID: 19135992; PMCID: PMC2729134.
      Citations: 17     Fields:    Translation:AnimalsCells
    41. Souopgui J, Klisch TJ, Pieler T, Henningfeld KA. Expression and regulation of Xenopus CRMP-4 in the developing nervous system. Int J Dev Biol. 2007; 51(4):339-43. PMID: 17554687.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Souopgui J, Juergens K, Rust B, Pieler T, Henningfeld KA, Klisch TJ. Mxi1 is essential for neurogenesis in Xenopus and acts by bridging the pan-neural and proneural genes. Dev Biol. 2006 Apr 15; 292(2):470-85. PMID: 16457797.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Karabinos A, Schulze E, Klisch T, Wang J, Weber K. Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans. Mech Dev. 2002 Sep; 117(1-2):311-4. PMID: 12204276.
      Citations: 7     Fields:    Translation:AnimalsCells
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