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NOAH SHROYER

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    R01DK127037     (SAHIN, ERGUN)Jun 1, 2022 - Mar 31, 2027
    NIH
    Mechanisms of telomere-induced disease: Role of intestinal malabsorption, barrier dysfunction and dsybiosis.
    Role: Co-Principal Investigator
    R01DK118904     (SHROYER, NOAH FREEMAN)Sep 20, 2018 - Jun 30, 2021
    NIH
    Mechanisms of intestinal stem cell differentiation and plasticity.
    Role: Principal Investigator
    U01DK103117     (HELMRATH, MICHAEL A.)Sep 1, 2014 - Aug 31, 2024
    NIH
    Defining the intestinal stem cell niche during organoid development into a functional human intestine
    Role: Co-Principal Investigator
    R01DK092456     (WELLS, JAMES M)Apr 7, 2012 - Feb 28, 2018
    NIH
    Human Endocrine Cell Development
    Role: Co-Principal Investigator
    R01DK092306     (SHROYER, NOAH FREEMAN)Jul 5, 2011 - Jun 30, 2016
    NIH
    KLF5 regulation of intestinal development and stem cell homeostasis
    Role: Principal Investigator
    R01CA142826     (SHROYER, NOAH FREEMAN)Feb 23, 2010 - Jan 31, 2017
    NIH
    The role of ATOH1 as a tumor suppressor in colorectal cancer
    Role: Principal Investigator
    R03DK084167     (SHROYER, NOAH FREEMAN)Jul 15, 2009 - Jun 30, 2011
    NIH
    SPDEF in intestinal differentiation.
    Role: Principal Investigator
    K01DK071686     (SHROYER, NOAH FREEMAN)Aug 24, 2005 - Jul 31, 2009
    NIH
    Intestinal secretory lineage development and function
    Role: Principal Investigator
    F32DK063747     (SHROYER, NOAH FREEMAN)May 1, 2003 - Apr 30, 2005
    NIH
    Math1 in intestinal cell specification and function.
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deans-Fielder K, Wu T, Nguyen T, To S, Huang YZ, Bark SJ, Mills JC, Shroyer NF. Mechanisms driving fasting-induced protection from genotoxic injury in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2024 May 01; 326(5):G504-G524. PMID: 38349111; PMCID: PMC11376978.
      Citations: 1     Fields:    Translation:Animals
    2. Yue F, Ku AT, Stevens PD, Michalski MN, Jiang W, Tu J, Shi Z, Dou Y, Wang Y, Feng XH, Hostetter G, Wu X, Huang S, Shroyer NF, Zhang B, Williams BO, Liu Q, Lin X, Li Y. Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer. bioRxiv. 2024 Jan 11. PMID: 38260423; PMCID: PMC10802575.
      Citations: 1     
    3. Beanland BT, McNeill EP, Sequeira DJ, Xue H, Shroyer NF, Speer AL. Investigation of murine host sex as a biological variable in epithelial barrier function and muscle contractility in human intestinal organoids. FASEB J. 2022 11; 36(11):e22613. PMID: 36250916; PMCID: PMC9645459.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Tsai HY, Bronner MP, March JK, Valentine JF, Shroyer NF, Lai LA, Brentnall TA, Pan S, Chen R. Metabolic targeting of NRF2 potentiates the efficacy of the TRAP1 inhibitor G-TPP through reduction of ROS detoxification in colorectal cancer. Cancer Lett. 2022 11 28; 549:215915. PMID: 36113636; PMCID: PMC11262000.
      Citations:    
    5. Aita R, Aldea D, Hassan S, Hur J, Pellon-Cardenas O, Cohen E, Chen L, Shroyer N, Christakos S, Verzi MP, Fleet JC. Genomic analysis of 1,25-dihydroxyvitamin D3 action in mouse intestine reveals compartment and segment-specific gene regulatory effects. J Biol Chem. 2022 08; 298(8):102213. PMID: 35779631; PMCID: PMC9358460.
      Citations:    Fields:    
    6. McNeill EP, Gupta VS, Sequeira DJ, Shroyer NF, Speer AL. Evaluation of Murine Host Sex as a Biological Variable in Transplanted Human Intestinal Organoid Development. Dig Dis Sci. 2022 12; 67(12):5511-5521. PMID: 35334015; PMCID: PMC10251489.
      Citations:    Fields:    
    7. Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022 04; 42(4):381-394. PMID: 35172604; PMCID: PMC8957608.
      Citations:    Fields:    Translation:AnimalsCells
    8. Rosselot AE, Park M, Kim M, Matsu-Ura T, Wu G, Flores DE, Subramanian KR, Lee S, Sundaram N, Broda TR, McCauley HA, Hawkins JA, Chetal K, Salomonis N, Shroyer NF, Helmrath MA, Wells JM, Hogenesch JB, Moore SR, Hong CI. Ontogeny and function of the circadian clock in intestinal organoids. EMBO J. 2022 12 17; 41(2):e106973. PMID: 34704277; PMCID: PMC8762567.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Criss ZK, Bhasin N, Di Rienzi SC, Rajan A, Deans-Fielder K, Swaminathan G, Kamyabi N, Zeng XL, Doddapaneni H, Menon VK, Chakravarti D, Estrella C, Yu X, Patil K, Petrosino JF, Fleet JC, Verzi MP, Christakos S, Helmrath MA, Arimura S, DePinho RA, Britton RA, Maresso AW, Grande-Allen KJ, Blutt SE, Crawford SE, Estes MK, Ramani S, Shroyer NF. Drivers of transcriptional variance in human intestinal epithelial organoids. Physiol Genomics. 2021 11 01; 53(11):486-508. PMID: 34612061; PMCID: PMC8616596.
      Citations: 3     Fields:    Translation:HumansCells
    10. Shirwaikar Thomas A, Criss ZK, Shroyer NF, Abraham BP. Vitamin D Receptor Gene Single Nucleotide Polymorphisms and Association With Vitamin D Levels and Endoscopic Disease Activity in Inflammatory Bowel Disease Patients: A Pilot Study. Inflamm Bowel Dis. 2021 07 27; 27(8):1263-1269. PMID: 33165606; PMCID: PMC8785942.
      Citations: 2     Fields:    Translation:Humans
    11. Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA. Telomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). PMID: 34253611; PMCID: PMC8307535.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Swaminathan G, Kamyabi N, Carter HE, Rajan A, Karandikar U, Criss ZK, Shroyer NF, Robertson MJ, Coarfa C, Huang C, Shannon TE, Tadros M, Estes MK, Maresso AW, Grande-Allen KJ. Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli. Acta Biomater. 2021 09 15; 132:245-259. PMID: 34280559; PMCID: PMC8434991.
      Citations: 1     Fields:    Translation:HumansCells
    13. Olvera A, Carter H, Rajan A, Carlin LG, Yu X, Zeng XL, Shelburne S, Bhatti M, Blutt SE, Shroyer NF, Jenq R, Estes MK, Maresso A, Okhuysen PC. Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clin Infect Dis. 2021 05 18; 72(10):e620-e629. PMID: 32930708; PMCID: PMC8130029.
      Citations: 2     Fields:    Translation:HumansCells
    14. Li S, De La Cruz J, Hutchens S, Mukhopadhyay S, Criss ZK, Aita R, Pellon-Cardenas O, Hur J, Soteropoulos P, Husain S, Dhawan P, Verlinden L, Carmeliet G, Fleet JC, Shroyer NF, Verzi MP, Christakos S. Analysis of 1,25-Dihydroxyvitamin D3 Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids. Mol Cell Biol. 2020 12 21; 41(1). PMID: 33139494; PMCID: PMC7849401.
      Citations: 7     Fields:    Translation:HumansAnimals
    15. Boyle MA, Sequeira DJ, McNeill EP, Criss ZK, Shroyer NF, Speer AL. In?Vivo Transplantation of Human Intestinal Organoids Enhances Select Tight Junction Gene Expression. J Surg Res. 2021 03; 259:500-508. PMID: 33168233; PMCID: PMC8634850.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AW, Margalef-Catal? M. Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog. 2020 09; 16(9):e1008851. PMID: 32986782; PMCID: PMC7553275.
      Citations: 12     Fields:    Translation:HumansCells
    17. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 09 21; 11(1):4766. PMID: 32958778; PMCID: PMC7505960.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Engevik MA, Luck B, Visuthranukul C, Ihekweazu FD, Engevik AC, Shi Z, Danhof HA, Chang-Graham AL, Hall A, Endres BT, Haidacher SJ, Horvath TD, Haag AM, Devaraj S, Garey KW, Britton RA, Hyser JM, Shroyer NF, Versalovic J. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis. Cell Mol Gastroenterol Hepatol. 2021; 11(1):221-248. PMID: 32795610; PMCID: PMC7683275.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    19. Hewes SA, Wilson RL, Estes MK, Shroyer NF, Blutt SE, Grande-Allen KJ. In Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions. Tissue Eng Part B Rev. 2020 08; 26(4):313-326. PMID: 32046599; PMCID: PMC7462033.
      Citations: 5     Fields:    Translation:HumansAnimals
    20. Hassan M, Moghadamrad S, Sorribas M, Muntet SG, Kellmann P, Nanni P, Wolski W, Keller I, Hapfelmeier S, Shroyer NF, Wiest R, Trentesaux C, Fraudeau M, Romagnolo B, De Gottardi A. Paneth cells promote angiogenesis and regulate portal hypertension?in response to microbial signals. J Hepatol. 2020 09; 73(3):628-639. PMID: 32205193.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, Chandra D, O'Connor MH, Mertelsmann AM, Vinci P, Kuttiyara J, Devlin SM, Middendorp S, Calafiore M, Egorova A, Kleppe M, Lo Y, Shroyer NF, Cheng EH, Levine RL, Liu C, Kolesnick R, Lindemans CA, Hanash AM. T cell-derived interferon-? programs stem cell death in immune-mediated intestinal damage. Sci Immunol. 2019 12 06; 4(42). PMID: 31811055; PMCID: PMC7239329.
      Citations: 40     Fields:    Translation:AnimalsCells
    22. Christakos S, Li S, De La Cruz J, Shroyer NF, Criss ZK, Verzi MP, Fleet JC. Vitamin D and the intestine: Review and update. J Steroid Biochem Mol Biol. 2020 02; 196:105501. PMID: 31655181; PMCID: PMC6954280.
      Citations: 13     Fields:    Translation:HumansAnimals
    23. Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MK. Use of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852. PMID: 31589468; PMCID: PMC7132322.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM, M?nera JO. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2019 May 02; 24(5):829. PMID: 31051135; PMCID: PMC6530774.
      Citations: 4     Fields:    
    25. Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF. Growth Factor-Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer. Mol Cancer Res. 2019 03; 17(3):697-708. PMID: 30606770; PMCID: PMC7387124.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    26. Jones JC, Brindley CD, Elder NH, Myers MG, Rajala MW, Dekaney CM, McNamee EN, Frey MR, Shroyer NF, Dempsey PJ. Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cell Mol Gastroenterol Hepatol. 2019; 7(3):533-554. PMID: 30827941; PMCID: PMC6402430.
      Citations: 31     Fields:    Translation:AnimalsCells
    27. Steele NG, Chakrabarti J, Wang J, Biesiada J, Holokai L, Chang J, Nowacki LM, Hawkins J, Mahe M, Sundaram N, Shroyer N, Medvedovic M, Helmrath M, Ahmad S, Zavros Y. An Organoid-Based Preclinical Model of Human Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2019; 7(1):161-184. PMID: 30522949; PMCID: PMC6279812.
      Citations: 37     Fields:    Translation:HumansAnimals
    28. Gracz AD, Samsa LA, Fordham MJ, Trotier DC, Zwarycz B, Lo YH, Bao K, Starmer J, Raab JR, Shroyer NF, Reinhardt RL, Magness ST. Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates. Gastroenterology. 2018 11; 155(5):1508-1523.e10. PMID: 30055169; PMCID: PMC6232678.
      Citations: 25     Fields:    Translation:AnimalsCells
    29. Tsai YH, Czerwinski M, Wu A, Dame MK, Attili D, Hill E, Colacino JA, Nowacki LM, Shroyer NF, Higgins PDR, Kao JY, Spence JR. A Method for Cryogenic Preservation of Human Biopsy Specimens and?Subsequent Organoid?Culture. Cell Mol Gastroenterol Hepatol. 2018; 6(2):218-222.e7. PMID: 30105282; PMCID: PMC6085494.
      Citations: 30     Fields:    Translation:HumansCells
    30. Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AW. Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids. mBio. 2018 02 20; 9(1). PMID: 29463660; PMCID: PMC5821088.
      Citations: 42     Fields:    Translation:HumansCells
    31. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. PMID: 29386123; PMCID: PMC5798462.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Sundaram N, Rankin SA, Hill D, Watson C, Mahe M, Vallance JE, Shroyer NF, Sinagoga KL, Zarzoso-Lacoste A, Hudson JR, Howell JC, Chatuvedi P, Spence JR, Shannon JM, Zorn AM, Helmrath MA, Wells JM, M?nera JO. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling. Cell Stem Cell. 2017 07 06; 21(1):51-64.e6. PMID: 28648364; PMCID: PMC5531599.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    33. Lo YH, Noah TK, Chen MS, Zou W, Borras E, Vilar E, Shroyer NF. SPDEF Induces Quiescence of Colorectal Cancer Cells by?Changing the Transcriptional Targets of ?-catenin. Gastroenterology. 2017 07; 153(1):205-218.e8. PMID: 28390865; PMCID: PMC7297058.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Daeffler KN, Galley JD, Sheth RU, Ortiz-Velez LC, Bibb CO, Shroyer NF, Britton RA, Tabor JJ. Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation. Mol Syst Biol. 2017 04 03; 13(4):923. PMID: 28373240; PMCID: PMC5408782.
      Citations: 55     Fields:    Translation:AnimalsCells
    35. Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death Differ. 2017 05; 24(5):855-865. PMID: 28304405; PMCID: PMC5423110.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    36. Jattan J, Rodia C, Li D, Diakhate A, Dong H, Bataille A, Shroyer NF, Kohan AB. Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine. J Lipid Res. 2017 05; 58(5):853-865. PMID: 28159868; PMCID: PMC5408603.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Lo YH, Chung E, Li Z, Wan YW, Mahe MM, Chen MS, Noah TK, Bell KN, Yalamanchili HK, Klisch TJ, Liu Z, Park JS, Shroyer NF. Transcriptional Regulation by ATOH1 and its Target SPDEF in?the?Intestine. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):51-71. PMID: 28174757; PMCID: PMC5247424.
      Citations: 29     Fields:    
    38. Shroyer NF. Tumor Organoids Fill the Niche. Cell Stem Cell. 2016 06 02; 18(6):686-687. PMID: 27257754.
      Citations: 10     Fields:    Translation:Humans
    39. Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Dec 24; 528(7583):560-564. PMID: 26649819; PMCID: PMC4720437.
      Citations: 379     Fields:    Translation:HumansAnimalsCells
    40. Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH. Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Sci Rep. 2015 Nov 24; 5:17185. PMID: 26597788; PMCID: PMC4665766.
      Citations: 25     Fields:    Translation:AnimalsCells
    41. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest. 2015 Jul 01; 125(7):2646-60. PMID: 26053663; PMCID: PMC4563672.
      Citations: 36     Fields:    Translation:AnimalsCells
    42. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In?Vitro and In?Vivo. Stem Cell Reports. 2015 Jun 03. PMID: 26050928; PMCID: PMC4471827.
      Citations: 95     Fields:    
    43. Goodell MA, Nguyen H, Shroyer N. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol. 2015 May; 16(5):299-309. PMID: 25907613; PMCID: PMC5317203.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    44. Moore SR, Vallance J, Maier EA, Betz KJ, Aihara E, Mahe MM, Shroyer NF, Guedes MM, Costa TB, Lima AA, Ori? RB. Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids. Am J Physiol Gastrointest Liver Physiol. 2015 May 15; 308(10):G831-9. PMID: 25792564; PMCID: PMC4437023.
      Citations: 21     Fields:    Translation:AnimalsCells
    45. Mahe MM, Sundaram N, Watson CL, Shroyer NF, Helmrath MA. Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp. 2015 Mar 06; (97). PMID: 25866936; PMCID: PMC4401205.
      Citations: 61     Fields:    Translation:HumansCells
    46. Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y. The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27. PMID: 25605613; PMCID: PMC4405744.
      Citations: 53     Fields:    Translation:AnimalsCells
    47. Zhang R, Gilbert S, Yao X, Vallance J, Steinbrecher K, Moriggl R, Zhang D, Eluri M, Chen H, Cao H, Shroyer N, Denson L, Han X. Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses. Pharmacol Res Perspect. 2015 Mar; 3(2):e00118. PMID: 26038694; PMCID: PMC4448980.
      Citations: 12     Fields:    
    48. Gilbert S, Nivarthi H, Mayhew CN, Lo YH, Noah TK, Vallance J, Jegga AG, Tang W, Zhang D, Helmrath M, Shroyer N, Moriggl R, Han X, R?licke T, M?ller M. Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration. Stem Cell Reports. 2015 Feb 10; 4(2):209-25. PMID: 25579133; PMCID: PMC4325270.
      Citations: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS. The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J. 2015 Mar; 29(3):786-95. PMID: 25398765; PMCID: PMC4763883.
      Citations: 6     Fields:    Translation:AnimalsCells
    50. Watson CL, Mahe MM, Howell JC, Sundaram N, Poling HM, Schweitzer JI, Vallance JE, Mayhew CN, Sun Y, Grabowski G, Finkbeiner SR, Spence JR, Shroyer NF, Wells JM, Helmrath MA, M?nera J. An in vivo model of human small intestine using pluripotent stem cells. Nat Med. 2014 Nov; 20(11):1310-4. PMID: 25326803; PMCID: PMC4408376.
      Citations: 217     Fields:    Translation:HumansAnimalsCells
    51. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. 2015 May; 64(5):720-30. PMID: 25123931; PMCID: PMC4329117.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    52. Bell KN, Shroyer NF. Kr?pple-like factor 5 is required for proper maintenance of adult intestinal crypt cellular proliferation. Dig Dis Sci. 2015 Jan; 60(1):86-100. PMID: 25069574; PMCID: PMC4286443.
      Citations: 8     Fields:    Translation:AnimalsCells
    53. Moore SR, Pruszka J, Vallance J, Aihara E, Matsuura T, Montrose MH, Shroyer NF, Hong CI. Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine. Dis Model Mech. 2014 Sep; 7(9):1123-30. PMID: 24997189; PMCID: PMC4142732.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    54. Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y. Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9. PMID: 24859162; PMCID: PMC4211430.
      Citations: 25     Fields:    Translation:AnimalsCells
    55. Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF. Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol. 2013 Dec 19; 3(4):217-40. PMID: 25105065; PMCID: PMC4120977.
      Citations: 141     Fields:    
    56. Fuller MK, Faulk DM, Sundaram N, Mahe MM, Stout KM, von Furstenberg RJ, Smith BJ, McNaughton KK, Shroyer NF, Helmrath MA, Henning SJ. Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res. 2013 Nov; 354(2):441-50. PMID: 23820734; PMCID: PMC3812345.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    57. Melendez J, Liu M, Sampson L, Akunuru S, Han X, Vallance J, Witte D, Shroyer N, Zheng Y. Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice. Gastroenterology. 2013 Oct; 145(4):808-19. PMID: 23792201; PMCID: PMC3876942.
      Citations: 56     Fields:    Translation:Animals
    58. Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF. SPDEF functions as a colorectal tumor suppressor by inhibiting ?-catenin activity. Gastroenterology. 2013 May; 144(5):1012-1023.e6. PMID: 23376423; PMCID: PMC3738069.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    59. Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N, Whitsett JA. Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15; 375(2):128-39. PMID: 23266329; PMCID: PMC3582784.
      Citations: 23     Fields:    Translation:AnimalsCells
    60. Shroyer NF, Noah TK. Notch in the intestine: regulation of homeostasis and pathogenesis. Annu Rev Physiol. 2013; 75:263-88. PMID: 23190077.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    61. Wolfs TG, Kallapur SG, Knox CL, Thuijls G, Nitsos I, Polglase GR, Collins JJ, Kroon E, Spierings J, Shroyer NF, Newnham JP, Jobe AH, Kramer BW. Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner. Mucosal Immunol. 2013 May; 6(3):547-56. PMID: 23149664.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    62. Finkbeiner SR, Zeng XL, Utama B, Atmar RL, Shroyer NF, Estes MK. Stem cell-derived human intestinal organoids as an infection model for rotaviruses. mBio. 2012; 3(4):e00159-12. PMID: 22761392; PMCID: PMC3398537.
      Citations: 121     Fields:    Translation:HumansCells
    63. Softic S, Kirby M, Berger NG, Shroyer NF, Woods SC, Kohli R. Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins. PLoS One. 2012; 7(6):e38952. PMID: 22745692; PMCID: PMC3380053.
      Citations: 9     Fields:    Translation:AnimalsCells
    64. Donahue B, Letourneur F, Cagnard N, Slomianny C, Perret C, Shroyer NF, Durand A, Peignon G, Romagnolo B. Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):8965-70. PMID: 22586121; PMCID: PMC3384132.
      Citations: 150     Fields:    Translation:AnimalsCells
    65. Fuller MK, Faulk DM, Sundaram N, Shroyer NF, Henning SJ, Helmrath MA. Intestinal crypts reproducibly expand in culture. J Surg Res. 2012 Nov; 178(1):48-54. PMID: 22564827; PMCID: PMC3654833.
      Citations: 35     Fields:    Translation:AnimalsCells
    66. Gilbert S, Zhang R, Denson L, Moriggl R, Steinbrecher K, Shroyer N, Lin J, Han X. Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med. 2012 Feb; 4(2):109-24. PMID: 22228679; PMCID: PMC3306555.
      Citations: 36     Fields:    Translation:AnimalsCells
    67. Noah TK, Donahue B, Shroyer NF. Intestinal development and differentiation. Exp Cell Res. 2011 Nov 15; 317(19):2702-10. PMID: 21978911; PMCID: PMC3210330.
      Citations: 118     Fields:    Translation:HumansAnimals
    68. Kazanjian A, Shroyer NF. NOTCH Signaling and ATOH1 in Colorectal Cancers. Curr Colorectal Cancer Rep. 2011 Jun; 7(2):121-127. PMID: 21980310; PMCID: PMC3184527.
      Citations: 19     
    69. van Es JH, Makrini L, Mellitzer G, Robine S, Shroyer NF, Pignodel C, Clevers H, Jay P, Gerbe F, Brulin B, Romagnolo B, Bourgaux JF. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011 Mar 07; 192(5):767-80. PMID: 21383077; PMCID: PMC3051826.
      Citations: 169     Fields:    Translation:HumansAnimals
    70. Wu D, Ahrens R, Osterfeld H, Noah TK, Groschwitz K, Foster PS, Steinbrecher KA, Rothenberg ME, Shroyer NF, Matthaei KI, Finkelman FD, Hogan SP. Interleukin-13 (IL-13)/IL-13 receptor alpha1 (IL-13Ralpha1) signaling regulates intestinal epithelial cystic fibrosis transmembrane conductance regulator channel-dependent Cl- secretion. J Biol Chem. 2011 Apr 15; 286(15):13357-69. PMID: 21303908; PMCID: PMC3075682.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    71. Cacheux W, Ayrault O, Laurent-Puig P, Shroyer NF, Van Seuningen I, Honjo T, Perret C, Peignon G, Durand A, Terris B, Romagnolo B. Complex interplay between ?-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut. 2011 Feb; 60(2):166-76. PMID: 21205878; PMCID: PMC3022366.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    72. Beuling E, Baffour-Awuah NY, Stapleton KA, Aronson BE, Noah TK, Shroyer NF, Duncan SA, Fleet JC, Krasinski SD. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology. 2011 Apr; 140(4):1219-1229.e1-2. PMID: 21262227; PMCID: PMC3541694.
      Citations: 56     Fields:    Translation:AnimalsCells
    73. Spence JR, Lauf R, Shroyer NF. Vertebrate intestinal endoderm development. Dev Dyn. 2011 Mar; 240(3):501-20. PMID: 21246663; PMCID: PMC3079549.
      Citations: 76     Fields:    Translation:HumansAnimals
    74. Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011 Feb 03; 470(7332):105-9. PMID: 21151107; PMCID: PMC3033971.
      Citations: 705     Fields:    Translation:HumansCells
    75. Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011 Jan 20; 469(7330):415-8. PMID: 21113151; PMCID: PMC3547360.
      Citations: 1040     Fields:    Translation:HumansAnimalsCells
    76. Phelan JD, Shroyer NF, Cook T, Gebelein B, Grimes HL. Gfi1-cells and circuits: unraveling transcriptional networks of development and disease. Curr Opin Hematol. 2010 Jul; 17(4):300-7. PMID: 20571393; PMCID: PMC2910316.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    77. Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ, Kohli R. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G652-60. PMID: 20595624; PMCID: PMC2950688.
      Citations: 85     Fields:    Translation:Animals
    78. Kazanjian A, Noah T, Brown D, Burkart J, Shroyer NF. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology. 2010 Sep; 139(3):918-28, 928.e1-6. PMID: 20621629; PMCID: PMC3197859.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    79. Noah TK, Kazanjian A, Whitsett J, Shroyer NF. SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp Cell Res. 2010 Feb 01; 316(3):452-65. PMID: 19786015; PMCID: PMC3004755.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    80. Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, Boivin GP, Luciani J, Fuks F, Chuah M, VandenDriessche T, Marynen P, Cools J, Shroyer NF, Hassan BA. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol. 2009 Feb 24; 7(2):e39. PMID: 19243219; PMCID: PMC2652388.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    81. Kiesslich R, Goetz M, Angus EM, Hu Q, Guan Y, Potten C, Allen T, Neurath MF, Shroyer NF, Montrose MH, Watson AJ. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy. Gastroenterology. 2007 Dec; 133(6):1769-78. PMID: 18054549.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    82. Shroyer NF, Wong MH. BMP signaling in the intestine: cross-talk is key. Gastroenterology. 2007 Sep; 133(3):1035-8. PMID: 17854606.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    83. Shroyer NF, Helmrath MA, Wang VY, Antalffy B, Henning SJ, Zoghbi HY. Intestine-specific ablation of mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis. Gastroenterology. 2007 Jun; 132(7):2478-88. PMID: 17570220.
      Citations: 161     Fields:    Translation:Animals
    84. Shroyer NF, Wallis D, Venken KJ, Bellen HJ, Zoghbi HY. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Genes Dev. 2005 Oct 15; 19(20):2412-7. PMID: 16230531; PMCID: PMC1257395.
      Citations: 140     Fields:    Translation:AnimalsCells
    85. Yatsenko AN, Shroyer NF, Lewis RA, Lupski JR. An ABCA4 genomic deletion in patients with Stargardt disease. Hum Mutat. 2003 Jun; 21(6):636-44. PMID: 12754711.
      Citations: 15     Fields:    Translation:HumansCells
    86. Shroyer NF, Lewis RA, Yatsenko AN, Lupski JR. Null missense ABCR (ABCA4) mutations in a family with stargardt disease and retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2001 Nov; 42(12):2757-61. PMID: 11687513.
      Citations: 34     Fields:    Translation:Humans
    87. Shroyer NF, Lewis RA, Yatsenko AN, Wensel TG, Lupski JR. Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. Hum Mol Genet. 2001 Nov 01; 10(23):2671-8. PMID: 11726554.
      Citations: 53     Fields:    Translation:HumansCells
    88. Shroyer NF, Lewis RA, Lupski JR. Analysis of the ABCR (ABCA4) gene in 4-aminoquinoline retinopathy: is retinal toxicity by chloroquine and hydroxychloroquine related to Stargardt disease? Am J Ophthalmol. 2001 Jun; 131(6):761-6. PMID: 11384574.
      Citations: 29     Fields:    Translation:Humans
    89. Katsanis N, Shroyer NF, Lewis RA, Cavender JC, Al-Rajhi AA, Jabak M, Lupski JR. Fundus albipunctatus and retinitis punctata albescens in a pedigree with an R150Q mutation in RLBP1. Clin Genet. 2001 Jun; 59(6):424-9. PMID: 11453974.
      Citations: 27     Fields:    Translation:HumansCells
    90. Yatsenko AN, Shroyer NF, Lewis RA, Lupski JR. Late-onset Stargardt disease is associated with missense mutations that map outside known functional regions of ABCR (ABCA4). Hum Genet. 2001 Apr; 108(4):346-55. PMID: 11379881.
      Citations: 60     Fields:    Translation:Humans
    91. Shroyer NF, Lewis RA, Lupski JR. Complex inheritance of ABCR mutations in Stargardt disease: linkage disequilibrium, complex alleles, and pseudodominance. Hum Genet. 2000 Feb; 106(2):244-8. PMID: 10746567.
      Citations: 10     Fields:    Translation:HumansCells
    92. Shroyer NF, Lewis RA, Allikmets R, Singh N, Dean M, Leppert M, Lupski JR. The rod photoreceptor ATP-binding cassette transporter gene, ABCR, and retinal disease: from monogenic to multifactorial. Vision Res. 1999 Jul; 39(15):2537-44. PMID: 10396622.
      Citations: 52     Fields:    Translation:HumansCells
    93. Lewis RA, Shroyer NF, Singh N, Allikmets R, Hutchinson A, Li Y, Lupski JR, Leppert M, Dean M. Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease. Am J Hum Genet. 1999 Feb; 64(2):422-34. PMID: 9973280; PMCID: PMC1377752.
      Citations: 115     Fields:    Translation:HumansCells
    94. Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS, Peiffer A, Zabriskie NA, Li Y, Hutchinson A, Dean M, Lupski JR, Leppert M. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science. 1997 Sep 19; 277(5333):1805-7. PMID: 9295268.
      Citations: 264     Fields:    Translation:Humans
    95. Allikmets R, Singh N, Sun H, Shroyer NF, Hutchinson A, Chidambaram A, Gerrard B, Baird L, Stauffer D, Peiffer A, Rattner A, Smallwood P, Li Y, Anderson KL, Lewis RA, Nathans J, Leppert M, Dean M, Lupski JR. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997 Mar; 15(3):236-46. PMID: 9054934.
      Citations: 486     Fields:    Translation:HumansAnimalsCells
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