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THOMAS HORVATH

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address6621 FANNIN
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gutierrez A, Chetta KE, Puckett B, Haidacher SJ, Horvath TD, Engevik MA. Human milk and infant formula influence lactobacilli metabolism in a species-specific manner. NPJ Sci Food. 2026 Apr 02; 10(1). PMID: 41927583; PMCID: PMC13216266.
      Citations:    
    2. Horvath AE, Grozis M, Baker PRS, Gorti SKK, Proos R, Imran A, Brim H, Horvath TD, Engevik MA, Ashktorab H. Saffron Alters Microbial Amino Acid Metabolism and Neurotransmitter Production in a Defined Gut Consortium. Food Sci Nutr. 2026 Apr; 14(4):e71694. PMID: 41948379; PMCID: PMC13052059.
      Citations:    
    3. Midani FS, Lee DH, Moon Y, Seale M, Horvath TD, Ardis AK, Cant? J, Coles E, Pizzini JD, Zhu D, Dooling SW, Ahern GJ, Ardis CK, Beckford A, Ruggiero NM, Shin J, Joos R, Stanton C, Ross RP, Dai DLY, Mandhane PJ, Petersen C, Turvey SE, Kiely ME, Murray DM, Costa-Mattioli M, Tolias KF, Britton RA, Danhof HA. Infant gut microbiomes contribute to metabolic states that impact brain function. bioRxiv. 2026 Mar 10. PMID: 41959053; PMCID: PMC13060970.
      Citations:    
    4. Gutierrez AS, Chetta KE, Thapa S, Haidacher SJ, Hoch KM, Baatz JE, Haag AM, Oezguen N, Horvath TD, Wagner CL, Engevik MA. A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites. Physiol Rep. 2026 Mar; 14(5):e70774. PMID: 41776817; PMCID: PMC12956843.
      Citations:    Fields:    Translation:Humans
    5. McKee PR, Edens-Valentine R, Stubler R, Rocha do Nascimento R, Packirisamy C, van Altena C, Giordano L, LeBlanc C, Shore S, Hartman JH, Muise-Helmricks R, Percy A, Horvath TD, Engevik KA, Engevik MA, Engevik AC. Myosin 5b deficiency alters liver proliferation, zonation, and bile acid composition. Hepatol Commun. 2026 Mar 01; 10(3). PMID: 41678294.
      Citations:    Fields:    Translation:AnimalsCells
    6. Charron-Lamoureux V, Xing S, Patan A, Walker C, Monter RA, Abiead YE, Zhao HN, Patel L, Weng Y, Gonzalez A, Ackermann G, Deleray V, Gandhi V, Mohanty I, Caraballo-Rodriguez AM, Kvitne KE, Zuffa S, Norman A, Martin A, Chin L, Paz-Gonzalez R, Sala-Climent M, Suryawinata N, Zemlin J, Gouda H, Hu Z, Norton G, Rajkumar P, Molina AJ, Bergstrom J, Pinner M, Giddings S, Aron AT, Liang L, Dahesh S, Lamichhane S, Reilly ER, Nizet V, Skrip A, Lukowski AL, Shore SFH, Ghoshal S, Engevik MA, Horvath TD, Renwick S, Agongo J, Marco ML, Mazmanian SK, Wang M, Yang H, McDonald D, Guma M, Stegmann E, Hernandez Perez N, Stincone P, Kemen E, Pakkir Shah AK, Bode L, Petras D, Siegel D, Raffatellu M, Patterson AD, Devkota S, Jinich A, Knight R, Zengler K, Dorrestein PC. A searchable metadata network graph for microbiome metabolomics. bioRxiv. 2026 Feb 05. PMID: 41676651; PMCID: PMC12889665.
      Citations:    
    7. Chard E, Horvath AE, Grozis M, do Nascimento RR, Baker PRS, Gorti SKK, Proos R, Horvath TD, Engevik MA. MUC2 shifts the metabolic profiles of commensal bacteria in defined microbial communities. Microbiome Res Rep. 2026; 5(1):1. PMID: 42007376; PMCID: PMC13091087.
      Citations:    
    8. Ayele H, Jo J, Begum K, Hu C, Le TM, Alam MJ, Eubank TA, Haidacher SJ, Horvath TD, Hanson BM, Garey KW. A Randomized Phase 1 Study Investigating Gut Microbiome Changes With Moxifloxacin vs Oral Vancomycin: Implications for Clostridioides difficile Risk. J Infect Dis. 2025 Dec 20; 232(6):1446-1456. PMID: 41081530.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    9. Tingler AM, Packirisamy C, Gutierrez A, Horvath AE, Grozis M, Haidacher SJ, Hoch KM, Haag AM, Oezguen N, Engevik KA, Engevik AC, Horvath TD, Engevik MA. Commensal human gut microbes produce species specific neuroactive compounds. iScience. 2026 Feb 20; 29(2):114424. PMID: 41630915; PMCID: PMC12860712.
      Citations:    
    10. Mushimiyimana I, Richardson L, Horvath TD, Orlovsky V, Harrington B, Calori IR, Kammala AK, Menon R. Heat-Induced Pathophysiological and Metabolic Changes at the Feto-Maternal Interface Predisposing to Preterm Birth. FASEB J. 2025 Nov 30; 39(22):e71252. PMID: 41247231; PMCID: PMC13032771.
      Citations:    Fields:    Translation:HumansCells
    11. Jo J, Carlson TJ, Hu C, Williamson JC, Belin YT, Horvath TD, Haidacher SJ, Bass?res E, Begum K, Alam MJ, Garey KW. Faecal pharmacokinetics, microbiome, and bile acid changes in healthy subjects given intravenous followed by oral omadacycline; a Phase 1 clinical trial. J Antimicrob Chemother. 2025 Oct 03; 80(10):2719-2726. PMID: 40796204; PMCID: PMC12494138.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    12. Eubank TA, Jo J, Alam MJ, Begum K, McPherson JK, Le TM, Horvath TD, Haidacher SJ, Poggio EC, Lin R, Yue CS, Ducharme MP, Koudssi G, Mercier J, Alder JD, Silverman MH, Garey KW, Ibezapolstat Phase 2 Investigator Group. Efficacy, safety, pharmacokinetics, and associated microbiome changes of ibezapolstat compared with vancomycin in adults with Clostridioides difficile infection: a phase 2b, randomised, double-blind, active-controlled, multicentre study. Lancet Microbe. 2025 Aug; 6(8):101126. PMID: 40516571; PMCID: PMC13003532.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    13. Williams MD, Sweeney TR, Trieu S, Orugunty R, Barbour A, Younesi F, Glogauer M, Hansanant N, Shin R, Lu S-E, Cao K, Tenorio A, Haidacher SJ, Haag AM, Horvath TD, Smith L. Antibiofilm properties of 4-hydroxy-3-methyl-2-alkenylquinoline, a novel Burkholderia-derived alkaloid. mSphere. 2025 May 27; 10(5):e0108124. PMID: 40338090; PMCID: PMC12108052.
      Citations: 1     Fields:    Translation:CellsPHPublic Health
    14. Jo J, Hu C, Horvath TD, Haidacher SJ, Begum K, Alam MJ, Garey KW. Phase I trial comparing bile acid and short-chain fatty acid alterations in stool collected from human subjects treated with omadacycline or vancomycin. Antimicrob Agents Chemother. 2025 02 13; 69(2):e0125124. PMID: 39819014; PMCID: PMC11823362.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    15. Huang X, Johnson AE, Brehm JN, Do TVT, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Sorg JA, Haag AM, Auchtung JM. Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model. mSphere. 2025 Feb 25; 10(2):e0104924. PMID: 39817755; PMCID: PMC11852769.
      Citations: 5     Fields:    Translation:HumansCells
    16. Huang X, Johnson AE, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Haag AM, Auchtung JM, Huang X, Johnson AE, Brehm JN, Thanh Do TV, Auchtung TA, McCullough HC, Lerma AI, Haidacher SJ, Hoch KM, Horvath TD, Sorg JA, Haag AM, Auchtung JM, Brehm JN, Thanh Do TV, Sorg JA. Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model. bioRxiv. 2024 Dec 11. PMID: 39071387; PMCID: PMC11275744.
      Citations:    
    17. Engevik KA, Hazzard A, Puckett B, Hoch KM, Haidacher SJ, Haag AM, Spinler JK, Versalovic J, Engevik MA, Horvath TD. Phylogenetically diverse bacterial species produce histamine. Syst Appl Microbiol. 2024 Sep; 47(5):126539. PMID: 39029335.
      Citations: 8     Fields:    Translation:HumansCells
    18. Kellermayer R, Carbone M, Horvath TD, Szigeti RG, Buness C, Hirschfield GM, Lewindon PJ. Identifying a therapeutic window of opportunity for people living with primary sclerosing cholangitis: Embryology and the overlap of inflammatory bowel disease with immune-mediated liver injury. Hepatology. 2025 Oct 01; 82(4):949-959. PMID: 38743006.
      Citations: 7     Fields:    Translation:Humans
    19. Lillie IM, Booth CE, Horvath AE, Mondragon M, Engevik MA, Horvath TD. Characterizing arginine, ornithine, and putrescine pathways in enteric pathobionts. Microbiologyopen. 2024 Apr; 13(2):e1408. PMID: 38560776; PMCID: PMC10982811.
      Citations: 7     Fields:    
    20. Horvath TD, Devaraj S. Liquid Chromatography-Tandem Mass Spectrometry-Based Therapeutic Monitoring of Plasma Atovaquone Concentrations in Pediatric Patients. Methods Mol Biol. 2024; 2737:67-77. PMID: 38036811.
      Citations:    Fields:    Translation:Humans
    21. Engevik MA, Thapa S, Lillie IM, Yacyshyn MB, Yacyshyn B, Percy AJ, Chace D, Horvath TD. Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples. Am J Physiol Gastrointest Liver Physiol. 2024 02 01; 326(2):G95-G106. PMID: 38014449; PMCID: PMC11208030.
      Citations:    Fields:    Translation:Humans
    22. Engevik KA, Gonzalez H, Daniels C, Stavert RK, Oezguen N, Engevik MA, Horvath TD. A high-throughput protocol for measuring solution pH of bacterial cultures using UV-Vis absorption spectrophotometry. STAR Protoc. 2023 09 15; 4(3):102540. PMID: 37682718; PMCID: PMC10493592.
      Citations: 1     Fields:    
    23. Barbour A, Smith L, Oveisi M, Williams M, Huang RC, Marks C, Fine N, Sun C, Younesi F, Zargaran S, Orugunty R, Horvath TD, Haidacher SJ, Haag AM, Sabharwal A, Hinz B, Glogauer M. Discovery of phosphorylated lantibiotics with proimmune activity that regulate the oral microbiome. Proc Natl Acad Sci U S A. 2023 05 30; 120(22):e2219392120. PMID: 37216534; PMCID: PMC10235938.
      Citations: 2     Fields:    Translation:HumansCells
    24. Hughes LD, Tsueng G, DiGiovanna J, Horvath TD, Rasmussen LV, Savidge TC, Stoeger T, Turkarslan S, Wu Q, Wu C, Su AI, Pache L, NIAID Systems Biology Data Dissemination Working Group. Addressing barriers in FAIR data practices for biomedical data. Sci Data. 2023 02 23; 10(1):98. PMID: 36823198; PMCID: PMC9950056.
      Citations: 3     Fields:    
    25. Horvath TD, Haidacher SJ, Engevik MA, Luck B, Ruan W, Ihekweazu F, Bajaj M, Hoch KM, Oezguen N, Spinler JK, Versalovic J, Haag AM. Interrogation of the mammalian gut-brain axis using LC-MS/MS-based targeted metabolomics with in vitro bacterial and organoid cultures and in vivo gnotobiotic mouse models. Nat Protoc. 2023 02; 18(2):490-529. PMID: 36352124.
      Citations: 4     Fields:    Translation:AnimalsCells
    26. Oezguen N, Yilmaz V, Horvath TD, Akbayir E, Haidacher SJ, Hoch KM, Thapa S, Palacio J, T?rkoglu R, K?rt?nc? M, Engevik MA, Versalovic J, Haag AM, T?z?n E. Serum 3-phenyllactic acid level is reduced in benign multiple sclerosis and is associated with effector B cell ratios. Mult Scler Relat Disord. 2022 Dec; 68:104239. PMID: 36279598.
      Citations:    Fields:    
    27. Horvath TD, Poventud-Fuentes I, Olayinka L, James A, Haidacher SJ, Hoch KM, Stevens AM, Haag AM, Devaraj S. Validation of atovaquone plasma levels by liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring in pediatric patients. J Mass Spectrom Adv Clin Lab. 2022 Nov; 26:23-27. PMID: 36388060; PMCID: PMC9641598.
      Citations: 1     
    28. Blackman AC, Thapa S, Venkatachalam A, Horvath TD, Runge JK, Haidacher SJ, Hoch KM, Haag AM, Luna RA, Anagnostou A. Insights into Microbiome and Metabolic Signatures of Children Undergoing Peanut Oral Immunotherapy. Children (Basel). 2022 Aug 09; 9(8). PMID: 36010081; PMCID: PMC9406383.
      Citations:    
    29. Xavier JB, Monk JM, Poudel S, Norsigian CJ, Sastry AV, Liao C, Bento J, Suchard MA, Arrieta-Ortiz ML, Peterson EJR, Baliga NS, Stoeger T, Ruffin F, Richardson RAK, Gao CA, Horvath TD, Haag AM, Wu Q, Savidge T, Yeaman MR. Mathematical models to study the biology of pathogens and the infectious diseases they cause. iScience. 2022 Apr 15; 25(4):104079. PMID: 35359802; PMCID: PMC8961237.
      Citations:    
    30. Fultz R, Ticer T, Ihekweazu FD, Horvath TD, Haidacher SJ, Hoch KM, Bajaj M, Spinler JK, Haag AM, Buffington SA, Engevik MA. Unraveling the Metabolic Requirements of the Gut Commensal Bacteroides ovatus. Front Microbiol. 2021; 12:745469. PMID: 34899632; PMCID: PMC8656163.
      Citations: 1     
    31. Luck B, Horvath TD, Engevik KA, Ruan W, Haidacher SJ, Hoch KM, Oezguen N, Spinler JK, Haag AM, Versalovic J, Engevik MA. Neurotransmitter Profiles Are Altered in the Gut and Brain of Mice Mono-Associated with Bifidobacterium dentium. Biomolecules. 2021 07 23; 11(8). PMID: 34439760; PMCID: PMC8392031.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. Engevik MA, Danhof HA, Hall A, Engevik KA, Horvath TD, Haidacher SJ, Hoch KM, Endres BT, Bajaj M, Garey KW, Britton RA, Spinler JK, Haag AM, Versalovic J. The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal. BMC Microbiol. 2021 05 24; 21(1):154. PMID: 34030655; PMCID: PMC8145834.
      Citations: 5     Fields:    Translation:HumansCells
    33. Horvath TD, Dagan S, Scaraffia PY. Unraveling mosquito metabolism with mass spectrometry-based metabolomics. Trends Parasitol. 2021 08; 37(8):747-761. PMID: 33896683; PMCID: PMC8282712.
      Citations:    
    34. Ihekweazu FD, Engevik MA, Ruan W, Shi Z, Fultz R, Engevik KA, Chang-Graham AL, Freeborn J, Park ES, Venable S, Horvath TD, Haidacher SJ, Haag AM, Goodwin A, Schady DA, Hyser JM, Spinler JK, Liu Y, Versalovic J. Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid-Driven Colonic Inflammation. Am J Pathol. 2021 04; 191(4):704-719. PMID: 33516788; PMCID: PMC8027925.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Engevik MA, Herrmann B, Ruan W, Engevik AC, Engevik KA, Ihekweazu F, Shi Z, Luck B, Chang-Graham AL, Esparza M, Venable S, Horvath TD, Haidacher SJ, Hoch KM, Haag AM, Schady DA, Hyser JM, Spinler JK, Versalovic J. Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation. Gut Microbes. 2021 Jan-Dec; 13(1):1-21. PMID: 33985416; PMCID: PMC8128206.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    36. Engevik MA, Luck B, Visuthranukul C, Ihekweazu FD, Engevik AC, Shi Z, Danhof HA, Chang-Graham AL, Hall A, Endres BT, Haidacher SJ, Horvath TD, Haag AM, Devaraj S, Garey KW, Britton RA, Hyser JM, Shroyer NF, Versalovic J. Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut-Brain Axis. Cell Mol Gastroenterol Hepatol. 2021; 11(1):221-248. PMID: 32795610; PMCID: PMC7683275.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    37. Horvath TD, Haidacher SJ, Oezguen N, Hoch KM, Auchtung JM, Haag AM. Ruggedness testing of liquid chromatography-tandem mass spectrometry system components using microbiome-relevant methods and matrices. J Microbiol Methods. 2020 10; 177:106020. PMID: 32795635.
      Citations: 1     Fields:    Translation:HumansCells
    38. Horvath TD, Haidacher SJ, Hoch KM, Auchtung JM, Haag AM. A high-throughput LC-MS/MS method for the measurement of the bile acid/salt content in microbiome-derived sample sets. MethodsX. 2020; 7:100951. PMID: 32637329; PMCID: PMC7327831.
      Citations:    
    39. Petchampai N, Isoe J, Horvath TD, Dagan S, Tan L, Lorenzi PL, Hawke DH, Scaraffia PY. Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes. Insect Biochem Mol Biol. 2020 06; 121:103366. PMID: 32276114; PMCID: PMC7249512.
      Citations:    
    40. Horvath TD, Ak S, Haidacher SJ, Hoch KM, Savidge TC, Haag AM. Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. J Microbiol Methods. 2019 09; 164:105669. PMID: 31356842; PMCID: PMC6732000.
      Citations:    Fields:    Translation:CellsPHPublic Health
    41. Horvath TD, Chan WK, Pontikos MA, Martin LA, Du D, Tan L, Konopleva M, Weinstein JN, Lorenzi PL. Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer. Metabolites. 2019 Jan 09; 9(1). PMID: 30634463; PMCID: PMC6359345.
      Citations: 3     
    42. Khong H, Volmari A, Sharma M, Dai Z, Imo CS, Hailemichael Y, Singh M, Moore DT, Xiao Z, Huang XF, Horvath TD, Hawke DH, Overwijk WW. Peptide Vaccine Formulation Controls the Duration of Antigen Presentation and Magnitude of Tumor-Specific CD8+ T Cell Response. J Immunol. 2018 05 15; 200(10):3464-3474. PMID: 29643190; PMCID: PMC5940548.
      Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
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