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WILLIAM LAGOR

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Collapse Research 
    Collapse research activities and funding
    R01DK124477     (LAGOR, WILLIAM RAYMOND)Apr 6, 2020 - Feb 29, 2024
    NIH
    Physiological Dissection of the Mevalonate Pathway
    Role: Principal Investigator
    UG3HL151545     (BAO, GANG)Sep 1, 2019 - Jul 31, 2022
    NIH
    Velcro AAV Vector for tissue-specific delivery of genome editing reagents with enhanced cargo capacity
    Role: Co-Principal Investigator
    U42OD026645     (DICKINSON, MARY E;HEANEY, JASON D ;LAGOR, WILLIAM RAYMOND)Sep 18, 2018 - Jul 31, 2024
    NIH
    BCM-Rice resource for the analysis of somatic gene editing in mice
    Role: Co-Principal Investigator
    R01HL132840     (LAGOR, WILLIAM RAYMOND)Dec 20, 2016 - Mar 31, 2026
    NIH
    Genetic Repair of Familial Hypercholesterolemia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Moore OM, Aguilar-Sanchez Y, Lahiri SK, Hulsurkar MM, Alberto Navarro-Garcia J, Word TA, Keefe JA, Barazi D, Munivez EM, Moore CT, Parthasarathy V, Davidson J, Lagor WR, Park SH, Bao G, Miyake CY, Wehrens XHT. Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Aging. 2024 Jan; 4(1). PMID: 38464671; PMCID: PMC10919902.
      Citations:    
    2. Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Commun Biol. 2023 09 14; 6(1):942. PMID: 37709832; PMCID: PMC10502019.
      Citations:    Translation:Animals
    3. De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene. bioRxiv. 2023 Jul 29. PMID: 37546995; PMCID: PMC10402145.
      Citations:    
    4. Huang Q, Chen AT, Chan KY, Sorensen H, Barry AJ, Azari B, Zheng Q, Beddow T, Zhao B, Tobey IG, Moncada-Reid C, Eid FE, Walkey CJ, Ljungberg MC, Lagor WR, Heaney JD, Chan YA, Deverman BE. Targeting AAV vectors to the central nervous system by engineering capsid-receptor interactions that enable crossing of the blood-brain barrier. PLoS Biol. 2023 07; 21(7):e3002112. PMID: 37467291; PMCID: PMC10355383.
      Citations: 8     Fields:    Translation:AnimalsCells
    5. Chuecos MA, Lagor WR. Liver directed adeno-associated viral vectors to treat metabolic disease. J Inherit Metab Dis. 2024 Jan; 47(1):22-40. PMID: 37254440; PMCID: PMC10687323.
      Citations:    Fields:    
    6. Assini JM, Clark JR, Youssef A, Xing C, Doerfler AM, Park SH, Saxena L, Yaseen AB, B?ren J, Gros R, Bao G, Lagor WR, Boffa MB, Koschinsky ML. High levels of lipoprotein(a) in transgenic mice exacerbate atherosclerosis and promote vulnerable plaque features in a sex-specific manner. Atherosclerosis. 2023 11; 384:117150. PMID: 37290980.
      Citations:    Fields:    
    7. Barzi M, Johnson CG, Chen T, Rodriguiz RM, Hemmingsen M, Gonzalez TJ, Rosales A, Beasley J, Peck CK, Ma Y, Stiles AR, Wood TC, Maeso-Diaz R, Diehl AM, Young SP, Everitt JI, Wetsel WC, Lagor WR, Bissig-Choisat B, Asokan A, El-Gharbawy A, Bissig KD. Rescue of glutaric aciduria type I in mice by liver-directed therapies. Sci Transl Med. 2023 04 19; 15(692):eadf4086. PMID: 37075130; PMCID: PMC10676743.
      Citations:    Fields:    Translation:Animals
    8. Wang Y, Hurley A, De Giorgi M, Tanner MR, Hu RC, Pennington MW, Lagor WR, Beeton C. Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver. PLoS One. 2023; 18(4):e0283996. PMID: 37040361; PMCID: PMC10089316.
      Citations:    Fields:    Translation:AnimalsCells
    9. Walkey CJ, Lagor WR. CaMKIId gene editing- A base hit for the heart. J Cardiovasc Aging. 2023; 3(2). PMID: 37065676; PMCID: PMC10104458.
      Citations:    
    10. Lorincz R, Alvarez AB, Walkey CJ, Mendon?a SA, Lu ZH, Martinez AE, Ljungberg C, Heaney JD, Lagor WR, Curiel DT. In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector. Biomed Pharmacother. 2023 Feb; 158:114189. PMID: 36587560.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WR. LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study. Mol Ther Methods Clin Dev. 2022 Dec 08; 27:337-351. PMID: 36381302; PMCID: PMC9630778.
      Citations: 1     
    12. Hurley A, Lagor WR. Treating Cardiovascular Disease with Liver Genome Engineering. Curr Atheroscler Rep. 2022 02; 24(2):75-84. PMID: 35230602; PMCID: PMC8886347.
      Citations:    Fields:    Translation:HumansAnimals
    13. Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022 04; 42(4):381-394. PMID: 35172604; PMCID: PMC8957608.
      Citations:    Fields:    Translation:AnimalsCells
    14. De Giorgi M, Jarrett KE, de Aguiar Vallim TQ, Lagor WR. In Vivo Gene Editing in Lipid and Atherosclerosis Research. Methods Mol Biol. 2022; 2419:673-713. PMID: 35237996.
      Citations:    Fields:    Translation:Animals
    15. Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y. Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 2022 02; 482:91-100. PMID: 34929174.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Lagor WR. Anti-Cas9 immunity: A formidable challenge for muscle genome editing. Mol Ther. 2022 01 05; 30(1):10-12. PMID: 34895501; PMCID: PMC8753515.
      Citations:    Fields:    
    17. Schneller JL, Lee CM, Venturoni LE, Chandler RJ, Li A, Myung S, Cradick TJ, Hurley AE, Lagor WR, Bao G, Venditti CP. In?vivo genome editing at the albumin locus to treat methylmalonic acidemia. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:619-632. PMID: 34901307; PMCID: PMC8634044.
      Citations:    
    18. Liang SQ, Walkey CJ, Martinez AE, Su Q, Dickinson ME, Wang D, Lagor WR, Heaney JD, Gao G, Xue W. AAV5 delivery of CRISPR-Cas9 supports effective genome editing in mouse lung airway. Mol Ther. 2022 Jan 05; 30(1):238-243. PMID: 34695545; PMCID: PMC8753568.
      Citations: 1     Fields:    Translation:Animals
    19. De Giorgi M, Li A, Hurley A, Barzi M, Doerfler AM, Cherayil NA, Smith HE, Brown JD, Lin CY, Bissig KD, Bao G, Lagor WR. Targeting the Apoa1 locus for liver-directed gene therapy. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:656-669. PMID: 34141821; PMCID: PMC8166646.
      Citations: 2     
    20. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J, SCGE Consortium. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. PMID: 33828315; PMCID: PMC8026397.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281. PMID: 34036256; PMCID: PMC8138774.
      Citations: 6     
    22. De Giorgi M, Jarrett KE, Burton JC, Doerfler AM, Hurley A, Li A, Hsu RH, Furgurson M, Patel KR, Han J, Borchers CH, Lagor WR. Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase. J Lipid Res. 2020 12; 61(12):1675-1686. PMID: 33109681; PMCID: PMC7707164.
      Citations: 4     Fields:    
    23. Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, Settembre C, Finegold MJ, Forbes SJ, Ballabio A. TFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 05 18; 11(1):2461. PMID: 32424153; PMCID: PMC7235048.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Doerfler AM, Walkey CJ, Lagor WR. Recent advances in genome editing for cardiovascular disease. Curr Opin Cardiol. 2020 05; 35(3):242-248. PMID: 32073405; PMCID: PMC7372933.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR. AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. Mol Ther. 2020 Jun 03; 28(6):1432-1441. PMID: 32348718; PMCID: PMC7264438.
      Citations: 49     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BW. Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism. Cell Metab. 2020 04 07; 31(4):741-754.e5. PMID: 32197071; PMCID: PMC7184639.
      Citations: 7     Fields:    Translation:HumansAnimals
    27. Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu H. Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):72-85. PMID: 31619061; PMCID: PMC6991890.
      Citations: 8     Fields:    Translation:AnimalsCells
    28. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442. PMID: 31356139; PMCID: PMC6699770.
      Citations: 7     Fields:    Translation:AnimalsCells
    29. Furgurson M, Lagor WR. CRISPR: a promising tool for lipid physiology and therapeutics. Curr Opin Lipidol. 2019 06; 30(3):172-176. PMID: 30893109; PMCID: PMC6530964.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    30. Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262. PMID: 30582449; PMCID: PMC6336523.
      Citations: 18     Fields:    Translation:AnimalsCells
    31. De Giorgi M, Lagor WR. Gene Delivery in Lipid Research and Therapies. Methodist Debakey Cardiovasc J. 2019 Jan-Mar; 15(1):62-69. PMID: 31049151; PMCID: PMC6489604.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    32. Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR. A Self-Deleting AAV-CRISPR System for In?Vivo Genome Editing. Mol Ther Methods Clin Dev. 2019 Mar 15; 12:111-122. PMID: 30619914; PMCID: PMC6313841.
      Citations: 44     
    33. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963. PMID: 30355031; PMCID: PMC6206886.
      Citations: 20     Fields:    Translation:AnimalsCells
    34. Jarrett KE, Lee C, De Giorgi M, Hurley A, Gillard BK, Doerfler AM, Li A, Pownall HJ, Bao G, Lagor WR. Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):1997-2006. PMID: 30026278; PMCID: PMC6202188.
      Citations: 37     Fields:    Translation:AnimalsCells
    35. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115; PMCID: PMC6420307.
      Citations: 9     Fields:    Translation:AnimalsCells
    36. Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544. PMID: 29670083; PMCID: PMC5906443.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Musunuru K, Lagor WR, Miano JM. What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine? Circ Cardiovasc Genet. 2017 10; 10(5). PMID: 28974517; PMCID: PMC5658039.
      Citations: 3     Fields:    Translation:Humans
    38. Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340. PMID: 28487442; PMCID: PMC5878048.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    39. Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659. PMID: 28337975; PMCID: PMC5376670.
      Citations: 34     Fields:    Translation:AnimalsCells
    40. Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624. PMID: 28300165; PMCID: PMC5353616.
      Citations: 43     Fields:    Translation:AnimalsCells
    41. Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res. 2017 04; 58(4):731-741. PMID: 28137768; PMCID: PMC5392748.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    42. Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet. 2016 07 15; 25(14):3042-3054. PMID: 27270415; PMCID: PMC5181598.
      Citations: 8     Fields:    Translation:HumansCells
    43. Gillard BK, Rodriguez PJ, Fields DW, Raya JL, Lagor WR, Rosales C, Courtney HS, Gotto AM, Pownall HJ. Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo. Biochim Biophys Acta. 2016 Mar; 1861(3):196-204. PMID: 26709142; PMCID: PMC4804621.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    44. Lagor WR, Tong F, Jarrett KE, Lin W, Conlon DM, Smith M, Wang MY, Yenilmez BO, McCoy MG, Fields DW, O'Neill SM, Gupta R, Kumaravel A, Redon V, Ahima RS, Sturley SL, Billheimer JT, Rader DJ. Deletion of murine Arv1 results in a lean phenotype with increased energy expenditure. Nutr Diabetes. 2015 Oct 19; 5:e181. PMID: 26479315; PMCID: PMC4631934.
      Citations:    
    45. Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 2015 Sep 25; 290(39):23751-65. PMID: 26245899; PMCID: PMC4583036.
      Citations: 21     Fields:    Translation:AnimalsCells
    46. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744; PMCID: PMC4557302.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    47. O'Neill SM, Hinkle C, Chen SJ, Sandhu A, Hovhannisyan R, Stephan S, Lagor WR, Ahima RS, Johnston JC, Reilly MP. Targeting adipose tissue via systemic gene therapy. Gene Ther. 2014 Jul; 21(7):653-61. PMID: 24830434; PMCID: PMC4342115.
      Citations:    
    48. Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids. 2014 Jun; 49(6):505-15. PMID: 24777581; PMCID: PMC4724200.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    49. Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 2014 Mar; 233(1):234-41. PMID: 24529150; PMCID: PMC3936605.
      Citations: 11     Fields:    Translation:AnimalsCells
    50. Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods Mol Biol. 2013; 1027:273-307. PMID: 23912992.
      Citations: 13     Fields:    Translation:AnimalsCells
    51. Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Hum Gene Ther. 2013 Jan; 24(1):19-26. PMID: 22985273; PMCID: PMC3555111.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    52. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. PMID: 22363685; PMCID: PMC3282742.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    53. Boone LR, Lagor WR, Moya Mde L, Niesen MI, Rothblat GH, Ness GC. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Atherosclerosis. 2011 Sep; 218(1):77-82. PMID: 21605865; PMCID: PMC3324859.
      Citations: 13     Fields:    Translation:AnimalsCells
    54. Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet Mv, Rader DJ, Tietge UJ. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochim Biophys Acta. 2011 Apr; 1811(4):294-9. PMID: 21296681.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    55. Lagor WR, Rader DJ. Phospholipidation of HDL--how much is too much? Clin Chem. 2011 Jan; 57(1):4-6. PMID: 21078838.
      Citations: 2     Fields:    Translation:HumansAnimals
    56. Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest. 2010 Dec; 120(12):4410-4. PMID: 21084752; PMCID: PMC2993600.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    57. Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res. 2010 Aug 06; 107(3):357-64. PMID: 20558822; PMCID: PMC2948973.
      Citations: 29     Fields:    Translation:AnimalsCells
    58. Davidson WS, Silva RA, Chantepie S, Lagor WR, Chapman MJ, Kontush A. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):870-6. PMID: 19325143; PMCID: PMC2845307.
      Citations: 177     Fields:    Translation:HumansCells
    59. Niesen MI, Osborne AR, Lagor WR, Zhang H, Kazemfar K, Ness GC, Blanck G. Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX. Acta Biochim Biophys Sin (Shanghai). 2009 Mar; 41(3):198-205. PMID: 19280058.
      Citations: 1     Fields:    Translation:AnimalsCells
    60. Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):40-6. PMID: 19008531; PMCID: PMC2766561.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    61. Lagor WR, Heller R, de Groh ED, Ness GC. Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation. Exp Biol Med (Maywood). 2007 Mar; 232(3):353-61. PMID: 17327468.
      Citations: 10     Fields:    Translation:AnimalsCells
    62. Lagor WR, de Groh ED, Ness GC. Diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter. J Biol Chem. 2005 Nov 04; 280(44):36601-8. PMID: 16127173.
      Citations: 8     Fields:    Translation:AnimalsCells
    63. Osborne AR, Pollock VV, Lagor WR, Ness GC. Identification of insulin-responsive regions in the HMG-CoA reductase promoter. Biochem Biophys Res Commun. 2004 Jun 11; 318(4):814-8. PMID: 15147943.
      Citations: 9     Fields:    Translation:AnimalsCells
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