"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
|
| MeSH Number(s) |
G05.308.203.374.394
|
| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 2 | 0 | 2 |
| 2015 | 2 | 3 | 5 |
| 2016 | 8 | 5 | 13 |
| 2017 | 8 | 12 | 20 |
| 2018 | 11 | 15 | 26 |
| 2019 | 10 | 17 | 27 |
| 2020 | 12 | 11 | 23 |
| 2021 | 11 | 11 | 22 |
| 2022 | 6 | 8 | 14 |
| 2023 | 9 | 5 | 14 |
| 2024 | 6 | 10 | 16 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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Large-scale CRISPR/Cas9 deletions within the WFDC gene cluster uncover gene functionality and critical roles in mammalian reproduction. Proc Natl Acad Sci U S A. 2024 Dec 17; 121(51):e2413195121.
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Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene. Bone Res. 2024 Dec 06; 12(1):70.
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Evidence that CRISPR-Cas9 Y537S-mutant expressing breast cancer cells activate Yes-associated protein 1 to driving the conversion of normal fibroblasts into cancer-associated fibroblasts. Cell Commun Signal. 2024 Nov 14; 22(1):545.
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RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model. J Genet Genomics. 2024 Dec; 51(12):1389-1403.
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Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines. Sci Rep. 2024 09 30; 14(1):22626.
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Simulation of CRISPR-Cas9 editing on evolving barcode and accuracy of lineage tracing. Sci Rep. 2024 08 19; 14(1):19213.
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SMYD5 is a regulator of the mild hypothermia response. Cell Rep. 2024 Aug 27; 43(8):114554.
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Novel mutation leading to splice donor loss in a conserved site of DMD gene causes Duchenne muscular dystrophy with cryptorchidism. J Med Genet. 2024 Jul 19; 61(8):741-749.
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Integration of ?-deficient CARs into the CD3? gene conveys potent cytotoxicity in T and NK cells. Blood. 2024 06 20; 143(25):2599-2611.
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SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells. Elife. 2024 Jun 18; 12.