"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
Descriptor ID |
D064113
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MeSH Number(s) |
G05.308.203.374.394
|
Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2014 | 2 | 0 | 2 |
2015 | 2 | 3 | 5 |
2016 | 8 | 4 | 12 |
2017 | 8 | 12 | 20 |
2018 | 11 | 14 | 25 |
2019 | 10 | 17 | 27 |
2020 | 13 | 11 | 24 |
2021 | 10 | 13 | 23 |
2022 | 4 | 9 | 13 |
2023 | 7 | 3 | 10 |
2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing. Genesis. 2024 Apr; 62(2):e23589.
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Recovering a Targeted Mutation in Mice from Embryonic Stem Cell Chimeras or CRISPR-Cas Founders. Cold Spring Harb Protoc. 2024 Jan 02; 2024(1):pdb.over107959.
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Mouse Gene-Targeting Strategies for Maximum Ease and Versatility. Cold Spring Harb Protoc. 2024 Jan 02; 2024(1):pdb.over107957.
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CRISPR-Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames. Nat Struct Mol Biol. 2023 Dec; 30(12):1878-1892.
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Programmable RNA detection with CRISPR-Cas12a. Nat Commun. 2023 09 05; 14(1):5409.
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Disrupting Protein Expression with Double-Clicked sgRNA-Cas9 Complexes: A Modular Approach to CRISPR Gene Editing. ACS Chem Biol. 2023 10 20; 18(10):2156-2162.
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Evidence-Based Guide to Using Artificial Introns for Tissue-Specific Knockout in Mice. Int J Mol Sci. 2023 Jun 17; 24(12).
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Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity. Commun Biol. 2023 06 10; 6(1):626.
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Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice. Sci Adv. 2023 05 12; 9(19):eade0059.
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Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells. Genome Biol. 2023 04 24; 24(1):89.