"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
|
| MeSH Number(s) |
G05.308.203.374.394
|
| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 3 | 4 |
| 2016 | 8 | 5 | 13 |
| 2017 | 8 | 5 | 13 |
| 2018 | 8 | 15 | 23 |
| 2019 | 6 | 14 | 20 |
| 2020 | 6 | 9 | 15 |
| 2021 | 5 | 10 | 15 |
| 2022 | 6 | 7 | 13 |
| 2023 | 6 | 4 | 10 |
| 2024 | 8 | 10 | 18 |
| 2025 | 8 | 12 | 20 |
| 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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FACS-based genome-wide CRISPR screening platform identifies modulators of CD47. Front Immunol. 2025; 16:1684539.
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Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors. Nat Commun. 2025 Dec 09; 16(1):10987.
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Multiple LDLR?family members act as entry receptors for yellow fever virus. Nature. 2026 Jan; 649(8095):173-182.
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HLA matching or CRISPR editing of HLA class I/II enables engraftment and effective function of allogeneic human regulatory T cell therapy in a humanized mouse transplantation model. Nat Commun. 2025 Oct 13; 16(1):9090.
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A miniature CRISPR-Cas10 enzyme confers immunity by inhibitory signalling. Nature. 2025 Nov; 647(8091):997-1004.
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Next-generation multiplex-edited CAR-NK cells: more edits, more power? J Immunother Cancer. 2025 Sep 15; 13(9).
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AsCas12a tolerates insertions in target DNA. Nucleic Acids Res. 2025 Sep 05; 53(17).
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Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer. Cancer Lett. 2025 Nov 01; 632:217977.
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Hide-and-Seek genome editing reveals that Gephyrin is required for axo-axonic synapse assembly. Proc Natl Acad Sci U S A. 2025 Aug 12; 122(32):e2500726122.
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Barcoded viral tracing identifies immunosuppressive astrocyte-glioma interactions. Nature. 2025 Aug; 644(8078):1097-1106.