"Gene Silencing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
| Descriptor ID |
D020868
|
| MeSH Number(s) |
G05.308.203.374
|
| Concept/Terms |
Gene Silencing- Gene Silencing
- Silencing, Gene
- Gene Inactivation
- Inactivation, Gene
|
Below are MeSH descriptors whose meaning is more general than "Gene Silencing".
Below are MeSH descriptors whose meaning is more specific than "Gene Silencing".
This graph shows the total number of publications written about "Gene Silencing" by people in this website by year, and whether "Gene Silencing" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 3 | 3 | 6 |
| 2004 | 2 | 4 | 6 |
| 2005 | 1 | 6 | 7 |
| 2006 | 3 | 3 | 6 |
| 2007 | 2 | 7 | 9 |
| 2008 | 4 | 6 | 10 |
| 2009 | 4 | 8 | 12 |
| 2010 | 1 | 6 | 7 |
| 2011 | 5 | 9 | 14 |
| 2012 | 5 | 9 | 14 |
| 2013 | 3 | 10 | 13 |
| 2014 | 3 | 15 | 18 |
| 2015 | 0 | 8 | 8 |
| 2016 | 1 | 8 | 9 |
| 2017 | 1 | 6 | 7 |
| 2018 | 1 | 5 | 6 |
| 2019 | 1 | 5 | 6 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 6 | 6 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 3 | 4 |
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Below are the most recent publications written about "Gene Silencing" by people in Profiles.
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Monitoring the stability of transgene expression in lettuce using the RUBY reporter. Plant Cell Rep. 2025 Nov 26; 44(12):281.
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Adeno-associated Virus-mediated Silencing of Sox4 Leads to Long-Term Amelioration of Liver Phenotypes in Mouse Models of Alagille Syndrome. Gastroenterology. 2025 Oct; 169(5):1000-1016.
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Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells. ACS Synth Biol. 2025 02 21; 14(2):384-397.
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Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nat Biotechnol. 2025 Dec; 43(12):2054-2067.
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VSIG-3/IGSF11 silencing in A2058 melanoma cells simultaneously suppresses melanoma progression and induces anti-tumoral cytokine profile in human T cells: In silico and in vitro study. Naunyn Schmiedebergs Arch Pharmacol. 2025 04; 398(4):3861-3880.
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ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome. Hepatology. 2023 11 01; 78(5):1337-1351.
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Mesenchymal stromal cell-derived syndecan-2 regulates the immune response during sepsis to foster bacterial clearance and resolution of inflammation. FEBS J. 2022 01; 289(2):417-435.
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Polycystin-1 regulates cardiomyocyte mitophagy. FASEB J. 2021 08; 35(8):e21796.
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DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Neurotherapeutics. 2021 07; 18(3):1710-1728.
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Interdependencies between Toll-like receptors in Leishmania infection. Immunology. 2021 09; 164(1):173-189.