"Soluble Guanylyl Cyclase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
| Descriptor ID |
D000071756
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| MeSH Number(s) |
D08.811.520.650.600.750 D12.644.360.350.500 D12.776.476.350.500
|
| Concept/Terms |
Soluble Guanylyl Cyclase- Soluble Guanylyl Cyclase
- Cyclase, Soluble Guanylyl
- Guanylyl Cyclase, Soluble
- Soluble Guanylate Cyclase
- Cyclase, Soluble Guanylate
- Guanylate Cyclase, Soluble
- Nitric Oxide-Sensitive Guanylyl Cyclase
- Nitric Oxide Sensitive Guanylyl Cyclase
- Receptor, Nitric Oxide
- Nitric Oxide Receptor
- Oxide Receptor, Nitric
- Nitric Oxide Receptors
- Oxide Receptors, Nitric
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Below are MeSH descriptors whose meaning is more general than "Soluble Guanylyl Cyclase".
Below are MeSH descriptors whose meaning is more specific than "Soluble Guanylyl Cyclase".
This graph shows the total number of publications written about "Soluble Guanylyl Cyclase" by people in this website by year, and whether "Soluble Guanylyl Cyclase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Soluble Guanylyl Cyclase" by people in Profiles.
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Mechanical pressure unloading therapy reverses thoracic aortic structural and functional changes in a hypertensive rat model. J Hypertens. 2018 12; 36(12):2350-2361.
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Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury. Neuropharmacology. 2017 Oct; 125:156-165.
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Disrupted nitric oxide signaling due to GUCY1A3 mutations increases risk for moyamoya disease, achalasia and hypertension. Clin Genet. 2016 10; 90(4):351-60.
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Hyperglycemia down-regulates cGMP-dependent protein kinase I expression in first trimester cytotrophoblast cells. Mol Cell Biochem. 2015 Jul; 405(1-2):81-8.
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Hyperoxia inhibits nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1. Antioxid Redox Signal. 2014 Nov 01; 21(13):1823-36.
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Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity. Biochemistry. 2014 Apr 08; 53(13):2153-65.
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Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. PLoS One. 2012; 7(7):e41099.
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How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase. Antioxid Redox Signal. 2012 Nov 01; 17(9):1246-63.
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Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma. Mol Pharmacol. 2011 Dec; 80(6):1076-84.
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RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase. Nitric Oxide. 2011 Oct 30; 25(3):265-74.