Dosage Compensation, Genetic
"Dosage Compensation, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
| Descriptor ID |
D004303
|
| MeSH Number(s) |
G05.308.203.249
|
| Concept/Terms |
Dosage Compensation, Genetic- Dosage Compensation, Genetic
- Compensation, Genetic Dosage
- Genetic Dosage Compensation
- Genetic Dosage Compensations
- Gene Dosage Compensation
- Compensation, Gene Dosage
- Dosage Compensation, Gene
- Gene Dosage Compensations
- Dosage Compensation (Genetics)
- Compensation, Dosage (Genetics)
X-Chromosome Hypertranscription- X-Chromosome Hypertranscription
- X Chromosome Hypertranscription
- Hypertranscription, X-Chromosome
- Hypertranscription, X Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Dosage Compensation, Genetic".
Below are MeSH descriptors whose meaning is more specific than "Dosage Compensation, Genetic".
This graph shows the total number of publications written about "Dosage Compensation, Genetic" by people in this website by year, and whether "Dosage Compensation, Genetic" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 3 | 4 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 2 | 4 |
| 2002 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Dosage Compensation, Genetic" by people in Profiles.
-
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming. Nat Genet. 2018 02; 50(2):238-249.
-
siRNAs from an X-linked satellite repeat promote X-chromosome recognition in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16460-5.
-
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev. 2011 May 01; 25(9):959-71.
-
Atypical X-chromosome inactivation in an X;1 translocation patient demonstrating Xq28 functional disomy. Am J Med Genet A. 2009 Mar; 149A(3):408-14.
-
The DNA sequence of the human X chromosome. Nature. 2005 Mar 17; 434(7031):325-37.
-
Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem. 2004 Dec 17; 279(51):52812-5.
-
X-chromosome inactivation patterns are unbalanced and affect the phenotypic outcome in a mouse model of rett syndrome. Am J Hum Genet. 2004 Mar; 74(3):511-20.
-
Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females. Am J Hum Genet. 2002 Oct; 71(4):838-53.
-
Balanced X chromosome inactivation patterns in the Rett syndrome brain. Am J Med Genet. 2002 Aug 01; 111(2):164-8.
-
Compensating for central nervous system dysmyelination: females with a proteolipid protein gene duplication and sustained clinical improvement. Ann Neurol. 2001 Dec; 50(6):747-54.