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CLAVIA WOOTON-KEE

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    Collapse Research 
    Collapse research activities and funding
    R01DK129579     (WOOTON-KEE, CLAVIA RUTH)Jul 18, 2022 - May 31, 2027
    NIH
    Nuclear Receptor Dysfunction Reprograms Metabolism and Cellular Proliferation in Wilson's Disease
    Role: Principal Investigator
    K01DK111716     (WOOTON-KEE, CLAVIA RUTH)Feb 17, 2017 - Jan 31, 2022
    NIH
    Nuclear Receptors as Novel Therapeutic Targets for Wilson?s Disease
    Role: Principal Investigator
    F32DK089689     (WOOTON-KEE, CLAVIA RUTH)Sep 25, 2010 - Sep 24, 2012
    NIH
    Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wooton-Kee CR. Therapeutic implications of impaired nuclear receptor function and dysregulated metabolism in Wilson's disease. Pharmacol Ther. 2023 Nov; 251:108529. PMID: 37741465; PMCID: PMC10841433.
      Citations:    Fields:    Translation:HumansAnimals
    2. Kim KH, Wooton-Kee CR. Editorial for the MCE special issue on "FXR and metabolism". Mol Cell Endocrinol. 2023 04 05; 565:111889. PMID: 36804839.
      Citations:    Fields:    
    3. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2076-2083. PMID: 31924743; PMCID: PMC6994990.
      Citations: 15     Fields:    Translation:HumansAnimals
    4. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001; PMCID: PMC6312660.
      Citations: 3     Fields:    
    5. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115; PMCID: PMC6420307.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446. PMID: 29718219; PMCID: PMC7263843.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Muchenditsi A, Yang H, Hamilton JP, Koganti L, Housseau F, Aronov L, Fan H, Pierson H, Bhattacharjee A, Murphy R, Sears C, Potter J, Wooton-Kee CR, Lutsenko S. Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 01; 313(1):G39-G49. PMID: 28428350; PMCID: PMC5538836.
      Citations: 16     Fields:    Translation:AnimalsCells
    8. Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Newgard CB, Moore DD, St?hlman M, Bor?n J. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 2016 Jan; 63(1):95-106. PMID: 26267291; PMCID: PMC5662191.
      Citations: 9     Fields:    Translation:AnimalsCells
    9. Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep; 125(9):3449-60. PMID: 26241054; PMCID: PMC4588285.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    10. Athippozhy A, Huang L, Wooton-Kee CR, Zhao T, Jungsuwadee P, Stromberg AJ, Vore M. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics. 2011 Feb 03; 12:95. PMID: 21291544; PMCID: PMC3045338.
      Citations: 8     Fields:    Translation:AnimalsCells
    11. Coy DJ, Wooton-Kee CR, Yan B, Sabeva N, Su K, Graf G, Vore M. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G228-35. PMID: 20413720; PMCID: PMC2904104.
      Citations: 5     Fields:    Translation:Animals
    12. Wooton-Kee CR, Coy DJ, Athippozhy AT, Zhao T, Jones BR, Vore M. Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology. 2010 Jan; 51(1):277-85. PMID: 19957370; PMCID: PMC2799537.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Wooton-Kee CR, Cohen DE, Vore M. Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1009-16. PMID: 18292185; PMCID: PMC2408447.
      Citations: 9     Fields:    Translation:Animals
    14. Wood M, Ananthanarayanan M, Jones B, Wooton-Kee R, Hoffman T, Suchy FJ, Vore M. Hormonal regulation of hepatic organic anion transporting polypeptides. Mol Pharmacol. 2005 Jul; 68(1):218-25. PMID: 15840840.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Wooton-Kee CR, Boyanovsky BB, Nasser MS, de Villiers WJ, Webb NR. Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol. 2004 Apr; 24(4):762-7. PMID: 14962950.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    16. Tabb AL, Utsugi T, Wooten-Kee CR, Sasaki T, Edling SA, Gump W, Kikuchi Y, Ellis SR. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Genetics. 2001 Mar; 157(3):1107-16. PMID: 11238398; PMCID: PMC1461576.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Wooton-Kee CR, Clark BJ. Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene. Endocrinology. 2000 Apr; 141(4):1345-55. PMID: 10746638.
      Citations: 23     Fields:    Translation:AnimalsCells
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