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MATTHEW MCMILLIN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Education, Innovation & Technology
Address2401 S 31st St
Temple, TX 76508
ORCID ORCID Icon0000-0002-5980-0921 Additional info
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    Collapse Biography 
    Collapse education and training
    Baylor University, Waco, TXB.S.12/2008Psychology
    Texas A&M University, College Station, TXPh.D.12/2013Neuroscience

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ?zkan A, Stolley DL, Cressman ENK, McMillin M, Yankeelov TE, Rylander MN. Vascularized Hepatocellular Carcinoma on a Chip to Control Chemoresistance through Cirrhosis, Inflammation and Metabolic Activity. Small Struct. 2023 Sep; 4(9). PMID: 38073766; PMCID: PMC10707486.
      Citations: 1     
    2. Petrescu AD, Grant S, Williams E, An SY, Seth N, Shell M, Amundsen T, Tan C, Nadeem Y, Tjahja M, Weld L, Chu CS, Venter J, Frampton G, McMillin M, DeMorrow S. Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis. Am J Pathol. 2022 03; 192(3):484-502. PMID: 34896073; PMCID: PMC8895426.
      Citations:    
    3. Stolley DL, Cressman ENK, McMillin M, DeMorrow S, Yankeelov TE, Rylander MN, ?zkan A. Tumor Microenvironment Alters Chemoresistance of Hepatocellular Carcinoma Through CYP3A4 Metabolic Activity. Front Oncol. 2021; 11:662135. PMID: 34262860; PMCID: PMC8273608.
      Citations:    
    4. Braissant O, Capobianco D, Mastromarino P, McMillin M, DeMorrow S, Rackayov? V, Flatt E, Grosse J, McLin VA, Cudalbu C. Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease. Sci Rep. 2021 01 26; 11(1):2269. PMID: 33500487; PMCID: PMC7838316.
      Citations:    
    5. Frampton G, Reddy P, Jefferson B, Ali M, Khan D, McMillin M. Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice. Toxicol Appl Pharmacol. 2020 12 15; 409:115323. PMID: 33176120; PMCID: PMC8364670.
      Citations:    
    6. Petrescu AD, Grant S, Williams E, Frampton G, Reinhart EH, Nguyen A, An S, McMillin M, DeMorrow S. Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep. 2020 09 29; 10(1):16024. PMID: 32994489; PMCID: PMC7525536.
      Citations:    
    7. Stolley D, Cressman ENK, McMillin M, DeMorrow S, Yankeelov TE, Rylander MN, ?zkan A. The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review. Micromachines (Basel). 2020 May 09; 11(5). PMID: 32397454; PMCID: PMC7281532.
      Citations: 4     
    8. Petrescu AD, Grant S, Williams E, Frampton G, Parks N, Blaney H, Davies M, John R, Reinhart EH, McMillin M, DeMorrow S. Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice. Am J Pathol. 2020 03; 190(3):586-601. PMID: 31953035; PMCID: PMC7074378.
      Citations:    
    9. McMillin M. Can Weather Influence the Prevalence of Acute-on-chronic Liver Failure? J Clin Transl Hepatol. 2019 Dec 28; 7(4):285-286. PMID: 31915595; PMCID: PMC6943213.
      Citations:    
    10. Jefferson B, Ali M, Grant S, Frampton G, Ploof M, Andry S, DeMorrow S, McMillin M. Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor ?1. Am J Pathol. 2020 02; 190(2):347-357. PMID: 31734229; PMCID: PMC7013272.
      Citations:    
    11. Jaeger V, DeMorrow S, McMillin M. The Direct Contribution of Astrocytes and Microglia to the Pathogenesis of Hepatic Encephalopathy. J Clin Transl Hepatol. 2019 Dec 28; 7(4):352-361. PMID: 31915605; PMCID: PMC6943208.
      Citations:    
    12. McMillin M, Grant S, Frampton G, Petrescu AD, Williams E, Jefferson B, DeMorrow S. The TGF?1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice. Toxicol Sci. 2019 05 01; 170(2):549-561. PMID: 31132129; PMCID: PMC6821297.
      Citations:    
    13. McMillin M, Grant S, Frampton G, Petrescu AD, Williams E, Jefferson B, Thomas A, Brahmaroutu A, DeMorrow S. Elevated circulating TGF?1 during acute liver failure activates TGF?R2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice. J Neuroinflammation. 2019 Apr 02; 16(1):69. PMID: 30940161; PMCID: PMC6446280.
      Citations:    
    14. Petrescu AD, Grant S, Frampton G, McMillin M, Kain J, Kodali M, Shetty AK, DeMorrow S. Gulf war illness-related chemicals increase CD11b/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model. Sci Rep. 2018 09 03; 8(1):13147. PMID: 30177688; PMCID: PMC6120951.
      Citations:    
    15. Grant S, McMillin M, Frampton G, Petrescu AD, Williams E, Jaeger V, Kain J, DeMorrow S. Direct Comparison of the Thioacetamide and Azoxymethane Models of Type A Hepatic Encephalopathy in Mice. Gene Expr. 2018 08 22; 18(3):171-185. PMID: 29895352; PMCID: PMC6190119.
      Citations:    
    16. McMillin M, Grant S, Frampton G, Petrescu AD, Kain J, Williams E, Haines R, Canady L, DeMorrow S. FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy. Cell Mol Gastroenterol Hepatol. 2018; 6(1):47-63. PMID: 29928671; PMCID: PMC6008252.
      Citations:    
    17. Petrescu AD, Grant S, Frampton G, Kain J, Hadidi K, Williams E, McMillin M, DeMorrow S. Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model. Int J Mol Sci. 2017 Nov 10; 18(11). PMID: 29125588; PMCID: PMC5713358.
      Citations:    
    18. McMillin M, DeMorrow S, Glaser S, Venter J, Kyritsi K, Zhou T, Grant S, Giang T, Greene JF, Wu N, Jefferson B, Meng F, Alpini G. Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G410-G418. PMID: 28751425; PMCID: PMC5792219.
      Citations:    
    19. McMillin M, Frampton G, Grant S, Khan S, Diocares J, Petrescu A, Wyatt A, Kain J, Jefferson B, DeMorrow S. Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice. Front Cell Neurosci. 2017; 11:191. PMID: 28725183; PMCID: PMC5496949.
      Citations:    
    20. McMillin M, Frampton G, Grant S, DeMorrow S. The Neuropeptide Galanin Is Up-Regulated during Cholestasis and Contributes to Cholangiocyte Proliferation. Am J Pathol. 2017 Apr; 187(4):819-830. PMID: 28196718; PMCID: PMC5397710.
      Citations:    
    21. Nizamutdinov D, DeMorrow S, McMillin M, Kain J, Mukherjee S, Zeitouni S, Frampton G, Bricker PC, Hurst J, Shapiro LA. Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury. Sci Rep. 2017 01 20; 7:40112. PMID: 28106051; PMCID: PMC5247752.
      Citations:    
    22. McMillin M, Grant S, Frampton G, Andry S, Brown A, DeMorrow S. Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice. J Neuroinflammation. 2016 08 26; 13(1):198. PMID: 27561705; PMCID: PMC5000400.
      Citations:    
    23. McMillin M, DeMorrow S. Effects of bile acids on neurological function and disease. FASEB J. 2016 11; 30(11):3658-3668. PMID: 27468758; PMCID: PMC5067249.
      Citations:    
    24. McMillin M, Frampton G, Quinn M, Ashfaq S, de los Santos M, Grant S, DeMorrow S. Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure. Am J Pathol. 2016 Feb; 186(2):312-23. PMID: 26683664; PMCID: PMC4729266.
      Citations:    
    25. McMillin M, Frampton G, Quinn M, Divan A, Grant S, Patel N, Newell-Rogers K, DeMorrow S. Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling. Mol Endocrinol. 2015 Dec; 29(12):1720-30. PMID: 26431088; PMCID: PMC4664228.
      Citations:    
    26. McMillin M, Frampton G, Tobin R, Dusio G, Smith J, Shin H, Newell-Rogers K, Grant S, DeMorrow S. TGR5 signaling reduces neuroinflammation during hepatic encephalopathy. J Neurochem. 2015 Nov; 135(3):565-76. PMID: 26179031; PMCID: PMC5031412.
      Citations:    
    27. Venter J, Francis H, Meng F, DeMorrow S, Kennedy L, Standeford H, Hargrove L, Wu N, Wan Y, Frampton G, McMillin M, Marzioni M, Gaudio E, Onori P, Glaser S, Alpini G. Development and functional characterization of extrahepatic cholangiocyte lines from normal rats. Dig Liver Dis. 2015 Nov; 47(11):964-72. PMID: 26277684; PMCID: PMC4624466.
      Citations:    
    28. McMillin MA, Frampton GA, Seiwell AP, Patel NS, Jacobs AN, DeMorrow S. TGF?1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5. Lab Invest. 2015 Aug; 95(8):903-13. PMID: 26006017; PMCID: PMC5040071.
      Citations:    
    29. Ray D, Han Y, Franchitto A, DeMorrow S, Meng F, Venter J, McMillin M, Kennedy L, Francis H, Onori P, Mancinelli R, Gaudio E, Alpini G, Glaser SS. Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms. Am J Pathol. 2015 Apr; 185(4):1061-72. PMID: 25794706; PMCID: PMC4380841.
      Citations:    
    30. McMillin M, Galindo C, Pae HY, Frampton G, Di Patre PL, Quinn M, Whittington E, DeMorrow S. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor ?1 in mice. J Hepatol. 2014 Dec; 61(6):1260-6. PMID: 25046848; PMCID: PMC4253574.
      Citations:    
    31. McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, Alpini G, DeMorrow S. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10; 11:121. PMID: 25012628; PMCID: PMC4128607.
      Citations:    
    32. Quinn M, McMillin M, Galindo C, Frampton G, Pae HY, DeMorrow S. Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms. Dig Liver Dis. 2014 Jun; 46(6):527-34. PMID: 24629820; PMCID: PMC4065628.
      Citations:    
    33. Meng F, DeMorrow S, Venter J, Frampton G, Han Y, Francis H, Standeford H, Avila S, McDaniel K, McMillin M, Afroze S, Guerrier M, Quezada M, Ray D, Kennedy L, Hargrove L, Glaser S, Alpini G. Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G759-68. PMID: 24603459; PMCID: PMC4010652.
      Citations:    
    34. Frampton G, Ueno Y, Quinn M, McMillin M, Pae HY, Galindo C, Leyva-Illades D, DeMorrow S. The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 01; 303(11):G1202-11. PMID: 23086914; PMCID: PMC3532458.
      Citations:    
    35. Huang L, Frampton G, Rao A, Zhang KS, Chen W, Lai JM, Yin XY, Walker K, Culbreath B, Leyva-Illades D, Quinn M, McMillin M, Bradley M, Liang LJ, DeMorrow S. Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events. Lab Invest. 2012 Oct; 92(10):1451-60. PMID: 22906985; PMCID: PMC3959781.
      Citations:    
    36. Leyva-Illades D, McMillin M, Quinn M, Demorrow S. Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment. Transl Gastrointest Cancer. 2012; 1(1):71-80. PMID: 23002431; PMCID: PMC3448449.
      Citations:    
    37. Frampton G, Invernizzi P, Bernuzzi F, Pae HY, Quinn M, Horvat D, Galindo C, Huang L, McMillin M, Cooper B, Rimassa L, DeMorrow S. Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism. Gut. 2012 Feb; 61(2):268-77. PMID: 22068162; PMCID: PMC4498955.
      Citations:    
    38. Quinn M, Ueno Y, Pae HY, Huang L, Frampton G, Galindo C, Francis H, Horvat D, McMillin M, Demorrow S. Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 01; 302(1):G182-93. PMID: 21979757; PMCID: PMC3345968.
      Citations:    
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