Copper-transporting ATPases
"Copper-transporting ATPases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
| Descriptor ID |
D000073840
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| MeSH Number(s) |
D08.811.277.040.025.314.500 D12.776.157.530.450.250.656 D12.776.157.530.813.500 D12.776.543.585.450.250.656 D12.776.543.585.813.500
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| Concept/Terms |
Copper-transporting ATPases- Copper-transporting ATPases
- ATPases, Copper-transporting
- Copper transporting ATPases
- Cu(+)-transporting ATPases
- Copper-transporting Adenosine Triphosphatases
- Adenosine Triphosphatases, Copper-transporting
- Copper transporting Adenosine Triphosphatases
- Triphosphatases, Copper-transporting Adenosine
- Copper-transporting ATPase
- ATPase, Copper-transporting
- Copper transporting ATPase
- Cu-transporting ATPases
- ATPases, Cu-transporting
- Cu transporting ATPases
Wilson Disease Protein- Wilson Disease Protein
- ATP7B Cu-binding P type ATPase
- ATP7B Cu binding P type ATPase
- Copper-transporting ATPase 2
- Copper transporting ATPase 2
- ATPase, Cu++ transporting, beta Polypeptide (Wilson Disease)
- Wilson Disease Cu-binding P Type ATPase
- Wilson Disease Cu binding P Type ATPase
Copper-transporting ATPase 1- Copper-transporting ATPase 1
- ATPase 1, Copper-transporting
- Copper transporting ATPase 1
- Copper Pump 1
- Menkes Disease-associated Protein
- Menkes Disease associated Protein
- ATP7A Protein
- ATPase Copper Transporting alpha
Pineal Night-specific ATPase- Pineal Night-specific ATPase
- ATPase, Pineal Night-specific
- Night-specific ATPase, Pineal
- Pineal Night specific ATPase
- PINA Enzyme
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Below are MeSH descriptors whose meaning is more general than "Copper-transporting ATPases".
Below are MeSH descriptors whose meaning is more specific than "Copper-transporting ATPases".
This graph shows the total number of publications written about "Copper-transporting ATPases" by people in this website by year, and whether "Copper-transporting ATPases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 3 | 3 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Copper-transporting ATPases" by people in Profiles.
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A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. PLoS Genet. 2020 11; 16(11):e1009106.
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Modelling the pathogenesis of X-linked distal hereditary motor neuropathy using patient-derived iPSCs. Dis Model Mech. 2020 01 13; 13(2).
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Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2076-2083.
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Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 01; 313(1):G39-G49.
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IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma. J Natl Cancer Inst. 2016 12; 108(12).
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Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep; 125(9):3449-60.
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Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis. Dev Cell. 2014 Jun 23; 29(6):686-700.
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Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Lung Cancer. 2012 Feb; 75(2):228-34.
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Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy. Am J Hum Genet. 2010 Mar 12; 86(3):343-52.
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Therapeutic Targeting of ATP7B in Ovarian Carcinoma. Clin Cancer Res. 2009 Jun 01; 15(11):3770-80.