Cholesterol 7-alpha-Hydroxylase
"Cholesterol 7-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
| Descriptor ID |
D002790
|
| MeSH Number(s) |
D08.244.453.890.500 D08.244.453.915.200 D08.811.682.690.708.170.890.500 D08.811.682.690.708.170.915.200 D12.776.422.220.453.890.500 D12.776.422.220.453.915.200
|
| Concept/Terms |
Cholesterol 7-alpha-Hydroxylase- Cholesterol 7-alpha-Hydroxylase
- Cholesterol 7 alpha Hydroxylase
- Cholesterol 7alpha-Hydroxylase
- Cholesterol 7alpha Hydroxylase
- Cholesterol-7-Hydroxylase
- Cholesterol 7 Hydroxylase
- Cytochrome P-450 CYP7
- Cytochrome P 450 CYP7
- CYP7A
- Cholesterol 7-alpha-Monooxygenase
- Cholesterol 7 alpha Monooxygenase
- Cytochrome P450 7
- CYP7
- CYP 7A
- CYP 7
|
Below are MeSH descriptors whose meaning is more general than "Cholesterol 7-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol 7-alpha-Hydroxylase".
This graph shows the total number of publications written about "Cholesterol 7-alpha-Hydroxylase" by people in this website by year, and whether "Cholesterol 7-alpha-Hydroxylase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 2 | 3 |
| 2003 | 2 | 1 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 1 | 2 |
| 2012 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2021 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cholesterol 7-alpha-Hydroxylase" by people in Profiles.
-
Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs. Am J Physiol Gastrointest Liver Physiol. 2022 01 01; 322(1):G117-G133.
-
Yeast ?-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models. Am J Physiol Gastrointest Liver Physiol. 2021 12 01; 321(6):G639-G655.
-
Determination of 7a-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 01; 1025:76-82.
-
Cholesterol 7a-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 07; 57(7):1144-54.
-
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure. Am J Pathol. 2016 Feb; 186(2):312-23.
-
New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. J Lipid Res. 2014 Mar; 55(3):466-77.
-
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology. 2012 Dec; 153(12):6136-44.
-
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. J Cardiovasc Pharmacol. 2012 Mar; 59(3):254-9.
-
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest. 2011 Jan; 121(1):86-95.
-
Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology. 2010 Jan; 51(1):277-85.