Cholesterol Side-Chain Cleavage Enzyme
"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
| Descriptor ID |
D002786
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| MeSH Number(s) |
D08.244.453.484.250 D08.244.453.915.212 D08.811.682.690.708.170.425.250 D08.811.682.690.708.170.915.212 D12.776.422.220.453.484.250 D12.776.422.220.453.915.212
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| Concept/Terms |
Cholesterol Side-Chain Cleavage Enzyme- Cholesterol Side-Chain Cleavage Enzyme
- Cholesterol Side Chain Cleavage Enzyme
- Cholesterol Desmolase
- Cytochrome P-450(scc)
- CYP11A1
- CYP 11A1
- Cytochrome P450 11A1
- Cytochrome P-450 CYP11A1
- Cytochrome P 450 CYP11A1
- Cholesterol Monooxygenase (Side-Chain-Cleaving)
- 20,22-Desmolase
- 20,22 Desmolase
- Cytochrome P450scc
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Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".
This graph shows the total number of publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in this website by year, and whether "Cholesterol Side-Chain Cleavage Enzyme" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in Profiles.
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Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations. Arch Toxicol. 2024 08; 98(8):2695-2709.
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DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence. Prostate. 2015 Nov; 75(15):1790-801.
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Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Mol Cell Endocrinol. 2015 Mar 05; 403:39-45.
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Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3a,5a-THP and reduces long-term operant ethanol self-administration. J Neurosci. 2014 Apr 23; 34(17):5824-34.
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Sub-acute intravenous administration of silver nanoparticles in male mice alters Leydig cell function and testosterone levels. Reprod Toxicol. 2014 Jun; 45:59-70.
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Luteinizing hormone/human chorionic gonadotropin-mediated activation of mTORC1 signaling is required for androgen synthesis by theca-interstitial cells. Mol Endocrinol. 2012 Oct; 26(10):1732-42.
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Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Carcinogenesis. 2011 Oct; 32(10):1500-6.
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Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null mice. Mol Cell Endocrinol. 2011 Jun 06; 339(1-2):151-8.
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Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol. 2009 Aug; 23(8):1171-82.
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Transforming growth factor-beta1 inhibits luteinization and promotes apoptosis in bovine granulosa cells. Reproduction. 2009 Jun; 137(6):969-77.