"Aromatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
| Descriptor ID |
D001141
|
| MeSH Number(s) |
D08.244.453.489.500 D08.244.453.915.099 D08.811.682.690.708.170.447.500 D08.811.682.690.708.170.915.099 D12.776.422.220.453.489.500 D12.776.422.220.453.915.099
|
| Concept/Terms |
Aromatase- Aromatase
- Estrogen Synthetase
- Estrogen Synthase
- Cytochrome P450 19
- CYP19 Protein
- Protein, CYP19
- Cytochrome P-450(AROM)
- CYP 19
- Cytochrome P-450 CYP19
- Cytochrome P 450 CYP19
- P450AROM
- Androstenedione Aromatase
- Aromatase, Androstenedione
- CYP19
|
Below are MeSH descriptors whose meaning is more general than "Aromatase".
Below are MeSH descriptors whose meaning is more specific than "Aromatase".
This graph shows the total number of publications written about "Aromatase" by people in this website by year, and whether "Aromatase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aromatase" by people in Profiles.
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Oral follicle-stimulating hormone receptor agonist affects granulosa cells differently than recombinant human FSH. Fertil Steril. 2023 11; 120(5):1061-1070.
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Leptin Signaling Contributes to Aromatase Inhibitor Resistant Breast Cancer Cell Growth and Activation of Macrophages. Biomolecules. 2020 04 03; 10(4).
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Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene. Endocrine. 2019 09; 65(3):692-706.
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Shift from androgen to estrogen action causes abdominal muscle fibrosis, atrophy, and inguinal hernia in a transgenic male mouse model. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):E10427-E10436.
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The acceleration of reproductive aging in Nrg1flox/flox ;Cyp19-Cre female mice. Aging Cell. 2017 12; 16(6):1288-1299.
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High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass. Eur J Endocrinol. 2015 Aug; 173(2):167-74.
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Molecular biology of endometriosis: from aromatase to genomic abnormalities. Semin Reprod Med. 2015 May; 33(3):220-4.
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Does estrogen deficiency cause lacrimal gland inflammation and aqueous-deficient dry eye in mice? Exp Eye Res. 2014 Oct; 127:153-60.
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Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth. Breast Cancer Res Treat. 2014 Jul; 146(2):273-85.
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Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs. Mol Endocrinol. 2013 Sep; 27(9):1403-14.