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DENNIS VILLAREAL

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address2002 HOLCOMBE
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse Research 
    Collapse research activities and funding
    I01CX002161     (VILLAREAL, DENNIS T.)Oct 1, 2020 - Sep 30, 2025
    NIH
    Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with Obesity
    Role: Principal Investigator
    R01DK109950     (VILLAREAL, DENNIS T.)Jun 1, 2017 - May 31, 2024
    NIH
    DOES LIFESTYLE INTERVENTION IN OBESE OLDER ADULTS IMPROVE BONE QUALITY?
    Role: Principal Investigator
    IS1BX003142     (VILLAREAL, DENNIS T.)Jan 1, 2015 - Sep 30, 2015
    NIH
    Request for High-Resolution Peripheral Quantitative Computed Tomography
    Role: Principal Investigator
    I01CX000906     (VILLAREAL, DENNIS T.)Apr 1, 2014 - Dec 31, 2019
    NIH
    Testosterone Replacement to Augment Lifestyle Therapy in Obese Older Veterans
    Role: Principal Investigator
    R01AG031176     (VILLAREAL, DENNIS T.)May 1, 2009 - Apr 30, 2020
    NIH
    EXERCISE INTERVENTIONS DURING VOLUNTARY WEIGHT LOSS IN OBESE OLDER ADULTS
    Role: Principal Investigator
    R01AG025501     (VILLAREAL, DENNIS T.)Jan 1, 2005 - Dec 31, 2013
    NIH
    Weight Loss and Exercise in Frail Obese Elderly Subjects
    Role: Principal Investigator
    K23RR016191     (VILLAREAL, DENNIS T.)Apr 1, 2001 - Mar 31, 2005
    NIH
    DHEA+EXERCISE-EFFECT ON SARCOPENIA &OSTEOPENIA OF AGING
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bathina S, Colleluori G, Villareal DT, Aguirre L, Chen R, Armamento-Villareal R. A PRDM16-driven signal regulates body composition in testosterone-treated hypogonadal men. Front Endocrinol (Lausanne). 2024; 15:1426175. PMID: 39286266; PMCID: PMC11402695.
      Citations:    Fields:    Translation:HumansCells
    2. Gonzalez-Gil AM, Barnouin Y, Celli A, Viola V, Villarreal MD, Duremdes Nava ML, Sciuk A, Qualls C, Armamento-Villareal R, Villareal DT. Metabolic effects of testosterone added to intensive lifestyle intervention in older men with obesity and hypogonadism. J Clin Endocrinol Metab. 2024 Apr 12. PMID: 38606934; PMCID: PMC11470114.
      Citations:    Fields:    
    3. Batsis JA, Villareal DT. What weight changes really happened during COVID-19 among older adults? J Nutr Health Aging. 2024 04; 28(4):100221. PMID: 38593615; PMCID: PMC11343315.
      Citations:    Fields:    Translation:HumansCells
    4. Batsis JA, Porter Starr KN, Villareal DT. Should the Incretin hype be the same for older adults: Promise + cautions. J Am Geriatr Soc. 2024 Jul; 72(7):2266-2268. PMID: 38393783; PMCID: PMC11226360.
      Citations:    Fields:    Translation:Humans
    5. Heisey HD, Qualls C, Villareal DT, Segoviano-Escobar MB, Nava MLD, Gatchel JR, Kunik ME. Depressive Symptoms are Associated With C-Reactive Protein in Older Adults With Obesity. J Geriatr Psychiatry Neurol. 2024 Jul; 37(4):332-338. PMID: 37950647; PMCID: PMC11087374.
      Citations:    Fields:    
    6. Gregori G, Paudyal A, Barnouin Y, Celli A, Segoviano-Escobar MB, Armamento-Villareal R, Napoli N, Qualls C, Villareal DT. Indices of sarcopenic obesity are important predictors of finite element analysis-derived bone strength in older adults with obesity. Front Endocrinol (Lausanne). 2023; 14:1279321. PMID: 38027147; PMCID: PMC10660264.
      Citations:    Fields:    Translation:Humans
    7. Kumar M, Orkaby A, Tighe C, Villareal DT, Billingsley H, Nanna MG, Kwak MJ, Rohant N, Patel S, Goyal P, Hummel S, Al-Malouf C, Kolimas A, Krishnaswami A, Rich MW, Kirkpatrick J, Damluji AA, Kuchel GA, Forman DE, Alexander KP. Life's Essential 8: Optimizing Health in Older Adults. JACC Adv. 2023 Sep; 2(7). PMID: 37664644; PMCID: PMC10470487.
      Citations:    
    8. Panda S, Maier G, Villareal DT. Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating. J Gerontol A Biol Sci Med Sci. 2023 06 16; 78(Suppl 1):79-85. PMID: 37325958; PMCID: PMC10272989.
      Citations: 4     Fields:    Translation:HumansAnimals
    9. Gortan Cappellari G, Guillet C, Poggiogalle E, Ballesteros Pomar MD, Batsis JA, Boirie Y, Breton I, Frara S, Genton L, Gepner Y, Gonzalez MC, Heymsfield SB, Kiesswetter E, Laviano A, Prado CM, Santini F, Serlie MJ, Siervo M, Villareal DT, Volkert D, Voortman T, Weijs PJ, Zamboni M, Bischoff SC, Busetto L, Cederholm T, Barazzoni R, Donini LM, SOGLI Expert Panel. Sarcopenic obesity research perspectives outlined by the sarcopenic obesity global leadership initiative (SOGLI) - Proceedings from the SOGLI consortium meeting in rome November 2022. Clin Nutr. 2023 05; 42(5):687-699. PMID: 36947988.
      Citations: 3     Fields:    Translation:Humans
    10. Villareal DT. Editorial: Obesity and Accelerated Aging. J Nutr Health Aging. 2023; 27(5):312-313. PMID: 37248754; PMCID: PMC10349370.
      Citations:    Fields:    Translation:Humans
    11. Colleluori G, Villareal DT. Weight strategy in older adults with obesity: calorie restriction or not? Curr Opin Clin Nutr Metab Care. 2023 01 01; 26(1):17-22. PMID: 36125224; PMCID: PMC9780150.
      Citations:    
    12. Ballato E, Deepika F, Prado M, Russo V, Fuenmayor V, Bathina S, Villareal DT, Qualls C, Armamento-Villareal R. Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2022; 13:936159. PMID: 36171900; PMCID: PMC9511027.
      Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
    13. Celli A, Barnouin Y, Jiang B, Blevins D, Colleluori G, Mediwala S, Armamento-Villareal R, Qualls C, Villareal DT. Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial. Diabetes Care. 2022 09 01; 45(9):1943-1952. PMID: 35880801; PMCID: PMC9472494.
      Citations:    Fields:    
    14. Schwingshackl L, Batsis JA, Villareal DT, Stroebele-Benschop N, Visser M, Galicia Ernst I, Torbahn G, Kn?ttel H, Kob R, Kemmler W, Sieber CC, Volkert D, Kiesswetter E, Schoene D. Outcomes addressed in randomized controlled lifestyle intervention trials in community-dwelling older people with (sarcopenic) obesity-An evidence map. Obes Rev. 2022 10; 23(10):e13497. PMID: 35891613.
      Citations:    Fields:    
    15. Deepika F, Ballato E, Colleluori G, Aguirre L, Chen R, Qualls C, Villareal DT, Armamento-Villareal R. Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy. Front Endocrinol (Lausanne). 2022; 13:915309. PMID: 35898448; PMCID: PMC9309506.
      Citations:    Fields:    Translation:Humans
    16. Ballato E, Deepika FNU, Russo V, Colleluori G, Fuenmayor V, Chen R, Villareal DT, Qualls C, Armamento-Villareal R, Fleires-Guti?rrez A. One-Year Mean A1c of?>?7% is Associated with Poor Bone Microarchitecture and Strength in Men with Type 2 Diabetes Mellitus. Calcif Tissue Int. 2022 09; 111(3):267-278. PMID: 35665818; PMCID: PMC9549604.
      Citations:    Fields:    
    17. Donini LM, Busetto L, Bischoff SC, Cederholm T, Batsis JA, Bauer JM, Boirie Y, Dicker D, Frara S, Gepner Y, Giustina A, Gonzalez MC, Han HS, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Siervo M, Vettor R, Villareal DT, Yu J, Zamboni M, Barazzoni R, Ballesteros-Pomar MD, Cruz-Jentoft AJ, Fr?hbeck G, Genton L, Sieber CC, Volkert D. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Obes Facts. 2022; 15(3):321-335. PMID: 35196654; PMCID: PMC9210010.
      Citations: 2     Fields:    Translation:Humans
    18. Donini LM, Busetto L, Bischoff SC, Cederholm T, Batsis JA, Bauer JM, Boirie Y, Dicker D, Frara S, Gepner Y, Giustina A, Gonzalez MC, Han HS, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Siervo M, Vettor R, Villareal DT, Yu J, Zamboni M, Barazzoni R, Ballesteros-Pomar MD, Cruz-Jentoft AJ, Fr?hbeck G, Genton L, Sieber CC, Volkert D. Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement. Clin Nutr. 2022 04; 41(4):990-1000. PMID: 35227529.
      Citations: 7     Fields:    Translation:Humans
    19. Waters DL, Aguirre L, Gurney B, Sinacore DR, Fowler K, Gregori G, Armamento-Villareal R, Qualls C, Villareal DT. Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults With Obesity While Dieting. J Gerontol A Biol Sci Med Sci. 2022 01 07; 77(1):131-139. PMID: 33839788; PMCID: PMC8751785.
      Citations: 3     Fields:    Translation:Humans
    20. Heisey HD, Kunik ME, Qualls C, Segoviano-Escobar MB, Villareal DT. Truncal Fat and Frailty Are Important Predictors of Cognitive Performance among Aging Adults with Obesity. J Nutr Health Aging. 2022; 26(5):425-429. PMID: 35587753; PMCID: PMC9126430.
      Citations:    Fields:    Translation:Humans
    21. Ho E, Qualls C, Villareal DT. Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial. J Nutr Health Aging. 2022; 26(6):552-557. PMID: 35718862; PMCID: PMC9236175.
      Citations:    Fields:    Translation:Humans
    22. Joad S, Ballato E, Deepika F, Gregori G, Fleires-Gutierrez AL, Colleluori G, Aguirre L, Chen R, Russo V, Fuenmayor Lopez VC, Qualls C, Villareal DT, Armamento-Villareal R. Hemoglobin A1c Threshold for Reduction in Bone Turnover in Men With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2021; 12:788107. PMID: 35027909; PMCID: PMC8750620.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    23. Gregori G, Celli A, Barnouin Y, Paudyal A, Armamento-Villareal R, Napoli N, Qualls C, Villareal DT. Cognitive response to testosterone replacement added to intensive lifestyle intervention in older men with obesity and hypogonadism: prespecified secondary analyses of a randomized clinical trial. Am J Clin Nutr. 2021 11 08; 114(5):1590-1599. PMID: 34375393; PMCID: PMC8588849.
      Citations: 1     Fields:    Translation:Humans
    24. Colleluori G, Villareal DT. Aging, obesity, sarcopenia and the effect of diet and exercise intervention. Exp Gerontol. 2021 11; 155:111561. PMID: 34562568; PMCID: PMC8807026.
      Citations: 9     Fields:    Translation:Humans
    25. Colleluori G, Aguirre L, Napoli N, Qualls C, Villareal DT, Armamento-Villareal R. Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes. J Clin Endocrinol Metab. 2021 07 13; 106(8):e3058-e3068. PMID: 33735389; PMCID: PMC8599870.
      Citations: 5     Fields:    Translation:Humans
    26. Vigevano F, Gregori G, Colleluori G, Chen R, Autemrongsawat V, Napoli N, Qualls C, Villareal DT, Armamento-Villareal R. In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength and Low Bone Turnover. J Clin Endocrinol Metab. 2021 04 23; 106(5):1362-1376. PMID: 33537757; PMCID: PMC8063237.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    27. Wu TD, Fawzy A, Brigham E, McCormack MC, Rosas I, Villareal DT, Hanania NA. Association of Triglyceride-Glucose Index and Lung Health: A Population-Based Study. Chest. 2021 09; 160(3):1026-1034. PMID: 33839084; PMCID: PMC8449007.
      Citations: 4     Fields:    Translation:Humans
    28. Barnouin Y, Armamento-Villareal R, Celli A, Jiang B, Paudyal A, Nambi V, Bryant MS, Marcelli M, Garcia JM, Qualls C, Villareal DT. Testosterone Replacement Therapy Added to Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism. J Clin Endocrinol Metab. 2021 03 08; 106(3):e1096-e1110. PMID: 33351921.
      Citations: 6     Fields:    Translation:Humans
    29. Russo V, Colleluori G, Chen R, Mediwala S, Qualls C, Liebschner M, Villareal DT, Armamento-Villareal R. Testosterone therapy and bone quality in men with diabetes and hypogonadism: Study design and protocol. Contemp Clin Trials Commun. 2021 Mar; 21:100723. PMID: 33718653; PMCID: PMC7933702.
      Citations: 2     
    30. Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M, Izquierdo M, Garc?a-Hermoso A, Guti?rrez-Robledo LM, Ram?rez-V?lez R, Rodriguez-Ma?as L. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021; 25(7):824-853. PMID: 34409961.
      Citations: 36     Fields:    Translation:Humans
    31. Jia X, Sun C, Tang O, Gorlov I, Nambi V, Virani SS, Villareal DT, Taffet GE, Yu B, Bressler J, Boerwinkle E, Windham BG, de Lemos JA, Matsushita K, Selvin E, Michos ED, Hoogeveen RC, Ballantyne CM. Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. J Clin Endocrinol Metab. 2020 12 01; 105(12). PMID: 32785663; PMCID: PMC7526732.
      Citations: 5     Fields:    Translation:Humans
    32. Schwingshackl L, Batsis JA, Villareal DT, Stroebele-Benschop N, Torbahn G, Schoene D, R?cker G, Kn?ttel H, Kemmler W, Sieber CC, Volkert D, Kiesswetter E. Effective SLOPE: EffectS of Lifestyle interventions in Older PEople with obesity: a systematic review and network meta-analysis protocol. BMJ Open. 2020 10 07; 10(10):e038330. PMID: 33033022; PMCID: PMC7542917.
      Citations:    Fields:    Translation:Humans
    33. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 12; 69(12):2630-2641. PMID: 32994273; PMCID: PMC7679774.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Colleluori G, Chen R, Turin CG, Vigevano F, Qualls C, Johnson B, Mediwala S, Villareal DT, Armamento-Villareal R. Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects. Front Endocrinol (Lausanne). 2020; 11:277. PMID: 32499757; PMCID: PMC7243137.
      Citations: 4     Fields:    Translation:Humans
    35. Armamento-Villareal R, Aguirre L, Waters DL, Napoli N, Qualls C, Villareal DT. Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial. J Bone Miner Res. 2020 03; 35(3):430-439. PMID: 31797417; PMCID: PMC7064383.
      Citations: 16     Fields:    Translation:Humans
    36. Aguirre LE, Colleluori G, Robbins D, Dorin R, Shah VO, Chen R, Jan IZ, Qualls C, Villareal DT, Armamento-Villareal R. Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene. Endocrine. 2019 09; 65(3):692-706. PMID: 31325085; PMCID: PMC8077393.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    37. Kraus WE, Bhapkar M, Huffman KM, Pieper CF, Krupa Das S, Redman LM, Villareal DT, Rochon J, Roberts SB, Ravussin E, Holloszy JO, Fontana L, CALERIE Investigators. 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinol. 2019 09; 7(9):673-683. PMID: 31303390; PMCID: PMC6707879.
      Citations: 66     Fields:    Translation:HumansCTClinical Trials
    38. Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun Z, Brunetti L, Hyoung Park J, Kaipparettu BA, Putluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal DT. Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss. Cell Metab. 2019 08 06; 30(2):261-273.e6. PMID: 31279675; PMCID: PMC6685749.
      Citations: 21     Fields:    Translation:Humans
    39. Jiang BC, Villareal DT. Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity. J Nutr Gerontol Geriatr. 2019 Jan-Mar; 38(1):100-114. PMID: 30794099; PMCID: PMC6480356.
      Citations: 12     Fields:    Translation:Humans
    40. Jiang BC, Villareal DT. Therapeutic and lifestyle approaches to obesity in older persons. Curr Opin Clin Nutr Metab Care. 2019 01; 22(1):30-36. PMID: 30346314; PMCID: PMC6265116.
      Citations: 2     Fields:    Translation:Humans
    41. Jankowski CM, Wolfe P, Schmiege SJ, Nair KS, Khosla S, Jensen M, von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R, Weiss EP, Villareal DT, Kohrt WM. Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials. Clin Endocrinol (Oxf). 2019 02; 90(2):293-300. PMID: 30421439; PMCID: PMC6336516.
      Citations: 8     Fields:    Translation:Humans
    42. Colleluori G, Aguirre LE, Qualls C, Chen R, Napoli N, Villareal DT, Armamento-Villareal R. Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels. Nutrients. 2018 Sep 04; 10(9). PMID: 30181488; PMCID: PMC6164305.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    43. Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018 09; 14(9):513-537. PMID: 30065268; PMCID: PMC6241236.
      Citations: 212     Fields:    Translation:Humans
    44. Colleluori G, Chen R, Napoli N, Aguirre LE, Qualls C, Villareal DT, Armamento-Villareal R. Fat Mass Follows a U-Shaped Distribution Based on Estradiol Levels in Postmenopausal Women. Front Endocrinol (Lausanne). 2018; 9:315. PMID: 30013511; PMCID: PMC6036116.
      Citations: 10     Fields:    
    45. Pahor M, Kritchevsky SB, Waters DL, Villareal DT, Morley J, Hare JM, Vellas B. Designing Drug Trials for Frailty: ICFSR Task Force 2018. J Frailty Aging. 2018; 7(3):150-154. PMID: 30095144.
      Citations: 10     Fields:    Translation:Humans
    46. Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, Ruiz J, Sieber CC, Aubertin-Leheudre M, Waters DL, Visvanathan R, Landi F, Villareal DT, Fielding R, Won CW, Theou O, Martin FC, Dong B, Woo J, Flicker L, Ferrucci L, Merchant RA, Cao L, Cederholm T, Ribeiro SML, Anker SD, Lundy J, Bautmans I, Aprahamian I, Schols JMGA, Izquierdo M, Vellas B, Rodr?guez-Ma?as L, Guti?rrez Robledo LM. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. J Nutr Health Aging. 2018; 22(10):1148-1161. PMID: 30498820.
      Citations: 163     Fields:    Translation:HumansPHPublic Health
    47. Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, Bhapkar M, Martin CK, Redman LM, Fuss PJ, Roberts SB, Kraus WE. Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc. 2017 Nov; 49(11):2240-2249. PMID: 29045325; PMCID: PMC5647115.
      Citations: 19     Fields:    Translation:Humans
    48. Aguirre LE, Colleluori G, Dorin R, Robbins D, Chen R, Jiang B, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density. Calcif Tissue Int. 2017 12; 101(6):602-611. PMID: 28856390; PMCID: PMC8091556.
      Citations: 7     Fields:    Translation:Humans
    49. Colleluori G, Napoli N, Phadnis U, Armamento-Villareal R, Villareal DT. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxid Med Cell Longev. 2017; 2017:4807046. PMID: 28951766; PMCID: PMC5603129.
      Citations: 7     Fields:    Translation:Humans
    50. Villareal DT, Waters DL, Qualls C. Exercise Type in Dieting Obese Older Adults. N Engl J Med. 2017 08 10; 377(6):599-600. PMID: 28792874; PMCID: PMC7386465.
      Citations: 6     Fields:    Translation:Humans
    51. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C. Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med. 2017 05 18; 376(20):1943-1955. PMID: 28514618; PMCID: PMC5552187.
      Citations: 158     Fields:    Translation:Humans
    52. Colleluori G, Aguirre L, Dorin R, Robbins D, Blevins D, Barnouin Y, Chen R, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover. Bone. 2017 06; 99:14-19. PMID: 28323146; PMCID: PMC8312374.
      Citations: 15     Fields:    Translation:Humans
    53. Das SK, Roberts SB, Bhapkar MV, Villareal DT, Fontana L, Martin CK, Racette SB, Fuss PJ, Kraus WE, Wong WW, Saltzman E, Pieper CF, Fielding RA, Schwartz AV, Ravussin E, Redman LM, CALERIE-2 Study Group. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans. Am J Clin Nutr. 2017 04; 105(4):913-927. PMID: 28228420; PMCID: PMC5366044.
      Citations: 38     Fields:    Translation:Humans
    54. Qualls C, Waters DL, Vellas B, Villareal DT, Garry PJ, Gallini A, Andrieu S. Reversible States of Physical and/or Cognitive Dysfunction: A 9-Year Longitudinal Study. J Nutr Health Aging. 2017; 21(3):271-275. PMID: 28244566.
      Citations: 4     Fields:    Translation:Humans
    55. Weiss EP, Jordan RC, Frese EM, Albert SG, Villareal DT. Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity. Med Sci Sports Exerc. 2017 01; 49(1):206-217. PMID: 27580151; PMCID: PMC5161655.
      Citations: 36     Fields:    Translation:Humans
    56. Pokharel Y, Sun W, Villareal DT, Selvin E, Virani SS, Ndumele CE, Hoogeveen RC, Coresh J, Boerwinkle E, Butler KR, Solomon SD, Pankow JS, Bozkurt B, Ballantyne CM, Nambi V. Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study. Eur J Prev Cardiol. 2017 04; 24(6):628-638. PMID: 27941157; PMCID: PMC5405860.
      Citations: 6     Fields:    Translation:Humans
    57. Weiss EP, Reeds DN, Ezekiel UR, Albert SG, Villareal DT. Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity. Endocrine. 2017 Jan; 55(1):153-164. PMID: 27605038; PMCID: PMC5226911.
      Citations: 9     Fields:    Translation:Humans
    58. Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial. Am J Clin Nutr. 2016 Sep; 104(3):576-86. PMID: 27465384; PMCID: PMC4997297.
      Citations: 31     Fields:    Translation:Humans
    59. Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. Aging (Albany NY). 2016 07; 8(7):1416-31. PMID: 27410480; PMCID: PMC4993339.
      Citations: 59     Fields:    Translation:Humans
    60. Romashkan SV, Das SK, Villareal DT, Ravussin E, Redman LM, Rochon J, Bhapkar M, Kraus WE, CALERIE Study Group. Safety of two-year caloric restriction in non-obese healthy individuals. Oncotarget. 2016 Apr 12; 7(15):19124-33. PMID: 26992237; PMCID: PMC4991370.
      Citations: 23     Fields:    Translation:Humans
    61. Armamento-Villareal R, Wingkun N, Aguirre LE, Kulkarny V, Napoli N, Colleluori G, Qualls C, Villareal DT. The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults. Pharmacogenet Genomics. 2016 Apr; 26(4):154-160. PMID: 26709911; PMCID: PMC4919233.
      Citations: 3     Fields:    
    62. Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT. Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. J Nutr Health Aging. 2016 Mar; 20(3):334-40. PMID: 26892583; PMCID: PMC4811358.
      Citations: 26     Fields:    Translation:Humans
    63. Licastro D, Yang L, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Rep. 2016 Jan 26; 14(3):422-428. PMID: 26774472.
      Citations: 52     Fields:    Translation:Humans
    64. Fielding R, Bhasin S, Cerreta F, Goodpaster B, Guralnik JM, Kritchevsky S, Legrand V, Forkin C, Magaziner J, Morley JE, Rodriguez-Manas L, Roubenoff R, Studenski S, Villareal DT, Cesari M, International Conference on Frailtyand Sarcopenia Research Task Force, Vellas B. Sarcopenia Trials in Specific Diseases: Report by the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging. 2016; 5(4):194-200. PMID: 27883164.
      Citations: 12     Fields:    Translation:Humans
    65. Aguirre LE, Villareal DT. Physical Exercise as Therapy for Frailty. Nestle Nutr Inst Workshop Ser. 2015; 83:83-92. PMID: 26524568; PMCID: PMC4712448.
      Citations: 33     Fields:    Translation:Humans
    66. Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO, CALERIE Study Group. Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial. Aging Cell. 2016 Feb; 15(1):22-7. PMID: 26443692; PMCID: PMC4717266.
      Citations: 64     Fields:    Translation:Humans
    67. Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, Lewis M, Schwartz AV, CALERIE Study Group. Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. J Bone Miner Res. 2016 Jan; 31(1):40-51. PMID: 26332798; PMCID: PMC4834845.
      Citations: 61     Fields:    Translation:Humans
    68. Aguirre LE, Colleluori G, Fowler KE, Jan IZ, Villareal K, Qualls C, Robbins D, Villareal DT, Armamento-Villareal R. High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass. Eur J Endocrinol. 2015 Aug; 173(2):167-74. PMID: 26142101; PMCID: PMC8077967.
      Citations: 16     Fields:    Translation:HumansCells
    69. Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB, CALERIE Study Group. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. 2015 Sep; 70(9):1097-104. PMID: 26187233; PMCID: PMC4841173.
      Citations: 156     Fields:    Translation:Humans
    70. Weiss EP, Albert SG, Reeds DN, Kress KS, Ezekiel UR, McDaniel JL, Patterson BW, Klein S, Villareal DT. Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men. Diabetes Care. 2015 Jul; 38(7):1253-62. PMID: 25877812; PMCID: PMC4477336.
      Citations: 27     Fields:    Translation:Humans
    71. Armamento-Villareal R, Napoli N, Waters D, Villareal D. Fat, muscle, and bone interactions in obesity and the metabolic syndrome. Int J Endocrinol. 2014; 2014:247076. PMID: 25309593; PMCID: PMC4181788.
      Citations: 4     
    72. Aguirre LE, Jan IZ, Fowler K, Waters DL, Villareal DT, Armamento-Villareal R. Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults. Int J Endocrinol. 2014; 2014:507395. PMID: 25165472; PMCID: PMC4140116.
      Citations: 7     
    73. Aguirre L, Napoli N, Waters D, Qualls C, Villareal DT, Armamento-Villareal R. Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults. J Clin Endocrinol Metab. 2014 Sep; 99(9):3290-7. PMID: 24878039; PMCID: PMC4154102.
      Citations: 37     Fields:    Translation:Humans
    74. Napoli N, Shah K, Waters DL, Sinacore DR, Qualls C, Villareal DT. Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults. Am J Clin Nutr. 2014 Jul; 100(1):189-98. PMID: 24787497; PMCID: PMC4144098.
      Citations: 48     Fields:    Translation:Humans
    75. Waters DL, Wayne SJ, Andrieu S, Cesari M, Villareal DT, Garry P, Vellas B. Sexually dimorphic patterns of nutritional intake and eating behaviors in community-dwelling older adults with normal and slow gait speed. J Nutr Health Aging. 2014 Mar; 18(3):228-33. PMID: 24626748.
      Citations: 9     Fields:    Translation:HumansAnimals
    76. Shah K, Gleason L, Villareal DT. Vitamin K and bone health in older adults. J Nutr Gerontol Geriatr. 2014; 33(1):10-22. PMID: 24597993.
      Citations: 7     Fields:    Translation:Humans
    77. Bouchonville MF, Villareal DT. Sarcopenic obesity: how do we treat it? Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):412-9. PMID: 23974769; PMCID: PMC4046899.
      Citations: 42     Fields:    Translation:HumansAnimals
    78. Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore DR, Qualls C, Villareal DT. Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. Osteoporos Int. 2014 Feb; 25(2):551-8. PMID: 23892583; PMCID: PMC3903658.
      Citations: 29     Fields:    Translation:Humans
    79. Bouchonville M, Armamento-Villareal R, Shah K, Napoli N, Sinacore DR, Qualls C, Villareal DT. Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial. Int J Obes (Lond). 2014 Mar; 38(3):423-31. PMID: 23823329; PMCID: PMC3835728.
      Citations: 59     Fields:    Translation:Humans
    80. Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 2013 Aug; 12(4):645-51. PMID: 23601134; PMCID: PMC3714316.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    81. Waters DL, Ward AL, Villareal DT. Weight loss in obese adults 65years and older: a review of the controversy. Exp Gerontol. 2013 Oct; 48(10):1054-61. PMID: 23403042; PMCID: PMC3714333.
      Citations: 73     Fields:    Translation:Humans
    82. Waters DL, Vawter R, Qualls C, Chode S, Armamento-Villareal R, Villareal DT. Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults. J Nutr Health Aging. 2013 Jan; 17(1):3-7. PMID: 23299370; PMCID: PMC3580336.
      Citations: 24     Fields:    Translation:Humans
    83. Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO. Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell. 2012 Oct; 11(5):876-84. PMID: 22712469; PMCID: PMC3444670.
      Citations: 9     Fields:    Translation:Humans
    84. Shah K, Villareal DT. Weight loss and improved fitness slow down the decline in mobility in obese adults with type 2 diabetes. Evid Based Med. 2013 Apr; 18(2):e18. PMID: 22782922; PMCID: PMC3605213.
      Citations: 3     Fields:    Translation:Humans
    85. Smith GI, Villareal DT, Sinacore DR, Shah K, Mittendorfer B. Muscle protein synthesis response to exercise training in obese, older men and women. Med Sci Sports Exerc. 2012 Jul; 44(7):1259-66. PMID: 22246218; PMCID: PMC3354005.
      Citations: 19     Fields:    Translation:Humans
    86. Armamento-Villareal R, Sadler C, Napoli N, Shah K, Chode S, Sinacore DR, Qualls C, Villareal DT. Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training. J Bone Miner Res. 2012 May; 27(5):1215-21. PMID: 22392834; PMCID: PMC3361603.
      Citations: 63     Fields:    Translation:HumansCells
    87. Wice BM, Reeds DN, Tran HD, Crimmins DL, Patterson BW, Dunai J, Wallendorf MJ, Ladenson JH, Villareal DT, Polonsky KS. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. 2012 Jul; 61(7):1793-800. PMID: 22522617; PMCID: PMC3379667.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    88. Niekamp K, Zavorsky GS, Fontana L, McDaniel JL, Villareal DT, Weiss EP. Systemic acid load from the diet affects maximal-exercise RER. Med Sci Sports Exerc. 2012 Apr; 44(4):709-15. PMID: 21912302; PMCID: PMC3729016.
      Citations: 8     Fields:    Translation:Humans
    89. Bugg JM, Shah K, Villareal DT, Head D. Cognitive and neural correlates of aerobic fitness in obese older adults. Exp Aging Res. 2012; 38(2):131-45. PMID: 22404537; PMCID: PMC3324124.
      Citations: 23     Fields:    Translation:Humans
    90. Shah K, Villareal DT. PREVENTING FRAILTY IN OBESE OLDER ADULTS. J Frailty Aging. 2012; 1(2):47-9. PMID: 25364705; PMCID: PMC4212326.
      Citations: 2     Fields:    
    91. Shah K, Armamento-Villareal R, Parimi N, Chode S, Sinacore DR, Hilton TN, Napoli N, Qualls C, Villareal DT. Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. J Bone Miner Res. 2011 Dec; 26(12):2851-9. PMID: 21786319; PMCID: PMC3206995.
      Citations: 72     Fields:    Translation:Humans
    92. Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP. Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction. J Appl Physiol (1985). 2012 Jan; 112(1):79-85. PMID: 22016371; PMCID: PMC3290417.
      Citations: 30     Fields:    Translation:Humans
    93. Villareal DT, Smith GI, Shah K, Mittendorfer B. Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults. Obesity (Silver Spring). 2012 Sep; 20(9):1780-6. PMID: 21938075; PMCID: PMC3291735.
      Citations: 16     Fields:    Translation:HumansCells
    94. Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO. Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY). 2011 May; 3(5):533-42. PMID: 21566261; PMCID: PMC3156603.
      Citations: 19     Fields:    Translation:HumansAnimals
    95. Shah K, Villareal DT. Combination treatment to CONQUER obesity? Lancet. 2011 Apr 16; 377(9774):1295-7. PMID: 21497686.
      Citations: 1     Fields:    Translation:Humans
    96. Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011 Mar 31; 364(13):1218-29. PMID: 21449785; PMCID: PMC3114602.
      Citations: 373     Fields:    Translation:Humans
    97. Villareal DT, Kotyk JJ, Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L. Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition. Aging Cell. 2011 Feb; 10(1):96-102. PMID: 20969721; PMCID: PMC3607368.
      Citations: 20     Fields:    Translation:Humans
    98. Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B. Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults. Obesity (Silver Spring). 2011 Feb; 19(2):312-8. PMID: 20489691; PMCID: PMC3069710.
      Citations: 40     Fields:    Translation:Humans
    99. Smith GI, Villareal DT, Lambert CP, Reeds DN, Mohammed BS, Mittendorfer B. Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions. J Appl Physiol (1985). 2010 Feb; 108(2):363-8. PMID: 19940095; PMCID: PMC2822667.
      Citations: 11     Fields:    Translation:Humans
    100. Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS. TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes. 2010 Feb; 59(2):479-85. PMID: 19934000; PMCID: PMC2809956.
      Citations: 63     Fields:    Translation:HumansCells
    101. Napoli N, Varadharajan A, Rini GB, Del Fiacco R, Yarramaneni J, Mumm S, Villareal DT, Armamento-Villareal R. Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density. Bone. 2009 Dec; 45(6):1169-74. PMID: 19679209; PMCID: PMC3689651.
      Citations: 10     Fields:    Translation:Humans
    102. Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS. Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes. 2009 Aug; 58(8):1869-78. PMID: 19491206; PMCID: PMC2712777.
      Citations: 38     Fields:    Translation:Humans
    103. Shah K, Stufflebam A, Hilton TN, Sinacore DR, Klein S, Villareal DT. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring). 2009 Dec; 17(12):2162-8. PMID: 19390517; PMCID: PMC2793412.
      Citations: 67     Fields:    Translation:Humans
    104. Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr. 2009 May; 89(5):1459-67. PMID: 19321570; PMCID: PMC2677000.
      Citations: 12     Fields:    Translation:Humans
    105. Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. 2008 10; 7(5):681-7. PMID: 18843793; PMCID: PMC2673798.
      Citations: 159     Fields:    Translation:HumansCTClinical Trials
    106. Sinacore DR, Hastings MK, Bohnert KL, Fielder FA, Villareal DT, Blair VP, Johnson JE. Inflammatory osteolysis in diabetic neuropathic (charcot) arthropathies of the foot. Phys Ther. 2008 Nov; 88(11):1399-407. PMID: 18801857; PMCID: PMC2579909.
      Citations: 23     Fields:    Translation:Humans
    107. Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C. Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res. 2008 Aug; 11(4):793-9. PMID: 18729811; PMCID: PMC2724865.
      Citations: 34     Fields:    Translation:HumansCells
    108. Weiss EP, Arif H, Villareal DT, Marzetti E, Holloszy JO. Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day. Am J Clin Nutr. 2008 Jul; 88(1):51-7. PMID: 18614723; PMCID: PMC2585377.
      Citations: 17     Fields:    Translation:Humans
    109. Frimel TN, Sinacore DR, Villareal DT. Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults. Med Sci Sports Exerc. 2008 Jul; 40(7):1213-9. PMID: 18580399; PMCID: PMC2650077.
      Citations: 77     Fields:    Translation:Humans
    110. Racette SB, Weiss EP, Schechtman KB, Steger-May K, Villareal DT, Obert KA, Holloszy JO. Influence of weekend lifestyle patterns on body weight. Obesity (Silver Spring). 2008 Aug; 16(8):1826-30. PMID: 18551108; PMCID: PMC3740215.
      Citations: 38     Fields:    Translation:Humans
    111. Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol (1985). 2008 Aug; 105(2):473-8. PMID: 18535122; PMCID: PMC2519937.
      Citations: 96     Fields:    Translation:Humans
    112. Shah K, Wingkun NJ, Lambert CP, Villareal DT. Weight-loss therapy improves endurance capacity in obese older adults. J Am Geriatr Soc. 2008 Jun; 56(6):1157-9. PMID: 18554372; PMCID: PMC3680883.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    113. Weiss EP, Villareal DT, Racette SB, Steger-May K, Premachandra BN, Klein S, Fontana L. Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res. 2008 Jun; 11(3):605-9. PMID: 18593278; PMCID: PMC2649744.
      Citations: 10     Fields:    Translation:Humans
    114. Villareal DT, Banks MR, Patterson BW, Polonsky KS, Klein S. Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring). 2008 Jun; 16(6):1349-54. PMID: 18388888; PMCID: PMC2799929.
      Citations: 25     Fields:    Translation:HumansCells
    115. Smith GI, Atherton P, Villareal DT, Frimel TN, Rankin D, Rennie MJ, Mittendorfer B. Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS One. 2008 Mar 26; 3(3):e1875. PMID: 18365020; PMCID: PMC2267222.
      Citations: 56     Fields:    Translation:HumansCells
    116. Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S. Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab. 2008 Jun; 93(6):2181-7. PMID: 18364384; PMCID: PMC2435639.
      Citations: 65     Fields:    Translation:Humans
    117. Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, Kov?cs SJ. The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1174-82. PMID: 18162561.
      Citations: 24     Fields:    Translation:Humans
    118. Arif H, Racette SB, Villareal DT, Holloszy JO, Weiss EP. Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images. Obesity (Silver Spring). 2007 Sep; 15(9):2240-4. PMID: 17890492.
      Citations: 6     Fields:    Translation:Humans
    119. Smith GI, Villareal DT, Mittendorfer B. Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E666-71. PMID: 17535855.
      Citations: 21     Fields:    Translation:HumansCells
    120. Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007 May-Jun; 14(3 Pt 1):481-8. PMID: 17213752; PMCID: PMC2366994.
      Citations: 25     Fields:    Translation:Humans
    121. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E197-202. PMID: 17389710.
      Citations: 96     Fields:    Translation:Humans
    122. Villareal DT, Miller BV, Banks M, Fontana L, Sinacore DR, Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr. 2006 Dec; 84(6):1317-23. PMID: 17158411.
      Citations: 74     Fields:    Translation:Humans
    123. Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med. 2006 Dec 11-25; 166(22):2502-10. PMID: 17159017.
      Citations: 121     Fields:    Translation:Humans
    124. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO, Washington University School of Medicine CALERIE Group. Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol (1985). 2007 Feb; 102(2):634-40. PMID: 17095635; PMCID: PMC4376253.
      Citations: 69     Fields:    Translation:Humans
    125. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr. 2006 Nov; 84(5):1033-42. PMID: 17093155; PMCID: PMC1941677.
      Citations: 147     Fields:    Translation:Humans
    126. Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, Fontana L, Klein S, Holloszy JO, Washington University School of Medicine CALERIE Group. One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci. 2006 Sep; 61(9):943-50. PMID: 16960025; PMCID: PMC4376245.
      Citations: 98     Fields:    Translation:Humans
    127. Villareal DT, Holloszy JO. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1003-8. PMID: 16787962.
      Citations: 41     Fields:    Translation:Humans
    128. Villareal DT, Banks M, Sinacore DR, Siener C, Klein S. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med. 2006 Apr 24; 166(8):860-6. PMID: 16636211.
      Citations: 98     Fields:    Translation:Humans
    129. Villareal DT, Apovian CM, Kushner RF, Klein S, American Society for Nutrition, NAASO, The Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr. 2005 Nov; 82(5):923-34. PMID: 16280421.
      Citations: 223     Fields:    Translation:Humans
    130. Villareal DT, Apovian CM, Kushner RF, Klein S, American Society for Nutrition, NAASO, The Obesity Society. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res. 2005 Nov; 13(11):1849-63. PMID: 16339115.
      Citations: 177     Fields:    Translation:Humans
    131. Fontana L, Shew JL, Holloszy JO, Villareal DT. Low bone mass in subjects on a long-term raw vegetarian diet. Arch Intern Med. 2005 Mar 28; 165(6):684-9. PMID: 15795346.
      Citations: 19     Fields:    Translation:Humans
    132. Evans EM, Racette SB, Peterson LR, Villareal DT, Greiwe JS, Holloszy JO. Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. J Appl Physiol (1985). 2005 Jan; 98(1):40-5. PMID: 15591302.
      Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
    133. Napoli N, Villareal DT, Mumm S, Halstead L, Sheikh S, Cagaanan M, Rini GB, Armamento-Villareal R. Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb; 20(2):232-9. PMID: 15647817; PMCID: PMC9036542.
      Citations: 33     Fields:    Translation:Humans
    134. Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10; 292(18):2243-8. PMID: 15536111.
      Citations: 63     Fields:    Translation:HumansCTClinical Trials
    135. Spina RJ, Meyer TE, Peterson LR, Villareal DT, Rinder MR, Ehsani AA. Absence of left ventricular and arterial adaptations to exercise in octogenarians. J Appl Physiol (1985). 2004 Nov; 97(5):1654-9. PMID: 15475554.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    136. Villareal DT, Banks M, Siener C, Sinacore DR, Klein S. Physical frailty and body composition in obese elderly men and women. Obes Res. 2004 Jun; 12(6):913-20. PMID: 15229329.
      Citations: 156     Fields:    Translation:Humans
    137. Villareal DT, Steger-May K, Schechtman KB, Yarasheski KE, Brown M, Sinacore DR, Binder EF. Effects of exercise training on bone mineral density in frail older women and men: a randomised controlled trial. Age Ageing. 2004 May; 33(3):309-12. PMID: 15082440.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    138. Villareal DT, Grant E, Miller JP, Storandt M, McKeel DW, Morris JC. Clinical outcomes of possible versus probable Alzheimer's disease. Neurology. 2003 Sep 09; 61(5):661-7. PMID: 12963758.
      Citations: 11     Fields:    Translation:Humans
    139. Ehsani AA, Spina RJ, Peterson LR, Rinder MR, Glover KL, Villareal DT, Binder EF, Holloszy JO. Attenuation of cardiovascular adaptations to exercise in frail octogenarians. J Appl Physiol (1985). 2003 Nov; 95(5):1781-8. PMID: 12857764.
      Citations: 28     Fields:    Translation:HumansCTClinical Trials
    140. Villareal DT, Binder EF, Yarasheski KE, Williams DB, Brown M, Sinacore DR, Kohrt WM. Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women. J Am Geriatr Soc. 2003 Jul; 51(7):985-90. PMID: 12834519.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    141. Peterson LR, Rinder MR, Schechtman KB, Spina RJ, Glover KL, Villareal DT, Ehsani AA. Peak exercise stroke volume: associations with cardiac structure and diastolic function. J Appl Physiol (1985). 2003 Mar; 94(3):1108-14. PMID: 12433864.
      Citations: 6     Fields:    Translation:Humans
    142. Villareal DT. Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy? Treat Endocrinol. 2002; 1(6):349-57. PMID: 15832488.
      Citations: 6     Fields:    Translation:Humans
    143. Villareal DT, Binder EF, Williams DB, Schechtman KB, Yarasheski KE, Kohrt WM. Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial. JAMA. 2001 Aug 15; 286(7):815-20. PMID: 11497535.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    144. Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf). 2000 Nov; 53(5):561-8. PMID: 11106916.
      Citations: 35     Fields:    Translation:HumansCTClinical Trials
    145. Villareal DT, Morris JC. The diagnosis of Alzheimer's disease. J Alzheimers Dis. 1999 Nov; 1(4-5):249-63. PMID: 12214123.
      Citations: 1     Fields:    
    146. Reams G, Villareal D, Wu Z, Luger A, Knaus J, Bauer J. Glomerular function and structure in the sodium-replete and sodium-deplete uninephrectomized spontaneously hypertensive rat: effect of blood pressure reduction, glomerular structure, and blood pressure reduction. Am J Med Sci. 1995 Jan; 309(1):35-42. PMID: 7825651.
      Citations:    Fields:    Translation:Animals
    147. Morley JE, Kumar VB, Mattammal M, Villareal DT. Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice. Life Sci. 1995; 57(14):1327-31. PMID: 7564879.
      Citations: 7     Fields:    Translation:AnimalsCells
    148. Villareal DT, Morley JE. Trophic factors in aging. Should older people receive hormonal replacement therapy? Drugs Aging. 1994 Jun; 4(6):492-509. PMID: 8075475.
      Citations: 6     Fields:    Translation:HumansAnimals
    149. Civitelli R, Villareal DT, Armamento-Villareal R. Estrogen status and bone mass in the premenopausal period: is osteoporosis a developmental disease? J Endocrinol Invest. 1993 Nov; 16(10):829-39. PMID: 8144859.
      Citations:    Fields:    Translation:Humans
    150. Lacey DL, Grosso LE, Moser SA, Erdmann J, Tan HL, Pacifici R, Villareal DT. IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3. J Clin Invest. 1993 Apr; 91(4):1731-42. PMID: 8473513; PMCID: PMC288153.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    151. Armamento-Villareal R, Villareal DT, Avioli LV, Civitelli R. Estrogen status and heredity are major determinants of premenopausal bone mass. J Clin Invest. 1992 Dec; 90(6):2464-71. PMID: 1469098; PMCID: PMC443403.
      Citations: 37     Fields:    Translation:Humans
    152. Civitelli R, Villareal DT, Agnusdei D, Nardi P, Avioli LV, Gennari C. Dietary L-lysine and calcium metabolism in humans. Nutrition. 1992 Nov-Dec; 8(6):400-5. PMID: 1486246.
      Citations: 34     Fields:    Translation:Humans
    153. Villareal DT, Murphy WA, Teitelbaum SL, Arens MQ, Whyte MP. Painful diffuse osteosclerosis after intravenous drug abuse. Am J Med. 1992 Oct; 93(4):371-81. PMID: 1329508.
      Citations: 12     Fields:    Translation:HumansCells
    154. Villareal DT, Rupich RC, Pacifici R, Griffin MG, Maggio D, Avioli LV, Civitelli R. Effect of estrogen and calcitonin on vertebral bone density and vertebral height in osteoporotic women. Osteoporos Int. 1992 Mar; 2(2):70-3. PMID: 1536982.
      Citations: 4     Fields:    Translation:Humans
    155. Chines A, Villareal D, Pacifici R. Paget's disease of bone affecting a single vertebra: clinical, radiologic, and histopathologic correlations. Calcif Tissue Int. 1992 Feb; 50(2):115-7. PMID: 1571828.
      Citations: 2     Fields:    Translation:Humans
    156. Villareal DT, Civitelli R, Gennari C, Avioli LV. Is there an effective treatment for glucocorticoid-induced osteoporosis? Calcif Tissue Int. 1991 Aug; 49(2):141-2. PMID: 1913293.
      Citations: 1     Fields:    Translation:Humans
    157. Villareal DT, Civitelli R, Chines A, Avioli LV. Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. J Clin Endocrinol Metab. 1991 Mar; 72(3):628-34. PMID: 1997517.
      Citations: 43     Fields:    Translation:Humans
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