25-Hydroxyvitamin D3 1-alpha-Hydroxylase
"25-Hydroxyvitamin D3 1-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
| Descriptor ID |
D015090
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| MeSH Number(s) |
D08.244.453.499.500 D08.244.453.915.400 D08.811.682.690.708.170.493.500 D08.811.682.690.708.170.915.400 D12.776.422.220.453.499.500 D12.776.422.220.453.915.400
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| Concept/Terms |
25-Hydroxyvitamin D3 1-alpha-Hydroxylase- 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
- 25 Hydroxyvitamin D3 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol 1-Hydroxylase
- Calcidiol 1-Monooxygenase
- Calcidiol 1 Monooxygenase
- 25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
- 25-Hydroxyvitamin D 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyvitamin D
- 25 Hydroxyvitamin D 1 alpha Hydroxylase
- CYP27B1
- Cytochrome P-450 CYP27B1
- Cytochrome P 450 CYP27B1
- 25-Hydroxyergocalciferol 1-alpha-Hydroxylase
- 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
- 25 Hydroxyergocalciferol 1 alpha Hydroxylase
- 25-Hydroxycholecalciferol-1-Hydroxylase
- 25 Hydroxycholecalciferol 1 Hydroxylase
- 25-Hydroxyvitamin D2 1-hydroxylase
- 1-hydroxylase, 25-Hydroxyvitamin D2
- 25 Hydroxyvitamin D2 1 hydroxylase
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Below are MeSH descriptors whose meaning is more general than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "25-Hydroxyvitamin D3 1-alpha-Hydroxylase".
This graph shows the total number of publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in this website by year, and whether "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2010 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "25-Hydroxyvitamin D3 1-alpha-Hydroxylase" by people in Profiles.
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Cholecalciferol induces apoptosis via autocrine metabolism in epidermoid cervical cancer cells. Biochem Cell Biol. 2022 Oct 01; 100(5):387-402.
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Vitamin D Pathway and Other Related Polymorphisms and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial. Cancer Prev Res (Phila). 2020 06; 13(6):521-530.
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Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis. 2017 Jan; 76(1):153-158.
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1, 25(OH)2D3 inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes. Curr Med Chem. 2013; 20(33):4131-41.
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Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study. Breast Cancer Res. 2012 Apr 04; 14(2):R58.
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A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients. Cancer Res. 2011 Jan 15; 71(2):413-23.
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Vitamin D pathway gene variants and prostate cancer prognosis. Prostate. 2010 Sep 15; 70(13):1448-60.
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Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells. Clin Cancer Res. 2004 Dec 01; 10(23):8018-27.
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Regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity in the mouse after uninephrectomy. Endocrinology. 1989 May; 124(5):2118-21.
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Current concepts of the chemical conformation, metabolism, and interaction of the steroid, vitamin D, with the endocrine system for calcium homeostasis. Calcif Tissue Res. 1976 Aug; 21 Suppl:153-9.