"Cytochrome P-450 CYP11B2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
| Descriptor ID |
D019405
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| MeSH Number(s) |
D08.244.453.484.500 D08.244.453.915.050 D08.811.682.690.708.170.425.500 D08.811.682.690.708.170.915.050 D12.776.422.220.453.484.500 D12.776.422.220.453.915.050
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| Concept/Terms |
Cytochrome P-450 CYP11B2- Cytochrome P-450 CYP11B2
- Cytochrome P 450 CYP11B2
- Aldosterone Synthase
- Aldosterone Synthase Cytochrome P-450
- Aldosynthase
- Cytochrome P450Aldo
- P450c11AS
- Cytochrome P450 11B2
- Cytochrome P-450c11AS
- Cytochrome P 450c11AS
- CYP11B2
- Steroid 18-Hydroxylase
- Steroid 18 Hydroxylase
- CYP 11B2
|
Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP11B2".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP11B2".
This graph shows the total number of publications written about "Cytochrome P-450 CYP11B2" by people in this website by year, and whether "Cytochrome P-450 CYP11B2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 CYP11B2" by people in Profiles.
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Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679.
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An interaction between carotene-15,15'-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone. Int J Cancer. 2012 Jul 15; 131(2):E143-8.
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A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide. Pharmacogenet Genomics. 2005 May; 15(5):287-93.
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Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation. 2004 Mar 16; 109(10):1284-91.
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Congenital hyperreninemic hypoaldosteronism unlinked to the aldosterone synthase (CYP11B2) gene. J Clin Endocrinol Metab. 2001 Nov; 86(11):5379-82.