Cytochrome P-450 Enzyme System
"Cytochrome P-450 Enzyme System" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
| Descriptor ID |
D003577
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| MeSH Number(s) |
D08.244.453 D08.811.682.690.708.170 D12.776.422.220.453
|
| Concept/Terms |
Cytochrome P-450 Enzyme System- Cytochrome P-450 Enzyme System
- Cytochrome P 450 Enzyme System
- Cytochrome P450
- P-450 Enzymes
- Enzymes, P-450
- P 450 Enzymes
- P450 Enzymes
- Enzymes, P450
- CYP450 Family
- Cytochrome P450 Superfamily
- Superfamily, Cytochrome P450
- Cytochrome P-450 Superfamily
- Cytochrome P 450 Superfamily
- Superfamily, Cytochrome P-450
- Cytochrome p450 Families
- Cytochrome P-450 Families
- Cytochrome P 450 Families
- CYP450 Superfamily
- Superfamily, CYP450
- Cytochrome P-450
- Cytochrome P 450
- Cytochrome P-450 Enzymes
- Cytochrome P 450 Enzymes
- Enzymes, Cytochrome P-450
- P-450 Enzymes, Cytochrome
Cytochrome P-450 Monooxygenase- Cytochrome P-450 Monooxygenase
- Cytochrome P 450 Monooxygenase
- Monooxygenase, Cytochrome P-450
- Cytochrome P-450-Dependent Monooxygenase
- Cytochrome P 450 Dependent Monooxygenase
- Monooxygenase, Cytochrome P-450-Dependent
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 Enzyme System".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 Enzyme System".
This graph shows the total number of publications written about "Cytochrome P-450 Enzyme System" by people in this website by year, and whether "Cytochrome P-450 Enzyme System" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 3 | 1 | 4 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 2 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 2 | 3 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cytochrome P-450 Enzyme System" by people in Profiles.
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Suppression of hepatic ChREBP?-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Mol Metab. 2024 Jul; 85:101957.
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A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39.
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Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome. Pediatr Crit Care Med. 2017 Mar; 18(3_suppl Suppl 1):S32-S45.
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Toxicological, Enzymatic, and Molecular Assessment of the Insecticide Susceptibility Profile of Triatoma infestans (Hemiptera: Reduviidae, Triatominae) Populations From Rural Communities of Santa Cruz, Bolivia. J Med Entomol. 2017 01 01; 54(1):187-195.
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Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 06 01; 109:70-82.
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Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J Biol Chem. 2015 Mar 20; 290(12):7871-86.
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CPY3A4-mediated a-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos. 2014 Feb; 42(2):213-20.
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Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells. J Cell Physiol. 2012 Jul; 227(7):2907-16.
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Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May; 44(2):192-208.
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Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma. Clin Cancer Res. 2007 Dec 15; 13(24):7401-6.