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MING HU

TitleProfessor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7047
Houston, TX 77204-5037
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gao S, Sun R, Singh R, Yu So S, Chan CTY, Savidge T, Hu M. The role of gut microbial ?-glucuronidase in drug disposition and development. Drug Discov Today. 2022 10; 27(10):103316. PMID: 35820618; PMCID: PMC9717552.
      Citations:    Fields:    
    2. Du T, Sun R, Etim I, Zheng Z, Liang D, Hu M, Gao S. Age-and Region-Dependent Disposition of Raloxifene in Rats. Pharm Res. 2021 Aug; 38(8):1357-1367. PMID: 34322833; PMCID: PMC8452384.
      Citations:    
    3. Rong Y, Tu Y, Yin T, Meng Z, Dou G, Hu M. Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo. Arch Toxicol. 2020 11; 94(11):3737-3749. PMID: 32918091.
      Citations:    
    4. Duan S, Niu L, Yin T, Li L, Gao S, Yuan D, Hu M. A novel strategy for screening bioavailable quality markers of traditional Chinese medicine by integrating intestinal absorption and network pharmacology: Application to Wu Ji Bai Feng Pill. Phytomedicine. 2020 09; 76:153226. PMID: 32521487.
      Citations: 2     Fields:    
    5. Singh R, Lu R, Hu M. Flavonoids interference in common protein assays: Effect of position and degree of hydroxyl substitution. Anal Biochem. 2020 05 15; 597:113644. PMID: 32105737; PMCID: PMC9154353.
      Citations:    
    6. Yun C, Dashwood WM, Li L, Yin T, Ulusan AM, Shatzer K, Gao S, Ruan KH, Hu M. Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc?am1137) rat with celecoxib. Inflamm Res. 2020 Jan; 69(1):131-137. PMID: 31797003.
      Citations: 2     Fields:    Translation:Animals
    7. He Y, Zhou L, Gao S, Yin T, Tu Y, Rayford R, Wang X, Hu M. Development and validation of a sensitive LC-MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies. J Pharm Biomed Anal. 2018 Jan 30; 148:65-72. PMID: 28965046; PMCID: PMC8519014.
      Citations: 5     Fields:    Translation:Animals
    8. Yun C, Dashwood WM, Kwong LN, Gao S, Yin T, Ling Q, Singh R, Dashwood RH, Hu M. Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS. J Pharm Biomed Anal. 2018 Jan 30; 148:42-50. PMID: 28957718; PMCID: PMC5698167.
      Citations: 3     Fields:    Translation:Animals
    9. Xie C, Yan TM, Chen JM, Li XY, Zou J, Zhu LJ, Lu LL, Wang Y, Zhou FY, Liu ZQ, Hu M. LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine. Sci Rep. 2017 06 20; 7(1):3858. PMID: 28634336; PMCID: PMC5478605.
      Citations:    
    10. Wang M, Yang G, He Y, Xu B, Zeng M, Ge S, Yin T, Gao S, Hu M. Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway. Mol Nutr Food Res. 2016 09; 60(9):1967-83. PMID: 26833852; PMCID: PMC5358013.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Yun C, Yin T, Shatzer K, Burrin DG, Cui L, Tu Y, Hu M. Determination of 7a-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 01; 1025:76-82. PMID: 27218859; PMCID: PMC5358015.
      Citations: 3     Fields:    Translation:AnimalsCells
    12. Basu S, Zeng M, Yin T, Gao S, Hu M. Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:34-41. PMID: 26894853; PMCID: PMC5215916.
      Citations: 6     Fields:    Translation:Animals
    13. Jiamboonsri P, Pithayanukul P, Bavovada R, Leanpolchareanchai J, Yin T, Gao S, Hu M. Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles. Molecules. 2015 Nov 30; 20(12):21254-73. PMID: 26633325; PMCID: PMC6332320.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Yan T, Lu L, Xie C, Chen J, Peng X, Zhu L, Wang Y, Li Q, Shi J, Zhou F, Hu M, Liu Z. Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients. Mol Cancer Ther. 2015 Dec; 14(12):2874-86. PMID: 26516155; PMCID: PMC4674380.
      Citations:    
    15. Ge S, Yin T, Xu B, Gao S, Hu M. Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP. Pharm Res. 2016 Mar; 33(3):590-602. PMID: 26502886; PMCID: PMC4744546.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Yang G, Gao S, Sun R, Yin T, Hu M. Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 01; 1002:13-8. PMID: 26295697; PMCID: PMC4659646.
      Citations:    Fields:    Translation:Animals
    17. Ma Y, Gao S, Hu M. Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15; 1001:202-11. PMID: 26281772; PMCID: PMC4659650.
      Citations: 5     Fields:    Translation:Animals
    18. Yang Z, Kulkarni K, Zhu W, Hu M. Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem. 2012 Dec; 12(10):1264-80. PMID: 22583407; PMCID: PMC4010305.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    19. Xia B, Zhou Q, Zheng Z, Ye L, Hu M, Liu Z. A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut. Mol Pharm. 2012 Nov 05; 9(11):3246-58. PMID: 23033922; PMCID: PMC3953453.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Abdelraouf K, He J, Ledesma KR, Hu M, Tam VH. Pharmacokinetics and renal disposition of polymyxin B in an animal model. Antimicrob Agents Chemother. 2012 Nov; 56(11):5724-7. PMID: 22908162; PMCID: PMC3486600.
      Citations: 26     Fields:    Translation:Animals
    21. Kulkarni KH, Yang Z, Niu T, Hu M. Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats. J Agric Food Chem. 2012 Aug 15; 60(32):7949-56. PMID: 22757747; PMCID: PMC4030716.
      Citations: 3     Fields:    Translation:Animals
    22. Gandhi AS, Guo T, Shah P, Moorthy B, Chow DS, Hu M, Ghose R. CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice. Br J Pharmacol. 2012 Aug; 166(7):2176-87. PMID: 22394353; PMCID: PMC3402780.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Wu B, Jiang W, Yin T, Gao S, Hu M. A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2). Pharm Res. 2012 Nov; 29(11):3199-208. PMID: 22752253; PMCID: PMC3953450.
      Citations: 6     Fields:    Translation:HumansCells
    24. Yang Z, Zhu W, Gao S, Yin T, Jiang W, Hu M. Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein. Drug Metab Dispos. 2012 Oct; 40(10):1883-93. PMID: 22736306; PMCID: PMC3463821.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    25. Abdelraouf K, Braggs KH, Yin T, Truong LD, Hu M, Tam VH. Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother. 2012 Sep; 56(9):4625-9. PMID: 22687519; PMCID: PMC3421883.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    26. Wu B, Wang X, Zhang S, Hu M. Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches. Pharm Res. 2012 Jun; 29(6):1544-61. PMID: 22302521; PMCID: PMC3409642.
      Citations: 6     Fields:    Translation:HumansCells
    27. Yang Z, Wang JR, Niu T, Gao S, Yin T, You M, Jiang ZH, Hu M. Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora. Drug Metab Dispos. 2012 Aug; 40(8):1538-44. PMID: 22584255; PMCID: PMC3400789.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    28. Meng S, Wu B, Singh R, Yin T, Morrow JK, Zhang S, Hu M. SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Mol Pharm. 2012 Apr 02; 9(4):862-73. PMID: 22352375; PMCID: PMC3404749.
      Citations: 10     Fields:    Translation:HumansCells
    29. Tang L, Zhou J, Yang CH, Xia BJ, Hu M, Liu ZQ. Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences. J Agric Food Chem. 2012 Mar 28; 60(12):3223-33. PMID: 22352802; PMCID: PMC3409651.
      Citations: 13     Fields:    Translation:Animals
    30. Dong D, Ako R, Hu M, Wu B. Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes. Xenobiotica. 2012 Aug; 42(8):808-20. PMID: 22385482; PMCID: PMC4390583.
      Citations: 8     Fields:    Translation:HumansCells
    31. Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012 May; 44(2):192-208. PMID: 22251142.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    32. Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH. Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5. PMID: 22232279; PMCID: PMC3318314.
      Citations: 30     Fields:    Translation:Cells
    33. Ye L, Gao S, Feng Q, Liu W, Yang Z, Hu M, Liu Z. Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine. Xenobiotica. 2012 Jun; 42(6):518-25. PMID: 22188409.
      Citations: 7     Fields:    Translation:Animals
    34. Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M. Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. Mol Carcinog. 2013 Jan; 52(1):49-56. PMID: 22086836.
      Citations: 5     Fields:    Translation:AnimalsCells
    35. Jiang W, Xu B, Wu B, Yu R, Hu M. UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Drug Metab Dispos. 2012 Feb; 40(2):336-45. PMID: 22071170; PMCID: PMC3263940.
      Citations: 19     Fields:    Translation:HumansCells
    36. Wu B, Basu S, Meng S, Wang X, Hu M. Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis. Curr Drug Metab. 2011 Nov; 12(9):900-16. PMID: 21933112; PMCID: PMC3426368.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    37. Wu B, Zhang S, Hu M. Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1. Mol Pharm. 2011 Dec 05; 8(6):2379-89. PMID: 21985641; PMCID: PMC3404744.
      Citations: 6     Fields:    Translation:HumansCells
    38. Yang Z, Gao S, Wang J, Yin T, Teng Y, Wu B, You M, Jiang Z, Hu M. Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. Drug Metab Dispos. 2011 Oct; 39(10):1866-72. PMID: 21757611; PMCID: PMC11024865.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    39. Yang CH, Tang L, Lv C, Ye L, Xia BJ, Hu M, Liu ZQ. Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison. J Pharm Pharmacol. 2011 Jul; 63(7):967-70. PMID: 21635263; PMCID: PMC4010317.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    40. Ye L, Wang T, Tang L, Liu W, Yang Z, Zhou J, Zheng Z, Cai Z, Hu M, Liu Z. Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein. J Pharm Sci. 2011 Nov; 100(11):5007-17. PMID: 21721007.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    41. Tam VH, Cao H, Ledesma KR, Hu M. In vitro potency of various polymyxin B components. Antimicrob Agents Chemother. 2011 Sep; 55(9):4490-1. PMID: 21709096; PMCID: PMC3165278.
      Citations: 14     Fields:    Translation:Cells
    42. Singh R, Wu B, Tang L, Hu M. Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids. J Agric Food Chem. 2011 Jul 13; 59(13):7452-64. PMID: 21413806; PMCID: PMC3391414.
      Citations: 16     Fields:    Translation:Humans
    43. Wu B, Kulkarni K, Basu S, Zhang S, Hu M. First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci. 2011 Sep; 100(9):3655-81. PMID: 21484808; PMCID: PMC3409645.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    44. Wu B, Xu B, Hu M. Regioselective glucuronidation of flavonols by six human UGT1A isoforms. Pharm Res. 2011 Aug; 28(8):1905-18. PMID: 21472492; PMCID: PMC3426363.
      Citations: 15     Fields:    Translation:HumansCells
    45. Chen Y, Wang J, Jia X, Tan X, Hu M. Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules. 2011 Feb 01; 16(2):1336-48. PMID: 21285919; PMCID: PMC6259646.
      Citations: 20     Fields:    Translation:AnimalsCells
    46. Gao S, Yang Z, Yin T, You M, Hu M. Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: application to pharmacokinetic and disposition studies. J Pharm Biomed Anal. 2011 May 15; 55(2):288-93. PMID: 21349678; PMCID: PMC3085908.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    47. Liu W, Zheng Z, Liu X, Gao S, Ye L, Yang Z, Hu M, Liu Z. Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide. J Pharm Biomed Anal. 2011 Apr 05; 54(5):1157-62. PMID: 21195574; PMCID: PMC4010304.
      Citations: 6     Fields:    Translation:Animals
    48. Chen Y, Jia X, Chen J, Wang J, Hu M. The pharmacokinetics of raloxifene and its interaction with apigenin in rat. Molecules. 2010 Nov 18; 15(11):8478-87. PMID: 21088662; PMCID: PMC6259217.
      Citations: 6     Fields:    Translation:Animals
    49. Wu B, Morrow JK, Singh R, Zhang S, Hu M. Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model. J Pharmacol Exp Ther. 2011 Feb; 336(2):403-13. PMID: 21068207; PMCID: PMC3033718.
      Citations: 16     Fields:    Translation:Humans
    50. Singh R, Wu B, Tang L, Liu Z, Hu M. Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector. J Agric Food Chem. 2010 Sep 08; 58(17):9384-95. PMID: 20687611; PMCID: PMC3404750.
      Citations: 23     Fields:    
    51. Zhu W, Xu H, Wang SW, Hu M. Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine. AAPS J. 2010 Dec; 12(4):525-36. PMID: 20582579; PMCID: PMC2976988.
      Citations: 30     Fields:    Translation:Animals
    52. Gao S, Jiang W, Yin T, Hu M. Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization. J Agric Food Chem. 2010 Jun 09; 58(11):6650-9. PMID: 20450158; PMCID: PMC2919490.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    53. Tang L, Ye L, Singh R, Wu B, Lv C, Zhao J, Liu Z, Hu M. Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm. 2010 Jun 07; 7(3):664-79. PMID: 20297805; PMCID: PMC2941766.
      Citations: 25     Fields:    Translation:HumansCells
    54. Gao S, Hu M. Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem. 2010 Jun; 10(6):550-67. PMID: 20370701; PMCID: PMC2919492.
      Citations: 54     Fields:    Translation:HumansAnimals
    55. Liu W, Tang L, Ye L, Cai Z, Xia B, Zhang J, Hu M, Liu Z. Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J. 2010 Sep; 12(3):424-36. PMID: 20467923; PMCID: PMC2895442.
      Citations: 22     Fields:    Translation:HumansAnimals
    56. Zhou Q, Zheng Z, Xia B, Tang L, Lv C, Liu W, Liu Z, Hu M. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res. 2010 Aug; 27(8):1568-83. PMID: 20411407; PMCID: PMC2897949.
      Citations: 17     Fields:    Translation:HumansCells
    57. Yang Z, Zhu W, Gao S, Xu H, Wu B, Kulkarni K, Singh R, Tang L, Hu M. Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J Pharm Biomed Anal. 2010 Sep 21; 53(1):81-9. PMID: 20378296; PMCID: PMC3397253.
      Citations: 20     Fields:    Translation:AnimalsCells
    58. Yang Z, Gao S, Yin T, Kulkarni KH, Teng Y, You M, Hu M. Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method. J Pharm Biomed Anal. 2010 Apr 06; 51(5):1120-7. PMID: 20034755; PMCID: PMC2859310.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    59. Xu H, Kulkarni KH, Singh R, Yang Z, Wang SW, Tam VH, Hu M. Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides. Mol Pharm. 2009 Nov-Dec; 6(6):1703-15. PMID: 19736994; PMCID: PMC2941777.
      Citations: 15     Fields:    Translation:AnimalsCells
    60. Tang L, Singh R, Liu Z, Hu M. Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol Pharm. 2009 Sep-Oct; 6(5):1466-82. PMID: 19545173; PMCID: PMC2941769.
      Citations: 37     Fields:    Translation:HumansCells
    61. Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, Ming H, Aggarwal BB, Rita G, Kumar AP. Butanol fraction containing berberine or related compound from nexrutine inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate. 2009 Apr 01; 69(5):494-504. PMID: 19107816; PMCID: PMC2674392.
      Citations: 17     Fields:    Translation:HumansCells
    62. Wang SW, Kulkarni KH, Tang L, Wang JR, Yin T, Daidoji T, Yokota H, Hu M. Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. J Pharmacol Exp Ther. 2009 Jun; 329(3):1023-31. PMID: 19264971; PMCID: PMC2683779.
      Citations: 18     Fields:    Translation:AnimalsCells
    63. Yuan Z, Xu H, Wang K, Zhao Z, Hu M. Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS. J Pharm Biomed Anal. 2009 Jul 12; 49(5):1226-32. PMID: 19304430; PMCID: PMC3391413.
      Citations: 5     Fields:    Translation:HumansCells
    64. Li YM, Li XM, Li GM, Du WC, Zhang J, Li WX, Xu J, Hu M, Zhu Z. In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts. J Agric Food Chem. 2008 Jul 23; 56(14):5550-7. PMID: 18570429; PMCID: PMC2782632.
      Citations: 8     Fields:    Translation:AnimalsCells
    65. Chen Y, Zhao YH, Jia XB, Hu M. Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res. 2008 Sep; 25(9):2190-9. PMID: 18459036; PMCID: PMC2574979.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    66. Wang SW, Chen Y, Joseph T, Hu M. Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein. J Altern Complement Med. 2008 Apr; 14(3):287-97. PMID: 18370585; PMCID: PMC2771774.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    67. Joseph TB, Wang SW, Liu X, Kulkarni KH, Wang J, Xu H, Hu M. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm. 2007 Nov-Dec; 4(6):883-94. PMID: 18052087; PMCID: PMC2532587.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    68. Hu M. Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm. 2007 Nov-Dec; 4(6):803-6. PMID: 18052085; PMCID: PMC2551754.
      Citations: 39     Fields:    Translation:HumansAnimals
    69. Liu X, Tam VH, Hu M. Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA. Mol Pharm. 2007 Nov-Dec; 4(6):873-82. PMID: 17927138; PMCID: PMC2597501.
      Citations: 16     Fields:    Translation:HumansCells
    70. Liu Z, Hu M. Natural polyphenol disposition via coupled metabolic pathways. Expert Opin Drug Metab Toxicol. 2007 Jun; 3(3):389-406. PMID: 17539746; PMCID: PMC2777985.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    71. Liu ZQ, Jiang ZH, Liu L, Hu M. Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm Res. 2006 Dec; 23(12):2768-80. PMID: 17063398.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    72. Wang SW, Chen J, Jia X, Tam VH, Hu M. Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties. Drug Metab Dispos. 2006 Nov; 34(11):1837-48. PMID: 16882763.
      Citations: 31     Fields:    Translation:AnimalsCells
    73. Jeong EJ, Liu X, Jia X, Chen J, Hu M. Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions. Curr Drug Metab. 2005 Oct; 6(5):455-68. PMID: 16248837.
      Citations: 29     Fields:    Translation:HumansAnimals
    74. Chen J, Wang S, Jia X, Bajimaya S, Lin H, Tam VH, Hu M. Disposition of flavonoids via recycling: comparison of intestinal versus hepatic disposition. Drug Metab Dispos. 2005 Dec; 33(12):1777-84. PMID: 16120792.
      Citations: 29     Fields:    Translation:AnimalsCells
    75. Jeong EJ, Jia X, Hu M. Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models. Mol Pharm. 2005 Jul-Aug; 2(4):319-28. PMID: 16053335.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    76. Jeong EJ, Liu Y, Lin H, Hu M. Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10. Drug Metab Dispos. 2005 Jun; 33(6):785-94. PMID: 15769887.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    77. Chua R, Anderson K, Chen J, Hu M. Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products. J Altern Complement Med. 2004 Dec; 10(6):1053-60. PMID: 15674001.
      Citations: 4     Fields:    Translation:Humans
    78. Chen J, Lin H, Hu M. Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Cancer Chemother Pharmacol. 2005 Feb; 55(2):159-69. PMID: 15455178.
      Citations: 38     Fields:    Translation:HumansCells
    79. Jia X, Chen J, Lin H, Hu M. Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J Pharmacol Exp Ther. 2004 Sep; 310(3):1103-13. PMID: 15128864.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    80. Hu M, Chen J. Nucleobase- and p-glycoprotein-mediated transport of AG337 in a Caco-2 cell culture model. Mol Pharm. 2004 May-Jun; 1(3):194-200. PMID: 15981922.
      Citations:    Fields:    Translation:HumansCells
    81. Jeong EJ, Lin H, Hu M. Disposition mechanisms of raloxifene in the human intestinal Caco-2 model. J Pharmacol Exp Ther. 2004 Jul; 310(1):376-85. PMID: 15020665.
      Citations: 19     Fields:    Translation:HumansCells
    82. Liu Y, Liu Y, Dai Y, Xun L, Hu M. Enteric disposition and recycling of flavonoids and ginkgo flavonoids. J Altern Complement Med. 2003 Oct; 9(5):631-40. PMID: 14629841.
      Citations: 28     Fields:    Translation:Animals
    83. Hu M, Chen J, Lin H. Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. J Pharmacol Exp Ther. 2003 Oct; 307(1):314-21. PMID: 12893842.
      Citations: 41     Fields:    Translation:HumansCells
    84. Hu M, Krausz K, Chen J, Ge X, Li J, Gelboin HL, Gonzalez FJ. Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab Dispos. 2003 Jul; 31(7):924-31. PMID: 12814970.
      Citations: 34     Fields:    Translation:HumansCells
    85. Hu M, Cheng Z, Zheng L. Functional and molecular characterization of rat intestinal prolidase. Pediatr Res. 2003 Jun; 53(6):905-14. PMID: 12646727.
      Citations: 4     Fields:    Translation:AnimalsCells
    86. Chen J, Lin H, Hu M. Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther. 2003 Mar; 304(3):1228-35. PMID: 12604700.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    87. Lin H, Hu M, Ruiz-Garc?a A, Pl?-Delfina JM. Kinetic characterization of secretory transport of a new ciprofloxacin derivative (CNV97100) across Caco-2 cell monolayers. J Pharm Sci. 2002 Dec; 91(12):2511-9. PMID: 12434394.
      Citations: 6     Fields:    Translation:HumansCells
    88. Liu Y, Hu M. Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos. 2002 Apr; 30(4):370-7. PMID: 11901089.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    89. Crespi CL, Fox L, Stocker P, Hu M, Steimel DT. Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. Eur J Pharm Sci. 2000 Nov; 12(1):63-8. PMID: 11121734.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    90. Liu Y, Hu M. P-glycoprotein and bioavailability-implication of polymorphism. Clin Chem Lab Med. 2000 Sep; 38(9):877-81. PMID: 11097343.
      Citations: 6     Fields:    Translation:HumansAnimals
    91. Hu M, Li Y, Davitt CM, Huang SM, Thummel K, Penman BW, Crespi CL. Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharm Res. 1999 Sep; 16(9):1352-9. PMID: 10496649.
      Citations: 15     Fields:    Translation:HumansCells
    92. Ling J, Hu M, Hagerup T, Campbell RK. Lispro insulin: adsorption and stability in selected intravenous devices. Diabetes Educ. 1999 Mar-Apr; 25(2):237-45. PMID: 10531849.
      Citations: 6     Fields:    Translation:HumansCells
    93. Hu M, Roland K, Ge L, Chen J, Li Y, Tyle P, Roy S. Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. J Pharm Sci. 1998 Jul; 87(7):886-90. PMID: 9649359.
      Citations: 11     Fields:    Translation:Animals
    94. Hu M. In vitro development and evaluation of prolidase lipozyme. PDA J Pharm Sci Technol. 1997 Nov-Dec; 51(6):238-41. PMID: 9448433.
      Citations:    Fields:    
    95. Crespi CL, Penman BW, Hu M. Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4. Pharm Res. 1996 Nov; 13(11):1635-41. PMID: 8956327.
      Citations: 15     Fields:    Translation:HumansCells
    96. Hu M, Chen J, Zheng L, Dantzig AH, Stratford RE. Uptake characteristics of loracarbef and cephalexin in the Caco-2 cell culture model: effects of the proton gradient and possible presence of a distinctive second component. J Pharm Sci. 1996 Jul; 85(7):767-72. PMID: 8819004.
      Citations: 1     Fields:    Translation:HumansCells
    97. Hu M, Zheng L, Chen J, Liu L, Zhu Y, Dantzig AH, Stratford RE. Mechanisms of transport of quinapril in Caco-2 cell monolayers: comparison with cephalexin. Pharm Res. 1995 Aug; 12(8):1120-5. PMID: 7494822.
      Citations: 10     Fields:    Translation:HumansCells
    98. Hu M, Zheng L, Chen J, Liu L, Li Y, Dantzig AH, Stratford RE. Peptide transporter function and prolidase activities in Caco-2 cells: a lack of coordinated expression. J Drug Target. 1995; 3(4):291-300. PMID: 8821003.
      Citations: 3     Fields:    Translation:HumansCells
    99. Zheng L, Chen J, Zhu Y, Yang H, Elmquist W, Hu M. Comparison of the transport characteristics of D- and L-methionine in a human intestinal epithelial model (Caco-2) and in a perfused rat intestinal model. Pharm Res. 1994 Dec; 11(12):1771-6. PMID: 7899243.
      Citations: 3     Fields:    Translation:AnimalsCells
    100. Hu M, Chen J, Zhu Y, Dantzig AH, Stratford RE, Kuhfeld MT. Mechanism and kinetics of transcellular transport of a new beta-lactam antibiotic loracarbef across an intestinal epithelial membrane model system (Caco-2). Pharm Res. 1994 Oct; 11(10):1405-13. PMID: 7855043.
      Citations: 23     Fields:    Translation:HumansCells
    101. Chen J, Zhu Y, Hu M. Mechanisms and kinetics of uptake and efflux of L-methionine in an intestinal epithelial model (Caco-2). J Nutr. 1994 Oct; 124(10):1907-16. PMID: 7931699.
      Citations: 13     Fields:    Translation:HumansCells
    102. Hu M, Chen J, Tran D, Zhu Y, Leonardo G. The Caco-2 cell monolayers as an intestinal metabolism model: metabolism of dipeptide Phe-Pro. J Drug Target. 1994; 2(1):79-89. PMID: 8069586.
      Citations: 11     Fields:    Translation:HumansCells
    103. Hu M. Comparison of uptake characteristics of thymidine and zidovudine in a human intestinal epithelial model system. J Pharm Sci. 1993 Aug; 82(8):829-33. PMID: 8377122.
      Citations: 3     Fields:    Translation:HumansCells
    104. Hu M, Borchardt RT. Transport of a large neutral amino acid in a human intestinal epithelial cell line (Caco-2): uptake and efflux of phenylalanine. Biochim Biophys Acta. 1992 Jun 29; 1135(3):233-44. PMID: 1623010.
      Citations: 14     Fields:    Translation:HumansCells
    105. Bai JP, Hu M, Subramanian P, Mosberg HI, Amidon GL. Utilization of peptide carrier system to improve intestinal absorption: targeting prolidase as a prodrug-converting enzyme. J Pharm Sci. 1992 Feb; 81(2):113-6. PMID: 1545347.
      Citations: 8     Fields:    Translation:Animals
    106. Hu M, Borchardt RT. Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pharm Res. 1990 Dec; 7(12):1313-9. PMID: 2095572.
      Citations: 15     Fields:    Translation:HumansCells
    107. Hu M, Subramanian P, Mosberg HI, Amidon GL. Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. Pharm Res. 1989 Jan; 6(1):66-70. PMID: 2717522.
      Citations: 14     Fields:    Translation:Animals
    108. Hu M, Amidon GL. Passive and carrier-mediated intestinal absorption components of captopril. J Pharm Sci. 1988 Dec; 77(12):1007-11. PMID: 3072405.
      Citations: 30     Fields:    Translation:Animals
    109. Hu M, Sinko PJ, deMeere AL, Johnson DA, Amidon GL. Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach. J Theor Biol. 1988 Mar 07; 131(1):107-14. PMID: 3419188.
      Citations: 19     Fields:    Translation:Animals
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