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LYNN ZECHIEDRICH

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology


    Collapse Biography 
    Collapse awards and honors
    1981 - 1982Freshman Academic Tuition Scholarship, University of Arkansas
    1989Vanderbilt University Travel Awards (three), Vanderbilt University School of Medicine
    1989First Place, Graduate Student Oral Presentation, The Eastern Student Research Forum, University of Miami School of Medicine
    1989Outstanding (First Place) Graduate Student Presentation, Student Research Day, Vanderbilt University
    1990Travel Award to attend Mathematical Approaches to DNA, Santa Fe, NM
    1991 - 1994National Institutes of Health Postdoctoral Fellowship
    1994National Institutes of Environmental Health Sciences Center Pilot Study Grant , University of California, Berkeley
    1994 - 1997Leukemia Society of America (Leukemia and Lymphoma Society) Special (Senior) Postdoctoral Fellowship
    1997Fellowship from Juan March Institute, Madrid, to speak at International workshop
    1998 - 1999Curtis Hankamer Research Award , Baylor College of Medicine
    1998 - 2002Burroughs Wellcome Fund New Investigator Award in the Toxicological Sciences
    2004Burroughs Wellcome Fund Award
    2007Finalist, NIH Director's Pioneer Award
    2009Applied Biosystems SOLiDTM 3 System $10K Genome Award
    2010 - 2013Human Frontier Science Program Research Grant
    2011 - 2013John S. Dunn Foundation Collaborative Research Award
    2013Baylor Research Advocates for Student Scientists (BRASS) mentor of the year award, Baylor College of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R35GM141793     (ZECHIEDRICH, LYNN)Sep 15, 2021 - Jul 31, 2026
    NIH
    Harnessing Supercoiling to Regulate DNA Activity
    Role: Principal Investigator
    R01GM115501     (ZECHIEDRICH, L.)Aug 15, 2015 - Nov 30, 2019
    NIH
    Molecular Mechanisms Underlying Fluoroquinolone Susceptibility and Resistance
    Role: Principal Investigator
    R56AI054830     (ZECHIEDRICH, ELIZABETH LYNN)Apr 1, 2003 - Jul 31, 2015
    NIH
    Combatting Antimicrobial Resistance
    Role: Principal Investigator
    R01AI054830     (ZECHIEDRICH, ELIZABETH LYNN)Apr 1, 2003 - Jul 31, 2014
    NIH
    Combatting Quinolone Antimicrobial Resistance
    Role: Principal Investigator
    F32GM014574     (ZECHIEDRICH, ELIZABETH LYNN)Dec 31, 1991
    NIH
    MECHANISM OF SITE-SPECIFIC RECOMBINATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vayssi?res M, Marechal N, Yun L, Lopez Duran B, Murugasamy NK, Fogg JM, Zechiedrich L, Nadal M, Lamour V. Structural basis of DNA crossover capture by Escherichia coli DNA gyrase. Science. 2024 04 12; 384(6692):227-232. PMID: 38603484; PMCID: PMC11108255.
      Citations: 2     Fields:    Translation:Cells
    2. Ranasinghe M, Fogg JM, Catanese DJ, Zechiedrich L, Demeler B. Suitability of double-stranded DNA as a molecular standard for the validation of analytical ultracentrifugation instruments. Eur Biophys J. 2023 Jul; 52(4-5):267-280. PMID: 37501021; PMCID: PMC10530205.
      Citations: 1     Fields:    Translation:Cells
    3. Waszkiewicz R, Ranasinghe M, Fogg JM, Catanese DJ, Ekiel-Jezewska ML, Lisicki M, Demeler B, Zechiedrich L, Szymczak P. DNA supercoiling-induced shapes alter minicircle hydrodynamic properties. Nucleic Acids Res. 2023 05 08; 51(8):4027-4042. PMID: 36971110; PMCID: PMC10164573.
      Citations: 2     Fields:    Translation:Cells
    4. Chou A, Sucgang R, Hamill RJ, Zechiedrich L, Trautner BW. Mortality difference from Klebsiella aerogenes vs Enterobacter cloacae bloodstream infections. Access Microbiol. 2023; 5(2):acmi000421. PMID: 36919079; PMCID: PMC10008348.
      Citations:    
    5. Waszkiewicz R, Ranasinghe M, Fogg JM, Catanese DJ, Ekiel-Jezewska ML, Lisicki M, Demeler B, Zechiedrich L, Szymczak P. DNA supercoiling-induced shapes alter minicircle hydrodynamic properties. bioRxiv. 2023 Jan 05. PMID: 36711572; PMCID: PMC9881935.
      Citations:    
    6. Blunck BN, Angelo LS, Henke D, Avadhanula V, Cusick M, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. Adult Memory T Cell Responses to the Respiratory Syncytial Virus Fusion Protein During a Single RSV Season (2018-2019). Front Immunol. 2022; 13:823652. PMID: 35422803; PMCID: PMC9002099.
      Citations:    Fields:    Translation:HumansCells
    7. Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. Antibody responses of healthy adults to the p27 peptide of respiratory syncytial virus fusion protein. Vaccine. 2022 01 24; 40(3):536-543. PMID: 34903371; PMCID: PMC8755595.
      Citations:    Fields:    Translation:HumansCells
    8. Fogg JM, Judge AK, Stricker E, Chan HL, Zechiedrich L. Supercoiling and looping promote DNA base accessibility and coordination among distant sites. Nat Commun. 2021 09 28; 12(1):5683. PMID: 34584096; PMCID: PMC8478907.
      Citations: 6     Fields:    Translation:Cells
    9. Blunck BN, Aideyan L, Ye X, Avadhanula V, Ferlic-Stark L, Zechiedrich L, Gilbert BE, Piedra PA. A prospective surveillance study on the kinetics of the humoral immune response to the respiratory syncytial virus fusion protein in adults in Houston, Texas. Vaccine. 2021 02 22; 39(8):1248-1256. PMID: 33509697; PMCID: PMC8152364.
      Citations: 3     Fields:    Translation:HumansCells
    10. Hardee CL, Fogg JM, Corman NR, Noorbakhsh C, Zechiedrich L, Ar?valo-Soliz LM. Improving therapeutic potential of non-viral minimized DNA vectors. Cell Gene Ther Insights. 2020 Nov; 6(10):1489-1505. PMID: 33953961; PMCID: PMC8095377.
      Citations: 2     
    11. Zechiedrich L, Fogg JM. BIOPHYSICS MEETS GENE THERAPY: HOW EXPLORING SUPERCOILING-DEPENDENT STRUCTURAL CHANGES IN DNA LED TO THE DEVELOPMENT OF MINIVECTOR DNA. Technol Innov. 2019 Aug; 20(4):427-439. PMID: 33815681; PMCID: PMC8015919.
      Citations: 2     
    12. Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L. Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli. PLoS One. 2019; 14(1):e0210547. PMID: 30633761; PMCID: PMC6329577.
      Citations: 4     Fields:    Translation:Cells
    13. Conley ZC, Bodine TJ, Chou A, Zechiedrich L. Wicked: The untold story of ciprofloxacin. PLoS Pathog. 2018 03; 14(3):e1006805. PMID: 29494701; PMCID: PMC5832386.
      Citations: 10     Fields:    Translation:HumansCells
    14. Fogg JM, Zechiedrich L, Bizard AH, Yang X, D?bat H, Strick TR, Garnier F, Nadal M. TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase. Nucleic Acids Res. 2018 01 25; 46(2):861-872. PMID: 29253195; PMCID: PMC5778498.
      Citations: 6     Fields:    Translation:Cells
    15. Koire A, Gilbert BE, Sucgang R, Zechiedrich L. Correction: Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice. PLoS One. 2017; 12(12):e0189384. PMID: 29206873; PMCID: PMC5716586.
      Citations:    Fields:    
    16. Wang Q, Irobalieva RN, Chiu W, Schmid MF, Fogg JM, Zechiedrich L, Pettitt BM. Influence of DNA sequence on the structure of minicircles under torsional stress. Nucleic Acids Res. 2017 Jul 27; 45(13):7633-7642. PMID: 28609782; PMCID: PMC5737869.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    17. Bodine TJ, Evangelista MA, Chang HT, Ayoub CA, Samuel BS, Sucgang R, Zechiedrich L. Escherichia coli DNA ligase B may mitigate damage from oxidative stress. PLoS One. 2017; 12(7):e0180800. PMID: 28700629; PMCID: PMC5507437.
      Citations: 1     Fields:    Translation:Cells
    18. Hardee CL, Hornstein BD, Zechiedrich L, Ar?valo-Soliz LM. Advances in Non-Viral DNA Vectors for Gene Therapy. Genes (Basel). 2017 Feb 10; 8(2). PMID: 28208635; PMCID: PMC5333054.
      Citations: 76     Fields:    
    19. Hornstein BD, Roman D, Engevik MA, Zechiedrich L, Ar?valo-Soliz LM. Effects of Circular DNA Length on Transfection Efficiency by Electroporation into HeLa Cells. PLoS One. 2016; 11(12):e0167537. PMID: 27918590; PMCID: PMC5137892.
      Citations: 26     Fields:    Translation:HumansCells
    20. Koire A, Gilbert BE, Sucgang R, Zechiedrich L. Repurposed Transcriptomic Data Reveal Small Viral RNA Produced by Influenza Virus during Infection in Mice. PLoS One. 2016; 11(10):e0165729. PMID: 27788253; PMCID: PMC5082947.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Bates D, Pettitt BM, Buck GR, Zechiedrich L. Importance of disentanglement and entanglement during DNA replication and segregation: Comment on: "Disentangling DNA molecules" by Alexander Vologodskii. Phys Life Rev. 2016 09; 18:160-164. PMID: 27666770; PMCID: PMC5320565.
      Citations: 1     Fields:    Translation:Cells
    22. Chou A, Nuila RE, Franco LM, Stager CE, Atmar RL, Zechiedrich L. Prevalence of hypervirulent Klebsiella pneumoniae-associated genes rmpA and magA in two tertiary hospitals in Houston, TX, USA. J Med Microbiol. 2016 Sep; 65(9):1047-1048. PMID: 27392968; PMCID: PMC5068137.
      Citations: 5     Fields:    Translation:HumansCells
    23. Chou A, Roa M, Evangelista MA, Sulit AK, Lagamayo E, Torres BC, Klinzing DC, Daroy ML, Navoa-Ng J, Sucgang R, Zechiedrich L. Emergence of Klebsiella pneumoniae ST273 Carrying blaNDM-7 and ST656 Carrying blaNDM-1 in Manila, Philippines. Microb Drug Resist. 2016 Oct; 22(7):585-588. PMID: 27032000; PMCID: PMC5073224.
      Citations: 12     Fields:    Translation:HumansCells
    24. Irobalieva RN, Fogg JM, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Erratum: Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 29; 6:8851. PMID: 26511109; PMCID: PMC7188467.
      Citations: 6     Fields:    
    25. Irobalieva RN, Fogg JM, Catanese DJ, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 12; 6:8440. PMID: 26455586; PMCID: PMC4608029.
      Citations: 57     Fields:    Translation:Cells
    26. Nobles CL, Zechiedrich L, Maresso AW, Pandey N, Silberg JJ. Combining random gene fission and rational gene fusion to discover near-infrared fluorescent protein fragments that report on protein-protein interactions. ACS Synth Biol. 2015 May 15; 4(5):615-24. PMID: 25265085; PMCID: PMC4487222.
      Citations: 10     Fields:    
    27. . Encyclopedia of Metagenomics (Karen E. Nelson, editor). Antibiotic Classes and Mechanisms of Resistance. 2014; (303370). View Publication.
    28. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064; PMCID: PMC3720592.
      Citations: 28     Fields:    Translation:HumansCells
    29. Swick MC, Evangelista MA, Bodine TJ, Easton-Marks JR, Barth P, Shah MJ, Bormann Chung CA, Stanley S, McLaughlin SF, Lee CC, Sheth V, Doan Q, Hamill RJ, Steffen D, Becnel LB, Sucgang R, Zechiedrich L. Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates. PLoS One. 2013; 8(6):e65961. PMID: 23824211; PMCID: PMC3688849.
      Citations: 6     Fields:    Translation:Cells
    30. Fogg JM, Randall GL, Pettitt BM, Sumners WL, Harris SA, Zechiedrich L. Bullied no more: when and how DNA shoves proteins around. Q Rev Biophys. 2012 Aug; 45(3):257-299. PMID: 22850561; PMCID: PMC4866820.
      Citations: 34     Fields:    Translation:HumansCells
    31. Zechiedrich L. Editorial comment to genome-wide transcriptome analysis of fluoroquinolone resistance in clinical isolates of Escherichia coli. Int J Urol. 2012 Apr; 19(4):368-9. PMID: 22394085.
      Citations:    Fields:    Translation:HumansCells
    32. Singh R, Swick MC, Ledesma KR, Yang Z, Hu M, Zechiedrich L, Tam VH. Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother. 2012 Apr; 56(4):1680-5. PMID: 22232279; PMCID: PMC3318314.
      Citations: 30     Fields:    Translation:Cells
    33. Catanese DJ, Fogg JM, Schrock DE, Gilbert BE, Zechiedrich L. Supercoiled Minivector DNA resists shear forces associated with gene therapy delivery. Gene Ther. 2012 Jan; 19(1):94-100. PMID: 21633394; PMCID: PMC3252587.
      Citations: 28     Fields:    Translation:HumansCells
    34. Swick MC, Morgan-Linnell SK, Carlson KM, Zechiedrich L. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrob Agents Chemother. 2011 Feb; 55(2):921-4. PMID: 21098250; PMCID: PMC3028778.
      Citations: 66     Fields:    Translation:HumansCells
    35. Zhao N, Fogg JM, Zechiedrich L, Zu Y. Transfection of shRNA-encoding Minivector DNA of a few hundred base pairs to regulate gene expression in lymphoma cells. Gene Ther. 2011 Mar; 18(3):220-4. PMID: 20962872; PMCID: PMC3154479.
      Citations: 25     Fields:    Translation:HumansCells
    36. Zechiedrich L, Osheroff N. Topoisomerase IB-DNA interactions: X marks the spot. Structure. 2010 Jun 09; 18(6):661-3. PMID: 20541502; PMCID: PMC2891060.
      Citations: 3     Fields:    
    37. Liu Z, Zechiedrich L, Chan HS. Action at hooked or twisted-hooked DNA juxtapositions rationalizes unlinking preference of type-2 topoisomerases. J Mol Biol. 2010 Jul 30; 400(5):963-82. PMID: 20460130; PMCID: PMC6794154.
      Citations: 15     Fields:    
    38. Liu Z, Zechiedrich L, Chan HS. Local site preference rationalizes disentangling by DNA topoisomerases. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Mar; 81(3 Pt 1):031902. PMID: 20365765; PMCID: PMC3645352.
      Citations: 6     Fields:    Translation:Cells
    39. Randall GL, Zechiedrich L, Pettitt BM. In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form. Nucleic Acids Res. 2009 Sep; 37(16):5568-77. PMID: 19586933; PMCID: PMC2760789.
      Citations: 35     Fields:    Translation:Cells
    40. Liu Z, Deibler RW, Chan HS, Zechiedrich L. The why and how of DNA unlinking. Nucleic Acids Res. 2009 Feb; 37(3):661-71. PMID: 19240147; PMCID: PMC2647305.
      Citations: 42     Fields:    Translation:Cells
    41. Morgan-Linnell SK, Becnel Boyd L, Steffen D, Zechiedrich L. Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):235-41. PMID: 18838592; PMCID: PMC2612180.
      Citations: 65     Fields:    Translation:HumansCells
    42. Becnel Boyd L, Maynard MJ, Morgan-Linnell SK, Horton LB, Sucgang R, Hamill RJ, Jimenez JR, Versalovic J, Steffen D, Zechiedrich L. Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolates. Antimicrob Agents Chemother. 2009 Jan; 53(1):229-34. PMID: 18838594; PMCID: PMC2612140.
      Citations: 30     Fields:    Translation:Cells
    43. Boyd LB, Atmar RL, Randall GL, Hamill RJ, Steffen D, Zechiedrich L. Increased fluoroquinolone resistance with time in Escherichia coli from >17,000 patients at a large county hospital as a function of culture site, age, sex, and location. BMC Infect Dis. 2008 Jan 15; 8:4. PMID: 18197977; PMCID: PMC2258293.
      Citations: 29     Fields:    Translation:HumansCellsPHPublic Health
    44. Morgan-Linnell SK, Hiasa H, Zechiedrich L, Nitiss JL. Assessing sensitivity to antibacterial topoisomerase II inhibitors. Curr Protoc Pharmacol. 2007 Dec; Chapter 3:Unit3.13. PMID: 21948169; PMCID: PMC2850120.
      Citations:    Fields:    
    45. Morgan-Linnell SK, Zechiedrich L. Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother. 2007 Nov; 51(11):4205-8. PMID: 17682104; PMCID: PMC2151436.
      Citations: 29     Fields:    Translation:Cells
    46. Deibler RW, Mann JK, Sumners de WL, Zechiedrich L. Hin-mediated DNA knotting and recombining promote replicon dysfunction and mutation. BMC Mol Biol. 2007 May 25; 8:44. PMID: 17531098; PMCID: PMC1904230.
      Citations: 30     Fields:    Translation:Cells
    47. Randall GL, Pettitt BM, Buck GR, Zechiedrich EL. Electrostatics of DNA-DNA juxtapositions: consequences for type II topoisomerase function. J Phys Condens Matter. 2006 Apr 12; 18(14):S173-S185. PMID: 19088861; PMCID: PMC2603137.
      Citations: 11     Fields:    
    48. Fogg JM, Kolmakova N, Rees I, Magonov S, Hansma H, Perona JJ, Zechiedrich EL. Exploring writhe in supercoiled minicircle DNA. J Phys Condens Matter. 2006 Apr 12; 18(14):S145-S159. PMID: 19337583; PMCID: PMC2662687.
      Citations: 33     Fields:    
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