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DIANA S-L. CHOW

TitleProfessor
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7049
Houston, TX 77204-5037
Houston TX 77204-5037
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    Collapse Research 
    Collapse research activities and funding
    R01CA257842     (LI, CHUN)Aug 1, 2022 - Jun 30, 2026
    NIH
    Pre-IND Development of Polymeric Micelles with Dual Drug Payloads for HCC Therapy
    Role: Co-Principal Investigator
    P20CA221729     (MATZUK, MARTIN M.)Sep 20, 2018 - Aug 31, 2022
    NIH
    2/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Co-Principal Investigator
    P20CA221731     (CHOW, DIANA S-L.)Sep 20, 2018 - Aug 31, 2022
    NIH
    1/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chow DS, Nguyen A, Park J, Wu L, Toups EG, Harrop JS, Guest JD, Schmitt KM, Aarabi B, Fehlings MG, Boakye M, Grossman RG. Riluzole in Spinal Cord Injury Study (RISCIS)-Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial. J Neurotrauma. 2023 09; 40(17-18):1889-1906. PMID: 37130044.
      Citations:    Fields:    Translation:Humans
    2. Fehlings MG, Moghaddamjou A, Harrop JS, Stanford R, Ball J, Aarabi B, Freeman BJC, Arnold PM, Guest JD, Kurpad SN, Schuster JM, Nassr A, Schmitt KM, Wilson JR, Brodke DS, Ahmad FU, Yee A, Ray WZ, Brooks NP, Wilson J, Chow DS, Toups EG, Kopjar B. Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. J Neurotrauma. 2023 09; 40(17-18):1878-1888. PMID: 37279301; PMCID: PMC10460693.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    3. Bui D, McWilliams LA, Wu L, Zhou H, Wong SJ, You M, Chow DS, Singh R, Hu M. Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans. Cancers (Basel). 2022 Dec 23; 15(1). PMID: 36612086; PMCID: PMC9817974.
      Citations: 1     
    4. Tu SM, Guo CC, Chow DS, Zacharias NM. Stem Cell Theory of Cancer: Implications for Drug Resistance and Chemosensitivity in Cancer Care. Cancers (Basel). 2022 Mar 18; 14(6). PMID: 35326699; PMCID: PMC8946169.
      Citations:    
    5. Nguyen A, Chow DS, Wu L, Teng YA, Sarkar M, Toups EG, Harrop JS, Schmitt KM, Johnson MM, Guest JD, Aarabi B, Shaffrey CI, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent. J Clin Pharmacol. 2021 09; 61(9):1232-1242. PMID: 33908635; PMCID: PMC8457124.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    6. Awosemo O, Neelakantan H, Watowich S, Ma J, Wu L, Chow DS, Liang D. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies. J Pharm Biomed Anal. 2021 Sep 10; 204:114255. PMID: 34304009.
      Citations: 1     Fields:    Translation:Animals
    7. Agu L, Skiles JL, Masters AR, Renbarger JL, Chow DS. Simultaneous quantification of vincristine and its major M1 metabolite from dried blood spot samples of Kenyan pediatric cancer patients by UPLC-MS/MS. J Pharm Biomed Anal. 2021 Sep 05; 203:114143. PMID: 34111732; PMCID: PMC9441314.
      Citations:    Fields:    Translation:Humans
    8. Gao X, Wu L, Tsai RYL, Ma J, Liu X, Chow DS, Liang D, Xie H. Pharmacokinetic Model Analysis of Supralingual, Oral and Intravenous Deliveries of Mycophenolic Acid. Pharmaceutics. 2021 Apr 17; 13(4). PMID: 33920640; PMCID: PMC8072905.
      Citations: 1     
    9. Lincha VR, Hsiao CH, Zhao J, Li C, Chow DS. Sensitive and rapid UHPLC-MS/MS assay for simultaneous quantifications of calcipotriol and paclitaxel in rat whole blood and plasma samples. J Pharm Biomed Anal. 2021 Jan 05; 192:113685. PMID: 33099115.
      Citations: 1     Fields:    Translation:Animals
    10. Sheth RA, Wen X, Li J, Melancon MP, Ji X, Wang YA, Hsiao CH, Chow DS, Whitley EM, Li C, Gupta S. Doxorubicin-loaded hollow gold nanospheres for dual photothermal ablation and chemoembolization therapy. Cancer Nanotechnol. 2020; 11(1). PMID: 34335988; PMCID: PMC8323745.
      Citations: 2     
    11. Chityala PK, Wu L, Chow DS, Ghose R. Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model. Chem Biol Interact. 2020 Jan 25; 316:108933. PMID: 31870839.
      Citations: 1     Fields:    Translation:Animals
    12. Shi S, Li T, Wen X, Wu SY, Xiong C, Zhao J, Lincha VR, Chow DS, Liu Y, Sood AK, Li C. Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention. Bioconjug Chem. 2019 10 16; 30(10):2675-2683. PMID: 31560538; PMCID: PMC6947533.
      Citations: 19     Fields:    Translation:AnimalsCells
    13. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins. Obes Surg. 2019 08; 29(8):2571-2583. PMID: 31004269; PMCID: PMC6660378.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    14. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Correction to: Longitudinal Impacts of Gastric Bypass Surgery on Pharmacodynamics and Pharmacokinetics of Statins. Obes Surg. 2019 Aug; 29(8):2584. PMID: 31037595.
      Citations:    Fields:    
    15. Hsiao CH, Zhao J, Gao S, Farhan N, Wang Y, Li C, Chow DS. Development and validation of a rapid and sensitive UPLC-MS/MS assay for simultaneous quantification of paclitaxel and cyclopamine in mouse whole blood and tissue samples. Biomed Chromatogr. 2019 Sep; 33(9):e4518. PMID: 30805953.
      Citations: 1     Fields:    Translation:Animals
    16. Dong D, Hsiao CH, Giovanella BC, Wang Y, Chow DS, Li Z. Sustained delivery of a camptothecin prodrug - CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity. Int J Nanomedicine. 2019; 14:3799-3817. PMID: 31213802; PMCID: PMC6540077.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    17. Cui L, Xiong C, Zhou M, Shi S, Chow DS, Li C. Integrin av?3-Targeted [64Cu]CuS Nanoparticles for PET/CT Imaging and Photothermal Ablation Therapy. Bioconjug Chem. 2018 12 19; 29(12):4062-4071. PMID: 30404438; PMCID: PMC6693325.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. El-Zailik A, Cheung LK, Wang Y, Sherman V, Chow DS. Simultaneous LC-MS/MS analysis of simvastatin, atorvastatin, rosuvastatin and their active metabolites for plasma samples of obese patients underwent gastric bypass surgery. J Pharm Biomed Anal. 2019 Feb 05; 164:258-267. PMID: 30396053; PMCID: PMC6298799.
      Citations: 3     Fields:    Translation:Humans
    19. Zhao J, Xiao Z, Li T, Chen H, Yuan Y, Wang YA, Hsiao CH, Chow DS, Overwijk WW, Li C. Stromal Modulation Reverses Primary Resistance to Immune Checkpoint Blockade in Pancreatic Cancer. ACS Nano. 2018 10 23; 12(10):9881-9893. PMID: 30231203; PMCID: PMC6245606.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    20. Sarkar M, Grossman RG, Toups EG, Chow DS. Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats. Eur J Pharm Sci. 2018 Dec 01; 125:1-10. PMID: 30201516.
      Citations: 2     Fields:    Translation:Animals
    21. Kim YJ, Tu Y, Chow DS. Ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay for simultaneous quantifications of CZ48, lactone-stabilized camptothecin, and camptothecin and their pharmacokinetic and biliary evaluations in rats. J Pharm Biomed Anal. 2018 Nov 30; 161:122-128. PMID: 30149187.
      Citations:    Fields:    Translation:Animals
    22. Belkacemi L, Atkins JL, Yang LU, Gadgil P, Sater AK, Chow DS, Bose RN, Zhang SX. Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer. Anticancer Res. 2018 02; 38(2):623-646. PMID: 29374685.
      Citations: 1     Fields:    Translation:AnimalsCells
    23. Zhao J, Wang H, Hsiao CH, Chow DS, Koay EJ, Kang Y, Wen X, Huang Q, Ma Y, Bankson JA, Ullrich SE, Overwijk W, Maitra A, Piwnica-Worms D, Fleming JB, Li C. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials. 2018 03; 159:215-228. PMID: 29331808; PMCID: PMC6203960.
      Citations: 26     Fields:    Translation:AnimalsCells
    24. Sarkar M, Grossman RG, Toups EG, Chow DS. UPLC-MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients. J Pharm Biomed Anal. 2017 Nov 30; 146:334-340. PMID: 28917164.
      Citations: 2     Fields:    Translation:Humans
    25. Zhang D, Chow DS. Clinical Pharmacokinetics of Mycophenolic Acid in Hematopoietic Stem Cell Transplantation Recipients. Eur J Drug Metab Pharmacokinet. 2017 Apr; 42(2):183-189. PMID: 27677732.
      Citations: 6     Fields:    Translation:Humans
    26. Zhang D, Renbarger JL, Chow DS. Pharmacokinetic Variability of Mycophenolic Acid in Pediatric and Adult Patients With Hematopoietic Stem Cell Transplantation. J Clin Pharmacol. 2016 11; 56(11):1378-1386. PMID: 27060685.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    27. Farhan N, Fitzpatrick S, Shim YM, Paige M, Chow DS. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 05; 128:46-52. PMID: 27232150.
      Citations:    Fields:    Translation:Animals
    28. Zhang D, Chow DS, Renbarger JL. Simultaneous quantification of mycophenolic acid and its glucuronide metabolites in human plasma by an UPLC-MS/MS assay. Biomed Chromatogr. 2016 Oct; 30(10):1648-55. PMID: 27061819.
      Citations: 2     Fields:    Translation:Humans
    29. Manchandani P, Zhou J, Ledesma KR, Truong LD, Chow DS, Eriksen JL, Tam VH. Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model. Antimicrob Agents Chemother. 2016 Feb; 60(2):1029-34. PMID: 26643340; PMCID: PMC4750689.
      Citations: 19     Fields:    Translation:Animals
    30. Zhang D, Wu L, Chow DS, Tam VH, Rios DR. Quantitative determination of dopamine in human plasma by a highly sensitive LC-MS/MS assay: Application in preterm neonates. J Pharm Biomed Anal. 2016 Jan 05; 117:227-31. PMID: 26372947.
      Citations: 7     Fields:    Translation:Humans
    31. Abodakpi H, Gohlke J, Chang KT, Chow DS, Tam VH. Analytical and functional determination of polymyxin B protein binding in serum. Antimicrob Agents Chemother. 2015 Nov; 59(11):7121-3. PMID: 26324262; PMCID: PMC4604353.
      Citations: 3     Fields:    Translation:HumansCells
    32. Leyden KN, Hanneman SK, Padhye NS, Smolensky MH, Kang DH, Chow DS. The Utility of the Swine Model to Assess Biological Rhythms and Their Characteristics during Different Stages of Residence in a Simulated Intensive Care Unit: A Pilot Study. Chronobiol Int. 2015; 32(7):980-93. PMID: 26204131; PMCID: PMC4876865.
      Citations:    Fields:    Translation:HumansAnimals
    33. Wu L, Boyd JL, Daniels V, Wang Z, Chow DS, Putcha L. Dose escalation pharmacokinetics of intranasal scopolamine gel formulation. J Clin Pharmacol. 2015 Feb; 55(2):195-203. PMID: 25187210.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    34. Zhang D, Rios DR, Tam VH, Chow DS. Development and validation of a highly sensitive LC-MS/MS assay for the quantification of arginine vasopressin in human plasma and urine: Application in preterm neonates and child. J Pharm Biomed Anal. 2014 Oct; 99:67-73. PMID: 25072843.
      Citations: 3     Fields:    Translation:Humans
    35. Weeks PA, Teng Y, Wu L, Sun M, Yang Z, Chow DS. Chemical and physical compatibility of an intravenous solution of epinephrine with calcium chloride. Int J Pharm Compd. 2014 Mar-Apr; 18(2):152-8. PMID: 24881119.
      Citations: 1     Fields:    
    36. Cheung LK, Lal LS, Chow DS, Sherman V. Racial disparity in short-term outcomes after gastric bypass surgery. Obes Surg. 2013 Dec; 23(12):2096-103. PMID: 23868139.
      Citations: 9     Fields:    Translation:Humans
    37. Grossman RG, Fehlings MG, Frankowski RF, Burau KD, Chow DS, Tator C, Teng A, Toups EG, Harrop JS, Aarabi B, Shaffrey CI, Johnson MM, Harkema SJ, Boakye M, Guest JD, Wilson JR. A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. J Neurotrauma. 2014 Feb 01; 31(3):239-55. PMID: 23859435; PMCID: PMC3904533.
      Citations: 55     Fields:    Translation:HumansCTClinical Trials
    38. He J, Abdelraouf K, Ledesma KR, Chow DS, Tam VH. Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model. Int J Antimicrob Agents. 2013 Dec; 42(6):559-64. PMID: 24016799; PMCID: PMC3849129.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Wu Y, Satkunendrarajah K, Teng Y, Chow DS, Buttigieg J, Fehlings MG. Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. J Neurotrauma. 2013 Mar 15; 30(6):441-52. PMID: 23517137; PMCID: PMC3696918.
      Citations: 23     Fields:    Translation:Animals
    40. He J, Gao S, Hu M, Chow DS, Tam VH. A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. J Antimicrob Chemother. 2013 May; 68(5):1104-10. PMID: 23341128; PMCID: PMC3625435.
      Citations: 12     Fields:    Translation:Animals
    41. Chow DS, Teng Y, Toups EG, Aarabi B, Harrop JS, Shaffrey CI, Johnson MM, Boakye M, Frankowski RF, Fehlings MG, Grossman RG. Pharmacology of riluzole in acute spinal cord injury. J Neurosurg Spine. 2012 Sep; 17(1 Suppl):129-40. PMID: 22985379.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    42. Gandhi AS, Guo T, Shah P, Moorthy B, Chow DS, Hu M, Ghose R. CYP3A-dependent drug metabolism is reduced in bacterial inflammation in mice. Br J Pharmacol. 2012 Aug; 166(7):2176-87. PMID: 22394353; PMCID: PMC3402780.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Wu Y, Satkundrarajah K, Teng Y, Chow DS, Fehlings MG. Evaluation of the sodium-glutamate blocker riluzole in a preclinical model of ervical spinal cord injury. Evid Based Spine Care J. 2010 Aug; 1(2):71-2. PMID: 23637674; PMCID: PMC3623105.
      Citations: 5     
    44. He J, Figueroa DA, Lim TP, Chow DS, Tam VH. Stability of polymyxin B sulfate diluted in 0.9% sodium chloride injection and stored at 4 or 25 degrees C. Am J Health Syst Pharm. 2010 Jul 15; 67(14):1191-4. PMID: 20592326.
      Citations: 5     Fields:    Translation:CellsPHPublic Health
    45. He J, Ledesma KR, Lam WY, Figueroa DA, Lim TP, Chow DS, Tam VH. Variability of polymyxin B major components in commercial formulations. Int J Antimicrob Agents. 2010 Mar; 35(3):308-10. PMID: 20045285.
      Citations: 15     Fields:    Translation:Humans
    46. Nornoo AO, Chow DS. Cremophor-free intravenous microemulsions for paclitaxel II. Stability, in vitro release and pharmacokinetics. Int J Pharm. 2008 Feb 12; 349(1-2):117-23. PMID: 17869458.
      Citations: 10     Fields:    Translation:Animals
    47. Nornoo AO, Osborne DW, Chow DS. Cremophor-free intravenous microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis. Int J Pharm. 2008 Feb 12; 349(1-2):108-16. PMID: 17869459.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    48. Poon IO, Chow DS, Liang D. Dissolution profiles of nonprescription extended-release niacin and inositol niacinate products. Am J Health Syst Pharm. 2006 Nov 01; 63(21):2128-34. PMID: 17057051.
      Citations: 1     Fields:    Translation:Humans
    49. Li C, Wang W, Wu Q, Ke S, Houston J, Sevick-Muraca E, Dong L, Chow D, Charnsangavej C, Gelovani JG. Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe. Nucl Med Biol. 2006 Apr; 33(3):349-58. PMID: 16631083.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    50. Wen X, Wu QP, Ke S, Wallace S, Charnsangavej C, Huang P, Liang D, Chow D, Li C. Improved radiolabeling of PEGylated protein: PEGylated annexin V for noninvasive imaging of tumor apoptosis. Cancer Biother Radiopharm. 2003 Oct; 18(5):819-27. PMID: 14629830.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    51. Andersson BS, Madden T, Tran HT, Hu WW, Blume KG, Chow DS, Champlin RE, Vaughan WP. Acute safety and pharmacokinetics of intravenous busulfan when used with oral busulfan and cyclophosphamide as pretransplantation conditioning therapy: a phase I study. Biol Blood Marrow Transplant. 2000; 6(5A):548-54. PMID: 11071260.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    52. Shah JC, Chen JR, Chow D. Metastable polymorph of etoposide with higher dissolution rate. Drug Dev Ind Pharm. 1999 Jan; 25(1):63-7. PMID: 10028419.
      Citations: 2     Fields:    Translation:Cells
    53. Chow DS, Bhagwatwar HP, Phadungpojna S, Andersson BS. Stability-indicating high-performance liquid chromatographic assay of busulfan in aqueous and plasma samples. J Chromatogr B Biomed Sci Appl. 1997 Dec 19; 704(1-2):277-88. PMID: 9518161.
      Citations: 1     Fields:    Translation:Animals
    54. Shah JC, Chen JR, Chow D. Preformulation study of etoposide: identification of physicochemical characteristics responsible for the low and erratic oral bioavailability of etoposide. Pharm Res. 1989 May; 6(5):408-12. PMID: 2748532.
      Citations: 17     Fields:    
    55. Bruce S, Tschen JA, Chow D. Exogenous ochronosis resulting from quinine injections. J Am Acad Dermatol. 1986 Aug; 15(2 Pt 2):357-61. PMID: 3734183.
      Citations: 5     Fields:    Translation:Humans
    56. Chow DS, Kaka I, Wang TI. Concentration-dependent enhancement of 1-dodecylazacycloheptan-2-one on the percutaneous penetration kinetics of triamcinolone acetonide. J Pharm Sci. 1984 Dec; 73(12):1794-9. PMID: 6527259.
      Citations: 7     Fields:    Translation:AnimalsCells
    57. Senekjian HO, Lee CS, Kuo TH, Au DS, Krothapalli R. Absorption and disposition of ibuprofen in hemodialyzed uremic patients. Eur J Rheumatol Inflamm. 1983; 6(2):155-62. PMID: 6673979.
      Citations: 7     Fields:    Translation:HumansCells
    58. Tam YK, Au DS, Abbott FS. Improved gas-liquid chromatographic-flame ionization detection assay of acetylsalicylic and salicylic acids. J Chromatogr. 1979 Jun 01; 174(1):239-44. PMID: 546888.
      Citations:    Fields:    Translation:HumansPHPublic Health
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