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TAHIR HUSSAIN

TitleProfessor. Associate Dean for Research and Graduate Programs
InstitutionUniversity of Houston
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 5027
Houston, TX 77204-5039
Houston TX 77204-5039
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel SN, Kulkarni K, Faisal T, Hussain T. Angiotensin-II type 2 receptor-mediated renoprotection is independent of receptor Mas in obese Zucker rats fed high-sodium diet. Front Pharmacol. 2024; 15:1409313. PMID: 39135807; PMCID: PMC11317439.
      Citations:    
    2. Fatima N, Ali R, Faisal T, Kulkarni K, Patel S, Hussain T. Macrophage angiotensin AT2 receptor activation is protective against early phases of LPS-induced acute kidney injury. Am J Physiol Renal Physiol. 2023 11 01; 325(5):F552-F563. PMID: 37615049; PMCID: PMC10878726.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Kulkarni K, Patel S, Ali R, Hussain T. Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats. Sci Rep. 2023 03 15; 13(1):4277. PMID: 36922642; PMCID: PMC10017765.
      Citations:    Fields:    Translation:Animals
    4. Patel S, Kulkarni K, Hussain T. Protecting glomerulus: role of angiotensin-II type 2 receptor. Clin Sci (Lond). 2022 10 28; 136(20):1467-1470. PMID: 36287192.
      Citations:    Fields:    Translation:HumansCells
    5. Steckelings UM, Widdop RE, Sturrock ED, Lubbe L, Hussain T, Kaschina E, Unger T, Hallberg A, Carey RM, Sumners C. The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target. Pharmacol Rev. 2022 10; 74(4):1051-1135. PMID: 36180112; PMCID: PMC9553111.
      Citations: 9     Fields:    Translation:HumansCells
    6. Gray EA, Patel SN, Doris PA, Hussain T. Combining Neprilysin Inhibitor With AT2R Agonist Is Superior to Combination With AT1R Blocker in Providing Reno-Protection in Obese Rats. Front Pharmacol. 2021; 12:778953. PMID: 35197849; PMCID: PMC8859315.
      Citations:    
    7. Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021; 12:600163. PMID: 33935698; PMCID: PMC8082177.
      Citations:    
    8. Fatima N, Patel SN, Hussain T. Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling. Hypertension. 2021 06; 77(6):1845-1856. PMID: 33840201; PMCID: PMC8115429.
      Citations: 9     Fields:    Translation:HumansAnimals
    9. Ali R, Patel S, Hussain T. Angiotensin type 2 receptor activation limits kidney injury during the early phase and induces Treg cells during the late phase of renal ischemia. Am J Physiol Renal Physiol. 2021 05 01; 320(5):F814-F825. PMID: 33719572; PMCID: PMC8424555.
      Citations: 5     Fields:    Translation:AnimalsCells
    10. Patel S, Hussain T. Synergism between Angiotensin receptors ligands: Role of Angiotensin-(1-7) in modulating AT2 R agonist response on nitric oxide in kidney cells. Pharmacol Res Perspect. 2020 12; 8(6):e00667. PMID: 33197136; PMCID: PMC7668194.
      Citations:    Fields:    Translation:HumansCells
    11. Patel SN, Fatima N, Ali R, Hussain T. Emerging Role of Angiotensin AT2 Receptor in Anti-Inflammation: An Update. Curr Pharm Des. 2020; 26(4):492-500. PMID: 31939729; PMCID: PMC7457547.
      Citations: 9     Fields:    Translation:HumansCells
    12. Nag S, Patel S, Mani S, Hussain T. Role of angiotensin type 2 receptor in improving lipid metabolism and preventing adiposity. Mol Cell Biochem. 2019 Nov; 461(1-2):195-204. PMID: 31414336; PMCID: PMC6790297.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Patel S, Dhande I, Gray EA, Ali Q, Hussain T. Prevention of lipopolysaccharide-induced CD11b+ immune cell infiltration in the kidney: role of AT2 receptors. Biosci Rep. 2019 05 31; 39(5). PMID: 31072913; PMCID: PMC6533357.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Patel S, Hussain T. Correction to: Dimerization of AT2 and Mas Receptors in Control of Blood Pressure. Curr Hypertens Rep. 2018 05 12; 20(5):47. PMID: 29754183.
      Citations: 1     Fields:    
    15. Patel S, Hussain T. Dimerization of AT2 and Mas Receptors in Control of Blood Pressure. Curr Hypertens Rep. 2018 05 01; 20(5):41. PMID: 29717388; PMCID: PMC7479989.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. Patel SN, Narayan P, Goldberg ID, Naaz F, Hussain T, Ali Q. Kidney Appreciates Stable Blood Pressure. Am J Hypertens. 2018 04 13; 31(5):532-533. PMID: 29272328; PMCID: PMC5905659.
      Citations:    Fields:    Translation:Humans
    17. Patel S, Hussain T. Role of AT2R (Angiotensin Type 2 Receptor) in Maintaining Sodium-Potassium Balance. Hypertension. 2018 04; 71(4):563-565. PMID: 29483226; PMCID: PMC5843541.
      Citations: 2     Fields:    
    18. Boini KM, Hussain T, Li PL, Koka S. Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction. Cell Physiol Biochem. 2017; 44(1):152-162. PMID: 29130962; PMCID: PMC5828122.
      Citations: 71     Fields:    Translation:AnimalsCells
    19. Patel SN, Ali Q, Samuel P, Steckelings UM, Hussain T. Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney. Hypertension. 2017 10; 70(4):831-838. PMID: 28827476; PMCID: PMC5599348.
      Citations: 19     Fields:    Translation:Animals
    20. Ali Q, Dhande I, Samuel P, Hussain T. Angiotensin type 2 receptor null mice express reduced levels of renal angiotensin II type 2 receptor/angiotensin (1-7)/Mas receptor and exhibit greater high-fat diet-induced kidney injury. J Renin Angiotensin Aldosterone Syst. 2016 Jul; 17(3). PMID: 27496559; PMCID: PMC5843939.
      Citations: 8     Fields:    Translation:Animals
    21. Patel SN, Ali Q, Hussain T. Angiotensin II Type 2-Receptor Agonist C21 Reduces Proteinuria and Oxidative Stress in Kidney of High-Salt-Fed Obese Zucker Rats. Hypertension. 2016 May; 67(5):906-15. PMID: 27021008; PMCID: PMC4833537.
      Citations: 15     Fields:    Translation:Animals
    22. Ali Q, Patel S, Hussain T. Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese Zucker rats. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1379-85. PMID: 25855512; PMCID: PMC4469886.
      Citations: 24     Fields:    Translation:Animals
    23. Nag S, Khan MA, Samuel P, Ali Q, Hussain T. Chronic angiotensin AT2R activation prevents high-fat diet-induced adiposity and obesity in female mice independent of estrogen. Metabolism. 2015 Jul; 64(7):814-25. PMID: 25869303; PMCID: PMC4437825.
      Citations: 11     Fields:    Translation:Animals
    24. Dhande I, Ma W, Hussain T. Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production. Hypertens Res. 2015 Jan; 38(1):21-9. PMID: 25209104; PMCID: PMC4898267.
      Citations: 32     Fields:    Translation:HumansCells
    25. Ali Q, Wu Y, Nag S, Hussain T. Estimation of angiotensin peptides in biological samples by LC/MS method. Anal Methods. 2014 Jan 21; 6(1):215-222. PMID: 24489613; PMCID: PMC3904384.
      Citations: 8     Fields:    
    26. Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013 Nov; 84(5):931-9. PMID: 23823602; PMCID: PMC4091804.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    27. Dhande I, Ali Q, Hussain T. Proximal tubule angiotensin AT2 receptors mediate an anti-inflammatory response via interleukin-10: role in renoprotection in obese rats. Hypertension. 2013 Jun; 61(6):1218-26. PMID: 23547236; PMCID: PMC3709839.
      Citations: 43     Fields:    Translation:HumansAnimals
    28. Samuel P, Khan MA, Nag S, Inagami T, Hussain T. Angiotensin AT(2) receptor contributes towards gender bias in weight gain. PLoS One. 2013; 8(1):e48425. PMID: 23341867; PMCID: PMC3546084.
      Citations: 14     Fields:    Translation:HumansAnimals
    29. Ali Q, Hussain T. AT2 receptor: Its role in obesity associated hypertension. Int J Clin Pharmacol Toxicol. 2012 Oct; 1(1):15-19. PMID: 27588222; PMCID: PMC5004927.
      Citations: 1     
    30. Asghar M, Tayebati SK, Lokhandwala MF, Hussain T. Potential dopamine-1 receptor stimulation in hypertension management. Curr Hypertens Rep. 2011 Aug; 13(4):294-302. PMID: 21633929.
      Citations: 20     Fields:    Translation:Humans
    31. Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F700-6. PMID: 21209001; PMCID: PMC3064141.
      Citations: 38     Fields:    Translation:Animals
    32. Sabuhi R, Asghar M, Hussain T. Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats. Am J Physiol Renal Physiol. 2010 Oct; 299(4):F815-20. PMID: 20668101; PMCID: PMC2957256.
      Citations: 13     Fields:    Translation:Animals
    33. Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Thomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T, Cooper ME, Forbes JM. Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Diabetologia. 2010 Nov; 53(11):2442-51. PMID: 20631980; PMCID: PMC4926314.
      Citations: 30     Fields:    Translation:HumansAnimals
    34. Ali Q, Sabuhi R, Hussain T. High glucose up-regulates angiotensin II subtype 2 receptors via interferon regulatory factor-1 in proximal tubule epithelial cells. Mol Cell Biochem. 2010 Nov; 344(1-2):65-71. PMID: 20596758; PMCID: PMC3912838.
      Citations: 11     Fields:    Translation:AnimalsCells
    35. Siddiqui AH, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009 Feb; 53(2):256-61. PMID: 19114640; PMCID: PMC2746398.
      Citations: 22     Fields:    Translation:Animals
    36. Siddiqui AH, Hussain T. Impaired angiotensin II AT(1) receptor function and enhanced Na, K-ATPase affinity for sodium in proximal tubule of streptozotocin-treated diabetic rats. Clin Exp Hypertens. 2007 Oct; 29(7):435-44. PMID: 17994353.
      Citations: 2     Fields:    Translation:AnimalsCells
    37. Shahid G, Hussain T. GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. J Biol Chem. 2007 Jul 13; 282(28):20612-20. PMID: 17517892.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Siddiqui AH, Hussain T. Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1722-7. PMID: 17142345.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Hakam AC, Hussain T. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats. Hypertension. 2006 Jun; 47(6):1117-24. PMID: 16618840.
      Citations: 23     Fields:    Translation:AnimalsCells
    40. Hakam AC, Hussain T. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1430-6. PMID: 16380464.
      Citations: 38     Fields:    Translation:Animals
    41. Hakam AC, Siddiqui AH, Hussain T. Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol. 2006 Feb; 290(2):F503-8. PMID: 16204414.
      Citations: 27     Fields:    Translation:Animals
    42. Banday AA, Siddiqui AH, Menezes MM, Hussain T. Insulin treatment enhances AT1 receptor function in OK cells. Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1213-9. PMID: 15713908.
      Citations: 8     Fields:    Translation:AnimalsCells
    43. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension. 2005 Feb; 45(2):270-5. PMID: 15596573.
      Citations: 35     Fields:    Translation:AnimalsCells
    44. Banday AA, Hussain T, Lokhandwala MF. Renal dopamine D(1) receptor dysfunction is acquired and not inherited in obese Zucker rats. Am J Physiol Renal Physiol. 2004 Jul; 287(1):F109-16. PMID: 15068975.
      Citations: 10     Fields:    Translation:Animals
    45. Hussain T. Renal angiotensin II receptors, hyperinsulinemia, and obesity. Clin Exp Hypertens. 2003 Oct; 25(7):395-403. PMID: 14596364.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    46. Asghar M, Hussain T, Lokhandwala MF. Overexpression of PKC-betaI and -delta contributes to higher PKC activity in the proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1100-7. PMID: 12904329.
      Citations: 7     Fields:    Translation:Animals
    47. Banday AA, Asghar M, Hussain T, Lokhandwala MF. Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin. Hypertension. 2003 Jun; 41(6):1353-8. PMID: 12707290.
      Citations: 15     Fields:    Translation:AnimalsCells
    48. Hussain T, Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med (Maywood). 2003 Feb; 228(2):134-42. PMID: 12563019.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    49. Becker M, Umrani D, Lokhandwala MF, Hussain T. Increased renal angiotensin II AT1 receptor function in obese Zucker rat. Clin Exp Hypertens. 2003 Jan; 25(1):35-47. PMID: 12597523.
      Citations: 14     Fields:    Translation:Animals
    50. Umrani DN, Banday AA, Hussain T, Lokhandwala MF. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension. 2002 Dec; 40(6):880-5. PMID: 12468573.
      Citations: 13     Fields:    Translation:AnimalsCells
    51. Asghar M, Hussain T, Lokhandwala MF. Higher basal serine phosphorylation of D1A receptors in proximal tubules of old Fischer 344 rats. Am J Physiol Renal Physiol. 2002 Aug; 283(2):F350-5. PMID: 12110520.
      Citations: 9     Fields:    Translation:AnimalsCells
    52. Narkar VA, Hussain T, Lokhandwala MF. Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney. Am J Physiol Renal Physiol. 2002 Dec; 283(6):F1290-5. PMID: 12388408.
      Citations: 4     Fields:    Translation:AnimalsCells
    53. Lucas-Teixeira VA, Hussain T, Soares-da-Silva P, Lokhandwala MF, Serr?o P. Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake. Clin Exp Hypertens. 2002 Jul; 24(5):383-96. PMID: 12109778.
      Citations: 3     Fields:    Translation:AnimalsCells
    54. Narkar V, Hussain T, Lokhandwala M. Role of tyrosine kinase and p44/42 MAPK in D(2)-like receptor-mediated stimulation of Na(+), K(+)-ATPase in kidney. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F697-702. PMID: 11880331.
      Citations: 10     Fields:    Translation:AnimalsCells
    55. Vieira-Coelho MA, Hussain T, Lokhandwala MF, Soares-da-Silva P, Serr?o P. Salt intake and intestinal dopaminergic activity in adult and old Fischer 344 rats. Life Sci. 2001 Sep 14; 69(17):1957-68. PMID: 11589511.
      Citations: 1     Fields:    Translation:Animals
    56. Narkar VA, Hussain T, Pedemonte C, Lokhandwala MF. Dopamine D(2) receptor activation causes mitogenesis via p44/42 mitogen-activated protein kinase in opossum kidney cells. J Am Soc Nephrol. 2001 Sep; 12(9):1844-1852. PMID: 11518777.
      Citations: 8     Fields:    Translation:AnimalsCells
    57. Asghar M, Kansra V, Hussain T, Lokhandwala MF. Hyperphosphorylation of Na-pump contributes to defective renal dopamine response in old rats. J Am Soc Nephrol. 2001 Feb; 12(2):226-232. PMID: 11158212.
      Citations: 7     Fields:    Translation:AnimalsCells
    58. Hogan YH, Florent G, Hussain T, Alkadhi KA. Cyclic AMP antagonizes adenosine-induced inhibition of ganglionic transmission. Brain Res. 1998 Mar 23; 787(2):242-7. PMID: 9518635.
      Citations: 1     Fields:    Translation:AnimalsCells
    59. Hasan A, Hussain T, Mustafa SJ, Srivastava PC. 2-substituted thioadenine nucleoside and nucleotide analogues: synthesis and receptor subtype binding affinities (1). Bioconjug Chem. 1994 Jul-Aug; 5(4):364-9. PMID: 7948104.
      Citations:    Fields:    Translation:AnimalsCells
    60. Shukla GS, Hussain T, Srivastava RS, Chandra SV. Glutathione peroxidase and catalase in liver, kidney, testis and brain regions of rats following cadmium exposure and subsequent withdrawal. Ind Health. 1989; 27(2):59-69. PMID: 2745162.
      Citations: 11     Fields:    Translation:Animals
    61. Shukla GS, Hussain T, Chandra SV. Protective effect of vitamin E on cadmium-induced alterations in lipofuscin and superoxide dismutase in rat brain regions. Pharmacol Toxicol. 1988 Oct; 63(4):305-6. PMID: 3194351.
      Citations: 1     Fields:    Translation:Animals
    62. Shukla GS, Hussain T, Chandra SV. Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats. Life Sci. 1987 Nov 09; 41(19):2215-21. PMID: 3669920.
      Citations: 15     Fields:    Translation:Animals
    63. Hussain T, Ali MM, Chandra SV. The combined effect of Pb2+ and Mn2+ on monoamine uptake and Na+, K+-ATPase in striatal synaptosomes. J Appl Toxicol. 1987 Aug; 7(4):277-80. PMID: 3040846.
      Citations: 2     Fields:    Translation:AnimalsCells
    64. Hussain T, Shukla GS, Chandra SV. Effects of cadmium on superoxide dismutase and lipid peroxidation in liver and kidney of growing rats: in vivo and in vitro studies. Pharmacol Toxicol. 1987 May; 60(5):355-8. PMID: 3615346.
      Citations: 28     Fields:    Translation:AnimalsCells
    65. Saxena DK, Hussain T, Lal B, Chandra SV. Lead induced testicular dysfunction in weaned rats. Ind Health. 1986; 24(2):105-9. PMID: 3759508.
      Citations: 3     Fields:    Translation:Animals
    66. Chandra SV, Kalia K, Hussain T. Biogenic amines and some metals in brain of cadmium-exposed diabetic rats. J Appl Toxicol. 1985 Dec; 5(6):378-81. PMID: 4078219.
      Citations: 3     Fields:    Translation:Animals
    67. Bansal SK, Husain T, Murthy RC, Chandra SV. The effect of substrate and potassium on the inhibitory kinetics of MnCl2 on the enzyme K+-p-nitrophenyl phosphatase in rat brain. J Appl Toxicol. 1985 Feb; 5(1):35-8. PMID: 2985681.
      Citations:    Fields:    Translation:Animals
    68. Hussain T, Ali MM, Chandra SV. Effect of cadmium exposure on lipids, lipid peroxidation and metal distribution in rat brain regions. Ind Health. 1985; 23(3):199-205. PMID: 4066414.
      Citations: 2     Fields:    Translation:Animals
    69. Chandra SV, Murthy RC, Husain T, Bansal SK. Effect of interaction of heavy metals on (Na+ -K+) ATPase and the uptake of 3H-DA and 3H-NA in rat brain synaptosomes. Acta Pharmacol Toxicol (Copenh). 1984 Mar; 54(3):210-3. PMID: 6326468.
      Citations: 5     Fields:    Translation:AnimalsCells
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