"Genistein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
| Descriptor ID |
D019833
|
| MeSH Number(s) |
D03.383.663.283.266.450.400.375 D03.633.100.150.266.450.400.375
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Genistein".
Below are MeSH descriptors whose meaning is more specific than "Genistein".
This graph shows the total number of publications written about "Genistein" by people in this website by year, and whether "Genistein" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 0 | 2 |
| 2004 | 2 | 2 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 3 | 0 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 5 | 1 | 6 |
| 2014 | 1 | 2 | 3 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genistein" by people in Profiles.
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Clinical candidate and genistein analogue AXP107-11 has chemoenhancing functions in pancreatic adenocarcinoma through G protein-coupled estrogen receptor signaling. Cancer Med. 2019 12; 8(18):7705-7719.
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Genistein Prevents Development of Spontaneous Ovarian Cancer and Inhibits Tumor Growth in Hen Model. Cancer Prev Res (Phila). 2019 03; 12(3):135-146.
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Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates. Bioorg Med Chem. 2018 05 01; 26(8):1481-1487.
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Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein. Nutr Cancer. 2016; 68(1):154-64.
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Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010017.
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Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial. JAMA. 2015 May 26; 313(20):2033-43.
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Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death Dis. 2014 Nov 06; 5:e1509.
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Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells. Anticancer Res. 2014 Sep; 34(9):4685-92.
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Soy promotes juvenile granulosa cell tumor development in mice and in the human granulosa cell tumor-derived COV434 cell line. Biol Reprod. 2014 Oct; 91(4):100.
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Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014 May 27; 29(4):437-53.